Articles tagged with Myocardial Infarction
Researchers from Leicester and Cambridge discovered genetic markers that identify people at risk of developing potentially fatal blood clots. This breakthrough advances ways of detecting and treating coronary heart disease, a leading cause of premature death.
Researchers at Duke University Medical Center discovered a stem cell secreted protein that improves heart muscle repair after a heart attack. The protein, sfrp2, reduces collagen layering and prevents heart failure in study rats.
A Johns Hopkins study of 950 healthy men and women found that nearly 95% of heart attacks, strokes, or heart-related deaths occurred in those with measurable artery-hardening calcium buildup; healthy individuals without calcification had minimal coronary protection. Statin therapy should only be considered for those at greatest risk.
Researchers at the University of Cincinnati have identified a protein called HAX-1 that protects cardiac cells and muscle from damage during ischemia-reperfusion injury. The study found that HAX-1 levels were reduced in hearts after heart attack, but overproduction improved contractile performance and decreased cell death.
Researchers tested genetic variations in 1,262 people with no history of heart disease and found that genetic scores can modify the estimated risk of heart attack. The study suggests that genetic screening may be most valuable for individuals thought to be at intermediate risk using current models.
A new study suggests that fat-derived stem cells can safely improve heart function after a heart attack by reducing damaged tissue, increasing blood flow, and boosting the heart's pumping ability. The treatment was found to be effective in patients with severe heart attacks, but further research is needed to confirm its efficacy.
Researchers found that injecting a platelet inhibitor directly into the heart through a coronary artery may restore blood flow more effectively than conventional administration after a severe heart attack. In contrast, erythropoietin did not reduce heart damage but may increase it in patients over 70 years old. Additionally, measuring ...
Researchers at Mayo Clinic have shown that iron buildup is prevalent in unstable coronary artery plaque, making it a potential marker for risk of myocardial infarction and sudden death. Non-invasive imaging techniques, such as micro-CT scans, may soon be able to detect these plaques, allowing for earlier intervention.
Despite a high frequency of cardiac risk factors, many patients presenting with acute heart attacks are not on primary prevention medications. The study found that nearly 400,000 patients present annually with ST-elevated myocardial infarction (STEMI) in the US, highlighting the need for improved preventive care.
Researchers at the University of Cincinnati have developed a stem cell-infused patch that promotes cell migration to damaged cardiac tissue following a heart attack, resulting in improved function. The patch combines cardiomyocytes, endothelial cells, and embryonic fibroblasts to enhance regeneration of heart tissues.
Recently bereaved individuals experience elevated heart rates and potentially harmful heart rhythm changes, increasing the risk of heart attack and sudden cardiac death. These effects tend to normalize within six months.
A study presented at the American Heart Association's Scientific Sessions found that light to moderate drinking among male coronary artery bypass patients was associated with 25% fewer subsequent cardiovascular procedures and death compared to non-drinkers. However, heavy drinkers were twice as likely to have subsequent cardiovascular ...
Research found that women with high job strain have a 40% increased risk of cardiovascular disease, including heart attacks and the need for procedures to open blocked arteries. Job insecurity was also associated with risk factors for cardiovascular disease such as high blood pressure, increased cholesterol, and excess body weight.
A computer-automated monitoring system identified a drug-releasing stent with significantly higher rates of major adverse cardiac events compared to similar stents. The study found that automated surveillance of clinical registries can efficiently identify emerging postmarket safety risks.
A recent study found that patients with non-STEMI heart attacks often experience long delays to hospital arrival, with a median delay time of 2.6 hours. Despite efforts to improve timely care, many patients still wait over two hours before seeking medical attention.
A study published in Archives of Internal Medicine found that door-to-balloon time has dropped dramatically for heart attack patients, from 113 minutes in 2003 to 76 minutes in 2008. However, despite the quicker hospital care, mortality rates remained unchanged at around 4%.
A review published in the Canadian Journal of Cardiology finds that consuming egg yolks can significantly increase cardiovascular risk for patients at risk of vascular disease. The researchers advise limiting dietary cholesterol to less than 200mg per day and recommend alternative protein sources like egg whites.
A study of nearly 2,000 patients who had been treated for a heart attack found that many were not receiving the correct dose of beta blockers. The majority of patients were taking less than 50% of the target dose, which can lead to increased risk of subsequent heart attacks.
A recent study found that newer treatments for age-related macular degeneration, including intravitreous bevacizumab and ranibizumab, do not significantly increase the risk of cardiovascular complications or death. The study analyzed data from 146,942 Medicare beneficiaries treated for AMD in 2005 or 2006.
A team of researchers at the University of Pennsylvania School Medicine discovered a three-way control mechanism for fetal heart cell proliferation. This finding could help cardiologists understand the natural repair process after heart attacks and develop new therapies to expand cardiac stem cells.
A recent study led by St. Michael's nephrologist Dr. Ramesh Prasad has found that South Asian patients are more than twice as likely to suffer a heart attack after a kidney transplant compared to Caucasian, black and East Asian men and women.
Researchers found that inhibiting GRK2 protects heart cells from destruction after a heart attack, while excess GRK2 leads to more damage. The discovery suggests that anti-GRK2 gene therapy may help prevent permanent heart damage.
A US clinical trial demonstrated the strong safety profile of bone marrow-derived mononuclear cells in patients after a severe heart attack. The study found improvements in left ventricular ejection fraction and volumes at six months, suggesting potential benefits for cell therapy trials.
New findings from a major drug trial have revealed that the platelet function in patients taking ticagrelor recovered much quicker after the drug is stopped, compared to clopidogrel. Additionally, ticagrelor has been shown to prevent 1 in 5 deaths after a heart attack, even in patients with adverse effects like breathlessness.
Researchers at UT Health Science Center San Antonio will study protein fragments released into the bloodstream following heart attacks to identify those who need more intensive treatment. The goal is to develop a blood test to diagnose which heart attack survivors are at risk of heart failure.
Researchers at the University of Western Ontario have discovered a link between chronic stress and heart attacks using hair cortisol levels as a biological marker. The study found that heart attack patients had higher cortisol levels in their hair samples compared to control group, suggesting chronic stress as a contributing factor.
A study of 45,227 patients with atherothrombosis found that hypertension, hypercholesterolemia, and diabetes increased the risk of future cardiovascular events. Polyvascular disease was also identified as a strong risk factor for ischemic events.
A new study in mice shows that social support can minimize physical damages to the brain caused by a heart attack. Socially isolated mice suffered more cell death, depressive symptoms, and inflammation than those living with a partner.
High-risk patients undergoing coronary procedures with elective IABP insertion did not experience improved rates of events or death. The study found more minor bleeding in the IABP group, but no significant difference in major bleeding or MACCE.
A new study published by the American Heart Association compares the risks of diabetes drugs rosiglitazone and pioglitazone, finding that patients taking either medication have a similar risk of heart attack, heart failure, or death. The study included over 36,000 patients and followed them for 33 months.
A study found that long-term cumulative mortality was highest among patients with system delays of 121-180 minutes, increasing by 28.1% and 30.8% respectively. System delay was independently associated with mortality in multivariate analysis.
A study published by the American Psychological Association found that people with insecure attachments in relationships may be at higher risk for cardiovascular problems. Those with anxious attachments were particularly associated with a range of health conditions, including chronic pain and cardiovascular diseases. The researchers al...
Researchers implanted genetically engineered stem cells with cytokines HGF, SDF-1, and VEGF to reduce organ damage and improve cardiac function after a heart attack. The results showed that two therapies - SDF-1 and Akt1 overproduction - limited cardiac damage.
Sepsis and septic shock are common complications in general surgery patients, with a death rate of approximately 34% within 30 days. The study identified risk factors for sepsis and septic shock, including age, emergency surgery, and co-occurring illness.
The Cedars-Sinai Heart Institute has received a $1.66 million grant to develop a measurement system predicting patient vulnerability to sudden cardiac arrest. The study aims to identify patients at high risk of sudden cardiac arrest by analyzing electrocardiogram data.
A recent analysis of a large clinical trial found no increased rate of heart attack or death in patients taking rosiglitazone, despite previous concerns. The study compared patients treated with rosiglitazone to those not receiving any thiazolidinedione drug, showing a lower combined rate of death, heart attack, and stroke.
A new meta-analysis of clinical trials finds that rosiglitazone is associated with a significantly increased risk of myocardial infarction, while the risk of cardiovascular death was not elevated. The study suggests an unfavorable benefit-to-risk ratio for the diabetes drug, raising concerns about its safety.
A study of 12,064 survivors of heart attack found that folic acid and vitamin B12 supplementation did not lower the risk of heart attack, coronary death, or stroke. The researchers also found that folic acid supplementation did not increase the risk of cancer.
A team of bioengineers from the University of Pennsylvania Institute for Medicine and Engineering developed a simulator to predict how blood platelets respond to various conditions during a heart attack or stroke. The model accurately predicted intracellular calcium signaling responses, even distinguishing between different donors.
The INTERSTROKE study found that high blood pressure, smoking, waist-to-hip ratio, diet, physical activity, lipids, diabetes mellitus, alcohol intake, stress, and depression are significantly associated with stroke. Collectively, these risk factors accounted for 90% of the global risk of stroke.
Researchers found that monocyte-derived cells can induce myocardial protection by reducing cardiac cell apoptosis and enhancing endothelial cell proliferation. The cells also secrete growth factors with anti-inflammatory properties, which help protect heart tissues from programmed cell death.
A study of 46,000 patients found that the age- and sex-adjusted incidence of heart attack increased from 274 per 100,000 in 1999 to 208 per 100,000 in 2008, then declined. The relative incidence of serious heart attacks that do permanent damage also decreased by 62%.
A large national clinical trial has shown that carotid artery surgery and stenting are equally effective in preventing stroke, with personalized treatment options available for individual patients. The study found excellent safety and long-term results for both symptomatic and asymptomatic patients.
A nationwide smoking ban could save over 18,596 fewer hospitalizations for heart attack after one year of implementation, resulting in more than $92 million in savings. The study found that implementing a comprehensive smoking ban could lead to a 12% drop in heart attack admissions and a 11% reduction in heart attack rates.
A nationwide smoking ban would lead to a significant reduction in heart attack hospitalizations, with 18,596 fewer admissions expected. The ban could also save over $92 million in direct healthcare costs.
Men experiencing impotence should undergo thorough medical assessments due to significant proportion exhibiting early signs of coronary artery disease. The authors suggest that the link between the two conditions could be due to atherosclerosis, leading to restricted blood flow.
A long-running study of over 10,000 civil servants in London found that working overtime was associated with a 60% higher risk of heart-related problems. The study, published in the European Heart Journal, controlled for various risk factors and suggested that chronic stress may be a key mechanism behind this association.
A recent study published in the Journal of the American Medical Association found that pneumococcal vaccination has no association with reduced risk of heart attacks or strokes. Researchers used electronic health records to follow 84,170 ethnically diverse California men for an average of five years.
A study by Kaiser Permanente found that pneumococcal vaccination was not associated with a reduced risk of acute heart attack and stroke in men aged 45-69. The study, which included over 84,000 participants, showed no significant difference in myocardial infarction or stroke events between vaccinated and unvaccinated individuals.
A randomized trial found that high-dose B-vitamin therapy accelerated kidney function decline and increased cardiovascular events in patients with type 1 or 2 diabetes. The study suggests that B-vitamin therapy may not be an effective treatment for slowing disease progression, and potentially poses risks for these patients.
A new Northwestern University Feinberg School of Medicine study found that combining coronary artery calcium score (CACS) with traditional risk factors for heart disease is a better method than using traditional predictors alone to predict future heart attacks. The CACS was key in classifying people in the most extreme categories, iden...
A new study reveals that individual fibrin fibers play a crucial role in equitably distributing strain load and strengthening the entire network. The research found that fibers subjected to significant strain stiffen to resist stretch, thereby reducing strain concentrations.
Researchers at OHSU have developed a blood test that can identify individuals at risk of heart attacks, including those with normal cholesterol levels. The test measures gamma-prime fibrinogen and has been shown to be effective in predicting coronary artery disease.
New research found that smoking can negate the protective effect of moderate drinking on stroke risk in a UK study of 22,524 people. Moderate drinking was defined as up to 21 units of alcohol per week.
Policies restricting smoking in public have been shown to decrease the number of people who experience heart attacks and improve overall health indicators. The findings are based on a comprehensive review of 50 studies that monitored the impact of legislative bans on secondhand smoke exposure.
A 10-year population-based study found significant declines in hospital admissions for heart attacks, angina, stroke, asthma, emphysema, pneumonia, and bronchitis after the implementation of smoke-free legislation in Toronto, Canada. The largest decline was observed after the 2001 ban on smoking in restaurants.
Researchers found that eating dark chocolate daily can lower blood pressure and reduce heart disease risk by 39% compared to those who eat less. Flavanols in cocoa may be responsible for this effect, improving nitric oxide bioavailability and reducing inflammation.
Researchers found that adding chymase inhibitors to ACE inhibitors significantly boosted recovery of heart function in animals after a heart attack. This could lead to improved treatments for people with high blood pressure, heart failure, and other conditions.
The WPI research team aims to develop powerful diagnostic tools that can predict the likelihood of plaque rupture, which is responsible for most heart attacks and strokes. The new NIH award will enable the team to extend their research on arterial plaque development and predict potential rupture.
A smoking ban in New Zealand led to a 9% decrease in heart attack admissions among men aged 55-74 who had never smoked. Heart attacks fell by an average of 5% for people aged 30 and over after the ban, with benefits seen among ex-smokers and those in affluent neighborhoods.