Articles tagged with Adenine
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A new study by researchers from Rice University has uncovered a mechanism by which the identity of nucleotides following a given nucleotide in DNA affects transcription accuracy. The discovery offers insight into hidden factors that influence transcription accuracy and may improve synthetic and therapeutic RNA.
Researchers developed a transformation process to boost H₂Sₙ yield from garlic-derived compounds, achieving significant H. pylori eradication outcomes. The use of chitosan-encapsulated microreactors demonstrated enhanced efficacy and faster eradication rates compared to conventional methods.
Researchers used CRISPR/Cas9 to study the gene function of adenine phosphoribosyl transferase in beans. They found two functional mutants with distinct roles: one affects adenine recycling and the other regulates cytokinins, essential for root growth and nodules.
The OSIRIS-REx mission returned a large sample from asteroid Bennu, which Japanese collaborators detected includes all five nucleobases required for life. The analysis revealed high concentrations of ammonia and nitrogen-rich organic matter.
Researchers create adenine base editor with 'on/off' switch, reducing off-target edits by over 70% and increasing accuracy of on-target edits. The tool has potential to correct nearly half of disease-causing point mutations in human genome.
Researchers found that urine levels of adenine are predictive and causative biomarkers of looming progressive kidney failure in patients with diabetes. An oral therapeutic drug showed promise in mice by reducing kidney adenine levels and protecting against diabetic kidney disease.
Researchers from Institut Pasteur and CNRS discover the biosynthesis pathway of 2-aminoadenine, a new base in DNA, using crystallography platform. The discovery increases coding bases in DNA, enabling synthetic genetic biopolymers.
Researchers have discovered the biosynthesis pathway of 2-aminoadenine, a new DNA nucleobase found in bacteriophage S-2L. The pathway was identified through a homolog of the known enzyme succinoadenylate synthase and indicates that new bases can be enzymatically incorporated into genetic material.
A team developed a novel approach to generate precisely controlled, helical palladium-DNA systems that mimic the organization of natural base pairs in double-stranded DNA molecules. The process is based on self-organized assembly of a special palladium complex and single-stranded DNA molecules.
A new experiment has characterised the properties of electrons emitted when adenine, a key DNA nucleobase, is bombarded with high-velocity ions. The study's findings could improve understanding of how radiation damage increases cancer risk in cells.
Scientists have synthesized a new MOF that mimics DNA's hydrogen-bonding interactions between adenine and thymine. The MOF successfully traps thymine molecules, allowing researchers to catalyze a chemical reaction and isolate di-thymine, related to skin cancer.
Researchers at IBS have identified the mistake-rate of DNA editing tools using CRISPR and adenine base editors. The study reveals that ABE7.10, a widely used gene engineering tool, has an average of 60 off-target mistakes in the human genome.
A team of Emory scientists has identified an enzyme that removes N6-methyladenine from Drosophila DNA, crucial for neuronal development. The finding provides insights into the role of this modification in humans, particularly in relation to Polycomb proteins.
Researchers at LMU discover how cellular respiration generates reactive oxygen species that can cause DNA mutations, leading to cell dysfunction and cancer. The study highlights the importance of improving treatment options for cancer by inhibiting DNA repair processes in tumor cells.
Researchers found significant variations in ionization energy along adenine's reaction pathways, challenging previous understanding and implications for spectroscopic measurements.
Scientists at Rice University have discovered that poly(dA) repeats behave differently when stretched, requiring less force to lengthen without additional effort. The findings raise more questions about the role these repeats play in gene regulation and genome packaging.
A team of chemists at the University of Georgia has proposed a mechanism for how adenine, a key component of DNA, might be formed from five cyanide molecules under terrestrial conditions. The research suggests that simple molecules can combine chemically to form the building blocks of life, offering a new answer to an unsolved puzzle.
University of Missouri-Columbia researcher Rainer Glaser presents a novel origin-of-life theory suggesting that essential molecule adenine originated from interstellar dust clouds. The presence of highly concentrated hydrogen cyanide (HCN) in these clouds could indicate the existence of adenine, which is crucial for life on Earth.
Researchers at Duke University have made direct measurements of DNA's forces within single strands that wind around each other to form the double helix. The study, published in Physical Review Letters, reveals new insights into the stacking and pairing forces between base units.
Scientists develop a technique to control DNA strand density on gold substrates using short adenine 'tails' as anchors. This allows for precise optimization of DNA sensor arrays by adjusting the spacing between strands.