Articles tagged with Cholesterol
A recent study discovered a gene variant that significantly increases the risk of developing gallstones, with affected individuals being two to three times more likely to develop the condition. The relevant gene contains instructions for building a molecular pump that transports cholesterol into bile ducts.
A recent study suggests that people with high cholesterol levels may be more susceptible to severe cases of tick-borne disease. The study found that bacteria levels were 10 times greater in mice with high cholesterol, indicating a potential link between cholesterol and disease severity.
A study found that older patients with stable cardiovascular disease can benefit from high-dose statins, which lowered LDL cholesterol levels and reduced the risk of major cardiovascular events. The study suggests that aggressive use of high-dose statin therapy can be beneficial for these patients.
A study by the American Academy of Neurology found that more women than men experience a mid-life stroke between the ages of 45-54. The researchers identified increased waist size and coronary artery disease as predictors of stroke among women in this age group, with no sex differences observed in other age groups.
New data from the University of New Hampshire reveals that at least one-third of college students are overweight or obese. Additionally, a significant number of students have high blood pressure and are not meeting their nutritional needs for iron, calcium, or folate.
Scientists discovered that ezetimibe targets NPC1L1 protein in both the intestine and liver, lowering cholesterol levels by blocking absorption. This dual action may increase the risk of gallstones, highlighting the need for further research.
A daily dose of pistachios may improve risk factors for heart disease without weight gain, according to a study published in the Journal of the American College of Nutrition. The pistachio diet led to statistically significant reductions in certain blood lipids and an increase in HDL-C.
A new University of Michigan study shows that pill-splitting, slicing high-dose pills in half, can save Americans thousands of dollars on prescription drugs. Most participants said they would continue splitting pills if given a 50%-co-pay reduction, but some reported no issues with the practice.
Researchers have found a link between low HDL cholesterol and heart disease, suggesting that defective ABCA1 protein may play a role. Additionally, studies have shown that type 2 diabetes patients accumulate high levels of triglyceride-rich lipoprotein in the blood, which can contribute to heart disease.
Substituting soy nuts for protein sources improves blood pressure and cholesterol levels in postmenopausal women. The study found significant reductions in systolic and diastolic blood pressure, as well as decreased 'bad' cholesterol levels, in women with high blood pressure.
A meta-analysis of 25 studies found that regular exercise increases high-density lipoprotein (HDL) cholesterol levels by an average of 2.53 milligrams per deciliter, corresponding to a 5-7% reduced risk of cardiovascular disease.
A low-glycemic load diet was found to promote greater weight loss and improvements in HDL cholesterol and triglyceride concentrations among obese individuals with high insulin secretion patterns. However, no significant differences were observed between the two diets for those with normal insulin secretion.
A study by the American Heart Association found that women are less likely than men to have their LDL cholesterol controlled, with a notable 10% gender gap. The study analyzed data from commercial and Medicare managed care plans and showed equal or better outcomes for women in most dimensions of care, except for cholesterol control.
A three-year study found that patients with bleeding strokes received significantly less cholesterol-lowering medications, diabetes medication, and weight-loss management compared to those with ischemic strokes. Smoking cessation therapy also showed significant disparity between the two groups.
A study in mice deleted an enzyme that alters cholesterol structure, allowing them to consume saturated and trans fats without developing atherosclerosis. The findings suggest ACAT2 as a potential treatment target for protecting against heart disease.
Researchers found that diets high in fish, seafood, and grains reduce the risk of heart disease. Cholesterol buildup in lysosomes may contribute to heart disease, and restoring acidity could help clear arteries. A new link between Down Syndrome and Alzheimer's Disease was also discovered through cholesterol metabolism.
A study by the American Academy of Neurology found that cholesterol-lowering drugs, such as atorvastatin, reduced the risk of stroke by 4% for every 10% decrease in LDL 'bad' cholesterol. The study also showed a 7% reduction in heart attack risk. Participants with higher HDL 'good' cholesterol levels had an added protection against str...
A study by Penn State researchers found that incorporating macadamia nuts into a heart-healthy diet can reduce total cholesterol, low-density lipoprotein cholesterol and triglyceride levels. The Healthy Heart diet with macadamia nuts was compared to a standard American diet in a controlled feeding study.
Researchers found that pistachio amounts of 1.5 ounces reduced LDL cholesterol levels by 11.6% and total cholesterol by 8.4%, while the higher dose showed significant reductions in lipoprotein ratios. Pistachios also increased antioxidants in the blood, which may help reduce inflammation.
Researchers found that rats fed tart cherries had lower cholesterol, blood sugar, fat storage in the liver, oxidative stress, and improved fat handling. The study suggests a potential benefit from anthocyanin-rich foods like tart cherries for heart disease and diabetes prevention.
The Journal of Biological Chemistry published several studies revealing new insights into cholesterol metabolism without oxygen, a compound effective against blood cancer, bacteria's quorum sensing mechanism, and HIV infection. These discoveries could lead to the development of new pharmaceuticals and treatments for related diseases.
Researchers at the University of Alberta found a connection between high insulin levels and impaired intestinal lipid metabolism in an animal model, supporting the role of intestinal metabolic dysfunction in cardiovascular disease. Excessive insulin slows chylomicron removal from the bloodstream, leading to blockages and heart problems.
Research suggests a possible association between childhood obesity and otitis media with effusion, characterized by fluid buildup in the middle ear space. The study found higher body mass index (BMI) and total cholesterol levels among children with otitis media with effusion compared to those without the condition.
The study found an unexpected link between the immune system and elevated lipids in mice, suggesting a potential new avenue for studying coronary heart disease. The researchers discovered that altering T cell expression levels significantly impacted cholesterol and triglyceride levels.
The program, which teaches healthy habits and offers hope for a healthier future, has been successful in lowering diastolic blood pressure, total cholesterol, and LDL cholesterol levels among participants. With a significant drop in systolic blood pressures and blood glucose levels, the program aims to fight childhood obesity.
A recent study published in The Lancet found that eicosapentaenoic acid (EPA) supplementation reduced major coronary events by 19% in Japanese hypercholesterolaemic patients taking statins. This significant reduction also translated to a lower incidence of non-fatal myocardial infarction, unstable angina, and coronary revascularisation.
Scientists have identified a potential new approach to raising HDL cholesterol levels, using a previously tested B-vitamin called niacin. The goal is to develop drugs with improved efficacy and tolerability compared to current statins.
A new synthetic molecule has been developed to deliver an imaging enhancer to cholesterol-filled cells, improving detection by 79 percent. The technique allows physicians to diagnose unstable plaques and identify high-risk patients for early treatment.
Researchers found that reconstituted HDL infusion reduced atheroma volume by 3.4% and 5.3 mm³ compared to placebo, but the differences were not statistically significant. The study suggests potential favorable vascular effects of CSL-111 on coronary atherosclerosis.
Researchers found that combining torcetrapib with atorvastatin did not slow the progression of atherosclerosis, contrary to expectations. The study also noted significant increases in HDL-C and decreases in LDL-C levels.
A study by the American College of Cardiology found that torcetrapib increased good cholesterol levels but failed to slow plaque buildup in coronary arteries. The drug also raised blood pressure, leading researchers to question its efficacy as a treatment for cardiovascular disease.
The study found that Crestor arrested the progression of thickened carotid arteries in participants with moderately elevated cholesterol levels. The therapy also lowered low-density lipoprotein and increased high-density lipoprotein, as well as reduced triglycerides.
Researchers tested a new cholesterol treatment LY518674 (LY5) in two studies, but found it showed no benefits compared to fenofibrate. Both drugs raised safety concerns, particularly for kidney function.
The study found that the novel PPAR-alpha agonist LY518674 decreased triglycerides and increased HDL-C levels, but also raised safety concerns such as increased serum creatinine levels and cardiovascular toxicity. The results were generally similar to those of existing drugs like fenofibrate.
A study by Rutgers University and the US Department of Agriculture found that pterostilbene, a potent antioxidant in blueberries, reduced pre-cancerous lesions in rats with colon cancer by 57%. The compound also inhibited inflammation and cell proliferation.
Researchers at Duke University Medical Center found that adding cholesterol to zebrafish embryos exposed to small amounts of alcohol restored normal development. Fetal alcohol syndrome affects the nervous and cardiovascular systems, leading to growth retardation, facial abnormalities, and lowered mental functioning.
Research tracked over 3,000 participants from birth to age 53 and found that rapid height gain before 2 and after 15 lowered 'bad' cholesterol. Higher body fat and weight gain were associated with higher total cholesterol levels.
A study of 1,040 stroke patients found that 27% had cholesterol levels higher than recommended by national guidelines. Despite this, only 7% were at their ideal level for preventing future strokes and heart disease, emphasizing the importance of regular testing and treatment.
The Stanford University School of Medicine conducted a six-month study on the effects of garlic on cholesterol levels. Despite decades of conflicting studies, the researchers found that consuming raw garlic or two popular supplements did not lower LDL cholesterol levels among adults with moderately high cholesterol levels.
The Natural Fat-Loss Pharmacy highlights safe and effective supplements like HCA, MCT, green tea extract, and chromium that can aid in weight loss. Dr. Preuss separates the good from the bad and lists natural weight-loss aids available on the market.
A six-month study found that three forms of garlic, including raw and commercial supplements, did not significantly reduce low-density lipoprotein (LDL) cholesterol in adults. The results suggest that garlic may have other beneficial health effects, but its ability to lower LDL cholesterol is uncertain.
A diet rich in black soya beans could help control weight, lower fat and cholesterol levels, and aid in the prevention of diabetes. The soya protein may be having an effect on fat metabolism in the liver and adipose tissue, reducing synthesis of new fatty acids and cholesterol.
Scientists identified a variant of apolipoprotein C1 protein associated with higher body mass index, obesity, and Type 2 diabetes in American Indians and Mexicans. This discovery can help identify risk factors for diabetes and inform diet and lifestyle choices.
Researchers discovered Dap1, which controls the activity of enzymes involved in cholesterol synthesis and drug metabolism. The study found that genetic variations in Dap1 may influence how people react to certain drugs.
A large study of over 27,000 women found that those with high cholesterol were more than twice as likely to suffer a stroke compared to healthy women with lower cholesterol levels. The research suggests that avoiding unfavorable cholesterol levels may help prevent stroke.
Clinical trials show statin therapy promotes regression of coronary atherosclerosis through significant reductions in LDL-C and increases in HDL-C. Patients experiencing substantial decreases in LDL-C (<87.5 mg/dL) and percentage increases in HDL-C (>7.5%) exhibit notable atheroma regression.
Researchers at Université Laval found that taking calcium and vitamin D supplements while on a low-calorie diet reduces the risk of cardiovascular disease. The study, which lasted 15 weeks, showed significant drops in LDL cholesterol and increases in HDL cholesterol.
Researchers have created a virtual human metabolic network that allows them to quickly discover the effects of changing metabolic reactions on cell behavior. The tool can be used to study hundreds of human disorders and potentially tailor diets for weight control, as well as develop new cholesterol-lowering drugs.
A study found that switching patients to more affordable cholesterol and blood pressure medications saved the UK's National Health Service £26,000 annually. The switch was made without adverse events and was successful for the majority of patients.
A new study conducted at Brandeis University and Malaysia found that a modified fat replacing trans fat causes an increase in blood glucose levels and depresses insulin in humans. The researchers discovered that this interesterified fat had a similar impact on cholesterol levels as trans fat, but with weaker effects.
Researchers at Penn School of Medicine have shown a 51% reduction in low-density lipoprotein (LDL) cholesterol levels in patients with homozygous familial hypercholesterolemia. The new therapy, which targets the microsomal triglyceride transfer protein, also decreased total cholesterol and triglyceride levels.
A gene variant linked to exceptional longevity also helps maintain clear thinking and memory in centenarians, according to a new study published in Neurology. Researchers found that individuals with the CETP VV gene were twice as likely to have good brain function compared to those without it.
The trans fat ban in New York City is a step in the right direction, but restaurateurs need to replace partially hydrogenated fat with unsaturated fat. The regulation also requires restaurants to provide calorie information prominently, which may be even more important for addressing obesity and promoting heart health.
A study by Dr. Xuemei Huang found that participants with lower LDL cholesterol had a 3.5-fold higher occurrence of Parkinson's disease compared to those with higher LDL levels. The results suggest a link between low LDL cholesterol and an increased risk of developing the neurodegenerative disorder.
Researchers at Mayo Clinic have discovered a protein interaction that may explain how Huntington's disease affects the brain, leading to dramatic accumulation of cholesterol.
Studies found that eating fish regularly reduces the risk of colorectal cancer by 40%, while childhood soy intake is associated with a 58% decrease in breast cancer risk. Vitamin use and smoking also show protective effects, providing valuable insights into diet's role in cancer prevention.
A new study indicates that boosted Invirase results in comparable levels of viral suppression as lopinavir, while also reducing the risk of elevated cholesterol and triglycerides. The treatment also showed fewer gastrointestinal adverse events compared to lopinavir.
A recent study found that Hodgkin's lymphoma survivors who undergo lipid screening every five years live six months longer than those without screening. The study suggests that regular cholesterol screening is a cost-effective procedure to reduce the risk of heart disease in these patients.
Researchers found that universal-free school breakfast increases the likelihood of nutritionally sound breakfast consumption in children. Additionally, flavanol-enriched snack bars with plant sterols may help manage cholesterol levels.
A recent study from Brown Medical School and Harvard Medical School found significant racial disparities in Medicare managed care plans, even among high-performing plans. Blacks were more likely to have poor control of cholesterol, blood pressure, and blood sugar levels compared to whites.