Articles tagged with Cholesterol
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Researchers have solved a 72-year-old mystery surrounding cholesterol production, revealing that Insig proteins play a crucial role in regulating this process. The study found that mice lacking these proteins accumulate excessive cholesterol and fat in the liver, highlighting the importance of Insig in maintaining normal lipid metabolism.
Researchers have solved the mystery of the Shoenheimer effect, a 72-year-old cholesterol feedback mechanism. The study reveals that Insig proteins are essential components of this response and play a crucial role in regulating cholesterol synthesis.
Research reveals that aspirin resistance is a significant concern for certain patient groups, particularly those with coronary heart disease or high cholesterol levels. An alternative treatment option, Clopidogrel, has shown promise in reducing blood clotting and inflammation in these patients.
Researchers discover hemoglobin's novel function as a nitrite reductase, generating nitric oxide to regulate vasodilation. Separate studies reveal that M cells are not necessary for oral tolerance induction, while bacterial infections can break B cell tolerance by activating self-reactive B cells.
Researchers analyzed identical male twin pairs with differing lifestyles to study the impact of diet and exercise on LDL cholesterol. The study found a strong correlation between twins' responses to diet changes, highlighting the importance of genes in determining individual responses to dietary fat.
A new gene scanning technique called meltMADGE enables the discovery of rare genetic variations associated with various diseases. Researchers analyzed nearly 10,000 middle-aged individuals and found associations with high cholesterol levels and potential protective effects.
A new Penn State study found that a balanced diet with both polyunsaturated fatty acids (PUFAs) and monounsaturated fatty acids (MUFAs) is essential for lowering cholesterol levels. The study compared two heart-healthy oils, sunflower oil and olive oil, in a diet designed to reduce blood cholesterol.
A study on smokers and non-smokers found that it takes several years for changes in the blood to return to normal after smoking. After quitting, the inflammatory response had returned to normal by five years, highlighting the importance of quitting smoking. This finding emphasizes the health benefits of smoking cessation.
A recent study published in the Journal of Nutrition found that individuals with elevated C-reactive protein (CRP) levels cannot lower their LDL-cholesterol numbers with a Step 1 diet, even when soy protein is added. The study suggests that habitual consumption of a Step 1 diet may be beneficial for those with low CRP levels but delete...
A new study demonstrated add-on effects of ACTOS on diabetic dyslipidemia, reducing triglycerides and increasing HDL cholesterol. Patients with type 2 diabetes who switched from Avandia to ACTOS showed significant improvements in lipid levels, regardless of age or gender.
Researchers found that soy-based meal replacements led to greater weight loss and improved cholesterol levels compared to milk-based alternatives. Additionally, soy intake was shown to reduce serum glucose values, suggesting a role in maintaining overall health and slowing diabetes development.
A new study by the NHLBI found that children in an intervention group consumed more than 67% of their calories from heart-healthy foods, compared to less than 57% for those in a usual care group. Children who consumed more dairy products had lower BMIs and lower LDL levels.
A study examined the prevalence of metabolic syndrome in heart attack patients and found that 46% met the criteria. Patients with metabolic syndrome were older, more likely to be women, and had worse in-hospital outcomes, including increased risk of heart failure.
A concentrated form of Vitamin E called tocotrienol rich fraction (TRF) from rice bran oil may effectively reduce total cholesterol levels by up to 42% and LDL or 'bad' cholesterol levels by 62%. Researchers found that a minimum dose of TRF of 8 IU kg/day provided the maximum antioxidants and lowered cholesterol.
Researchers found that increased LXR expression in the liver improves cholesterol and triglyceride levels on high-fat diets, but loses effect with experimental drugs. The study suggests that targeting natural ligands may be more effective in treating metabolic diseases.
A new study reveals that mice with an excess of liver X receptor (LXRa) are protected from high-fat diet-induced cholesterol and blood vessel plaques. The findings suggest that natural variation in LXRa levels can influence susceptibility to heart disease, depending on diet.
A new study published in Cell Metabolism found that normal metabolism requires so-called "new" fat to maintain glucose, lipid, and cholesterol homeostasis. The researchers discovered that old fat stores alone failed to set critical metabolic pathways in motion, leading to a marked decline in gene activity.
A small-scale trial of atorvastatin calcium found significant reductions in circulating cholesterol levels and potential benefits on cognitive function and behavior in patients with mild to moderate Alzheimer's disease. The results hold promise for the treatment of AD, but further multicenter trials are needed to confirm these findings.
The study finds that major cardiovascular risk factors, such as obesity and high blood pressure, are increasing in low-income and middle-income countries, particularly in cities. As a result, these countries will face high levels of cardiovascular disease alongside infectious diseases.
Exercise therapy has a small beneficial effect on chronic low back pain but no impact on shorter-term pain, according to two new studies. A plant-based low-fat diet is also better at lowering LDL cholesterol levels than a similar diet without veggies.
A Stanford study compared two low-fat diets: one focused on avoiding saturated fat and cholesterol, the other including plenty of plant-based foods. The plant-based diet resulted in a significant 9.4% decrease in LDL cholesterol, while the conventional diet lowered it by 4.6%.
Researchers found that a fiber supplement significantly decreased LDL and increased HDL cholesterol levels in people with type 2 diabetes. The study suggests an alternative treatment option for those unable or unwilling to take statins.
A new study suggests that eliminating the enzyme ACAT2 could dramatically reduce cardiovascular disease risk. Research in animals shows that cholesterol altered by ACAT2 is more likely to build up in blood vessel walls and cause atherosclerosis.
Researchers discovered that LXRs regulate SREBP-1c, a key protein in fat metabolism, allowing animals to store fat when fed high-fat diets with cholesterol. The study also found that LXR's role is crucial in the biochemical pathway that regulates fat storage, suggesting a new target for obesity and heart disease treatments.
Researchers at Wake Forest University School of Medicine have found that the liver is the main source of high-density lipoprotein (HDL), or 'good' cholesterol. This discovery could lead to new treatments for raising HDL levels, particularly in individuals with less severe cholesterol disorders.
Researchers found that simvastatin prevents or reverses vascular injury by vasoprotective means, protecting against diabetes-induced endothelial cell dysfunction. The study suggests a potential role for statins in treating diabetic patients.
Researchers at UT Southwestern Medical Center found that deleting the Pcsk9 gene in mice increased LDL receptors and lowered LDL cholesterol levels. This discovery suggests new drugs targeting PCSK9 may be effective in lowering LDL cholesterol levels, particularly for individuals unable to take statins.
Researchers found that a gene controlling cholesterol production also senses oxygen levels, similar to human cells. This discovery offers a new strategy for killing infectious yeast while exploring potential connections between cholesterol and oxygen sensing in humans.
A study published in the Journal of Clinical Investigation reveals that HDL (high-density lipoprotein) activates an enzyme called eNOS, leading to a cellular signal that depends on cholesterol efflux. The activation of eNOS is mediated by two intact domains of SR-BI, which act as 'cholesterol sensors' triggering cellular events.
A Boston University team found an association between naturally high levels of blood cholesterol and improved mental functioning, including visual organization, memory, attention, and concentration. However, the benefits were modest and did not outweigh the risks of heart disease and stroke associated with high cholesterol.
Researchers at Boston Children's Hospital found that high cholesterol levels accelerate prostate cancer growth by activating a cell-survival pathway. Cholesterol-lowering drugs like simvastatin may inhibit tumor growth by inhibiting this pathway.
Researchers developed a new mouse model that mimics the effects of low-dose aspirin therapy, exploring its impact on blood clotting and reproductive functions. The study suggests that low-dose aspirin treatment may prevent preeclampsia without compromising reproductive function.
Researchers discover that lanosterol stimulates the degradation of cholesterol-building enzyme HMG CoA reductase, controlling cellular cholesterol production. This finding has important clinical implications for improving cholesterol control in statin therapy.
Dr. Goldstein and Dr. Brown will discuss their research on the regulated intramembrane proteolysis (RIP) of sterol regulatory element binding proteins (SREBPs), which regulates lipid biosynthesis and plasma cholesterol levels. Their work has been recognized with numerous awards, including Nobel Prize in Physiology or Medicine.
A new study found that cholesterol plays a crucial role in regulating cell signals by interacting with the oxysterol binding protein (OSBP), which controls the deactivation of ERK. This mechanism helps maintain proper levels of active ERK, preventing cancer growth.
Researchers found a biochemical switch, PGC-1beta, in liver cells that triggers the harmful effects of saturated and trans fats. The discovery offers hope for developing drug therapies to lower cholesterol levels and heart disease risk.
A study of 1,551 middle-aged Finnish men found that those consuming higher amounts of polyunsaturated fatty acids had a lower risk of cardiovascular death. The researchers suggest that dietary fat quality is more important than quantity in reducing cardiovascular disease mortality in men.
Current FOBT screening recommendations are being reexamined due to low test accuracy and non-compliance. A study of 3,121 people found that single office-based FOBT tests missed advanced precancerous lesions 95% of the time.
A study of 502 patients with coronary artery disease found that statin therapy lowered both LDL cholesterol and C-reactive protein levels, leading to slower disease progression. The research suggests that inflammation plays a key role in cardiovascular disease and may be useful in patient management.
A new study found that combining plant sterols with exercise can significantly improve cholesterol levels in previously sedentary adults. The combination therapy favourably altered lipid profiles by decreasing total cholesterol and increasing high-density lipoprotein (HDL) cholesterol levels.
Research reviews medical studies on mixed dementia and finds that treating cardiovascular risk factors like high blood pressure can be more effective in protecting brain function. This approach shows promise as a complementary strategy to memory-preserving drugs.
A recent study published in Journal of Agricultural and Food Chemistry found that drinking pomelit juice daily can lower LDL blood cholesterol and increase antioxidant activity. Hypercholesterolic patients may benefit from adding fresh Sweetie juice to their diet as a preventative measure against future heart disease.
A study analyzing claims data from 11 managed care health plans found that the risk of rhabdomyolysis is relatively low with three frequently prescribed statins. The study suggests that patients taking statins and fibrates combined, such as those with diabetes mellitus, should be monitored for symptoms suggestive of rhabdomyolysis.
Researchers found that activating FXR can prevent gallstone formation by restoring balance of bile acids and phospholipids. The study suggests a potential new direction for diagnosis and prevention of cholesterol gallstone disease, with implications for patients who have had their gallbladders removed.
Researchers found that Hispanic Americans were 36% less likely than non-Hispanic whites to have properly controlled cholesterol, while Chinese Americans showed no difference. Treatment was often insufficient to meet recommended goals, with only 22% of patients who qualified for medication having their LDL cholesterol under control.
Tailoring interventions to patient needs increases sustainability and improves outcomes in Ischemic Heart Disease. Patients benefit from clinician-led secondary prevention strategies.
The ARIES trial shows CRESTOR 10mg reduced LDL-C by 37%, compared to 32% for atorvastatin, with higher response rates among African-American patients. CRESTOR also improved HDL-C levels and reduced non-HDL-C and total cholesterol.
A new study shows that a cholesterol-lowering medication can improve symptoms of depression and cognition in people with mild-to-moderate Alzheimer's disease. The treatment, atorvastatin, reduced bad cholesterol by more than 50% and showed significant improvement in depression symptoms.
A diet high in walnuts decreases C-reactive protein, a marker of inflammation associated with heart disease. The study found that walnut consumption lowered total cholesterol, LDLs, and triglycerides, while also reducing inflammatory markers.
A large study reveals that co-administration of Zetia and fenofibrate significantly lowers LDL cholesterol, non-HDL cholesterol, and apo B to a greater extent than fenofibrate alone in mixed hyperlipidemia patients. This improvement is also seen in HDL cholesterol levels.
Genetic variation in ABCA1 transporter contributes to reduced HDL cholesterol levels in the general population. The study found that specific mutations affect HDL levels, with lower levels associated with a higher risk of cardiovascular disease.
In a subgroup of high-risk patients, VYTORIN significantly reduced LDL cholesterol by 59% compared to Lipitor. This resulted in more patients achieving an LDL cholesterol goal of less than 100mg/dL with VYTORIN, and increased HDL cholesterol levels.
A study found that a mitochondrial mutation may contribute to the development of metabolic syndrome, a cluster of disorders including high blood pressure and high cholesterol. Researchers discovered the link in a four-generation family affected by hypertension, hypercholesterolemia, and other conditions.
A study by Wake Forest University Baptist Medical Center found that the experimental drug Trichostatin A (TSA) significantly reduced atherosclerosis in mice. TSA treatment decreased aortic arch deposits and macrophage gathering, leading to increased plaque stability.
Researchers found that nevirapine significantly increases HDL cholesterol levels more than efavirenz, making it a preferable option for HIV-infected adults with increased cardiovascular risk. This study suggests that considering individual factors beyond cardiovascular risk can lead to more personalized treatment decisions.
Researchers found that taking Welchol, a bile acid sequestrant, with TriCor, a fibrate, resulted in no significant interaction. The study involved 30 healthy volunteers who received different treatment regimens involving the two drugs, showing that co-administration is safe and effective.
Researchers found that lean mass, intra-abdominal fat, and inflammation biomarker sTNFR1 are higher in women with metabolic syndrome, independently related to its severity. Analysis of these factors can help doctors identify postmenopausal women at increased risk for diabetes and heart disease.
Researchers found that an ACAT inhibitor reduced amyloid deposition and improved learning in female mice, suggesting a potential therapeutic approach for Alzheimer's. The study also showed promising results for male mice, which could lead to faster development of new treatments.
A new anti-cholesterol drug, CP-113,818, has shown promise in treating Alzheimer's disease by reducing amyloid plaque accumulation and improving learning and memory in mice. Treatment with the drug resulted in a significant reduction of cholesterol storage in the brain, as well as improved performance on cognitive tests.
A study found racial and gender differences in lipid profiles, with African-American women having the best distribution and white men having the worst. These differences can determine cardiovascular disease risk.