Articles tagged with Cholesterol
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A new study published in the Journal of the American Medical Association found that a vegetarian diet high in fibre, nuts, and plant sterols can lower LDL cholesterol levels by nearly 29%, comparable to the effects of a standard cholesterol-reducing drug. The findings suggest an evolutionary adaptation to a
A large-scale study will test three weight-maintenance strategies: self-directed/usual care, personal contact, and interactive technology. Participants who lose 9 or more pounds in the initial phase will be eligible to enroll in phase II.
Researchers at Vanderbilt University Medical Center conducted a double-blind, randomized, controlled study involving 240 participants with high cholesterol. The study showed a 16% reduction in low-density lipoprotein (LDL) cholesterol after taking green and black tea extracts enriched with the antioxidant theaflavin for 12 weeks.
A study led by Rory Collins found that statin therapy reduces the risk of primary outcomes for people with diabetes, including cardiac death, non-fatal heart attack, and stroke. The reduction in risk appeared to be greater among diabetic patients who did not have occlusive arterial disease.
A UK multi-centre randomised trial found that statins reduce the risk of heart attacks, strokes or revascularisation operations by about a third in diabetic patients, irrespective of their cholesterol levels. This could prevent at least 10,000 heart attacks, strokes and revascularisation operations each year worldwide.
Researchers analyzed lipid levels of HIV patients before and during HAART and found that average total and LDL cholesterol levels remained stable over three years. After initiation, cholesterol levels rose but returned to pre-infection levels after a year. However, triglyceride and HDL levels were higher than in similar-aged men.
A study of 448 children in New York Head Start preschool programs found that those with high cholesterol at ages 3 and 4 were more likely to have high cholesterol five years later. The study suggests that early intervention and primary prevention can be effective in reducing the risk of coronary heart disease.
Researchers at CDC found a rise in cholesterol levels among Japanese children, mirroring trends seen in Western countries. The study highlights the importance of early intervention measures to prevent heart disease and obesity.
A new blend of cooking oil made from medium chain triglycerides (MCT) has been shown to heighten metabolism, lower cholesterol levels, and promote weight loss. In two clinical trials, participants who consumed the oil for 27 days experienced significant reductions in body fat and upper body fat, as well as improved blood lipid profiles.
The XENDOS study shows that Xenical significantly improves weight loss, waist measurement, blood pressure, triglyceride levels, fasting plasma glucose, and HDL cholesterol in patients with Metabolic Syndrome. The treatment also reduces the risk of type 2 diabetes by 36%.
Greek Orthodox Christians who followed a fasting regimen experienced lower cholesterol and LDL levels in their blood. Regular fasting may provide long-term protection against heart disease by increasing the HDL/LDL ratio.
Duke University researchers found that exercise reduces potentially harmful cholesterol levels in the blood. The extent of this benefit depends on exercise amount and intensity, as well as gender. After a five-year trial, they discovered that high-intensity exercise led to sustained benefits in HDL cholesterol for both men and women.
Researchers found that participants on the Atkins diet lost an average of 14.7 pounds compared to 5.8 pounds in the conventional diet group after one year. Additionally, Atkins participants had greater increases in HDL cholesterol and reductions in triglycerides.
Researchers found that individuals with at least one copy of the klotho gene variant KL-VS are almost twice as likely to have undetected atherosclerosis. Lifestyle changes can modify this risk, suggesting genetic testing may be considered.
Drs. Brown and Goldstein's research on low-density lipoprotein receptors and Sterol Regulatory Element Binding Proteins (SREBPs) led to effective new drugs for high cholesterol treatment and discovery of a potential insulin-sensitive regulator for diabetes therapy.
Researchers found that participants taking statins lowered their brain cholesterol levels by 21.4 percent, potentially reducing amyloid plaque formation and severity of Alzheimer's disease. The study, led by Dr. Gloria Vega, showed no adverse side effects in patients with normal cholesterol levels.
Researchers developed a low-dose statin and fenofibrate combination, which significantly reduced triglycerides, increased HDL, and lowered LDL in patients with combined hyperlipidemia. This treatment addresses multiple lipid abnormalities and may be key to preventing cardiovascular heart disease.
Researchers found that workplace-based physical activity counseling programs significantly improved employees' physical activity levels and fitness. The program, called PACE, was tailored to individual readiness for change and showed greatest benefits for those with less-favorable health profiles.
A UT Southwestern research team found that inactivating LRP1 in vascular smooth muscle cells causes abnormal PDGF receptor signaling, leading to vessel wall susceptibility to cholesterol buildup. The researchers discovered that Gleevec significantly reduces atherosclerosis development by 50% in mouse models.
The STELLAR study found CRESTOR 10-40mg reduced LDL-C by 46 to 55 percent, while raising HDL-C by 7.6 to 9.6 percent compared to other statins. The study was part of AstraZeneca's GALAXY Program and included over 19,000 patients from 23 countries.
A recent study found that high levels of Lp-PLA2 and CRP are associated with an increased risk of coronary heart disease, even in patients with 'normal' LDL cholesterol levels. The study used the PLAC test to measure Lp-PLA2 levels in participants and found significant associations between Lp-PLA2, hs-CRP, and CHD incidence.
The study, published online in the Lancet, found that atorvastatin significantly reduces the likelihood of heart attacks and strokes in people with high blood pressure. The results are great news for those suffering from high blood pressure, as the drug also lowers cholesterol levels.
A study published in MERCURY I showed that CRESTOR 10mg effectively lowered LDL-C levels and enabled over eight out of ten patients to achieve their LDL-C goals. The medication demonstrated superior efficacy compared to atorvastatin, making it a valuable treatment option for managing high cholesterol and reducing cardiovascular risk.
A new study found that consuming cranberry juice daily can significantly increase levels of good cholesterol by an average of 10% and boost plasma antioxidant capacity by up to 121%. The effects are associated with a decreased risk of heart disease.
Researchers found that obese baboons had normal leptin levels, indicating that high cholesterol and obesity are triggered by different mechanisms. The study's findings suggest that humans can get away with indulging in unhealthy habits without suffering severe health consequences.
A study by the American Heart Association suggests that women approaching menopause should take steps to lower their heart disease risk. Researchers analyzed data from over 1,300 perimenopausal women and found that many would become eligible for cholesterol-lowering therapy after age 55 if current risk factors are not modified.
Roth's discovery led to the development of Lipitor, which has logged more than 36-million patient years of experience and involved over 400 clinical trials. His innovative approach to statin structure resulted in a simpler molecule with equal efficacy.
A global study identifies cost-effective strategies to reduce the burden of cardiovascular disease, prioritizing non-personal interventions such as salt reduction and health education. Combination treatments with blood pressure and cholesterol-lowering agents are also shown to be effective in reducing disease impact worldwide.
ApoB is a more robust indicator of cardiac events than cholesterol levels, according to MUHC cardiologists. Measuring apoB can help identify patients at risk of heart attacks even if their cholesterol levels are well-controlled.
A new study highlights the cost-effectiveness of reducing sodium in processed foods to limit cardiovascular disease, while also recommending a combination of treatments for high-risk individuals. The research found that targeting blood pressure and cholesterol levels could prevent over 21 million DALYs per year worldwide.
Recent studies suggest apolipoprotein B is a superior marker for predicting cardiovascular disease risk compared to total cholesterol or LDL cholesterol. The ratio of apolipoprotein B to apolipoprotein A-1 is also more effective in assessing cardiovascular risk than the traditional LDL/HDL ratio.
Researchers at Baylor College of Medicine found that a specific enzyme is associated with high levels of HDL, which may have both positive and negative effects on cardiovascular health. The study suggests that the enzyme's impact on cholesterol transport to the liver could be beneficial or detrimental.
The ACCORD clinical trial enrolls 10,000 adults with type 2 diabetes to test the effects of intensively controlling blood sugar along with aggressive control of blood pressure and lipids. The study aims to address the significant public health challenge of cardiovascular disease in people with type 2 diabetes.
A new study aims to investigate the effects of intensively controlling blood sugar, blood pressure, and lipid levels on cardiovascular disease risk in adults with type 2 diabetes. The ACCORD study will test three medical treatment strategies to determine their impact on CVD risk.
Researchers have identified a new gene, endothelial lipase (LIPG), that regulates HDL cholesterol levels and impacts the risk of developing heart disease. By altering LIPG expression in genetic models, scientists found an inverse relationship between HDL cholesterol and EL expression.
ACAT2 is crucial for atherosclerosis development in mice, with nearly twice the cholesterol levels found in control mice. The study suggests that inhibiting ACAT2 may be a potential therapy for treating hardening of the arteries.
A new UC Davis study reveals that C-reactive protein (CRP) plays a key role in the formation of blood clots and plaque buildup in arteries, increasing the risk of heart attacks and strokes. High CRP levels can be reduced by losing weight, exercising regularly, or taking statin drugs.
A study found that statin use doesn't reduce reproductive hormone levels in premenopausal, perimenopausal, or postmenopausal women with coronary risk factors. The results provide reassurance on the safety of statins for women in child-bearing age.
A large population-based study of over 5,000 subjects found no association between dietary fat and increased dementia risk. Researchers did not find a link between cholesterol lowering medications and reduced dementia risk.
A recent NHLBI study found that traditional diuretics are more effective than newer antihypertensive medications in treating high blood pressure and preventing cardiovascular events. The study, which involved over 42,000 participants, showed that diuretics reduced the risk of heart attacks and strokes by 34% compared to the other groups.
A new study finds that nutrition counseling for high cholesterol patients significantly improves their ability to manage their condition while maintaining or improving their overall health. Patients who received personalized feedback and educational materials reported increased satisfaction with their care and healthier eating habits.
Researchers have solved the three-dimensional structure of a low-density lipoprotein (LDL) receptor's extracellular domain, which may help develop treatments for familial hypercholesterolemia. The LDL receptor plays a crucial role in clearing LDL from the blood and maintaining healthy cholesterol levels.
Scientists use lab mice to identify genetic basis of cholesterol absorption, aiming to develop new treatments for heart disease. They pinpoint two chromosome regions as potential sites for genes regulating plant sterol levels, which reflect dietary cholesterol absorption.
A study published in Metabolism found that a vegetarian diet combining soy proteins, nuts, viscous fibers, and plant sterols reduces LDL cholesterol levels by 29%. The combination diet was as effective as the first generation of statin drugs in lowering blood cholesterol.
A study published in the American Journal of Clinical Nutrition found that drinking Concord grape juice for two weeks increases the resistance of LDL cholesterol to oxidation. This reduction in oxidative stress may contribute to a lower risk of heart disease and stroke.
Two new genes, Abcg5 and Abcg8, play a critical role in cholesterol secretion into the bile, essential for maintaining cholesterol homeostasis. Disrupting these genes can lead to increased plasma levels of cholesterol and plant sterols, associated with premature heart disease.
A study of 774 older men found that high hostility was associated with a higher risk of coronary heart disease, independent of other risk factors like high cholesterol. The study suggests that mental health interventions may be effective in reducing the risk of CHD for individuals with high hostility levels.
Researchers at Duke University Medical Center found that exercise, regardless of intensity or fitness level, can improve cholesterol levels by increasing the size of particles carrying good and bad cholesterol. The study also showed that standard lipid panels may not accurately measure risk of heart disease.
The World Health Report 2002 reveals that childhood and maternal underweight, unsafe sex, high blood pressure, and tobacco consumption are the leading causes of global burden of disease. Increasing fruit and vegetable consumption can be a simple step towards reducing certain risk factors.
The ASCOT trial found that atorvastatin significantly reduced heart attacks and strokes among patients with hypertension and low cholesterol. Patients given atorvastatin suffered less heart attacks and strokes compared to those receiving a placebo treatment.
A study by Johns Hopkins Medicine found that nurse case management significantly improves risk factor management in patients with coronary heart disease. The program led to healthier diet and exercise patterns, as well as higher achievement of recommended cholesterol levels, compared to minimal intervention.
A randomized trial of simvastatin in 173 children with heterozygous familial hypercholesterolemia found significant reductions in all cholesterol measures. The drug was well-tolerated and did not affect growth or pubertal development, making it a safe option for treating inherited high cholesterol in children.
A population-based study of 2,786 diabetic and non-diabetic postmenopausal women found that HRT had a positive effect on blood levels of fats and glucose. Diabetic women on HRT had significantly lower fasting levels of total cholesterol and higher levels of beneficial high-density lipoprotein.
A study of 58 children with high cholesterol found that girls with hypercholesterolemia were more likely to become overweight or obese by age 11-12 compared to their peers. The researchers propose that abnormally high cholesterol may be a marker of an altered metabolism leading to excess adiposity.
A clinical trial found that consuming almonds daily significantly reduces LDL cholesterol levels in hyperlipidemic subjects. The study also showed that eating more almonds increased the reduction of 'bad' cholesterol even further, without resulting in weight gain.
A new study found that moderate alcohol consumption increases levels of good cholesterol, reduces inflammation, and protects against heart disease in post-menopausal women. The research suggests that drinking in moderation may be beneficial for women's heart health after menopause, similar to men.
Researchers at UCSD School of Medicine discovered that C-reactive protein (CRP) binds to oxidized LDL, suggesting a potential trigger for the development of atherosclerosis. The study highlights CRP's role in recognizing phosphocholine on oxidized LDL and apoptotic cells.
Researchers at UC Davis discover that c-reactive protein inhibits protective enzyme eNOS, leading to increased plaque formation and heart disease risk. This finding supports the need for new screening guidelines and highlights the importance of measuring c-reactive protein levels in high-risk groups.
A recent study found that simvastatin significantly reduced hsCRP levels in patients with high LDL cholesterol after just two weeks of treatment. The results suggest that statins may work through multiple mechanisms to reduce inflammation and prevent heart disease events.
Researchers found elevated levels of ceramides and cholesterol esters in spinal cords of people with ALS, leading to motor neuron degeneration. Treating these lipids with a drug called ISP-1 may prevent this process.