Articles tagged with Cholesterol
A randomized trial of simvastatin in 173 children with heterozygous familial hypercholesterolemia found significant reductions in all cholesterol measures. The drug was well-tolerated and did not affect growth or pubertal development, making it a safe option for treating inherited high cholesterol in children.
A population-based study of 2,786 diabetic and non-diabetic postmenopausal women found that HRT had a positive effect on blood levels of fats and glucose. Diabetic women on HRT had significantly lower fasting levels of total cholesterol and higher levels of beneficial high-density lipoprotein.
A study of 58 children with high cholesterol found that girls with hypercholesterolemia were more likely to become overweight or obese by age 11-12 compared to their peers. The researchers propose that abnormally high cholesterol may be a marker of an altered metabolism leading to excess adiposity.
A clinical trial found that consuming almonds daily significantly reduces LDL cholesterol levels in hyperlipidemic subjects. The study also showed that eating more almonds increased the reduction of 'bad' cholesterol even further, without resulting in weight gain.
A new study found that moderate alcohol consumption increases levels of good cholesterol, reduces inflammation, and protects against heart disease in post-menopausal women. The research suggests that drinking in moderation may be beneficial for women's heart health after menopause, similar to men.
Researchers at UCSD School of Medicine discovered that C-reactive protein (CRP) binds to oxidized LDL, suggesting a potential trigger for the development of atherosclerosis. The study highlights CRP's role in recognizing phosphocholine on oxidized LDL and apoptotic cells.
A recent study found that simvastatin significantly reduced hsCRP levels in patients with high LDL cholesterol after just two weeks of treatment. The results suggest that statins may work through multiple mechanisms to reduce inflammation and prevent heart disease events.
Researchers at UC Davis discover that c-reactive protein inhibits protective enzyme eNOS, leading to increased plaque formation and heart disease risk. This finding supports the need for new screening guidelines and highlights the importance of measuring c-reactive protein levels in high-risk groups.
Researchers found elevated levels of ceramides and cholesterol esters in spinal cords of people with ALS, leading to motor neuron degeneration. Treating these lipids with a drug called ISP-1 may prevent this process.
A new study found that moderate red wine consumption is associated with higher levels of HDL cholesterol in regular drinkers. The researchers discovered that the fatty acid composition of these HDL particles may play a beneficial role in reducing cardiovascular risk.
A study found that consuming soy protein-rich diets can lower total cholesterol and LDL levels, improving cardiovascular health. The effect was seen in both men and women, with no significant difference between high- and low-isoflavone diets.
Researchers found that low-dose extended-release niacin improves lipid levels and glycemic control in patients with diabetes. The therapy also raises high-density lipoprotein (HDL) cholesterol, a healthier type of cholesterol.
Researchers found atazanavir significantly lowers total cholesterol, low-density lipoprotein (
A new study confirms high cholesterol as a significant risk factor for stroke death in women, particularly those under 55. Cholesterol levels were found to be associated with an increased risk of ischemic stroke death across all age groups.
Researchers identified a new cholesterol disorder caused by mutations in the CYP7A1 gene, leading to elevated cholesterol levels and increased risk of heart disease. The study found that carriers of the mutation had significantly higher cholesterol levels and were more likely to develop gallstones.
A randomized trial found that lean ground beef fortified with soybean phytosterols lowered plasma total cholesterol by 9.3%, LDL cholesterol by 14.6%, and the ratio of total to high-density lipoprotein (HDL) cholesterol by 9.1% in 4 weeks. This study suggests a lower-fat alternative for lowering CVD risk.
Researchers found less racial variation in female preventive services than expected, with some disparities closing and disappearing. Having a usual source of care significantly boosted the chances of receiving screening for conditions like breast cancer and cervical cancer.
Researchers at Georgetown University Medical Center have discovered a key link between high cholesterol and the development of Alzheimer's disease. Elevated cholesterol levels increase the production of beta amyloid protein, leading to brain cell death and characteristic plaques found in Alzheimer's brains.
A recent study published in the Journal of Clinical Investigation has identified a potential detour for stalled intracellular lipid traffic. This novel approach could lead to the development of new treatments for various diseases, including those related to lipid metabolism.
Harden McConnell, a renowned Stanford University chemist, has been awarded the 2002 Welch Award for his pioneering discoveries about cell membranes. His work has provided new insights into how the body regulates cholesterol and activates its immune system.
Dr. McConnell's groundbreaking work on cellular behavior at the molecular level has shed light on interactions between cholesterol and phospholipids, as well as protein-peptide reactions. His research aims to improve understanding of immune surveillance and cholesterol function in cells.
A mobile screening program at 39 Winston Cup race weekends screened 24,000 people, revealing high blood pressure and cholesterol levels as risk factors for heart disease. The screenings also assessed erectile dysfunction and provided health information and advice to participants.
A study published in Science identifies guggulipid as a target for developing drugs to lower cholesterol. The extract, combined with a cholesterol-lowering diet, reduced cholesterol levels by up to 20%. Researchers are now studying the biochemical reasons behind this effect and its potential impact on other medications.
Research found that consuming at least 300mcg of folate per day reduces stroke and cardiovascular disease risk. Folate, a B-vitamin, is found in citrus fruits, leafy greens, beans, and grain products.
Researchers discovered that guggulsterone blocks the FXR receptor, regulating cholesterol metabolism. The study suggests that guggulsterone could lead to new drugs to control cholesterol levels and potentially treat hyperlipidemia.
Men and women who smoked cigarettes had a significantly increased risk of heart attack, with female smokers facing an 80% greater risk than their peers. This contradicts the initial assumption that leanness is cardio-protective, highlighting the need for further research.
A recent study found significant dietary deficiencies in African American females with low incomes, particularly in folate, iron, calcium, and vitamin D. The study also highlighted excessive energy intake and high levels of saturated fats. To address these concerns, nutrition education is essential to promote healthier eating habits.
Six studies presented at the 2002 Experimental Biology conference support almonds' role in lowering 'bad' cholesterol and protecting against cell damage. Eating a handful of almonds daily may significantly reduce total and LDL cholesterol levels, and even lower risk of heart disease by up to 10%.
A new peptide-based vaccine has been shown to reduce arterial plaque formation by 60-70% in mice with high cholesterol levels, according to a study led by Cedars-Sinai's P.K. Shah and the Swedish team of Gunilla Nordick-Fredricksson. The vaccine targets the major protein component of low-density lipoprotein (LDL) cholesterol.
A UCSF study found that high cholesterol levels are associated with poorer cognitive performance in elderly women. Using statins to lower cholesterol levels was linked to improved cognitive skills, suggesting a potential benefit for preventing Alzheimer's disease.
The study examined PON1 activity in children and adolescents with high lipid levels, finding associations between certain genotypes and HDL cholesterol levels. The researchers also found that dietary fat intake increased over time, contradicting expected trends in the nutritional intervention population.
A recent study published in European Journal of Clinical Nutrition found that wild game meat and grass-fed beef contain a balance of essential fats, including healthy omega-3 fatty acids and lower levels of unhealthy omega-6 fat. This ratio is associated with reduced cholesterol levels and lower risk of cardiovascular disease.
Researchers found that apolipoprotein B and A-I were strongly linked to increased risk of fatal heart attack in both men and women. Higher concentrations of ApoA-I had a protective effect, suggesting apolipoproteins may be valuable for diagnosis and treatment.
Researchers found that two statins, atorvastatin and simvastatin, significantly reduced remnant lipoprotein (RLP) cholesterol levels, while pravastatin had no effect. This suggests that these drugs may have additional mechanisms for reducing cardiovascular risk beyond just lowering LDL cholesterol.
A combination treatment of statin and niacin reduced cardiovascular events by 60-90%, reversing plaque buildup in the arteries. Antioxidant vitamins had no significant benefit on cardiovascular outcomes, contrary to previous assumptions.
Researchers have discovered that statins can help alleviate symptoms of cardiac hypertrophy without affecting cholesterol levels. The findings suggest that statins may modulate signaling pathways involved in hypertrophic growth, leading to improved cardiovascular outcomes.
The LIFE-SAVER trial found significant reductions in heart attacks and strokes among high-risk patients, including those with diabetes and low cholesterol levels. Statin treatment can prevent major vascular events in over 70% of patients.
Individuals with normal low-density lipoprotein (LDL) cholesterol may still be at increased risk of coronary artery disease (CAD), particularly if they carry additional risk factors like central obesity and insulin resistance. Targeting atherogenic dyslipidemia, including abdominal obesity, is recommended to prevent CAD risk.
Brain researchers find that glial cells produce surplus cholesterol to support nerve cell growth and synapse formation. The discovery sheds new light on an often-disdained molecule and offers perspectives for neurobiological research and potential strategies to cure brain lesions.
Researchers found that an egg phospholipid interferes with cholesterol absorption in the intestine, lowering its uptake by the intestine. This may explain why some studies have found no association between egg intake and blood cholesterol levels.
Researchers found that consuming flavonoid-rich chocolate can increase HDL cholesterol and slow down LDL oxidation. This effect may contribute to a reduced risk of cardiovascular disease.
A randomized, double-blind trial found colesevelam significantly lowered mean LDL levels by up to 18% without serious adverse events. This effect was independent of sex or age, making colesevelam a useful therapeutic alternative for patients with mild to moderate primary hypercholesterolemia.
Researchers at the University of Pennsylvania School of Medicine have discovered that a combination of Vitamin E and aspirin can significantly delay the development of atherosclerosis in mice with high cholesterol levels. The study found that the production of plaque in blood vessels was lowered by over 80%.
A study found that African Americans with diabetes often lack adequate blood sugar and cholesterol control, leading to increased risk of complications. Poor prevention and management habits are prevalent, with many participants failing to receive recommended exams or monitoring their glucose levels regularly.
A UCSF study found that significant reductions in heart disease risk factors have saved over 430,000 deaths annually, with population-wide dietary changes and widespread use of medications being cost-effective.
A recent study published in the American Journal of Clinical Nutrition found that women with good diets tend to eat more fruits and a greater variety of foods. The researchers also discovered a strong association between healthy eating indexes and socioeconomic status, suggesting that access to resources can influence dietary choices.
Researchers reexamine the process of reverse cholesterol transport, a critical mechanism for removing excess cholesterol from peripheral tissues. The study reveals that this process may have both protective and detrimental effects on cardiovascular health.
A new study on identical twins found that genetics plays a predominant role in differences in cholesterol levels, but diet also significantly contributes to variations in cholesterol levels. The researchers controlled for genetic factors and found an environmental association between diet and cholesterol levels.
The International Lipid Information Bureau (ILIB) emphasizes the importance of statins in lowering cholesterol and preventing coronary heart disease. Landmark clinical trials have shown that statins prevent CHD, heart attacks, revascularization, and strokes.
A new international survey reveals that people are largely unaware of their cholesterol risk, with 13% believing they're at high risk for heart disease. Despite having multiple risk factors, many individuals incorrectly assess their level of risk, highlighting the need for education and awareness campaigns.
A study of 183 Norwegian participants found that abstaining from filtered coffee reduced total cholesterol and tHcy levels, while increasing folate levels. This reduction in risk factors may be attributed to the presence of terpenoids in coffee that are only partially removed during filtering.
A study of 72,904 French women found that those who consumed alcohol had a 29.5% higher calorie intake compared to non-drinkers, with protein and cholesterol intake also increased. Heavy drinkers were more likely to be smokers and experienced negative health effects.
Researchers used NMR technology to analyze lipoprotein size and concentration in 262 patients with high-risk heart disease. The study found that a commonly prescribed statin, pravastatin, was equally effective in lowering bad cholesterol levels regardless of LDL particle size.
A large-scale population study found that low cholesterol concentrations were associated with higher death rates among elderly people. The study, which analyzed data from over 3,500 men aged 71-93, suggested that long-term persistence of low cholesterol concentration increases the risk of death.
A Johns Hopkins study finds that removing cholesterol from a cell's membrane can completely block HIV transmission. Researchers used microbicides containing a starchy substance that drains cholesterol, allowing for reduced or stopped HIV transmission.
Researchers found that consuming pork with a higher proportion of polyunsaturated fats led to significant reductions in serum total cholesterol (10%) and LDL cholesterol (24%) in young women. The modified pork diet also showed no adverse effects on glucose, insulin, or triacylglycerol levels.
Researchers found that a specific Apo-E gene variant increases the risk of coronary heart disease (CHD) in current smokers, with men carrying the E4 version facing a three times higher risk. The study suggests that quitting smoking can reduce this risk and highlights the importance of reducing smoking to avoid CHD.
A study by UB researchers found that more than half of survivors diagnosed with uncontrolled high blood pressure still had hypertension, and 46% of those with dangerously high cholesterol continued to have high levels. This highlights the need for improved secondary prevention strategies in the US population.
The study found associations between increased consumption of animal-based foods and higher risks of various diseases, including cardiovascular disease, cancer, obesity, diabetes, and liver cancer. Plant-based diets were inversely associated with these health problems.
Children with high blood cholesterol can benefit from a low-fat, low-cholesterol diet without adverse effects on growth or development. The Dietary Intervention Study in Children (DISC) found that reducing saturated fat and cholesterol intake lowered LDL cholesterol levels for up to three years.