Articles tagged with Cholesterol
Researchers found that taking Welchol, a bile acid sequestrant, with TriCor, a fibrate, resulted in no significant interaction. The study involved 30 healthy volunteers who received different treatment regimens involving the two drugs, showing that co-administration is safe and effective.
Researchers found that lean mass, intra-abdominal fat, and inflammation biomarker sTNFR1 are higher in women with metabolic syndrome, independently related to its severity. Analysis of these factors can help doctors identify postmenopausal women at increased risk for diabetes and heart disease.
Researchers found that an ACAT inhibitor reduced amyloid deposition and improved learning in female mice, suggesting a potential therapeutic approach for Alzheimer's. The study also showed promising results for male mice, which could lead to faster development of new treatments.
A new anti-cholesterol drug, CP-113,818, has shown promise in treating Alzheimer's disease by reducing amyloid plaque accumulation and improving learning and memory in mice. Treatment with the drug resulted in a significant reduction of cholesterol storage in the brain, as well as improved performance on cognitive tests.
A study found racial and gender differences in lipid profiles, with African-American women having the best distribution and white men having the worst. These differences can determine cardiovascular disease risk.
A new study suggests that early initiation of intensive statin treatment after a heart attack may lower the risk of future cardiovascular events. The research found that participants who received high-dose simvastatin had better outcomes than those on a placebo, despite an increased risk of muscle-related side effects.
A new laboratory study using rat liver cells found that the blueberry compound pterostilbene activates the PPAR-alpha receptor, reducing cholesterol and other lipids. Pterostilbene was shown to be similar in activity to a commercial drug, but with fewer side effects.
The American Chemical Society has recognized four companies for developing innovative therapies for various ailments, including eye disease and high cholesterol. These breakthroughs were made possible by the work of industrial chemists and chemical engineers who have led to commercially successful products that improve quality of life.
Researchers identified rare genetic mutations that significantly increase heart disease risk by focusing on individuals at the extreme ends of HDL levels. These findings provide direct evidence that rare variations in DNA can affect HDL levels, opening up new avenues for treatment and diagnostic targets.
A UK study found that a significant proportion of people with type 2 diabetes are managed solely through diet, receiving inadequate monitoring and care. This highlights the need for better routine surveillance and consistency in clinical practice to address the high rate of complications among these patients.
A randomized trial found that pravastatin therapy reduced LDL-C levels by 24.1% and carotid intima-media thickness by regression in children with familial hypercholesterolemia. The study's findings suggest that statin treatment can reverse increased arterial wall thickness progression in these patients.
Research suggests that managing blood pressure, cholesterol, blood sugar levels, and body weight can promote healthier aging and reduce Alzheimer's risk. Studies found a consistent increase in cognitive health with higher HDL (good) cholesterol levels and some hypertension medications associated with reduced Alzheimer's risk.
A study of over 1,000 children followed into adulthood found a strong association between extensive TV viewing and increased risk of obesity, high cholesterol, smoking, and poor cardiovascular fitness. Parents are advised to limit children's TV viewing to 1-2 hours per day to prevent long-term health consequences.
The updated report recommends lower LDL cholesterol levels as a direct relationship with reduced risk for major coronary events. Therapeutic lifestyle changes are also emphasized for cholesterol management.
A randomized trial found that tenofovir disoproxil fumarate achieved high viral load suppression rates, comparable to stavudine-based regimens. Tenofovir DF was also associated with lower toxicity and better lipid profiles.
Researchers discovered that replenishing depleted neurosteroid hormone allopregnanolone significantly delayed neurological deficits and doubled the lifespan of mice with neurodegenerative disease. The treatment was particularly potent when administered early in life and showed promise for delaying symptom onset and progression.
A large-scale study found that soy protein supplementation with isoflavones had no effect on cognitive function, bone mineral density, or cholesterol levels in postmenopausal women. The authors suggest that the timing of supplementation may be a key factor in determining its efficacy.
A recent study found that nearly half of adults with hypertension also have high cholesterol, which can be treated with existing medications. However, many individuals are not receiving adequate treatment for their cholesterol problems, highlighting the need for aggressive management of both conditions to prevent cardiovascular disease.
A study found two common genetic polymorphisms associated with reduced statin effectiveness, affecting total and LDL cholesterol levels. The findings suggest personalized medicine and genetic screening could improve treatment outcomes.
Researchers genetically modified mice to lack the CT or PEMT pathways, resulting in significant reductions of lipoproteins and homocysteine levels. This suggests pharmacological inhibition of PC manufacture in the liver as a potential approach to lower LDL cholesterol and homocysteine levels.
A new study shows that estrogen skin patches can counteract high cholesterol associated with hormone therapy for prostate cancer. The patches decreased overall cholesterol levels by 10 percent and increased good cholesterol (HDL), while also improving lipid profiles.
A landmark UK study sponsored by Diabetes UK, Department of Health, and Pfizer UK showed that 10mg atorvastatin reduced cardiovascular events by 37% in patients with diabetes without existing CVD. Stroke was substantially reduced by 48% in these patients.
Exercise has been shown to improve physical fitness, lower back pain, and cholesterol levels in early postmenopausal women. After 26 months, the exercise group experienced significant increases in physical fitness and reductions in bone loss compared to the control group.
Researchers found that moderate exercise, combined with antioxidant vitamins C and E and the amino acid L-arginine, significantly reduced atherosclerosis lesions by 40% compared to high cholesterol diet alone. Exercise also lowered blood pressure and prevented unwanted blood clotting.
A Phase II study found LEA29Y effective in preventing acute rejection, but showed significant improvements in kidney function, blood pressure, and cholesterol levels compared to cyclosporine therapy.
A randomized, controlled trial found that a low-carb diet with vitamin supplements led to greater weight loss, body fat reduction, and improved cholesterol levels than a low-fat diet. However, the low-carb group experienced more adverse physical effects.
Two studies found that low-carbohydrate diets led to greater weight loss in obese adults than conventional diets. The low-carb group showed improvements in triglyceride levels and better control of blood sugar for those with diabetes.
A compound found in orange and tangerine peels has shown promise as a natural alternative for lowering LDL cholesterol without side effects. The compound, called polymethoxylated flavones (PMFs), was found to lower cholesterol levels by 32-40% in animal studies.
A study highlights the significant risk of cardiovascular disease in women with type 2 diabetes, emphasizing the importance of controlling blood glucose levels, managing cholesterol, and preventing diabetes. The researchers outline strategies for treating diabetic women and CVD, including intensive therapy and lifestyle modifications.
A new animal study suggests that antioxidant vitamins may increase the secretion of VLDL in liver cells, leading to higher levels of LDL cholesterol. The study found that vitamins hampered a process in the liver that prevents the production of harmful lipoproteins.
ACTOS, an insulin sensitizer, is shown to improve diabetic dyslipidemia components when administered in combination with other diabetes therapies. The study found significant increases in average and peak LDL and HDL particle size, accompanied by a decrease in particle density.
A newly discovered gene, Pcsk9, has been found to regulate the uptake of bad cholesterol from the blood by affecting liver cells' LDL receptors. This study provides a potential therapeutic approach to treating high blood cholesterol levels, a major risk factor for heart disease.
Research found a 50% increased risk of total stroke and 70% increased risk of ischemic stroke in women with migraine with aura, compared to those without. High cholesterol levels were also associated with an increased risk of ischemic stroke.
Researchers found that cholesterol levels peak in the winter and decrease in the summer, with women experiencing greater seasonal variability. The study suggests that changes in plasma volume explain the observed increases in cholesterol levels during the winter months.
The American College of Physicians recommends statin therapy for adults with type 2 diabetes, regardless of cholesterol levels, due to the high risk of cardiovascular disease. The guidelines also emphasize the importance of monitoring liver function and muscle enzymes only in patients with pre-existing conditions.
A study found that long-term calorie restriction significantly reduces risk of atherosclerosis, diabetes, and high blood pressure. Participants on low-calorie diets had lower cholesterol, triglyceride, and fasting glucose levels compared to those on typical Western diets.
A new animal study has found that trans fats can significantly increase total cholesterol and LDL-C levels, as well as TC/HDL-C ratios, in a swine model. The study suggests that high-trans fat diets may promote the rapid development of cardiovascular disease.
A new study reveals that torcetrapib significantly increases levels of HDL cholesterol in patients with low levels, which can help reduce the risk of heart disease. The drug works by inhibiting the transfer of cholesterol from HDL to LDL, and its effectiveness is maintained when given in combination with a statin.
A USC study found that human ancestors developed meat-tolerant genes to resist diseases associated with a meat-rich diet, leading to slower aging and longer lifespan. However, the researchers argue that modern-day humans' sedentary lifestyle and lack of moderation may be contributing factors to high cholesterol and vascular disease.
Researchers at UT Southwestern have made significant progress in understanding lipodystrophies, rare disorders characterized by partial or total loss of fat tissues. Recent studies have identified gene mutations and novel therapeutic approaches for these patients, which may also be applicable to obese individuals with abnormal fat dist...
According to Dr. McDougall, high-fat low-carbohydrate diets can increase the risk of heart disease, kidney failure, colon cancer, and more. In contrast, populations that consume high-carbohydrate foods tend to have a lower risk of these conditions.
A recent five-year study found that simvastatin therapy significantly reduces the incidence of ischemic strokes by 30%, while having no adverse effect on hemorrhagic strokes. The study also shows a substantial reduction in combined major vascular events among patients with cerebrovascular disease.
A new study found that only 4% of women with coronary heart disease met all four lifestyle goals, including non-smoking status and exercise. Researchers say the findings underscore the need for more effective interventions to improve compliance among high-risk women.
Researchers at Thomas Jefferson University have discovered a complex of two proteins in the intestine that plays a crucial role in cholesterol transport. Treating mice with ezetimibe disrupts this complex, leading to impaired cholesterol absorption, suggesting new therapeutic possibilities.
A 10-week study found that consuming plant sterol-fortified orange juice lowered total and LDL cholesterol levels by 7.2% and 12.4%, respectively. The researchers suggest this could be a healthy and appealing option for individuals with mildly elevated cholesterol.
Schering-Plough scientists identified NPC1L1 as a critical protein in the intestinal cholesterol absorption pathway. The discovery provides new insights into how the body regulates cholesterol levels and suggests that Zetia, a cholesterol absorption inhibitor, works by interacting with NPC1L1.
A new study found that people with short variants of the APOB gene region have significantly lower total and low-density lipoprotein cholesterol levels in their blood. This association may contribute to a protective role of these variants in younger adults, while being detrimental to longevity in older individuals.
Scientists propose that alterations in cholesterol and ceramide contribute to neurodegenerative cascade destroying neurons in Alzheimer's disease. Oxidative stress triggered by beta amyloid peptide leads to ceramide accumulation, causing nerve cell death.
Researchers present findings on various stroke treatments, including the effectiveness of IV magnesium in reducing death and improving functional outcome. Additionally, studies show promise for statins, oxygen therapy, and clot-busting therapies in improving neurological outcomes after ischemic stroke.
Patients with a history of high cholesterol had a lower risk of cognitive impairment three to six months after stroke. The study found that statin treatment, rather than the cholesterol itself, may be responsible for this effect.
A new study suggests that treating metabolic syndrome's risk-factor components might reduce stroke risk before Type 2 diabetes develops. Men with metabolic syndrome have a 78% greater stroke risk, while women have more than double the risk compared to those without the condition.
A new study published in the American Journal of Clinical Nutrition found that a moderate-fat diet may be more beneficial for heart health than a low-fat diet. After six weeks, participants on the moderate-fat diet had a healthier heart profile, with reduced cardiovascular risk and improved lipid profiles.
Dialysis patients with inflammation or malnutrition have lower cholesterol levels than those without. Higher cholesterol is associated with lower mortality among patients without these conditions, but not among those with them.
A recent study found that only 37% of adults with diagnosed diabetes are achieving the American Diabetes Association's goal for blood glucose control, while nearly half have high cholesterol and high blood pressure. The lack of lifestyle changes, such as exercise and weight loss, is a major contributor to this issue.
A study examining trends in adults with diagnosed diabetes found that only a small percentage met recommended targets for HbA1c, blood pressure, and total cholesterol. The authors highlight the need for ongoing monitoring, empowering clinicians and patients to improve care quality and reduce vascular disease risk.
A cholesterol-free mouse model was generated, supporting the 'sterol synergism' theory and highlighting the importance of cholesterol in developmental stages. The knock-out pups showed poorer growth characteristics than normal animals.
A new UCLA test measures HDL cholesterol's ability to reduce inflammation, potentially better predicting heart disease risk. The study found that patients with pro-inflammatory HDL had a higher risk of heart disease despite normal or high cholesterol levels.
Dr. Mangelsdorf's work on lipid-sensing proteins and cholesterol metabolism has contributed to the understanding of how the body restores balance following an increase in cholesterol levels. He joins a legacy of renowned UT Southwestern scientists who have also received the Wieland Prize for their groundbreaking research.
A large study of nearly 44,000 healthy men found no association between dietary fat intake and stroke risk. The research suggests that saturated fat intake may actually be beneficial in reducing atherosclerosis, contrary to previous findings.
A new study examined lipid data from the DASH-Sodium Trial and found no notable increases in blood lipid levels among participants on low, intermediate, or high sodium intake levels. The findings are significant for public health recommendations to reduce sodium intake and lower high blood pressure.