Articles tagged with Immune Receptors
A research group from Purdue University analyzed the interaction between poliovirus and its receptor, finding that it uses a similar site to bind as human rhinoviruses. The study provides new insights into how viruses selectively attach to receptors and may suggest ways for developing drugs to prevent illnesses caused by viral pathogens.
Researchers link myxoma poxvirus to HIV-like immune deficiency in rabbits, supporting a new theory on the origins of HIV resistance. The discovery strengthens the hypothesis that smallpox may have imposed selective pressure for the CCR5 receptor mutation to persist.
Researchers at the Weizmann Institute have developed a new treatment for a myasthenia gravis-like disease in rats by administering genetically engineered receptor fragments through the nose. The approach may serve as a basis for treating this autoimmune disease in humans, where symptoms can be life-threatening.
Researchers have discovered that specialized proteins in the nose called olfactory receptors can bind with multiple odor molecules, creating a unique 'fingerprint' that the brain understands as a particular smell. This discovery could lead to new fragrances and flavors, as well as artificial smell sensors.
Scientists at Cedars-Sinai Medical Center have identified a key component of the immune system's over-aggressive response that leads to septic shock. The discovery confirms suspicions raised by recent studies and may lead to new treatment approaches for severe bacterial infections.
Researchers at Advanced Viral Research Corp. discovered that Reticulose markedly decreases the production of CCR5 receptors in CD4 positive T-lymphocytes, increasing resistance to HIV infection. This finding may enhance the effectiveness of AIDS cocktails and pave the way for combination therapy.
Researchers at Oregon Health Science University have uncovered a mechanism used by certain leukemia viruses to attach themselves to cell surfaces and sneak into cells. They've also developed a rapid cloning method for human genes encoding viral receptors, which could lead to new treatments for viral diseases.
The Northwestern University-led study determines the precise shape of the high-affinity immunoglobulin-E receptor, a trigger for allergic responses. The structure's discovery could lead to the development of targeted therapies blocking the receptor's binding to antibodies.
Researchers at the University of Illinois have isolated a rotaviral strain's receptors, which can be used to create a synthetic mimic that blocks the virus. The team hopes to use this alternative therapy to protect against disease without causing infection.
Scientists have identified a specific gene, the AH receptor, as a vital link in the chemical cascade that causes cancer when exposed to cigarette smoke. The study found that mice without this receptor showed no damage from cigarette smoke, suggesting it plays a crucial role in controlling gene damage.
Researchers at Emory University have identified a potential new approach for alleviating Parkinson's disease symptoms by blocking glutamate receptors in the brain. This could lead to combination therapies that improve treatment outcomes and reduce side effects.
Researchers at Cedars-Sinai Medical Center have discovered that a combination of the diabetes drug Troglitazone and Accutane can permanently inhibit the growth of breast cancer cells and induce programmed cell death. The treatment has shown no adverse effects on healthy cells in laboratory studies and animal experiments.
Researchers at Columbia University have linked a particular odor to the proteins in the human nose that detect it for the first time. They matched the smell of meat to a specific protein in rat nerve cells, shedding light on how the sense of smell works.
Researchers found a genetic mutation that increases susceptibility to allergies, making individuals 10 times more likely to develop allergies. The discovery could lead to targeted medications and help identify high-risk individuals for intervention strategies.
A new study on IL-4 receptors expands scientists' understanding of the role in genetic predisposition to asthma and allergies. Researchers hope to develop innovative treatments by targeting IL-4 receptors in clinical trials.
Researchers have discovered a small peptide called ALX40-4C that blocks the CXCR4 coreceptor used by HIV-1 to infect T cells. This breakthrough suggests a potential new generation of combination therapies that could delay or prevent HIV infection and AIDS progression.
Researchers have discovered a naturally occurring chemokine antagonist, vMIP-II, which can block both CCR5 and CXCR4 receptors used by HIV to infect human cells. This breakthrough may lead to novel approaches for HIV therapy, including prevention of initial infection and slowing disease progression.
Scientists pinpoint exact spot where snake venom latches onto receptor, paving way for synthetic antidote. The new treatment could be more effective and faster-acting than current method, eliminating risk of allergy.
A potent chemokine, AOP-RANTES, has been shown to inhibit HIV-1 entry into macrophages and lymphocytes at the nanomolar level. Researchers believe this could lead to a new treatment approach for HIV/AIDS by targeting host cells to prevent viral entry.
Researchers identified specific receptors for interleukin-1 on somatotrope cells in the pituitary gland, suggesting a direct link between the immune and endocrine systems. This discovery may help understand how the immune system regulates animal growth and disease.