Articles tagged with Nucleosides
Researchers at Osaka Metropolitan University found compounds in nucleic acids from salmon DNA and torula yeast RNA inhibit cancer cell growth. These compounds may prevent cancer by stopping cell replication.
Researchers at Linköping University develop a new method to deliver strong compounds specifically to bacteria, allowing for efficient and safe treatment of infections. The TOUCAN strategy uses nucleases to target bacterial DNA, reducing side effects associated with current antibiotics.
A study published in Journal of Hepatology found that some patients with chronic hepatitis B can achieve sustained immune control by discontinuing antiviral therapy after four years. This suggests a potential cure for the disease, which affects an estimated 350 million people worldwide.
Researchers found that after 96 weeks, some patients achieved loss of detectable HBsAg and reduced liver inflammation levels, indicating functional cure. The study suggests that discontinuing long-term antiviral therapy may be more effective than continuing it for certain patients.
Researchers discovered that leukemia cells immediately unresponsive to treatment have high levels of SAMHD1, while those with acquired resistance use the enzyme DCK to activate nucleoside analogues. This finding may lead to better cancer therapies.
The new method streamlines DNA production by automating the synthesis of phosphoramidites, eliminating manual labor and storage issues. This breakthrough has significant implications for disease identification, drug manufacturing, and other medical applications.
A new process developed by SFU chemist Robert Britton and his team allows for the creation of new nucleoside analogues in a fraction of the time previously required. This breakthrough has significant implications for treating viral infections and cancer.
Researchers have identified a unified chemical pathway that generates both purine and pyrimidine nucleosides, key building blocks of RNA. The 'wet-dry' cycling approach provides a plausible solution to the formation of Watson-Crick bases, but synthesis specifics of carbohydrates remain unclear.
Researchers have identified a mutation in the SLC28A1 gene, affecting the synthesis of the hCNT1 protein and altering pyrimidine metabolism. The study provides insights into the potential role of nucleoside transporters in regulating cellular processes and may lead to new therapeutic approaches for cancer treatment.
Scientists have shown that alternation of wet and dry conditions can drive the prebiotic synthesis of RNA nucleosides. The new experiments demonstrate a plausible route for the formation of these building blocks, which constitute the informational components of RNA.
Researchers have devised a carbon-nitrogen bond forming strategy leading to new nucleoside analogues with interesting fluorescence properties, expanding on previous modifications.
Researchers developed a CRISPR-based system, called REPAIR, which can edit single RNA letters in human cells. This new system has potential to treat diseases without permanently affecting the genome.
City College of New York scientists discover a rapid method to produce new molecules inhibiting the HIV virus, focusing on modifying nucleosides and their impact on biological activity. The research yields diverse compounds that can be tested for structural effects against the virus.
Researchers created a time-lapse animation of the concentrative nucleoside transporter (CNT) transporting nucleosides into cells. The study provides important structural information for designing smarter, more specific anticancer and antiviral drugs.
Researchers from Tianjin University and Nankai University have unraveled the puzzle of how Zika virus replicates. They discovered a tunnel in the enzyme that holds viral RNA, allowing it to unwind its genetic material. This breakthrough could lead to the development of antiretroviral drugs against this spreading disease.
Scientists at Scripps Research Institute have found a way to apply powerful new DNA-editing technology more broadly than ever before. They report their breakthrough in using designer TALE proteins that can target any DNA sequence, enabling precise gene manipulation for biotech and medical applications.
A study published in Nature Structural and Molecular Biology reveals that cellular modifications to tRNA enhance its ability to decode genetic information at the atomic level. The research supports Agris' Modified Wobble Hypothesis, suggesting that modified nucleosides enable tRNA to decode more than one DNA code.
Two studies compare the efficacy and adherence of the triple nucleoside regimen of Ziagen/Combivir versus PI-containing regimens. Preliminary data show that patients on the Ziagen/Combivir regimen had better viral load suppression, with 68% achieving <400 copies/ml at 24 weeks, compared to 57% on the PI-containing regimen.