Articles tagged with T Cell Migration
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Research shows that sleep promotes the migratory potential of immune cells, specifically T cells, towards lymph nodes. This process is mediated by growth hormone and prolactin, two hormones that display sleep-dependent changes in concentration.
Researchers at the Francis Crick Institute have discovered that immune cells use an influx of water and ions to propel themselves forward, a process regulated by the WNK1 protein. This mechanism is essential for T cell migration and has implications for understanding cancer spread.
Researchers at the University of Bonn have identified a mechanism that helps dendritic cells migrate more quickly to lymph nodes. The discovery reveals that forming multiple centrosomes enables these immune cells to stay on course longer before continuing their search.
A University of Houston engineer has developed technology to determine which patients are likely to respond to CAR T-cell therapy for lymphoma, saving time and increasing success rates. The TIMING method analyzes interactions between T cells and tumor cells, identifying a key ligand molecule that predicts patient response.
Researchers found that 'killer' T-cells used in immunotherapy can also destroy tumour lymphatic vessels, greatly reducing the risk of metastasis. This synergistic effect could increase treatment effectiveness against cancers with high lymphangiogenesis.
Human immune cells occupy certain tissues and remain there for years, contrary to previous belief. T cells found to be optimally adapted to their local environment, potentially supporting barrier function.
Researchers at Johns Hopkins Medicine discovered a peptide on the SARS-CoV-2 spike protein that triggers an immune response in humans and is also recognized by cells of the immune system, suggesting potential for protection against future zoonotic outbreaks. The study supports the development of multivalent vaccines against a broad spe...
A study published in Cell Reports reveals that LPS protects against developing asthma when combined with allergens containing cysteine protease enzymatic activity, but promotes development when paired with allergens lacking this enzyme. This protective effect relies on the production of GM-CSF by non-classical monocytes.
Researchers at the University of Cincinnati discovered a potential new target to enhance T cell infiltration in solid tumors. Targeting the KCa3.1 potassium channel can restore CD8+ T cell migration, suggesting a new therapy option for solid tumor treatment.
B cells use a unique migration strategy in the bone marrow that allows them to exit slowly and be passively swept out by blood flow. The researchers found that the absence of CXCR4 significantly slows down B cell movement, highlighting the importance of this protein in regulating immune cell egress.
Scientists found that immune cells only need to contact specific antigens on the transplanted organ to be activated and reject it. This discovery could lead to new anti-rejection therapies for organ transplantation.
Transplant researchers at Pitt School of Medicine found that chemokine receptors are not necessary to start the rejection response. Instead, dendritic cells identify antigens and present them to the recipient's immune system, leading to organ rejection.
Researchers discovered HIV exploits immune system by using infected T cells to travel and infect other CD4 T cells. The study used a humanized mouse model and found that infected cells carry virus to remote locations, supporting the development of new treatment strategies.
Researchers at the University of Rochester Medical Center have found a way to selectively block the ability of white blood cells to migrate toward sites of injury and infection, which drives disease. This discovery suggests a new approach for treating autoimmune diseases such as rheumatoid arthritis, lupus, and multiple sclerosis.
Researchers used advanced microscopy techniques to visualize T cells actively migrating through and killing tumor cells in real-time. The study provides new insights into the mechanisms of interaction between T cells and tumor cells, with the presence of antigen determining migration and interaction.