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Immunology: good sleep stimulates the immune system

Research shows that sleep promotes the migratory potential of immune cells, specifically T cells, towards lymph nodes. This process is mediated by growth hormone and prolactin, two hormones that display sleep-dependent changes in concentration.

Influx of water and salts propel immune cells through the body

Researchers at the Francis Crick Institute have discovered that immune cells use an influx of water and ions to propel themselves forward, a process regulated by the WNK1 protein. This mechanism is essential for T cell migration and has implications for understanding cancer spread.

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Newly discovered process brings immune cells up to speed

Researchers at the University of Bonn have identified a mechanism that helps dendritic cells migrate more quickly to lymph nodes. The discovery reveals that forming multiple centrosomes enables these immune cells to stay on course longer before continuing their search.

Technology developed at UH could advance treatment of lymphoma

A University of Houston engineer has developed technology to determine which patients are likely to respond to CAR T-cell therapy for lymphoma, saving time and increasing success rates. The TIMING method analyzes interactions between T cells and tumor cells, identifying a key ligand molecule that predicts patient response.

Cancer: The double advantage of killer T-cells

Researchers found that 'killer' T-cells used in immunotherapy can also destroy tumour lymphatic vessels, greatly reducing the risk of metastasis. This synergistic effect could increase treatment effectiveness against cancers with high lymphangiogenesis.

Immune cells as squatters

Human immune cells occupy certain tissues and remain there for years, contrary to previous belief. T cells found to be optimally adapted to their local environment, potentially supporting barrier function.

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Infection-fighting B cells go with the flow

B cells use a unique migration strategy in the bone marrow that allows them to exit slowly and be passively swept out by blood flow. The researchers found that the absence of CXCR4 significantly slows down B cell movement, highlighting the importance of this protein in regulating immune cell egress.

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HIV-infected T cells help transport the virus throughout the body

Researchers discovered HIV exploits immune system by using infected T cells to travel and infect other CD4 T cells. The study used a humanized mouse model and found that infected cells carry virus to remote locations, supporting the development of new treatment strategies.

Researchers find new way to block destructive rush of immune cells

Researchers at the University of Rochester Medical Center have found a way to selectively block the ability of white blood cells to migrate toward sites of injury and infection, which drives disease. This discovery suggests a new approach for treating autoimmune diseases such as rheumatoid arthritis, lupus, and multiple sclerosis.

Innovative movies show real-time immune-cell activity within tumors

Researchers used advanced microscopy techniques to visualize T cells actively migrating through and killing tumor cells in real-time. The study provides new insights into the mechanisms of interaction between T cells and tumor cells, with the presence of antigen determining migration and interaction.