Articles tagged with Mouse Models
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A mouse model of Rett Syndrome displays reduced cortical activity, suggesting a primary cellular defect. The study found that the excitatory-inhibitory balance in the cortex is shifted towards inhibition, which may underlie cognitive, motor, and social symptoms in RTT.
Researchers at U Iowa have made significant breakthroughs in treating Huntington's disease by reducing protein levels in genetically engineered mice. The study, published in PNAS, demonstrates the effectiveness of RNA interference in improving HD-like symptoms in a mouse model.
A new mouse model mimics the effects of low-dose aspirin therapy, reducing platelet aggregation and inhibiting thrombosis. The study suggests that low-dose aspirin treatment may prevent preeclampsia without compromising reproductive function.
The study developed mice with a mutant form of ELOVL4, which causes significant lipofuscin accumulation and photoreceptor death, closely resembling human AMD and STGD. This model now permits testing of potential therapies for the dry version of age-related AMD and STGD.
Researchers found that a protein called STAT3 is crucial for the development of psoriasis and can be reversed with a specific treatment. The study's findings offer a potential new target for medications to relieve symptoms of psoriasis.
The study found that LR11 plays a crucial role in regulating beta amyloid levels, suggesting its potential as a therapeutic target for Alzheimer's disease. The Emory researchers used lentiviruses to selectively reduce and enhance LR11 expression in mouse brains and cultured cells.
Dr. Li-Huei Tsai's groundbreaking study reveals p25 protein's role in Alzheimer's disease, a key feature of which is the presence of beta amyloid plaques and neurofibrillary tangles. The research also suggests an intervention after stroke could lower or prevent additional risk of Alzheimer's
Asthma researchers at Yale discovered a new protein, AMCase, that contributes to inflammation in the airways. Blocking this protein may provide relief for humans with asthma, but its mechanism of action is not yet fully understood.
A research study found that inhibition of cathepsin cysteine proteases impairs tumor growth and progression in transgenic mouse models of cancer. Treatment with a pharmacological inhibitor also disrupted both early and late stages of tumor development, suggesting its potential as an anticancer therapeutic.
Researchers have created a new mouse model of Alzheimer's disease to study the effects of toxic protein p25 on brain degeneration. The model, developed by Harvard Medical School scientists, shows high levels of p25 accumulation leading to neuronal death and tau pathology after just 12 weeks.
The article describes a biologically well-characterized mouse model for cystinuria type I, a human disease caused by impaired renal function. The model closely mimics the human disease state and is expected to improve biomedical research in areas like disease analysis and drug testing.
Researchers have developed a new mouse model that mimics progeria, a rare condition characterized by accelerated aging. The mouse model shares symptoms with human patients, including growth retardation, skin thinning, and premature death, providing valuable tools for studying the aging process.
Researchers have discovered that mouse models of Alzheimer's disease duplicate their DNA and make an attempt at cell division, just like human nerve cells. This suggests that the underlying mechanism of cell death is the same in both species, potentially making these model systems more suitable for testing experimental therapies.
Researchers created a mouse model of Rett syndrome to study the gene MECP2 and its role in fine-tuning the developing nervous system. The study may improve understanding of the disorder and lead to potential treatments for patients.