Articles tagged with Adipogenesis
A new study found that miR-145-5p and miRNA-27b-3p interfere with fat cell formation in children with Hutchinson-Gilford progeria syndrome, a rare and fatal premature aging disorder. These microRNAs silence genes required for fat cell growth and function, suggesting they could be a promising therapeutic strategy to restore fat tissue.
Researchers found that CD44-deficient mice stayed lean despite a high-fat diet, while control mice developed obesity. The study suggests CD44 inhibitors could serve as a complementary treatment for obesity and related metabolic disorders.
Researchers discovered novel regulatory molecules in adipogenesis, specifically membrane receptors like GPCRs. ADGRD1 promotes differentiation of adipose progenitor cells while GPR39 inhibits this process.
Researchers have identified a population of mesothelial-like cells in omental adipose tissue that limit fat cell formation, offering new insights into the mechanisms underlying obesity. These cells secrete Insulin-like Growth Factor Binding Protein 2, which inhibits adipogenesis and regulates metabolic behavior.
A NYUAD study reveals that the β-actin protein plays a crucial role in activating genes essential for fat tissue formation. The discovery sheds light on the molecular basis of adipogenesis, which can help researchers develop new treatments for metabolic diseases such as diabetes and obesity.
Muscle gradually increases Annexin A2 expression in the absence of dysferlin, driving fatty deposits and promoting adipocyte formation from fibro/adipogenic precursors. Shutting down Annexin A2 or blocking FAP differentiation arrests disease progression.
A study by EPFL researchers found that the KRAB domain-containing zinc finger protein Zfp30 initially repressed a retrotransposon, but later evolved to activate genes involved in fat-cell formation instead, surprising scientists
Researchers found that adding NELL-1 to BMP2 therapy produces tightly woven trabecular bone within the defect area, whereas BMP2 alone leads to adipose tissue interspersed with sparse trabecular bone. The combination treatment inhibits adipogenesis and promotes osteogenesis.
A new adipogenic cocktail D&R has been developed to induce functional mature adipocytes from MSCs. This cocktail improves energy homeostasis by inducing cells with characteristics of a mature adipocyte, including fat droplets and sensitivity to insulin.
A compound found in red wine and fruits can block the development of immature fat cells, according to a Purdue University study. The compound, piceatannol, alters gene expressions and insulin action during adipogenesis, delaying or inhibiting the formation of mature fat cells.
Researchers identify PPARgamma2 as critical player in fat cell differentiation process. The discovery provides a molecular target for rational drug design to combat obesity.