Articles tagged with Lupus
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
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Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
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Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers have discovered that autoreactive B cells escape normal controls by proliferating and undergoing somatic hypermutation outside the germinal center, leading to the production of autoantibodies in autoimmune diseases like lupus. The study reveals a new understanding of how B cells contribute to the origins of these diseases.
The FDA has cleared a new diagnostic test that aims to detect 20% of SLE cases that previously went undiagnosed due to the limitations of existing blood tests. The test, developed by Mark Roth, uses molecules called SR proteins as biomarkers, improving doctors' ability to make accurate diagnoses and predict disease flare-ups.
The Antiphospholipid Syndrome Collaborative Registry aims to enroll 2,000 patients over five years to better understand the disease, its causes, and treatment options. The registry will facilitate research, diagnosis, and development of diagnostic tests and treatments for antiphospholipid syndrome.
Researchers at Princeton University have pinpointed what appears to be a central cause of lupus, an autoimmune disease that affects 1.4 million Americans. The discovery highlights a specific mechanism in B cells that produces disease-fighting antibodies, which can mistakenly attack the body's own DNA.
Researchers at National Jewish Health have discovered a unique 'flap' on protein Tall-1 crucial to its function, which could lead to new treatments for autoimmunity. The flap-free version of the molecule triggers no biological activity but still binds to receptors.
Researchers have discovered that antibodies attacking DNA in people with lupus can also target molecules controlling glutamate activity, leading to neuron death and possible cognitive symptoms. This finding suggests a potential pathway for neurological complications and may lead to new therapeutic options.
Researchers found that abnormal alpha-interferon secretion in lupus patients leads to hyperactivation of dendritic cells, causing the immune system to attack healthy cells. This abnormal reaction can result in chronic inflammation affecting various organs, including the skin, kidneys, and joints.
Researchers found that bovine thrombin causes an immune response similar to lupus in mice and can lead to post-operative complications. Bovine thrombin is a potent enzyme used in surgical procedures, but its use should be restricted to life-saving surgeries due to the risk of autoimmune responses.
A Phase III study found that Aslera significantly improved disease activity and symptoms in patients with systemic lupus erythematosus (SLE), a chronic autoimmune disease. The treatment also showed benefits for bone mineral density, particularly in women on steroids.
GL701 significantly reduced lupus flares, with 18% of patients experiencing flares compared to 34% on placebo. The study also showed improved quality of life and reduced adverse events.
A Phase III study found that Aslera improved bone mineral density in female lupus patients by 1.8% compared to a loss of 1.8%, with greater increases observed in postmenopausal patients. This suggests that Aslera may be effective in preventing osteoporosis and fractures in women with SLE.
Researchers found that high-dose immune suppression and stem-cell transplantation can lead to long-term remission in lupus patients. The treatment approach has implications for the treatment of other immune disorders, including multiple sclerosis and some types of cancers.
Scientists at Fred Hutchinson Cancer Center developed a new diagnostic test for lupus using SR proteins as biomarkers. The color-coded test can identify 50-70% of undiagnosed lupus patients, promising to bridge the detection gap.
Research highlights potential causes of autoimmune diseases, including prenatal exposure to environmental chemicals and certain dietary factors. Studies also explore links between ultraviolet radiation, stress, and exposure to heavy metals.
Dr. Lee Hartwell, president of the Fred Hutchinson Cancer Research Center, will join four biotechnology leaders in discussing the future of biotechnology. They will address topics such as new methods for diagnosing diseases like lupus and leukemia, and the potential impact on drug development.
Northwestern University researchers have identified key peptides that can halt and even reverse kidney disease in lupus. The peptides were found to be effective in delaying the onset of severe kidney disease in young mice and prolonging survival in adult mice with established kidney disease.
Andrew Caton, a Wistar Institute scientist, will receive the Lupus Foundation of Philadelphia's prestigious Sheryl N. Hirsch Award for his work on systemic lupus erythematosus. The award recognizes Dr. Caton's efforts to shed light on the role of infections in lupus initiation and exacerbation.
The Lupus Foundation of America has awarded a summer internship to Yale student Su-jean Seo, who is conducting research on antigens targeted in autoimmune diseases like lupus erythematosus at the Wistar Institute. The fellowship will support her work under the supervision of Dr. Jan Erikson.
Caroline Sokol, a researcher at The Wistar Institute, has been awarded the Goldie Simon Preceptorship Award for her work on autoreactive B-cells in systemic lupus erythematosus. She aims to earn a joint M.D./Ph.D. to conduct clinical research and improve understanding of the chronic autoimmune disease.
Rockefeller University researchers identify a critical link between autoantibodies and inflammation, suggesting novel ways to uncouple this connection. They found that preventing the activation of antibody receptors by autoantibodies is an effective way to treat autoimmune diseases like lupus.
Researchers have synthesized two protein fragments that effectively immunize mice against lupus. These findings may lead to more focused treatments with fewer side effects.
The new test developed by Prof. Roald Nezlin of the Weizmann Institute solves a problem with standard tests by measuring the quantity of DNA in harmful complexes, indicating effective treatment. This approach could also be used to measure antibody complexes involved in other autoimmune diseases.