Articles tagged with Intellectual Disabilities
Researchers identified a strong association between a 12 bp mutation in a newly discovered X-chromosome gene and X-linked mental retardation. The mutation was found in 7 percent of all institutionalized mentally retarded males surveyed, as well as in higher frequency among those with Autism.
The study provides evidence that FMRP is transported into the cell's nucleus where it forms a complex with particular mRNAs and then is transported out of the nucleus to join ribosomes in the neuronal cytoplasm. The researchers discovered that free ribosomes, found in dendrites and dendritic spines, associate with FMRP.