Chemokines regulate immune cell infiltration and local immunity in tumors, and targeting their receptor axis has emerged as a promising therapeutic target in cancer immunotherapy. Chemokine-modulating strategies combining with other immunotherapies have demonstrated considerable synergistic potential.
SourceChinese Medical Journals Publishing House Co., Ltd.·JournalChinese Medical Journal·TypeLiterature review·DateApr 20, 2026
Researchers at the University of Plymouth investigate why drugs used to treat other tumours are ineffective against NF2-related schwannoma and meningioma tumours. They explore repurposing clinically tested cancer drugs to target MDR mechanisms, which may lead to effective therapies for patients with these tumours.
Researchers developed patient-specific Cancer Chips to model esophageal tumor microenvironments, enabling accurate prediction of chemotherapy responses. The approach can rapidly stratify patients into responders and non-responders, paving the way for personalized medicine.
SourceWyss Institute for Biologically Inspired Engineering at Harvard·JournalJournal of Translational Medicine·TypeExperimental study·DateJun 27, 2025
Researchers found that pancreatic cancer cells gain a survival edge by carrying copies of critical cancer genes on circular pieces of DNA outside chromosomes. The discovery highlights the importance of targeting extrachromosomal DNA in treating the disease.
SourceChampalimaud Centre for the Unknown·JournalNature·TypeExperimental study·DateMar 12, 2025
Sky-Watcher EQ6-R Pro Equatorial Mount
Sky-Watcher EQ6-R Pro Equatorial Mount provides precise tracking capacity for deep-sky imaging rigs during long astrophotography sessions.
Hepatic biliary adenofibroma (BAF) is a rare, benign tumor with histological characteristics distinct from other biliary tumors. Emerging case reports suggest potential for malignant transformation and overlap with intrahepatic cholangiocarcinoma (iCCA), highlighting diagnostic challenges and need for further research.
SourceXia & He Publishing Inc.·JournalJournal of Clinical and Translational Pathology·DateFeb 28, 2025
Key molecular applications in diagnosing and managing hematopoietic and lymphocytic neoplasms include comprehensive mutational profiling, aiding accurate diagnosis and prognostication. The use of targeted therapies against specific genetic abnormalities further refines treatment selection.
SourceXia & He Publishing Inc.·JournalJournal of Clinical and Translational Pathology·DateFeb 27, 2025
The study compared FDG-PET/CT and CT for evaluating treatment response in unresectable malignant pleural mesothelioma patients. The results showed that both imaging modalities provided accurate findings for tumor response evaluation, with high concordance between the two methods.
SourceImpact Journals LLC·JournalOncotarget·TypeImaging analysis·DateJul 15, 2024
The 2022 WHO classification of kidney epithelial tumors introduces significant updates to renal tumor pathology, incorporating both morphological and molecular criteria. Key changes include the reorganization of established tumors and the introduction of a new category for molecularly defined tumors.
SourceXia & He Publishing Inc.·JournalJournal of Clinical and Translational Pathology·DateJun 18, 2024
Researchers developed Tripath to analyze 3D tissue samples, predicting clinical outcomes based on 3D morphological features. This approach outperformed traditional methods, providing promising potential for guiding critical treatment decisions.
SourceMass General Brigham·JournalCell·TypeExperimental study·DateMay 9, 2024
SAMSUNG T9 Portable SSD 2TB
SAMSUNG T9 Portable SSD 2TB transfers large imagery and model outputs quickly between field laptops, lab workstations, and secure archives.
Long-term treatment with methylene blue (MB) and mitoquinone (MitoQ) did not alter age-related bone loss in mice. Antioxidant interventions are insufficient to inhibit skeletal aging, suggesting alternative approaches may be needed.
SourceImpact Journals LLC·JournalAging-US·TypeExperimental study·DateApr 3, 2024
A new study found that postmenopausal women exhibit smaller cortical surface areas in certain brain regions, reduced thalamic subnuclei volumes, and decreased functional connectivity, suggesting a link between menopause-related symptoms and brain changes.
SourceImpact Journals LLC·JournalAging-US·TypeObservational study·DateApr 1, 2024
Researchers characterized changes in cognitive behaviors, neuronal morphology and gene expression in a tauopathy mouse model. The study found significant decreases in dendritic arborization and synaptic gene upregulation over time.
SourceImpact Journals LLC·JournalAging-US·TypeExperimental study·DateNov 15, 2023
A novel droplet digital PCR assay detects KMT2A fusion markers in AML patients, enabling sensitive MRD detection and guiding treatment decisions. This breakthrough may improve patient outcomes by assessing response to therapy and long-term surveillance.
SourceElsevier·JournalJournal of Molecular Diagnostics·TypeExperimental study·DateNov 13, 2023
DJI Air 3 (RC-N2)
DJI Air 3 (RC-N2) captures 4K mapping passes and environmental surveys with dual cameras, long flight time, and omnidirectional obstacle sensing.
Researchers developed an AI-based method for virtual staining of histopathological tissue samples, producing images that closely resemble actual chemical-stained samples. This reduces chemical burden and manual work while enabling the use of tissues for other purposes.
SourceUniversity of Turku·JournalLaboratory Investigation·DateApr 14, 2023
Researchers used MRI scans and texture analysis to differentiate between two types of benign oral bone lesions, ameloblastomas and odontogenic keratocysts. The study found that certain pixel and voxel organizational parameters in the MRI images were statistically significant, enabling more accurate diagnosis and treatment planning.
SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournalScientific Reports·DateFeb 15, 2023
A recent study published in Oncotarget reveals that Nectin-4 is widely expressed in head and neck squamous cell carcinoma (HNSCC), with significant correlations to clinico-pathological parameters. Non-smokers and p16-positive HNSCC showed higher expression of Nectin-4, leading to better survival rates for positive tumors.
SourceImpact Journals LLC·JournalOncotarget·TypeExperimental study·DateNov 3, 2022
A Brazilian group developed a peptide called Rb4 that triggers necrosis in murine melanoma cells and inhibits the viability of human cancer cells. In mice, Rb4 reduced lung metastasis and slowed subcutaneous melanoma growth, increasing survival by 25%.
SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournalScientific Reports·DateMay 20, 2022
Breakthrough research reveals Tuberous Sclerosis Complex arises from human-specific progenitor cells, explaining its pathology. Human-derived cerebral organoid models shed light on complex brain development and potential mechanisms for other diseases.
SourceIMBA- Institute of Molecular Biotechnology of the Austrian Academy of Sciences·JournalScience·TypeExperimental study·DateJan 27, 2022
Apple iPhone 17 Pro
Apple iPhone 17 Pro delivers top performance and advanced cameras for field documentation, data collection, and secure research communications.
Researchers have developed smart transformable nanoparticles that can alter their size and shape in response to physiological conditions, improving particle circulation, biodistribution, and targeted therapy for cancer theranostics. These particles promise enhanced tumor diagnoses and treatment by adapting to the physiology of tumors.
SourceAmerican Institute of Physics·JournalApplied Physics Reviews·TypeExperimental study·DateDec 7, 2021
Researchers found no correlation between breast cancer's different structures and chromosomal abnormalities, challenging the idea that genetic mutations drive tumor heterogeneity. Instead, they discovered specific genes contributing to each structure's formation, suggesting alternative mechanisms driving morphological diversity.
SourceNational Research Tomsk State University·JournalJournal of Clinical Pathology·DateSep 29, 2015
A recent study found that differences in HD types across regions play a major role in determining regional survival rates. Analysis revealed no significant difference in mortality risk between EUROCARE-west and the US SEER databases when adjusting for morphology, but morphology accounted for differences in EUROCARE-UK and EUROCARE-east...
Aranet4 Home CO2 Monitor
Aranet4 Home CO2 Monitor tracks ventilation quality in labs, classrooms, and conference rooms with long battery life and clear e-ink readouts.