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Gut branches of vagus nerve essential components of brain's reward and motivation system

Researchers have identified a novel gut-brain neural circuit establishing the vagus nerve as essential for regulating reward and motivation. The study reveals that stimulating the right branch of the vagus nerve can excite reward neurons in the brain, offering potential targets for therapy for eating and emotional disorders.

Could Parkinson's disease start in the gut?

A recent study found that people who had a truncal vagotomy at least five years earlier were 40% less likely to develop Parkinson's disease than those who did not have the surgery. The study suggests that the gut may play a role in the development of Parkinson's disease, which often involves gastrointestinal problems.

SourceAmerican Academy of Neurology·JournalNeurology·DateApr 26, 2017

Study shows vagus nerve stimulation significantly reduces rheumatoid arthritis symptoms

A new study published in PNAS shows that vagus nerve stimulation significantly improves measures of disease activity in patients with rheumatoid arthritis. The treatment, which involves stimulating the vagus nerve with an implantable device, has been shown to inhibit cytokine production and attenuate disease severity in humans.

SourceNorthwell Health·JournalProceedings of the National Academy of Sciences·DateJul 4, 2016

Study shows stimulation helps stroke patients

A new study published in the journal Stroke demonstrates that vagus nerve stimulation can improve recovery in stroke patients by reducing impairments and increasing motion and strength in affected arms. The trial involved 20 patients with arm weakness due to stroke, showing significant potential for reducing disabilities.

SourceUniversity of Texas at Dallas·JournalStroke·DateDec 8, 2015

Breath taking

Scientists have identified two sensory neuron subtypes controlling different respiratory functions in mice, revealing a complex vagus nerve system that may lead to targeted therapies. The study sheds light on the molecular mechanisms underlying breathing control and has implications for treating various conditions.

SourceHarvard Medical School·JournalCell·DateApr 16, 2015

Nerve stimulation for severe depression changes brain function

Researchers found that vagus nerve stimulation brings about changes in brain metabolism weeks or months before patients begin to feel better. The treatment was able to improve symptoms of depression in 9 out of 13 participants, with significant changes in brain metabolism occurring far in advance of any improvement in mood.

SourceWashU Medicine·JournalBrain Stimulation·DateMay 7, 2013

Vagus Nerve Stimulator successful for depression

A nationwide clinical trial showed that Vagus Nerve Stimulation (VNS) improved the condition of 40% of patients with severe treatment-resistant depression, enabling them to return to work and normal activities. The treatment has been compared to electroconvulsive therapy and may have potential as an alternative for some patients.

SourceUT Southwestern Medical Center·JournalBiological Psychiatry·DateDec 15, 1999