Researchers developed a time-resolved cryo-ET method to capture snapshots of cultured neuronal synapses. The study identified a 'kiss-shrink-run' pathway that unifies the debated 'kiss-and-run' and 'full-collapse' fusion mechanisms, providing a structural basis for efficient synaptic transmission.
Researchers at KAIST successfully clarified the three-dimensional, vortex-shaped polarization distribution inside ferroelectric nanoparticles using atomic electron tomography. This discovery has implications for ultra-high-density memory devices with capacities over 10,000 times greater than existing ones.
The São Paulo School of Advanced Science on Cryogenic Electron Microscopy will be held at the University of São Paulo from July 10-27, 2023. The event will cover theoretical and practical foundations of advanced CryoEM techniques, featuring renowned researchers and hands-on practical sessions.
Researchers developed IsoNet, a software package solving intrinsic 'missing-wedge' problem and low signal-to-noise ratio issues in cryoET. IsoNet uses iterative self-supervised deep learning to perform missing-edge correction and denoise tomographic data.
Researchers used high-resolution micro-CT scans to reveal key features in Palaeospondylus fossils, placing it as an early ancestor of tetrapods. The study resolves long-standing evolutionary mysteries, including the lack of teeth and dermal bones in the fossil record.
Researchers from the Max Planck Institute have obtained the first high-resolution 3D image of the muscle protein nebulin using electron cryo-tomography. The structure reveals that each nebulin repeat binds with an actin subunit, acting as a ruler to dictate filament length and interacting with neighboring actin subunits to stabilize it.
A team of researchers has solved the structure of the HIV capsid alone and in complex with host factors using a novel approach. The breakthrough could lead to the development of capsid-targeting antivirals, providing new hope for those affected by HIV/AIDS.
KAIST researchers have developed a deep learning approach to accurately determine the 3D surface atomic structure of nanoparticles. The method enhances precision by nearly 70% and improves surface atom identification, enabling the study of catalytic properties at the atomic scale.
Scientists at Graz University of Technology have successfully imaged surface phonons in three dimensions, revealing the spatial distribution of electromagnetic fields near nanosurfaces. This breakthrough could lead to improved thermal conduction, sensor technology, and energy storage.
Researchers at MIT and partners have created detailed 3D images of kerogen's internal structure, improving predictions of oil and gas recovery. The study reveals that mature kerogen has smaller pores connected by a network allowing for easier extraction.
Researchers have developed a new transmission electron microscopy technique that can determine the 3D position of individual atoms with atomic resolution. The technique uses image intensity measurements to reconstruct the atomic potentials, allowing for more quantitative reconstruction of weakly scattering samples.
Researchers have developed a high-speed electron tomography technique that sets new standards for 3D imaging of the nanoworld. The method enables visualization of dynamic processes and structures with sub-nanometre precision, opening up new horizons in life sciences and soft matter research.
Researchers have made a significant breakthrough in understanding the microscopic electronic structure of cuprate superconductors, a key step towards achieving room-temperature superconductivity. The study reveals a stripe-like pattern in the static electron configuration, which differs from previous theoretical models.
Researchers at NIBIB have developed a new technique called BF STEM tomography, which allows for high-resolution 3D imaging of thicker specimen samples. This enables the visualization of larger internal structures in cells, providing greater insight into cell organization and function.
Researchers at Caltech used electron tomography to study the transport of antibodies from mother's milk to newborns' bloodstream. The findings revealed that antibodies are shuttled through large vesicles and form 'tangled messes' before being delivered into the bloodstream.
The 3D-EM Network of Excellence aims to image macromolecules and molecular machines at atomic resolution, fostering innovation in European EM research. The network will provide training, a structural database, and user-friendly software to enhance structural analysis.