A phase II multicenter collaborative study found that Velcade significantly reduced disease in 67% of patients with advanced multiple myeloma, with some achieving complete or near-complete responses. The drug has shown great potential to improve patient outcomes in this incurable disease.
Researchers have successfully assembled three-dimensional patterns from two different types of nanoparticles with complementary properties. The combination may exhibit novel magneto-optical properties and key features for quantum computing.
The Howard Hughes Medical Institute has awarded grants to promote science education and literacy in diverse communities. Programs will engage students and teachers from underrepresented groups and focus on standards-based learning.
A recent study analyzed data from two Finnish cohorts and found the risk of any type of eye injury caused by airbags to be very slight, only 2.5 percent. Open eye injuries were more likely to occur among eyeglass wearers, but those who did not wear eyeglasses were more likely to suffer from injuries caused by airbag chemicals.
A study by Te Velde found that the Pringle manoeuvre increases tumour growth and recurrence after liver surgery, reducing patient survival chances. Medicines preventing blood vessel regeneration can be combined with chemotherapy to control tumours.
Researchers have calculated that internal waves can carry up to 50% of their original energy as they propagate through the ocean depths, with this energy directed towards mid-latitude areas. This finding has significant implications for understanding ocean mixing and its impact on global climate models.
Researchers evaluating environmental impact of common nightcrawler on forest ecosystem in the Northeast. The invasive earthworm species is feeding on leaf litter and duff layers, affecting native plant seeds and animals.
A study by Dr Lydia Plowman and Dr Rosemary Luckin found that young children can coordinate toy and screen interactions without confusion. However, the toys' limited ability to promote learning was noted, with children preferring human helpers over technology.
The Tulane center will prepare and distribute a continuous supply of marrow stromal cells (MSCs) using standardized protocols, addressing the need for standard MSC preparations. The center's availability will allow scientists to better understand the capabilities of these cells for potential therapeutic uses.
A new study by UT Southwestern finds that finasteride effectively reduces prostate cancer risk and improves symptoms in men with benign prostatic hyperplasia. The drug, already used to treat BPH, works by inhibiting the conversion of testosterone to dihydrotestosterone, which is involved in prostate cancer development.
Researchers develop soluble mimics of GPCRs to study their interactions with G-proteins, potentially leading to new drugs for various medical conditions. The technology could also be used to screen for drugs that block malfunctioning GPCRs.
Researchers used computer simulations to study the effect of foreign particles on crystal growth patterns. They found that these particles produced unique 'dizzy dendrite' patterns that can be replicated using specific methods.
The American College of Sports Medicine honors Dr. Mueller, a renowned expert in athletic injury research, for his 35-year dedication to making sports safer. His work has led to significant rule changes, safety equipment updates, and a reduction in injuries and fatalities across various sports.
A University of Washington linguist and the Aleuts will begin a two-year effort to preserve the Aleut language by recording everyday conversations on audio and videotapes. The goal is to document the language, which has declined from 620 speakers in 1990 to just over 100 today.
Researchers from NIST and NREL develop a method to accurately measure the dipole moment of quantum dots, enabling optimization for various applications in quantum computing and quantum communications.
A Lehigh University professor has developed a system that combines images from optical and millimeter-wave cameras to detect concealed weapons, which could save security guards seconds in the search process. The technology uses wireless communication links and has potential applications for law enforcement and military use.
Kenyans rely on mosquito nets to keep mosquitoes at bay, but don't view them as a means of preventing malaria. Insecticide-treated bednets can reduce fatal cases by 20%, but effectiveness depends on consistent use and re-impregnation with insecticide.
Researchers discovered protrusions in oil paintings, composed of metal soaps, which form when paint layers contain lead and zinc. The phenomenon affects both panels and canvases, causing a bumpy surface texture, and can still be active in some cases.
The US patient underwent the second procedure in the revised Phase I human clinical trials at Penn State Hershey Medical Center. The Arrow LionHeart device has shown promising results in lengthening and improving the lives of patients with end-stage heart failure.
Researcher Chris Molenaar developed a method to follow biomolecule movements in living cells, revealing interactions between proteins and RNA. The technique uses fluorescent probes and microscopy to visualize molecular mobility and interactions, providing insights into cell functioning.
Researchers found that 30% of diabetic patients with kidney disease do not exhibit common symptoms like protein in urine and eye disease. The current approach of screening for these symptoms alone is insufficient, and a blood test measuring kidney function directly is recommended.
The Wake Forest Problem-Based Learning Center has received a $539,352 grant from the Howard Hughes Medical Institute to support teacher professional development. The center's program, which uses problem-based learning to engage students in real-world science and math projects, has shown remarkable success, with 97% of tracked students ...
Researchers at the National Space Biomedical Research Institute are developing a new treadmill training system to help astronauts recover from balance problems after long-duration space flights. The system will also aid elderly patients and others with similar issues.
Researchers found that patients with a negative pretransplantation scan had a favorable outcome, with 25 still in complete remission after a median follow-up of 1,510 days. In contrast, patients with a positive scan relapsed more frequently, highlighting the potential for [F]FDG-PET to identify nonresponders.
Researchers used ultrafast light pulses to visualize the speed distribution of electrons in Rydberg atoms, revealing their wave-like behavior. This study provides new insights into the interaction between light and slow-moving electrons.
Researchers at St. Jude Children's Hospital have successfully treated four pediatric patients with retinoblastoma using a combination of chemotherapy, radiation therapy, and stem-cell transplantation. The study shows promising results, with two out of four patients surviving for over six years without disease recurrence.
The EVAP-COND software simulates the performance of evaporators and condensers with various cooling agents, enabling engineers to optimize designs. This tool helps conserve energy while reducing laboratory testing and design-to-production time.
Researchers used acoustic measurements to recognize differences in vowel pronunciation among 160 Dutch and Flemish teachers. The study found that acoustic methods can map sociological differences in pronunciation with high accuracy, outperforming phonetic transcription methods which require manual expert analysis.
Finasteride has been shown to prevent prostate cancer in both low-risk and high-risk men. However, those on finasteride were more likely to develop high-grade cancers.
A ferret protein called glucose-6-phosphate isomerase (GPI) plays a key role in the reproductive process, allowing fertilized embryos to implant successfully. The discovery also sheds light on the mechanism of cancer cells, which can co-opt this process to invade healthy tissues.
Contrast-enhanced MRI is a reliable method to measure blood flow to tumors, allowing for accurate assessment of chemotherapy response and tumor viability. The study found that patients who responded to treatment had significant decreases in angiogenesis, while non-responders showed increases.
The National Institute of Standards and Technology has developed a new instrument to study the metal of World Trade Center (WTC) steel. The apparatus rapidly compresses and heats samples at extremely high temperatures, helping to improve understanding of how steel responds under stress.
Women taking long-term combined HRT face a significant increase in breast-cancer risk, doubling the risk for invasive lobular and ductal breast cancer. The study found that both sequential and continuous progestin regimens were associated with similar increases in breast-cancer risk.
The study showed that FDHT-PET detected osseous lesions in patients with advanced metastatic prostate cancer, confirming its utility in evaluating prostate cancer patients. The test also revealed the presence of additional lymph node lesions not identified by CT scans, suggesting its potential to predict response to hormone therapy.
Researchers discover that Alzheimer's protein amyloid beta is transported into the brain by riding piggyback on a larger molecule called RAGE. This discovery opens up new possibilities for treating the disease. By blocking RAGE, blood flow to the brain can be restored and amyloid plaques reduced.
FDG PET demonstrates high accuracy for diagnosing infection and inflammation, with a sensitivity of 93% and specificity of 84%, according to a study analyzing 844 scans on 806 patients.
Researchers tested 'reverse CPR' on critically ill patients in intensive care units, improving average systolic and arterial blood pressure. The new approach could lead to better treatment outcomes in the community setting.
A PET scan study found that only a combination of methylphenidate and a behavioral stimulus resulted in increased dopamine levels. The increases were associated with improved perception of the task as interesting and motivating.
Researchers at Johns Hopkins Medicine found that pancreatic cancer may be triggered by the reactivation of a growth signal normally turned off in adult tissues. By blocking this pathway, they hope to prevent the early cellular changes leading to cancer.
Research suggests that individuals with higher education levels exhibit less cognitive decline in Alzheimer's disease due to increased brain adaptability and flexibility. The study, which analyzed autopsied brains of deceased participants, found a significant association between education and reduced AD pathology.
New guidelines improve pregnancy, labour, and delivery care for HIV-positive women. These updated recommendations allow for longer, healthier pregnancies and increased chances of healthy, HIV-free offspring.
Recent national surveys in the UK show that full-time employment remains dominant, while careers are not dead and job tenure has increased. The study also reveals that new technologies have not revolutionized the work experience of all employees, and labour markets have yet to experience any radical transformation.
Researchers at the University of Toronto have devised a new architecture for manufacturing photonic band gap materials, increasing available bandwidth for optical microchips. The technique uses x-rays to create a precise template, allowing for high-quality silicon photonic band gap materials.
The microPET Focus offers significant improvements in image resolution and system sensitivity compared to its predecessor. The new design features reduced detector crystal cross-sections and gap sizes, resulting in improved spatial resolution and increased sensitivity.
Researchers at Vanderbilt University Medical Center conducted a double-blind, randomized, controlled study involving 240 participants with high cholesterol. The study showed a 16% reduction in low-density lipoprotein (LDL) cholesterol after taking green and black tea extracts enriched with the antioxidant theaflavin for 12 weeks.
Researchers used microPET and optical CCD imaging to track transplanted rat cardiac cells, detecting higher uptake in areas where cells were transplanted compared to background tissues. This study provides valuable insight into cell transplant biology, enabling real-time monitoring of engrafted cells.
A new study found that Neoral is as effective as tacrolimus in preventing acute rejection but better tolerated, with lower rates of diabetes and diarrhoea. The study analyzed 499 patients and showed significant differences in tolerability between the two immunosuppressive therapies.
A study by Joanna Fowler and colleagues found significant reductions in MAO B activity in the heart, lungs, kidneys, and spleen of smokers compared to non-smokers, with reductions ranging from 33 to 46%. The findings suggest that smoking impacts peripheral organs and highlight the need for further examination of these consequences.
The NIAID is distributing the GeneChip SARS Array at no cost to qualified researchers worldwide, providing a powerful tool to better understand the SARS coronavirus and its spread. The array will help scientists achieve objectives such as constructing a family tree of SARS coronaviruses and tracing the virus's evolution.
A new technique allows for the growth of silicon nanowires and carbon nanotubes directly onto a microchip, eliminating cumbersome middle steps in sensor manufacturing. This method enables the production of ultra-sensitive biochemical sensors and early-stage disease detectors that can detect single viruses or toxic agents.
A study by Dr. Pio and colleagues found that FLT-PET imaging outperforms FDG-PET in predicting tumor response to chemotherapy in breast cancer patients. The researchers compared the two imaging modalities in 11 newly diagnosed patients, taking scans before treatment began, after the first dose, and following the final cycle.
A new study suggests radiosynoviorthesis is effective in treating osteoarthritis, providing significant pain relief to 2/3 of patients with proven synovitis. The procedure, which involves removing inflamed membrane using beta-emitting radionuclides, shows promise as a treatment option for OA.
A recent study found that heart failure patients cared for by cardiologists had significantly lower one-year death rates compared to those treated by other types of physicians. The study analyzed data from 38,702 Canadian patients and found that cardiologist-managed patients had a mortality rate of 28.5%, compared to 31.7% for general ...
FDHT PET detected 46 lesions, outperforming conventional methods, which identified 59. The agent rapidly absorbed in metastatic lesions indicating functioning androgen receptors. Notably, FDHT uptake reduced in patients starting testosterone therapy.
The Society of Nuclear Medicine has announced an image that represents a significant advance in achieving high throughput in PET scanning without sacrificing quality. The image showcases technology such as 3D-LSO PET/CT, which could decrease whole-body scan duration substantially, benefiting nuclear medicine professionals and patients.
A high C-reactive protein (CRP) level is an independent risk factor for stroke, with higher levels more closely related to stroke in people with thicker artery walls. Elevated CRP may denote plaque instability, increasing the likelihood of a blood clot forming and causing a stroke.
Researchers at the University of Illinois discovered that birds play a crucial role in protecting Neotropical forests by consuming leaf-eating insects. By eating caterpillars on leaves, birds drastically reduce damage to foliage, with average damage levels increasing by 86% where they could not reach.
A study using PET scans found that schizophrenics have elevated dopamine receptor levels in both basal forebrain and SN/VTA areas of the brain. Differences were observed in cortical dopamine levels, supporting the hypothesis of dysregulated neurotransmission leading to abnormal regulation of neurons.
A study found that people with diabetes in Saskatchewan accounted for $134.3 million in health care expenditures, with major comorbidities contributing to 36.4% of these costs. Targeted strategies to prevent diabetes could produce substantial savings and improved health outcomes.
A study by the American Academy of Neurology found that people with patent foramen ovale, a common heart condition, are at increased risk of stroke after air travel. Researchers analyzed data from over 155 million passengers and found that six percent of those who developed pulmonary embolism had strokes.