A team of researchers from Michigan and Connecticut has received an award for their work on a new antibiotic, linezolid. The drug is the first of its kind to be approved in 35 years and shows promise in treating serious Gram-positive infections that are resistant to conventional antibiotics.
A new species of the gentian family, Macrocarpaea apparata, has been discovered in Ecuador. The plant was found to have yellowish-white bell-shaped flowers that emerge only as darkness falls, mirroring the magical concept of apparition.
Scientists have discovered a layer of cells in the inner retina containing melanopsin, which enables certain animals to synchronize their biological rhythms with day/night cycles. Melanopsin-free mice were unable to react normally to light stimuli and synchronize their rhythms.
Researchers have identified a molecular fingerprint unique to individuals with HIV-associated dementia (HAD), suggesting the potential development of a simple blood test for its diagnosis. The study used proteomics to analyze protein patterns in patients and found correlations between certain proteins and HAD.
A three-year project studies the Dhyanna of Entering into Non-Conceptuality, an 8th-century scripture considered authentic Buddha's teaching. The research aims to show similarities between Chinese and Tibetan Buddhism and how they have been interpreted differently throughout the ages.
The study found that intracoronary infusion of progenitor cells after acute myocardial infarction (AMI) significantly increased mean signal intensity (MSI) in areas with AMI damage, regardless of the type of progenitor cells used. The treatment showed a positive effect on myocardial viability.
A study found that PET-CT scans were more accurate than PET scans alone in staging non-small cell lung cancer patients. The combined imaging technique correctly identified lung cancer with chest wall and vascular spread, downgrading tumor severity in 13.3% of cases.
A study by William Strange and Stuart Rosenthal found that start-up companies are strongly attracted to cities with similar companies nearby, diverse businesses, and outsourcing services. Cities play a vital role in providing new business growth and innovation for countries like Canada.
Researchers found that MYC binds to the WRN gene promoter, activating WRN expression and promoting cellular senescence in tumor cells. This discovery suggests a potential therapeutic target for cancer treatment by inhibiting WRN in MYC-induced tumor cells.
Researchers compared MPI and CCTA scans to determine a more comprehensive assessment of coronary artery disease. Combining functional SPECT MPI and anatomic CT scans provided valuable information on severe myocardial perfusion defects and calcium deposits.
Dr. Pfefferle, known as the 'father of catalytic combustion,' has developed a process to reduce nitrogen oxide emissions from gas turbines. His inventions include the Microlith(r) catalytic reactor and RCL™ catalytic combustor, enhancing combustion efficiency and air quality.
The medical publishing industry has seen a significant acceleration in its pace of production, driven by technological advancements and innovative strategies. This shift is expected to have a positive impact on the quality and timeliness of medical research and knowledge dissemination.
A new study found that repair enzymes can 'distinguish' between various positions on the DNA strand, varying in effectiveness depending on their orientation relative to the nucleosome. This discovery has significant implications for our understanding of DNA repair and its role in preventing diseases like cancer and Alzheimer's.
Researchers used MRI to assess brain function while participants experienced heat stimuli. People who reported higher pain levels showed increased activation in key brain areas, such as the primary somatosensory cortex and anterior cingulate cortex. This confirms the importance of self-reports in guiding pain treatment.
Researchers at Rush University Medical Center found that higher education is associated with better memory and learning ability in individuals with Alzheimer's disease. The study, published in Neurology, suggests that formal education may provide a cognitive reserve that reduces the effects of AD brain abnormalities.
A new SPECT collimator pair increases sensitivity, particularly in central brain structures, while maintaining spatial resolution. The best combination of fan-beam and cone-beam collimation has been found to greatly improve dual-head SPECT images.
Scientists investigated how day length affects soybean flowering, finding early flowering is more active and controlled by small developing leaves or buds. The study's results could help develop cultivars adapted to short growing seasons for northern Canadian soybean producers.
Researchers discuss new findings on HIV-associated dementia and its potential association with the presence of MDM. Additionally, studies suggest that treating post-Lyme disease with antibiotics does not provide benefits, while a possible link is found between insulin and Alzheimer's disease risk factors.
A recent study suggests that I-123 Altropane SPECT imaging can detect dopamine deficiency in patients with drug-naïve ADHD. The study's results indicate a higher binding ratio of the radiopharmaceutical to dopamine transporters in ADHD patients, supporting the idea of a potential diagnostic tool.
A recent study evaluated eZ-Scope's performance in identifying radioactive nodes during sentinel node biopsy. The results showed that eZ-Scope allowed for more accurate identification of nodes in less time.
Dr. Nora D. Volkow, the first woman to lead NIDA, has made significant contributions to understanding addiction through imaging studies. Her extensive publication record and awards recognize her as a leading expert in the field of drug addiction research.
Researchers used video sequences of people, soap operas, and radio shows to investigate face recognition. They found that for unfamiliar faces, memory appears dominated by external features, but once familiar, internal features become more important.
Researchers found that late-identified reading deficits can manifest differently among students, with some having difficulty comprehending text or identifying printed words. The study highlights the need for schools to use varied assessments and tailored intervention programs to address individual students' strengths and weaknesses.
Researchers have discovered that heat shock proteins from deep ocean vent microbes can increase the sensitivity of DNA tests by up to ten times. These unique proteins also enable genetically modified bacteria to survive at higher temperatures.
Dr. Barry Siegel is being recognized for his pioneering work in nuclear medicine, including the use of positron emission tomography (PET) in cancer detection and tumor staging. With over 220 publications to his credit, Dr. Siegel's contributions have significantly impacted the field of nuclear medicine.
Pregnant women should undergo thorough breast examinations to detect breast cancer, as diagnosis is often delayed due to hormonal changes. Ultrasonography is the best method for detecting cancerous lumps during pregnancy.
The NIH award will focus on oxidative stress research in baker's yeast, with the goal of developing new strategies to combat neurodegenerative diseases. The grant also provides opportunities for high school and undergraduate students from economically-depressed areas to receive bioinformatics training.
A recent study found that UK teachers are struggling to implement new teaching methods due to a lack of clear guidance. The research suggests that most teachers ask easy questions rather than open-ended ones to prompt classroom discussion, resulting in limited pupil engagement.
Eighty percent of patients treated with combination therapy experienced no radiographic progression, compared to 68% on ENBREL alone and 57% on methotrexate. Combination therapy and ENBREL monotherapy provided significant inhibition of joint damage.
Researchers have developed a new treatment strategy that combines chemo-radiation and surgery to prevent recurrence of rectal cancer. The study, conducted by Professor Andres Cervantes' team, demonstrated excellent results with no local relapse after two years.
The Virginia Tech program aims to develop improved wildlife management strategies for chimpanzee populations in east Africa. Researchers will use a multidisciplinary approach, combining data collection with information sharing and education.
In a global, double-blind, placebo-controlled study, ENBREL demonstrated significant improvements in Psoriasis Area and Severity Index (PASI 75) scores after 12 weeks of treatment. Nearly half of patients treated with 50mg or 25mg of ENBREL twice weekly achieved PASI 75 versus 3% of placebo-treated patients.
Researchers at Saint Louis University found that daily injections of growth hormone helped obese patients lose an average of five pounds. The weight loss was primarily due to the reduction of body fat, particularly in the abdominal area.
In a multi-center, double-blind study, ENBREL 50 mg administered once weekly achieved an ACR 20 response in 50% of patients, compared to 19% in the placebo group. ENBREL also showed comparable improvement in HAQ and patient-reported measures of global status and pain.
India's HIV prevalence rate is less than 1 percent, but a looming pandemic on the horizon due to shifting demographics and changing cultural values. The researchers recommend targeted prevention programs for high-risk groups, such as prostitutes and men who have sex with men, and offer circumcision as an additional avenue of prevention.
The European Society for Medical Oncology (ESMO) presented a new drug, ET743, which has shown promising results in treating advanced ovarian cancer. In a clinical trial, the drug reduced tumors in 47% of patients, with some experiencing complete responses.
Researchers Jules Berman and Donald Henson developed a classification system for cancer precursors, identifying 568 distinct concepts with over 4700 terms. This database is designed to be fully searchable and linked to other databases, providing a potential breakthrough in early detection and treatment.
A Phase 3 study showed ENBREL significantly improved back pain, mobility, and function in patients with ankylosing spondylitis. At 12 weeks, 60% of patients achieved a 20% improvement, while at 24 weeks, 58% did so.
A study on dynamic systems could lead to fewer falls and smoother rides by developing a method to predict the effects of discontinuities on stability. The research aims to create design criteria that can reduce or prevent unintended collisions, resulting in improved safety and comfort.
The evolution of fireworks is attributed to advancements in metal fuels, which produce hotter flames and more photons, resulting in brighter colors. Fine-tuning of ingredient percentages has also contributed to the improved display.
A recent brain study suggests that individual differences in temperament may be associated with persistent differences in brain activity related to emotion and novelty detection. Inhibited children showed a relatively high level of activity in the amygdala when shown unfamiliar faces, whereas uninhibited children showed less activity.
Giovanni Zocchi's team has created a nanoscale sensor that can detect specific genetic markers in DNA or RNA molecules with high sensitivity. The sensor uses evanescent wave scattering to analyze the conformational changes caused by target molecule binding, allowing for precise detection of single molecules.
Researchers have discovered cooperation between genetically similar but unrelated male blue-throated lizards, challenging the traditional theory of kin selection. The study found that these cooperative males exhibit higher fitness levels and improved reproductive success due to their neighborhood relationships.
A study analyzing data from pivotal trials of Actonel revealed that bone mineral density explains only a small portion of nonvertebral fracture risk reduction. The analysis found that BMD increases accounted for just 12.2% of the fracture risk reduction at lumbar spine, and 5.5% at femoral neck.
A 7-year study shows Actonel significantly reduces vertebral fracture incidence, with annualized rates of 4.7%, 5.2%, and 3.8% for the treatment group, respectively. Adverse events were similar to those in patients taking placebo during the first 5 years.
A study of 2,466 HIV-positive adults reveals that 53% use alternative medicine, often without informing their doctors. This can lead to adverse interactions with conventional treatment and increased risk of treatment failure.
Researchers deduced the structure of GRK2, a key regulatory enzyme that modulates G protein signaling. The three-dimensional structure reveals three distinct domains capable of performing multiple regulatory functions simultaneously.
A study of 100 working families in the UK and USA found that planners' assumptions about housing, transport, and work-life balance often clash with reality. Families often prioritize convenience over ideal living arrangements, leading to increased travel time and reliance on private transportation.
Postconflict psychiatric research reveals high prevalence of common mental disorders, particularly post-traumatic stress disorder and anxiety disorder. Exposure to violence is a potent risk factor for various disorders, with comorbidity analyses showing complex relationships between disorders.
Researchers are exploring neural transplantation as a potential treatment for Parkinson's disease, despite initial disappointing results from clinical trials. Further studies aim to improve the effectiveness of transplants and address concerns about side effects such as dyskinesias.
Mitchell, a veteran teacher, inspires students to engage in intellectual endeavors through events like Pi Day and Renaissance day. Her leadership in the Science Olympiad program grows the team from five students to over forty.
Researchers at U-M examined the effects of aging and menopause on bone health and found that natural estrogen withdrawal after menopause causes more significant bone loss. The study suggests that hormone replacement therapy may not be necessary for all middle-aged women with regular menstrual cycles.
Researchers discovered a new way to trigger self-destruction of certain cancer cells by targeting specific molecules. By blocking the action of a protein called mTOR, scientists can activate apoptosis in cancer cells lacking a gene called p53, leading to cell death.
A study of 800 women with relapsing ovarian cancer found that combination chemotherapy showed a modest survival benefit compared to platinum-based chemotherapy alone. Women assigned combination therapy survived for an average of five months more than those given platinum therapy.
Scientists at Fritz-Haber Institute find mechanical oscillations in catalytic foil during chemical reactions, leading to precise measurement of heat created. Mathematical models and computer simulations reveal delicate interplay between thermo-chemistry and thermo-mechanics.
A study by the University of Illinois at Urbana-Champaign found that enhancement with standard levels of salt and phosphate can improve the quality of lower-grade beef. Consumers reported a preference for enhanced roasts and steaks over non-enhanced cuts, which were found to be juicier and more flavorful.
A new Web-based calculator will warn public health officials when and where mosquitoes carrying West Nile virus thrive or die, based on climate data. The system will help track mosquito populations' development and aging, which is crucial for predicting outbreaks.
Researchers identify protein that bridges signaling and membrane movement, linking insulin's action to glucose uptake. This finding could provide clues for understanding type 2 diabetes, where muscle and fat tissues resist insulin.
Researchers found that blood vessel formation in the pancreas is crucial for normal insulin production in fetuses. Exendin-4, a pancreatic hormone analog, can rescue insulin-producing cells and prevent diabetes by regulating PDX protein.
A new study found that combining radiofrequency ablation with chemotherapy can effectively treat larger liver tumors. The treatment, which involves using heat to destroy tumor tissue and administering a chemotherapeutic agent intravenously, resulted in a tripling of survival rates compared to those receiving no treatment.