Researchers found that a single mutation in TB bacteria makes them resistant to antibiotics and elicits a weaker immune response, leading to higher mortality rates. The study suggests that the same approach may not work for drug-resistant TB strains.
Researchers at UVA have discovered that lymphatic vessels in the brain carry messages from the brain to the immune system, triggering MS symptoms. Blocking these messages may offer a new way to treat the condition, but more research is needed to understand their role and potential therapeutic targets.
Researchers at the University of Oregon have created a new class of fluorescent dyes, called nanohoops, that can be used to track multiple biological activities in live cells. These circular structures emit colors based on their size and can be guided to specific sites within cells.
Researchers found that hospitalized infants with both conditions were four times more likely to die than those with only congenital heart disease. Infants with central sleep apnea and a heart abnormality stayed twice as long and had double the hospital bills at discharge.
A team of researchers developed a multi-joint, personalized soft exosuit that assists users in walking by applying mechanical forces to critical joints. The device was tested in the field and found to reduce energy expenditure by up to 22% compared to walking without assistance.
A 2016 survey of US students found nearly 1 in 11 middle and high school students used cannabis in e-cigarettes. Researchers suggest strategies to reduce cannabis use in e-cigarettes are crucial given the findings
Researchers at RUDN University simulated a communication system using drones to increase cellular network coverage. The approach, which takes into account random distances and three-dimensional modeling, can significantly improve the quality and reliability of service.
A longitudinal study by researchers found that witnessing school violence in Grade 8 increases the risk of psycho-social and academic impairment in Grade 10. The study also revealed that bystander effects were similar to being victimized, with minor forms of violence predicting increases in social anxiety and depressive symptoms.
CSIRO has launched its ASEAN presence in Singapore to strengthen collaboration between Australia and Southeast Asia. The agency will work with partners to create new value through research and technology, tackling global challenges such as sustainable development and human health.
Aristide Dogariu and his team at the University of Central Florida have developed a new sensing method that can passively detect objects even when direct vision is impeded. This technique uses subtle similarities in scattered light to recover information about an object's presence, eliminating the need for controlled illumination.
A modified form of blebbistatin appears to be effective in preventing cravings and relapse in people with substance use disorders, including those using multiple drugs. The compound works by breaking down memories linked to methamphetamine use, offering a novel approach to treating addiction.
The POPULAR study confirms a significant association between neuromuscular blocking agents and respiratory complications after surgery. Established techniques to avoid residual paralysis did not lower the patients' risk of pulmonary complications.
Gunshot victims require significantly more blood transfusions due to severe injury severity, with a 14-fold increased risk of death compared to non-GSW trauma patients. Blood products cost a lot and are scarce, making it crucial for hospitals to improve outcomes for trauma victims.
Research by Professor Wing Hung Tam and colleagues found that excessive or inadequate weight gain during pregnancy is associated with increased risk of cardiometabolic problems in children aged 7, including higher blood pressure and poor blood sugar control. The study suggests balancing weight gain to minimize adverse outcomes while co...
The research collaboration aims to create human organs-on-chips using miniature devices that mimic specific tissues and organs. These organs-on-chips have the potential to predict drug activity and toxicity more accurately than animal models.
Researchers discovered that sea otters rely on the sensitivity of their paws and whiskers to hunt for food, distinguishing between grooves as small as 2mm with remarkable accuracy. This unique ability enables them to quickly locate prey in cloudy Monterey Bay waters.
A new multi-campus initiative funded by NSF aims to explore the intersection of agriculture, food, and technology. Researchers will investigate novel solutions such as lab-grown meat and drones that monitor plant stress to address challenges in sustainable food production.
Scientists at Michigan State University have discovered a light-induced super photobase that is 10 million times stronger than anything previously discovered. The discovery could lead to advances in solar energy capture and the development of new materials with potential applications in medicine and environmental monitoring.
Two variants of autoimmune disease SLE were identified in black Africans, including one previously unacknowledged. This breakthrough enables better management of the disease in southern Africa, where incidence and mortality rates are high.
Resveratrol supplementation significantly reduced pain severity and levels of inflammatory biomarkers, including TNF-α, interleukin IL-1ß, and IL-6, in patients with mild to moderate knee osteoarthritis. The study suggests resveratrol may be an effective add-on to NSAIDs for treating knee osteoarthritis.
A new study finds that people from black, Hispanic, and multiracial backgrounds, those with lower education levels and income, and the unemployed are more likely to have experienced childhood trauma. The most common adverse childhood experiences include emotional abuse, parental separation, and household substance abuse.
A new study by Ludwine Messiaen extends clinical manifestations of the three-base pair deletion p.Met992del in NF1, revealing mild symptoms but potential complications. The research expands on findings first reported in 2007, providing insight into a genotype-phenotype correlation that will aid families and clinicians.
Researchers at UT Southwestern Medical Center used CRISPR genome-wide screening to identify the IFI6 gene as a potent antiviral gene targeting flaviviruses, including West Nile and Zika viruses. The study found that cells with a working IFI6 gene inhibited infection by these viruses in cell culture studies.
University of Konstanz chemist Professor Stefan Mecking has developed a method to synthesize tailor-made bio-synthetics by precisely determining the length of molecular chains. The newly synthesized material exhibits an extraordinary layered structure with great potential for application in high-tech membranes, such as batteries and wa...
Researchers suggest the Large Magellanic Cloud may have engulfed a third luminous galaxy, explaining why stars in the cloud rotate at different rates. This phenomenon could also help explain the 'age-gap' problem observed in the cloud, where there are very old and young star clusters.
Researchers developed an mRNA-based nanotherapeutic to reintroduce functional copies of PTEN into cancer cells, restoring tumor suppressor function and killing cancer cells. The therapy showed significant suppression of tumor growth and progression in mouse models of prostate cancer.
Typhoon Mangkhut made landfall in southern China's Guangdong province on Sept. 16, triggering a Red Alert and heavy rainfall. The storm brought strong winds of 92 mph/148 kph and surges up to 3 meters around Hong Kong.
Post-tropical cyclone Helene is affecting Ireland and the United Kingdom with widespread cloud cover and showers. The U.K. Meteorological Service has issued a Yellow Alert for several regions due to expected windy weather with gusts reaching 50-60 mph.
Researchers developed an artificial neural network that can compare medical concepts to specific symptoms mentioned by patients on social media. The AI system uses semantic vector word representation and can identify symptoms like insomnia or vertigo with high accuracy.
Tropical Depression Joyce continues to lose its organization due to drier air moving into the depression. The National Hurricane Center forecasts it to weaken over the next 48 hours before potentially becoming a remnant low tonight or Tuesday.
A recently discovered pygmy moth species from Asia, Stigmella multispicata, has spread rapidly across Siberian elm trees in eastern North America. The species was first found in the US in 2010 and has since been identified in ten states and two Canadian provinces.
Researchers developed a novel sucking-flow liquid removal mechanism to promote both surface refreshing and droplet growth on a hierarchical mesh-covered surface, enhancing condensation heat transfer performance. This breakthrough addresses the long-standing challenge in pushing micro/nanostructured materials into practical applications.
Researchers found that targeting IL-1β reduced risk of gout attacks by half, with no change in serum urate levels, suggesting an independent mechanism. The study's findings could lead to new therapeutic avenues for both heart disease and crystal diseases like gout.
A new guideline published by the American Thoracic Society recommends weight loss strategies for adults with obstructive sleep apnea, particularly those who are overweight or obese. The guideline suggests comprehensive lifestyle interventions and behavioral counseling to help patients achieve weight loss.
Researchers at UNC School of Medicine have developed a powerful algorithm to quickly categorize long non-coding RNAs (lncRNAs) based on their molecular makeup and predicted functions. The method, called SEEKR, uses protein-binding sequences to identify lncRNA communities with similar functions in humans and other species.
A small study evaluates the association between medical scribe use and physician workflow, revealing improved efficiency and patient satisfaction. The study suggests that medical scribes can be a valuable tool to reduce documentation burdens in primary care settings.
Scientists are exploring a new propulsion idea that could eliminate fuel costs and make interplanetary travel easier. Dr. Mike McCulloch's quantised inertia theory predicts that objects can be pushed by differences in Unruh radiation in space.
The University of California, San Francisco (UCSF) will conduct a five-year study on the impacts of new tobacco products, including e-cigarettes and heated tobacco products. The research team aims to evaluate product characteristics, health effects, and behavior, with the goal of protecting public health.
Researchers at Duke University discovered a neural circuit that enables the brain to predict motion based on past experiences and sensory inputs, mirroring Bayesian statistical inference. This discovery could improve our understanding of motor control and eye movements.
A study found that rock climbers seek out sites with more single-pitch routes, better landscapes, and lower median difficulty to reduce injury risk. The results suggest that decreasing injury risk generates significant welfare gains for climbers, with estimated values ranging from $18 to $327 per site.
The Brigham Genomic Medicine program uses state-of-the-art genomic technologies to diagnose and discover genetic underpinnings of disease. By analyzing genomic data with a multidisciplinary team, the program has identified culprit genes for 30 families, providing critical information for diagnostics and treatment.
A blood test for microRNAs may help predict the likelihood of disease in dairy cows and improve animal welfare. This approach is already being applied to human disease diagnosis.
A recent study found that women veterans with chronic musculoskeletal pain are more likely to use complementary and integrative health (CIH) therapies, such as meditation, yoga, and acupuncture. The study, which analyzed data from nearly 500,000 men and women veterans, showed that rates of CIH use varied by race/ethnicity and age, with...
Researchers have discovered that spherical particles submerged in viscous liquids travel along flexible surfaces by 'catching a wave', offering new insights into biological processes and a gentler method for measuring cell membrane elasticity. This approach also enables easy sorting of particles by size, similar to an automatic coin-so...
Stanford researchers identify a key bacterial molecule, pEtN cellulose, that enhances adhesion of E. coli to bladder cells, potentially leading to new treatments for urinary tract infections. The finding could break the cycle of infection by preventing bacterial adhesion.
A study by University of Connecticut researchers found that increased trans-Arctic shipping could lead to a minor cooling effect in the Arctic, potentially offsetting some of the overall warming trend. However, this effect is relatively minor and may be offset by international regulation and trade agreements.
Research participants experienced improved blood pressure and heart rate regulation after receiving epidural stimulation, with stabilized levels even after stimulation was turned off. The therapy also increased independence and alertness, allowing individuals to live more normal lives and engage in activities without limitations.
Prescription drug shortages lead to estimated $230 million in annual costs due to rising prices and substitution drugs. Researchers found price increases reflect manufacturers' opportunistic behavior during shortages.
A team of researchers at Ulsan National Institute of Science and Technology has developed ultrathin, transparent, and conductive hybrid nanomembranes for skin-attachable loudspeakers and microphones. These wearable devices can produce sounds and detect vocal vibrations, opening up potential applications in sound input/output devices.
A study describes a microfluidic system to concentrate and encapsulate circulating tumor cells, which are cancer cells that can travel through the bloodstream. Experiments with prostate cancer cells revealed high matrix metalloprotease enzyme activity.
A new study links rapid deoxygenation in Canada's Gulf of St. Lawrence to large-scale climate change, specifically the shift of the Gulf Stream and Labrador Current. The research confirms that warmer water from the Gulf Stream is entering the St. Lawrence Seaway, causing oxygen levels to drop.
The American College of Cardiology emphasizes that combating obesity in the US will require individual and societal changes to reduce cardiovascular risks. Implementing policy-level interventions, increasing physical activity, and promoting healthier diets are key aspects of this approach.
Scientists create six-step cycle that uses magnetic materials to cool down, reducing greenhouse impact of traditional refrigerants. The technology could be more efficient than vapor compression and has potential for widespread use.
A new framework outlines how to measure key characteristics of animals and plants to inform policymakers' decisions. The study aims to provide data-driven insights into species' responses to climate change, habitat loss, and other human impacts.
Researchers have developed a new blood test that can detect pancreatic cancer in its earliest stages with 96% accuracy, providing a potential breakthrough for earlier diagnosis and treatment. The test uses an antibody microarray to identify specific immune-regulatory proteins and cancer-associated antigens.
Research finds that climate models and observational data match up well in predicting the widening of the tropics. The expansion may continue over the next several decades, with varying rates from year to year and location to location. The study's findings have added confidence to predictions based on current climate models.
Researchers at Virginia Tech developed a passive anti-frosting surface that keeps surfaces 90% dry and frost-free in humid, sub-freezing conditions. The surface uses intentional ice stripes to create low-pressure zones, pulling moisture from the air onto the nearest ice stripe.
A team of scientists is using a holistic approach to understand the causes of eelgrass wasting disease, deploying drones, artificial intelligence, and geographers to survey seagrass beds across 36 sites from San Diego to Alaska. The project aims to unravel why some eelgrasses fall victim to the disease while others resist it.
A new study published in PNAS found that engaging in self-transcendence tasks can increase receptivity to health messages and lead to increased physical activity. Participants who reflected on values bigger than themselves showed greater brain activity in reward regions compared to those who focused on their own least important values.
A cross-disciplinary team led by Rice University will investigate the formation of life-essential elements in rocky planets during their early evolution. The CLEVER Planets project aims to understand how these elements survive turbulent periods and ultimately lead to habitability, with a focus on rocky worlds beyond our solar system.