A study by Mount Sinai researchers found that more than half of patients taking ruxolitinib gained over 5% in body weight, associated with increased systolic blood pressure and liver enzymes. The study highlights the need for physicians to counsel patients about potential metabolic effects.
Researchers developed SleepFit, a new app to monitor Parkinson's disease, which showed good agreement between prospectively and retrospectively collected data. The study found that patients with higher disagreement tended to have more advanced disease or worse sleep quality.
A new study finds that a vaccine against pneumococcal bacteria reduces the likelihood of severe pneumonia in children by 35%. The research also highlights the importance of vaccinating children to protect the whole community and reduce the spread of pneumococcus. By evaluating the effectiveness of pneumococcal vaccines in Asia, the stu...
Researchers found that gene activity in brain regions called song nuclei is associated with species-specific patterns of singing in songbirds. The study identified a signaling molecule called BDNF as a mediator of changes in trans-regulated genes, which disrupted the structures of learned songs in adult zebra finches.
Researchers found that satellite data sets are reliable substitutes for reproducing water vapor features over the Tibetan Plateau, while reanalysis data sets have varying quality depending on time scales considered. A skill-weighted ensemble mean of reanalysis data shows promise for future studies.
Researchers at OIST Graduate University have created the first augmented reality experience to pair with a taxonomic research paper, presenting six new species of Strumigenys ants from Fiji. The app, Insects3D, allows users to view 3D models of ant specimens in AR and magnify them up to the size of a lion.
Etalumis, a probabilistic programming framework, has been developed to control existing simulators and run on large-scale HPC platforms. It enables researchers to interpret vast volumes of experimental data by essentially 'reversing' simulations, bringing new insights into complex physics problems.
Civil engineers create a sustainability-based optimization algorithm to help policymakers make informed decisions on projects like bridges, school roofs and waterfront developments. The algorithm considers the costs of a project over its lifetime and externalized costs, providing a more comprehensive view.
Researchers developed a low-cost, portable OCT system that can image structures in hard-to-reach areas like joints. The device uses an endoscopic delivery system to provide real-time quantitative information on cartilage thickness without damaging the tissue.
Biomedical engineers have combined ultrafast ultrasound imaging with ultrasonic tweezers to precisely track and target drug carriers within a phantom blood vessel. This new method could enable acoustic control and real-time tracking of drug release within the body, potentially improving targeted therapeutics.
A recent study by Goethe University Frankfurt identified 17 microRNA families that play a crucial role in the interface between the immune and neuronal systems, showing sex-specific differences in gene expression. These findings may lead to new therapeutic approaches for psychiatric diseases.
A team of researchers has successfully tested a superconducting rotor on an active wind turbine, demonstrating the compatibility of this technology with operational environments. The achievement marks a significant step towards wider adoption of superconducting generator technology in wind turbines.
The American College of Physicians recommends improving transparency, lowering out-of-pocket costs for patients, and enhancing access to affordable medications. The policies aim to stem the escalating costs of prescription drugs by increasing oversight and regulation of Pharmacy Benefit Managers and public health plans.
Researchers have discovered unconventional energy- and direction-dependent spin textures on the surface of pyrite-type crystals, enabling both in-plane and out-of-plane spin components. This finding opens new possibilities for topological spintronics devices and unlocks the potential of pyrite in future spintronics applications.
The Brookhaven-CFS project aims to develop breakthrough technologies for the fusion power industry, focusing on quench detection and protection systems. The team will collaborate to characterize high-temperature superconductors and test their ability to withstand damage-inducing events.
Scientists found that azoximer bromide increases the immunogenicity of anti-flu vaccines by tripling their efficiency. The study showed that this adjuvant helps the development of humoral and cell-mediated immune responses.
A study by Brazilian researchers found that listening to instrumental music attenuates cardiac stress while driving, increasing parasympathetic nervous system activity and reducing sympathetic nervous system activation. This can contribute to the creation of cardiovascular preventative measures for situations of acute stress.
A Scottish government-funded social prescribing initiative failed to improve patients' health-related quality of life. In a subgroup analysis, those who visited the practitioner three or more times showed improved quality of life, but many non-users did not fully utilize the program.
Researchers from Ruhr-University Bochum and University of Oxford studied a dripstone from India's Mawmluh Cave to reconstruct the Indian monsoon's past climate. They found the monsoon was less reliable 125,000 years ago, suggesting global warming may lead to similar changes.
New research reveals the last remaining Arctic ice refuge is disappearing due to increased ocean currents and atmospheric winds, with the oldest ice declining twice as fast as the rest. The Last Ice Area will soon be gone, threatening wildlife survival and potentially leading to the loss of species.
Researchers at Colorado State University have found that hops can be induced to flower without the traditional vernalization period, enabling year-round indoor production. This breakthrough could lead to a new era of sustainable and locally grown hops, supporting the craft brewing industry.
A study published by Professor Henrik Oster suggests that daily stress coupled with a disrupted internal clock increases the risk of developing metabolic disorders such as obesity and type 2 diabetes. This is because environmental stress can affect food intake, promote weight gain, and have long-lasting effects on stress responses.
A new Harvard study estimates climate and health benefits from renewable energy installation vary greatly by country. The study suggests that companies, investors, and policymakers can use this framework to make strategic decisions around achieving sustainable development goals.
A recent study found high prevalence and diversity of antibiotic-resistant genes in wildlife enteric bacteria from Catalonia. The study highlights the risk of human exposure to these resistant traits through wildlife.
A new study found that depression is linked to nutrition in middle-aged and older Canadians, with lower intakes of fruits and vegetables being a risk factor. The study also found that immigrant women were more likely to experience depression than Canadian-born women.
Researchers have identified a new target molecule for treating childhood cancer neuroblastoma, which may lead to more effective treatments. The study found that high levels of a long non-coding RNA called 'lncNB1' are associated with poor prognosis, and its inhibition can cause cancer cells to die.
A deep convolutional neural network-based software improved radiologist detection of malignant lung nodules by 70.3%, reducing false positives to 0.18 per X-ray. The study suggests machine learning methods can help overcome challenges in detecting lung lesions on chest X-rays.
Researchers at Paul Scherrer Institute have improved a method for small angle X-ray scattering to investigate fibre orientation in composites, enabling faster analysis with conventional X-ray tubes. This innovation has potential applications in medicine and security.
A study published in Thorax confirms that ICU patients experience delayed return-to-work and joblessness, with 20-27% requiring disability benefits at one year. Survivors incur substantial lost earnings, impacting quality of life.
Researchers developed a new alloy with improved wear and corrosion resistance by adding copper to high-speed steel. The innovative approach significantly enhances the performance of super engineering plastics in industrial and automotive applications.
Photodetectors convert light into electric signals, crucial for data centers and IoT technologies. Drexel's MXene materials enhance sensitivity and cut costs by replacing gold, a high-demand product.
Researchers used powerful imaging technology to discover a common indicator of brain inflammation in early-stage MS patients and its link to gray matter damage. The study found LME was present in nearly two-thirds of the patients, with significant correlations to lesions in gray matter regions.
Researchers at Children's Hospital Los Angeles have identified a critical role of lymphatic vessels in heart repair, which could lead to breakthroughs in treating congenital heart defects and cardiac injuries. The study provides new insights into the mechanisms of cardiac regeneration, paving the way for potential therapeutic targets.
Researchers have found that the cerebral cortex can directly control the activities of globus pallidus neurons in a manner that depends on the type of neuron. This discovery could improve our understanding of why certain symptoms occur in movement and learning behavioural disorders, such as Parkinson's disease.
Analysis of US heart transplant data reveals large discrepancies in how sick patients are when they receive transplants at different hospitals. The study finds that high-survival-benefit hospitals prioritize sicker patients, while low-survival-benefit centers give organs to less critical patients.
A study by INFORMS journal Organization Science found that one additional woman on the board results in a 2.3% decrease in market value on average, amounting to hundreds of millions of dollars. This negative effect is amplified for firms with higher diversity ratings across the organization.
Job dissatisfaction among general practitioners (GPs) varies greatly across countries, with higher rates found in Germany and lower in Norway. Factors such as workload, administrative burdens, and limitations on appointments contribute to dissatisfaction.
Researchers at Argonne National Laboratory have developed domain-aware neural networks to replace expensive parameterizations in the Weather Research and Forecasting (WRF) model. These algorithms can predict environmental data more accurately with significantly less training data, enabling faster and higher-resolution simulations.
A University of Queensland-led study found that healthy mangroves can support coral reef fisheries by providing alternative nurseries for fish. This allows them to grow larger and head out to the reef as adults, increasing their chances of survival.
A new study by the University of Plymouth explores how wild fishes behave spatially when reacting to an artificial stimulus, such as a laser. Researchers found that certain species would 'chase' the lasers, up to five metres, and that there were differences based on size and gender within species.
Researchers from the University of Basel found that adding white noise to a quiet environment improves the brain's ability to distinguish subtle tone differences. This is achieved through reduced neuronal activity in the auditory cortex, allowing for more precise sound perception and potentially improving cochlear implant results.
A US Army researcher has found that cultural cues can mitigate bias against humans and machines in human-machine interaction, promoting effective cooperation. By associating positive social groups with machines and emotional expressions, biases can be overcome.
A new AI-driven approach can accurately classify single blood cells, improving leukemia diagnostics and reducing variability. The method, trained on over 20,000 images, was compared to human expert accuracy, showing comparable performance in identifying diagnostic blast cells.
Researchers have published protocols for culturing Liberibacter crescens, a genetically similar bacterium, to study citrus greening. This advance enables the scientific community to use L. crescens as a realistic surrogate host for Ca. L. asiaticus.
A US Department of Energy-backed robotic system has successfully identified the source of nuclear radiation and verified if it was shielded. The 'inspector bot' could be part of a swarm to inspect facilities like gas centrifuge enrichment plants, detect undeclared uranium use, or verify disarmament treaties.
A study published in Nature Cell Biology has identified a protein called CD9 that drives growth of pancreatic cancer and could be a target for new treatments. The researchers found that CD9 is present on the surface of cancer stem cells, which are a driving force behind cancer growth.
A new study reveals that the Jezero crater landing site is home to hydrated silica deposits, which are exceptional at preserving microfossils and other biosignatures. The rover will be able to perform fine-scale chemical analysis and provide a close-up view of these deposits to help determine their origin.
Researchers found that the Australian CEF weakens moisture transportation and decreases monsoon rainfall over South Asia by a quarter. The presence of islands in the Maritime Continent also intercepts westward propagation of quasi-biweekly oscillation, leading to decreased rainfall.
New research finds that brand-name drug discount cards lead to higher health care spending in Canada, with private insurer costs increasing by 46 per cent. However, for some patients, using a discount card can result in increased out-of-pocket costs, potentially up to $10 more.
A new study shows that a commonly used vector for large gene transfer can deliver genes to retinal cells, but provokes an acute inflammatory response when injected subretinally into rats. The researchers conclude that further work is needed to understand the inflammatory pathways involved and modulate the immune response.
The new SLAS Technology auto-commentary discusses the challenges of gathering analytical measurements and introduces realized-based measurement systems as potential replacements. These systems use robots as central system integrators, providing flexibility and enabling decentralized open systems.
Researchers found that a 'pre-habilitation' program with trained peer coaches could empower and inform patients, leading to better outcomes. The study's results suggest that preparation and expectations for surgery are influenced by patients' prior experience and social support.
A new PSU study found 11 microplastic pieces per oyster and nine per clam along the Oregon coast. Microplastics were found in both Pacific oysters and razor clams collected from all 15 sample sites.
A new study published in The American Journal of Pathology suggests that medroxyprogesterone acetate (MPA) is effective in preventing the development of cervical cancer in mice with precancerous lesions. MPA also decreased existing precancerous lesions, offering a non-invasive approach to combat cervical cancer.
A study found that young male cancer survivors with low testosterone levels experienced an average decrease in fat mass and increase in lean mass when treated with testosterone replacement therapy. However, there was no effect on quality of life.
A new method for locating potential drilling sites covered by water has been presented by an international research team, combining bathymetry measurements with geochemical profiles. This approach allows the distinction between permeable and non-permeable structures, enabling more precise location of promising locations for drilling.
A population-based cohort study found that people with substantial changes in blood pressure over time were at greater risk of dementia. Variations in systolic and diastolic blood pressure led to similar findings, suggesting potential to prevent dementia through targeting blood pressure variability.
A study published by Aalto University found that mothers with high pregnancy-related anxiety gave birth to babies who had reduced brain responses to sad-sounding speech. The effect was more pronounced in mid-pregnancy, suggesting a potential link between maternal anxiety and infant emotional development.
Researchers at the University of Pennsylvania School of Medicine discovered an epigenetic pathway that controls social behavior in carpenter ants. The study found that Major ant soldiers can be successfully reprogrammed up to 5 days after they hatch, but not beyond 10 days, revealing a narrow window of epigenetic plasticity.
A study published in Development and Psychopathology reveals preterm birth and institutional deprivation have a comparable effect on child temperament, particularly self-control. This finding suggests that increasing self-control in these children may help prevent long-term developmental problems.