A compound developed by Johns Hopkins researchers has been shown to slow tumor growth, alter the tumor microenvironment, and promote durable and highly active anti-tumor T cells. The drug, a prodrug version of glutamine antagonist DON, was designed to target cancer cells' high demand for glutamine.
A new study from Cincinnati Children's Hospital Medical Center reveals that many teenagers who undergo bariatric surgery experience low iron and B12 levels years later. Regular nutrition check-ups and supplementation can minimize these risks, emphasizing the importance of annual assessments.
A new genetic mapping system for polyploid species has been developed in Brazil, allowing researchers to analyze the genes of complex organisms like sugarcane, kiwi, and blueberry. The open-source software package, MAPpoly, can be downloaded free of charge and has already been adopted by researchers at seven institutions worldwide.
Tropical Storm Halong weakened and transitioned into an extra-tropical cyclone as tracked by NASA-NOAA's Suomi NPP satellite on November 8. The storm had maximum sustained winds of 60 knots and was moving east-northeast at 24 knots.
Oral health risks for older adults include increased incidence of tooth decay, gum disease, and complete loss of teeth. Practicing good oral hygiene, using fluoride treatments, and getting regular dental care can help prevent these complications.
Typhoon Nakri intensified into a stronger typhoon after satellite imagery showed better organization and increased winds, moving westward towards Vietnam. The Joint Typhoon Warning Center expects landfall on Nov. 10 or 11, near Danang.
A new study published in the journal Nutrients found that glutamates such as monosodium glutamate (MSG) can be used to reduce sodium in the food supply. The substitution of glutamates for salt can reduce sodium intake by up to 7-8 percent, according to the study. This finding is consistent with previous research and dietary guidelines ...
Researchers investigated the effect of vitamin D and omega-3 supplements on chronic kidney disease (CKD) development or progression in adults with type 2 diabetes. The study found no significant difference in CKD progression between supplementation groups.
A new study found that most primary care doctors discuss the importance of exercise with African American female patients but fail to address hair care's role. Dr. Sophia Tolliver suggests incorporating hairstyling assessments into office visits to help overcome barriers to exercise.
Scientists at The Wistar Institute have developed a synthetic DNA-based platform to drive in vivo production of broadly neutralizing anti-HIV antibodies. These results show that the platform can produce potent antibodies with strong neutralization ability, comparable to recombinant antibodies. Additionally, combining multiple antibodie...
A new study found that eroding permafrost coastlines in the Arctic can release significant quantities of carbon dioxide, potentially exacerbating climate change. The research simulated erosion effects in a lab experiment and found CO2 was released as rapidly from thawing permafrost in seawater as it is from thawing permafrost on land.
Researchers have developed a new method to test the rheology of complex liquids, such as gelled desserts, using ultrasonic spinning rheometry. This updated method can capture time-dependent properties and has applications in chemical engineering, civil engineering, and cosmetics.
A record number of bushfires are raging on Australia's east coast, spanning across New South Wales and Queensland. The fires, fueled by hot and dry weather, have burned over 365,000 hectares, with temperatures expected to remain high for the next week.
Scientists designed a novel approach to create stable and predictable antibody drug conjugates (ADCs) using computational docking molecular simulations. The new therapy, called MAGNET-ADC, can deliver cancer drugs specifically to tumor tissue with reduced toxicity.
A new analysis found that 21% of adolescents and 32% of young adults used prescription opioids in the past year. Misuse rates were higher among young adults, with 57% obtaining them from friends or relatives. The study highlights the importance of screening for opioid use in this vulnerable population.
A multi-institutional study found that adolescents with Type 2 diabetes experienced improved hyperfiltration and reduced elevated urine albumin-to-creatinine ratio after gastric bypass surgery compared to adults. In contrast, adults with pre-existing diabetes did not show significant improvements until five years post-surgery.
A massive collaborative research incubator will develop trials for Alzheimer's disease interventions, funded by the National Institute on Aging. Regenstrief researchers will lead a two-year junior career development program to train researchers in embedded pragmatic clinical trials.
Researchers at Universitat Autonoma de Barcelona developed an optimal procedure to identify clusters of identically prepared quantum systems, solving the challenge of sorting quantum data. The new protocol outperforms classical strategies, particularly for large dimensional data.
A recent study by the American College of Allergy and Asthma found that most pediatric allergy patients are satisfied with telemedicine visits for allergies and asthma. Among surveyed parents, 37% were more satisfied, while 63% reported equal satisfaction, indicating a positive experience with telemedicine appointments.
A new diagnostic/treatment algorithm complements early guidance from the CDC for managing vaping product use associated lung injury (EVALI). The tool was developed by pulmonary and toxicology experts at the University of Rochester Medical Center and the New York State Department of Health.
A study published in the journal Science of Learning found that children's brains function similarly regardless of their gender when it comes to math skills. The research team, led by Jessica Cantlon, used functional MRI to compare brain activity in young girls and boys while watching educational videos on early math topics.
A study published in the Journal of the American Geriatrics Society found that interferon-free direct-acting antivirals are effective in treating hepatitis C in older adults, with high cure rates reported despite comorbid conditions. The treatment offers similar effectiveness as it does in younger patients.
Researchers at the University of Illinois are developing a smartphone-based diagnostic system that can detect pathogens in less than 30 minutes using a single drop of blood. The system, which will be handheld and cost less than $10, has the potential to provide fast and affordable results for patients in developing countries.
Researchers at Shenyang Institute of Automation develop contact aerial manipulator system for safe and efficient high-rise building inspection. The robot can avoid obstacles, jump over grooves, and conduct interactive operations while in flight.
A new study published in International Journal of Epidemiology found a strong association between air pollution and carotid intima-media thickness (CIMT) in peri-urban South India. People exposed to higher levels of fine particles had a higher CIMT index, indicating a higher risk of cardiovascular diseases.
A new risk calculator tool predicts accurate five-year risk of chronic kidney disease based on variables like age, hypertension, and diabetes status. The tool enables healthcare providers to identify patients at high risk and benefit from preventive interventions.
A new study has developed best practice treatment guidelines to quickly identify and treat patients with e-cigarette or vaping-associated lung injury (E-VALI). The guidelines recommend shorter courses of steroids for outpatients and higher doses for critically ill patients, resulting in improved clinical outcomes.
Scientists developed an investigational vaccine that protected cynomolgus macaques against Ebola, Sudan, Marburg, and Lassa viruses, all causing severe disease and death. The quadrivalent VesiculoVax vaccine showed promising results in a study published in the Journal of Clinical Investigation.
A group of international conservationists is urging governments to adopt a new approach to address the impact of economic development on the natural world. The new approach aims to achieve a net gain for nature and has been published in Nature Ecology & Evolution. The proposal calls for more ambitious measures to ensure greater benefit...
Oral food challenges (OFCs) are the most effective way to diagnose a food allergy, say two new studies. A child with atopic dermatitis and suspected peanut allergy passed an OFC despite prior skin testing results, while another boy who had removed peanuts from his diet after eczema flares developed anaphylaxis to peanut
Researchers at Texas Tech University Health Sciences Center have developed a novel drug combination using fenretinide and venetoclax to treat high-risk neuroblastoma. The study found that the combination of these two drugs showed significant activity against neuroblastoma cells, with multiple complete responses achieved in patients.
A large clinical trial found that vitamin D and omega-3 fatty acid supplements did not slow the decline of kidney function in adults with Type 2 diabetes. The study involved over 1,300 participants and measured their kidney function over five years.
Women are disproportionately affected by penicillin allergies, with a significantly higher rate of positive skin tests and reactions. Direct oral challenges without preliminary testing can safely rule out penicillin allergy in low-risk children, allowing them to have the allergy label removed from their medical records.
A new study shows an association between a family history of cancer and childhood asthma diagnosis in over 20% of children, highlighting the importance of extra asthma screening efforts.
The article discusses how hurricanes Irma and Maria's destruction in Puerto Rico exposed the country's critical social and environmental situation. Colonialism and neoliberal policies are identified as primary contributors to the crisis, causing poverty, inequality, and inadequate social services.
Researchers found that 44% of colonies of the invasive species Didemnum vexillum are formed by gene chimera, which could promote genetic diversity and colonization success. The creation of chimera may also be a mechanism to increase adaptive success in new environments.
A team of Clemson University astrophysicists has devised a new measurement of the Hubble Constant, which describes the rate of expansion of the universe. Their analysis of data from orbiting and ground-based telescopes yields a measurement of approximately 67.5 kilometers per second per megaparsec.
Researchers at Weill Cornell Medicine discovered that higher levels of protein adipsin in the blood protect against type 2 diabetes. Adipsin helps shield pancreatic beta cells, improving insulin production and preventing cell death.
A study analyzing ancient DNA samples from Rome and adjacent regions found at least two major migrations into the city, with influences from North Africa, Europe, and the Near East. The population's ancestry shifted significantly over time, reflecting Rome's shifting alliances and cultural exchange.
A panel of scientists recommends policy changes to address sexual harassment and gender bias in STEM fields, including requiring transparency in funding and internal grant funding. The recommendations aim to create inclusive professional environments for women in science.
A study by Carole Gee and colleagues confirms equisetum's importance as a digestible and nutritious food source for herbivorous dinosaurs in Mesozoic times. The researchers found that young and growing sauropods, which require rapid growth, would have relied on equisetum as a major food source.
Patients with diverse HLA genes respond better to immune checkpoint inhibitors, surviving longer with improved treatment outcomes.
A new study on a well-preserved femur fossil suggests that apes, humans, and Old World monkeys developed distinct hip joint morphologies, likely adapted to their respective environments. The findings imply that navigating the environment played a key role in driving the divergence of these primates.
A new warning system, WASAVIES, can estimate radiation doses due to solar energetic particles (SEP) up to 100 km above the ground in real-time. This system enables aircrew radiation dose monitoring and provides information for aviation operation management.
A Dutch study found that early onset of PD, memory and thinking impairment, and high levodopa medication use are linked to increased mortality. The study suggests that progressive motor impairment may be a key factor in the association between PD and reduced life expectancy.
Researchers used ultrashort X-ray pulses to study Photosystem I, a large biomolecular system converting sunlight into chemical energy. This breakthrough paves the way for time-resolved studies on electron transfer in photosynthesis, with potential applications in medicine and next-generation solar energy storage.
A NIH study found that only a third of prevention research projects measured leading risk factors for death, despite them being associated with half of US deaths. The study suggests an opportunity for the NIH to better align prevention research with leading causes and risk factors for death and disability.
Researchers at MIT have developed a robot with an extendable appendage that can twist and turn in various configurations, yet remains rigid enough to support heavy loads. The robot's design is inspired by the way plants grow, allowing it to adapt to different tasks and environments.
Researchers suggest that diseases may have played a crucial role in the extinction of Neanderthals. By employing mathematical models, they demonstrate how unique diseases harbored by Neanderthals and modern humans could have created an invisible disease barrier, ultimately allowing modern humans to supplant their cousins.
A study suggests that extending lifelong Medicare coverage of transplant medications would reduce healthcare costs and improve quality of life for kidney transplant recipients. This policy change could benefit patients who are currently left without coverage after 36 months.
Researchers developed an affordable, open-source monitoring system called GMpi using Raspberry Pi computers. The system allows flexible and secure remote monitoring of plant growth facilities, ensuring reproducibility and peace of mind.
Research suggests that family emotional climate has a significant effect on overall health, including the development or worsening of chronic conditions. In contrast, intimate partner relationships showed no significant associations with later health outcomes.
A study by University of Utah Health found nearly 33% of reproductive-age women with chronic conditions are using ineffective forms of birth control. Women with preexisting health problems are often missing out on crucial counseling about safe and effective birth control options.
Community house hem dialysis allows patients to perform treatment independently in a shared community space, reducing burden on family and promoting flexibility. The study found that this approach supports extended-hour dialysis and fosters social connections among patients of Maori and Pacific ethnicity.
Scientists at Okayama University created a human stem cell-based model of myocardial infarction, allowing for the evaluation of tissue damage and inflammation. This new model offers a more accurate representation of human heart conditions, enabling the development of more effective preventive and therapeutic medicines.
City of Hope researchers have created a modified CRISPR gene editing tool that improves the accuracy and efficiency of cutting out undesirable genetic information. The new design has shown promise in treating HIV and sickle cell disease by increasing desirable mutations and improving activity at specific target sites.
Researchers found measurable changes in brain regions after BCI training, which occurred within hours, not weeks. This suggests BCI could be used to stimulate specific brain areas for rehabilitation.
A recent study published in the Journal of Hazardous Materials found that simulated sunlight can degrade microplastics on the ocean surface. The research revealed that engineered polymer solutions degraded most rapidly under UV radiation, followed by polypropylene and polyethylene.
A new study published in PLOS Computational Biology reveals the mechanisms of memory formation and learning in the brain. The research team analyzed neuronal circuits and synaptic plasticity to understand how the nervous system adapts to changing conditions.
A new HIV vaccine strategy has been successfully demonstrated in proof-of-principle tests, targeting young immune cells and showing promise against the flu, dengue, malaria, and hepatitis C. The approach stimulates broadly neutralizing antibodies capable of neutralizing multiple strains of the virus.