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Science News Archive 2022 - Page 25


Page 25 of 448

New oral compound developed by Mass General researchers may help prevent and treat osteoporosis

Researchers at Massachusetts General Hospital have identified a promising oral compound that stimulates bone formation in mice, increasing blood levels of calcium and vitamin D. The compound, SK-124, boosts bone formation and mass without short-term toxicity, offering new hope for preventing and treating osteoporosis.

SourceMassachusetts General Hospital·JournalProceedings of the National Academy of Sciences·TypeExperimental study·DateDec 6, 2022

New study finds promising treatment for cognitive deficits associated with cholestatic liver disease

A new study found that obeticholic acid can reverse cognitive impairment in patients with cholestatic liver disease, improving short-term memory and restoring brain function. The study used a rodent model of bile duct ligation-induced cholestasis and found that the drug significantly improved cognitive deficits.

SourceElsevier·JournalAmerican Journal Of Pathology·TypeExperimental study·DateDec 6, 2022

Tailored activity program shows promise for Black people with dementia and their family caregivers

A recent study published in the Journal of American Geriatrics Society found that a tailored activity program (TAP) significantly improved behavioral symptoms in Black families compared to white families. The program, which provides activities tailored to interests and abilities, also reduced caregiver distress.

SourceDrexel University·JournalJournal of the American Geriatrics Society·DateDec 6, 2022

Race to finer and better imaging with structured terahertz light

Researchers investigate generating and performing terahertz structured light using flat photonic elements for object inspection and recognition tasks. Flat photonic elements offer advantages in creating non-diffracting beams that preserve internal structure, enabling high-resolution imaging with minimal background signal.

Scripps Research chemists develop reactions for the general synthesis of promising unexplored compounds

Researchers at Scripps Research have developed a general synthesis method for 1,2,3,5-tetrazines, a family of compounds with great promise for making new pharmaceuticals and chemical products. The new method is more efficient than previous approaches, requiring just five reaction steps to produce myriad versions of these compounds.

SourceScripps Research Institute·JournalThe Journal of Organic Chemistry·DateDec 6, 2022

Impaired glymphatic system may be linked with progression of Alzheimer's disease, finds new study

A new study found that impaired glymphatic system function is associated with Alzheimer's disease progression. Noninvasive MRI measures of the glymphatic system's volume and diffusivity were linked to amyloid beta deposition, neuronal damage, and cognitive impairment in patients with Alzheimer's.

SourceJuntendo University Research Promotion Center·JournalNeurology·TypeExperimental study·DateDec 6, 2022

New antimalarial drug requires higher doses to cure infection

A new antimalarial drug, tafenoquine, is found to require a higher dose of 450mg to achieve cure rates of 85% compared to the current 300mg dose of 70%. The study suggests that the single-dose tafenoquine is not as effective as optimal primaquine treatment in preventing vivax malaria relapses in all endemic regions.

SourceeLife·JournaleLife·DateDec 6, 2022

Doubling in proportion of male professional footballers’ hamstring injuries and lay-off days over past 20 years

The proportion of hamstring injuries and associated lay-off days among male professional European footballers has doubled over the past 20 years. Nearly one in five injuries were recurrences, occurring within two months of return to play, with most injuries being structural and resulting in more lay-off days.

SourceBMJ Group·JournalBritish Journal of Sports Medicine·TypeObservational study·DateDec 6, 2022

Oncotarget | Expression of p-STAT3 and c-Myc correlates with P2-HNF4α expression in nonalcoholic fatty liver disease (NAFLD)

Researchers found that P2-HNF4α expression is associated with p-STAT3 and c-Myc expression in NAFLD patients, suggesting potential biomarkers for hepatocellular carcinoma (HCC) risk. Additionally, p-STAT3 expression was linked to hypertension, while c-Myc expression was associated with advanced fibrosis.

SourceImpact Journals LLC·JournalOncotarget·TypeObservational study·DateDec 6, 2022

Cryptocurrencies can be more sustainable by following Ethereum’s lead, says researcher

Ethereum's shift from proof-of-work to proof-of-stake has significantly reduced its energy requirements. This change offers a model for other cryptocurrencies to follow and reduce their environmental impact. Policymakers and consumers can support this move by implementing policies such as carbon-disclosure requirements and environmenta...

SourceCell Press·JournalPatterns·TypeCommentary/editorial·DateDec 6, 2022

Black women with breast cancer may have worse outcomes than peers despite similar genetic recurrence scores

A recent study found that non-Hispanic Black women with hormone receptor-positive/HER2-negative breast cancer have poorer outcomes compared to other racial groups, even when their genetic recurrence scores are similar. The research also showed that these disparities were observed despite similar tumor sizes and lymph node involvement.

Cochrane review of COVID-19 vaccines shows they are effective

The Cochrane review analyzed data from 41 randomized controlled trials of 12 different COVID-19 vaccines, involving 433,838 people worldwide. The review found that most vaccines reduced the risk of COVID-19 infection and severe disease, with few reported side effects.

SourceWiley·JournalCochrane Database of Systematic Reviews·DateDec 6, 2022

Development of the technology to break down the shield which prevents the penetration of drugs and immune cells into intractable cancers

Researchers developed polymeric micelles to reprogram tumor microenvironment, enhancing nano-immunotherapy efficacy in mouse breast cancer models. The treatment response can be predicted from ultrasound shear wave elastography measurements prior to treatment initiation.

SourceInnovation Center of NanoMedicine·JournalNature Communications·TypeExperimental study·DateDec 6, 2022

People with mental disorders lose years of their working life

A new study from Aarhus University found that people diagnosed with mental disorders work 10.5 years less than the general population. The researchers analyzed data from over 5 million individuals in Denmark and found that all types of mental disorders are associated with a substantial loss of working life.

SourceAarhus University·JournalThe Lancet·TypeData/statistical analysis·DateDec 6, 2022

Megadrought: How the current Southwestern North American megadrought is affecting Earth's upper atmosphere

Research shows that the Southwestern North American megadrought caused a significant reduction (~30%) in wave activity after its onset, which may be related to reduced storm generation and altered precipitation patterns. The findings demonstrate that regional changes in the lower atmosphere can impact the upper atmosphere.

SourceUniversity of Illinois Grainger College of Engineering·JournalGeophysical Research Letters·DateDec 6, 2022

Following insect footprints to improve crop resilience and monitor pollinator biodiversity

Researchers used environmental DNA footprints to analyze insect biodiversity in four apple orchards, uncovering the importance of wild non-bee pollinators and multiple pest species. The study suggests that analyzing genetic footprints can provide a more comprehensive view of insect diversity, leading to new management strategies.

SourceWellcome Trust Sanger Institute·JournalEnvironmental DNA·DateDec 6, 2022

For people with dementia with Lewy bodies, treatment with acetylcholinesterase inhibitors, with or without memantine treatment, appears to be associated with both lower risk of mortality and duration of stay for unplanned hospital admissions for physical

Treatment with acetylcholinesterase inhibitors, with or without memantine, may reduce mortality risk and length of stay for unplanned hospital admissions among individuals with dementia with Lewy bodies. The study analyzed data from the UK to support this association.

SourcePLOS·JournalPLOS Medicine·TypeObservational study·DateDec 6, 2022

Scientists uncover biological explanation behind why upper respiratory infections are more common in colder temperatures

A newly discovered immune response inside the nose fights off viruses, but is suppressed by colder temperatures, making an infection more likely to occur. The study offers the first biological mechanism to explain why viruses like COVID-19 spike in colder seasons.

SourceMass Eye and Ear·JournalJournal of Allergy and Clinical Immunology·TypeExperimental study·DateDec 6, 2022

First-line ribociclib plus endocrine therapy may be more effective than combination chemotherapy in patients with aggressive breast cancer

Patients with hormone receptor-positive, HER2-negative tumors treated with ribociclib plus endocrine therapy had fewer adverse events and longer progression-free survival compared to those treated with combination chemotherapy. This treatment approach may allow for the avoidance of chemotherapy in aggressive patients.

Common workplace fumes and dusts may heighten rheumatoid arthritis risk

Exposure to common workplace agents is associated with a heightened risk of developing rheumatoid arthritis, which can be exacerbated by smoking and genetic predisposition. The study found that certain agents, such as quartz dust and gasoline fumes, are strongly linked to an increased risk of ACPA-positive disease.

SourceBMJ Group·JournalAnnals of the Rheumatic Diseases·TypeObservational study·DateDec 6, 2022

Gwangju Institute of Science and Technology researchers embrace uncertainty to make microgrids better

A new optimization model by GIST researchers reduces operating costs and load shedding in microgrids, achieving a 20% decrease in average ENS. The model accounts for variations and uncertainty in renewable energy supply using an ANN-based prediction model, with predicted power output accuracy of 9.7%.

SourceGIST (Gwangju Institute of Science and Technology)·JournalApplied Energy·TypeComputational simulation/modeling·DateDec 6, 2022

CU faculty lead report on 10 recommendations to promote firearm injury prevention

The University of Colorado Anschutz Medical Campus and the US Department of Defense have co-hosted a summit on firearm suicide prevention. The CU faculty lead report outlines 10 recommendations to improve evidence-based interventions, including repealing prohibitions on questioning service members about personal firearms and implementi...

SourceUniversity of Colorado Anschutz Medical Campus·JournalMilitary Medicine·TypeSystematic review·DateDec 6, 2022

Traveling with friends helps even mixed-up migrators find their way

A computer model simulates virtual groups of migrating animals and finds that sticking together is key to finding a destination, even when the magnetic compass is unreliable. The model showed that more than 70% of animals made it home simply by joining with others and following their lead.

SourceDuke University·JournalProceedings of the Royal Society B Biological Sciences·TypeComputational simulation/modeling·DateDec 6, 2022