Researchers at the Salk Institute have identified mechanisms that activate oncogenes in cancer cells, providing insights into predicting and treating the disease. The study found that structural variants in DNA can impact gene expression, leading to cancer, but most variants have no effect.
Alzheimer's disease is a growing health concern, affecting two-thirds of dementia patients. Prof. Michael Heneka's MINIALZ project aims to study immune cells and neurons in the brain to better understand disease progression and develop new diagnostic tools.
A research team used photogrammetry to build 3D models of flowers from two-dimensional images, gaining new insights into the shape and color of flowers. The technique allows for detailed study of flowers' morphology and colors, which act like magnets to attract pollinators.
Researchers have developed a text-to-audio model that can generate coherent and relevant music and sound from text, opening up new avenues for creative application and exploration. The model employed data compression methods to improve output quality and reduce training time.
A study published in the Journal of Consumer Research found that individuals who are feeling tense due to time pressures and financial constraints tend not to reward themselves with gifts or experiences. However, when researchers encouraged participants to engage in self-gifting activities, they reported increased happiness and relaxat...
The researchers successfully designed a BSA-magnetite nanotorpedo to deliver chemotherapy drugs, overcoming leakage issues and prolonging half-life in blood circulation. The nanotorpedo showed superior biosafety, stability, intracellular transport, and tumor inhibition, presenting great prospects for drug delivery in nanomedicine.
Scientists have identified two-million-year-old DNA fragments in northern Greenland's Ice Age sediment, providing insights into the past ecosystem and its potential to predict climate change. The discovery has sparked hopes that it could help academics build a picture of the DNA evolution of species still in existence today.
Researchers found that certain glycoalkaloids in plants like potatoes and tomatoes can inhibit cancer cell growth and promote cancer cell death. These compounds have huge potential for future treatments and may be used to develop new cancer drugs.
Insulin pump use has grown over two decades but disparities persist among racial, ethnic, and socioeconomic groups. Youth from lower-income backgrounds and minority groups are less likely to use insulin pumps.
A new study published in PLOS ONE suggests that different styles of social media use—passive, reactive and interactive—are related to psychological well-being. Interactive users reported greater feelings of social connectedness than passive or reactive users.
A new study suggests that Native American tribes once used controlled burns to weaken climate's impact on wildfires. For roughly 400 years, cultural burning practices appear to have broken the link between climate conditions and fire activity in the southwestern United States. This ancient approach may hold lessons for modern wildfire ...
A large cohort study in Tanzania found that antiviral treatment can reduce the risk of HIV transmission from mother to child by 99.5%. The study suggests that achieving the World Health Organization's goal of eliminating mother-to-child transmission is possible with modern antiviral drugs.
Engaged feeding practices, such as recognizing fullness cues and responsive feeding, can help parents guide their children towards healthier eating habits. By adopting these practices, parents can create a positive relationship with food that lasts into adulthood.
The Faraday Institution has launched the Battery Parameter eXchange (BPX) standard to provide a common language for accurate battery modeling. Physics-based models can deliver accuracy in long-term performance but have been limited by a lack of a common definition.
A new study estimates that at least 2.5 million 'sandwich generation' caregivers are serving as primary caregivers for both older and younger family members. These women face higher rates of financial difficulty and emotional distress compared to their peers who only care for an older adult.
A recent systematic review found that inclusion neither increases nor decreases learning and psychosocial adjustment in children with multiple disabilities. Individual assessments are crucial to determine each child's specific needs. The study highlights the importance of personalized approaches to support children with special needs.
A new analytical method has been developed to map climatic and environmental processes at high temporal resolution, revealing an abrupt intensification of seasonality in the tropical ocean during the last period of global climate change. This provides evidence of how global climate changes affect local, seasonal temperature variations.
A new study led by University of Colorado Denver professor Sara Yeatman found that exposure to the 2009 Colorado Family Planning Initiative increased women's bachelor's degree completion rates. The research tracked thousands of women over 11 years, revealing a six to 12 percent increase in college attainment.
Persistent pain was common among US adults aged 65+, with declines in physical function (64% persistent pain, 59% intermittent) and well-being (48% persistent pain, 45% intermittent). Cognitive decline was not significantly affected. The study highlights the importance of access to effective treatment for persistent pain in older adults.
The updated guideline provides recommendations on the use of radiation therapy and systemic therapy after surgery to treat patients with endometrial cancer. It considers the role of surgical staging and molecular profiling techniques in determining whether a patient should receive post-operative therapy.
Research found that sounds can influence how we perceive objects visually, making related sounds prioritize certain features. This effect was observed in three experiments, showing that audio input influences object-morph selection speed and accuracy when played during visual discrimination phase.
Scientists have identified the ancient yeast species necessary for lager beer production in Europe, with a previously unknown parent strain found in Ireland. The discovery sheds new light on the history of brewing and suggests that natural populations of the yeast may still remain hidden in European forests.
A study published in Nature reveals that cells' inability to repair DNA damage caused by aldehydes increases the risk of developing head and neck tumors, particularly in patients with Fanconi anemia. The findings also suggest a link between smoking and drinking, which can lead to similar genetic mutations.
Researchers at the University of Huddersfield used ancient DNA to reveal large-scale immigration in Early Bronze Age Orkney, contrary to popular belief. The findings also showed unusual female-dominated immigration during this period.
A recent gamma-ray burst has been identified as a kilonova, shedding light on the merging of neutron stars and black holes. The event produced an excess of infrared light and lasted about a minute, contradicting the typical short duration of such explosions.
Researchers found that while humans excel at categorizing interactions between humans, dogs, and monkeys, they struggle to predict aggressive behaviors in both species. Participants performed poorly on identifying aggression in dogs and humans, suggesting a potential bias towards assuming good intentions from others.
Researchers developed a novel liquid-phase laser irradiation route to fabricate Fe(a)@C-Fe3O4/CNTs catalyst, exhibiting superior activity toward electrocatalytic coupling of CO2 and NO3- for urea synthesis. The synergistic catalytic effect contributes excellent electrocatalytic performance.
Researchers have developed an algorithm to detect pressure activity indicative of dust devils in the Mojave Desert, which can inform their formation and life cycles on Mars. The study aims to improve Martian weather models and enhance robotic missions.
Researchers developed a Janus carbon electrocatalyst with different heteroatom doping levels on both sides to resolve the trade-off between intrinsic activity and electronic conductivity. The hybrid showed significantly improved activity in hydrazine oxidation reactions compared to single counterparts and physical mixtures.
Researchers found that rusty center pivots indicate a lack of nitrate in the groundwater they feed. In fact, most wells supplying full-rust and part-rust pivots had nitrate concentrations below the EPA's safety threshold. However, some part-rust pivots showed higher nitrate levels, highlighting the need for further investigation.
Researchers discovered a new ancient branch of life, Provora, comprising microbial predators that nibble prey to death. These microbes, called nibblerids and nebulids, were found in marine habitats globally and differ by 170-180 nucleotides from all other living things.
Scientists have discovered a long-sought plant water loss-regulating sensor, composed of two proteins working together to regulate stomatal movements in response to changing CO2 concentrations. This finding has significant implications for trees, crops, and wildfires, as well as efficient plant water use and CO2 uptake.
Researchers found that the Southern Hemisphere is stormier than the Northern, with a 24% difference attributed to ocean circulation and mountain ranges in the Northern Hemisphere. The study also shows that storminess has increased since the 1980s, consistent with climate change forecasts.
Researchers explored how customers react to positive emotions from AI chatbots compared to human agents. They found that adding emotions doesn't necessarily improve service quality or customer satisfaction.
A new investigation from the University of Pennsylvania School of Nursing found that patients perceived important benefits from Cancer Clinical Trials (CCT) participation, which was associated with trial retention. The study suggests that understanding these perceptions is crucial for improving trial retention rates.
Researchers developed a novel photocatalyst combining graphitic carbon nitride and sodium yttrium fluoride nanocrystals, extending light absorption to near-infrared region. The hybrid material exhibited enhanced solar harvesting ability and accelerated interfacial charge transfer, leading to improved solar-driven hydrogen evolution rates.
An experimental music piece by Alvin Lucier can be used to reveal details of the surrounding room and teach important lessons about acoustic resonance. Students can analyze the frequencies that make up the recording to determine which frequencies are resonances of the room, and then calculate the distance between pairs of walls.
Computational models of bacterial cell walls can predict interactions with antimicrobials, enabling rapid screening for effective molecules. The models reveal differences in cell wall permeability between Gram-negative and Gram-positive bacteria.
The Global Roadmap for Healthy Longevity aims to design societies that benefit both older and younger individuals. Investing in the health, well-being, and purpose of older adults can yield great rewards for all ages, fostering productive lives, social capital, and a sense of fulfillment.
Researchers develop an algorithm to automate feature extraction from HD maps and point cloud data. The model achieved high precision in detecting road signs and traffic lights, with zero false detections.
A study published by Tufts University has found a link between higher levels of vitamin D in brain tissue and improved cognitive function in adults. The research, which analyzed brain tissue from over 200 participants, suggests that vitamin D may play a role in protecting the aging brain against diseases such as Alzheimer's.
Scientists discovered that an artificial cell membrane can exhibit long-term potentiation, a hallmark of biological learning and memory, persisting for many hours. This finding has the potential to revolutionize next-generation computing materials and architectures by merging functions of processing and memory in neuromorphic computers.
A retrospective cohort study of 1,404 subjects with type 2 diabetes found that metformin use reduced the risk of delirium by 50% and decreased 3-year mortality rates. The study suggests that metformin may be a potential benefit for patients with diabetes, particularly in reducing age-related disorders such as dementia.
The phase III DESTINY-Breast02 trial showed that T-DXd led to higher response rates and longer survival compared to capecitabine-based regimens in patients with HER2-positive metastatic breast cancer previously treated with T-DM1. Overall, T-DXd demonstrated superior efficacy and safety in this patient population.
A team of astrophysicists has discovered that at least some long gamma-ray bursts (GRBs) can result from neutron star mergers, contradicting the long-held belief that they solely originate from massive star collapses. This finding also sheds new light on the formation of the heaviest elements in the universe.
The University of Texas at El Paso will provide scholarships, stipends, and research opportunities to underrepresented students as part of a $5M DOE grant. The program aims to develop electronics for extreme environments and increase the electrical engineering workforce.
A study published in PLOS ONE found that patients who used virtual reality (VR) during hand surgery required less sedation and had shorter recovery times compared to those who received monitored anesthesia care. VR use also improved patient comfort and reduced anxiety.
The event challenged scientists' understanding of gamma-ray bursts (GRBs), which are the most powerful events in the universe. The burst's high-energy light and kilonova visible and infrared light were detected by NASA's Swift Observatory and Fermi Gamma-ray Space Telescope, providing new insights into how heavy elements are created.
A new research project, led by the University of Reading and University of Southampton, aims to enhance primary foreign language teachers' knowledge and classroom skills using digital technology. The 'Digital Empowerment in Language Teaching' programme will be rolled out across England and Scotland to support teacher development.
Drs. Emilie T. Reas and Tara Tracy will lead transformative research in cognitive aging, focusing on blood-brain barrier dysfunction and the role of KIBRA protein in age-related memory loss. The awards aim to build a cadre of outstanding researchers to better understand and alleviate effects of age-related cognitive decline.
Scientists at Dana-Farber Cancer Institute have developed a potent drug that neutralizes SARS-CoV-2 and its variants by mimicking the ACE2 receptor, making it effective against emerging antibody-resistant strains. The investigational drug, DF-COV-01, could also be used to treat future coronaviruses.
Lying prone reduces the risk of needing a breathing tube in COVID-19 patients by 24.2% compared to usual care, but evidence for its effect on mortality or other outcomes is inconclusive. The intervention also results in 55 fewer intubations per 1,000 patients.
The number of active buprenorphine prescriptions remained constant during the first year of the COVID-19 pandemic, but new treatment episodes started significantly fewer than expected. This trend occurred despite emergency policies aimed at increasing access to the medication.
A new diagnostic pathway for prostate cancer reduces the number of harmless tumors found during screening, halving the risk of overdiagnosis. This strategy involves using MRI to guide targeted tissue sampling, reducing the need for unnecessary biopsies and associated complications.
A new study allows people with type 2 diabetes to choose their own medication after trying three different drugs in succession. The approach resulted in better glucose control and fewer side effects compared to other methods. Researchers conclude that patients should try before choosing a treatment for optimal results.
A team of astronomers used the Green Bank Telescope to image a galaxy cluster and revealed new information about a supermassive black hole. The study found that at least a portion of the pressure support in the cavities is due to non-thermal sources, such as relativistic particles and cosmic rays.
Researchers uncovered distinct DNA methylation profiles in ocean microbes, shedding light on population dynamics and interactions. The study's findings have significant implications for understanding pathogenicity and developing new approaches to monitoring environmental health.
Researchers at Notre Dame have discovered a way to enhance the effectiveness of existing drugs using a new 'raspberry-shaped' nanoparticle. By varying the loading procedure, they can create particles that release drugs at different rates.
Researchers discovered that trauma changes brain mechanisms involved in learning and survival, such as the salience network. The study found that people with PTSD struggle to distinguish between safe and dangerous stimuli when emotions are involved.
Researchers identified two methods of harvesting rice, which helped initiate rice domestication. The findings showed that the early Neolithic cultures in southern China used both 'finger-knife' and 'sickle' techniques to harvest rice, with the latter method becoming more widely used as rice became more domesticated.