Researchers identified four distinct DDT initiation pathways and the essential characteristics of the DDT process. The team's experiments revealed that energy focusing creates a local hot spot, which then transitions into a detonation wave.
A study published in Scientific Reports found that large rain events combined with sea level rise could cause severe flooding across 70% of Waikīkī, contaminating stormwater inlets and disrupting transportation. By 2050, the entire Waikīkī storm drainage system is expected to fail, posing a health hazard from contaminated water.
The FiLM-Scope surgical microscope offers precise 3D imaging using 48 tiny cameras, creating a detailed 3D map of the scene in real time. This technology can expand possibilities in manual and robotic microsurgery.
A new bioinformatic tool called Cell Marker Accordion has been developed to help researchers understand single-cell analysis results. The tool reveals the presence of altered cells that may be linked to diseases such as blood cancers or solid tumours, and can identify unique genes involved in these alterations.
Researchers have developed novel three-dimensional liver organoids using bile acids, which retain hepatocyte-like features and can be sustained in long-term cultures. These organoids demonstrate a unique gene expression profile similar to fetal hepatocytes and support replication of hepatitis viruses.
A new study demonstrates that retrieval-augmented generation can eliminate hallucinations in clinical LLMs while protecting patient privacy. The RAG-enhanced model responds significantly faster than cloud-based systems, delivering safer results without compromising data security.
Researchers have designed a thermal management scheme to efficiently cool high heat flux switch chips in co-packaged optics (CPO), addressing signal crosstalk and temperature homogeneity issues. The solution can be applied to CPOs with data rates of up to 51.2 Tbit/s, releasing the performance potential of this technology.
A novel nanocarrier system utilizing metal-polyphenols enables precise intracellular delivery of therapeutic antibodies into cancer cells. This technology overcomes endosomal entrapment, resulting in suppressed tumor growth and enhanced anti-cancer activity.
A study published in Nature Communications reveals that genetic diversity within groups of fruit flies improves their ability to evade predators and forage more efficiently. The research team identified a key gene, Ptp99A, that regulates group behavior and promotes survival performance.
Researchers investigated low-density amorphous ice and found it was not fully disordered but contained tiny crystals. This discovery challenges the assumption that space ice is similar to liquid water and has implications for theories like Panspermia.
Despite reducing HBV prevalence from 9.72% to 5.86%, China still struggles with chronic infection, diagnosed cases, and treatment accessibility, particularly in rural areas. Innovative treatments and digital health tools hold promise for improving compliance and achieving functional cure.
Researchers at Hefei Institutes of Physical Science developed advanced aerogel composites with high-temperature insulation and mechanical load-bearing capabilities. The composites achieved controllable fabrication of large-size samples and demonstrated strong potential for future thermal protection applications.
A new dual CAR-T cell therapy has been developed to target T-ALL, showing high efficacy and safety. The treatment targets two antigens simultaneously, making it more effective than previous therapies. Experimental results demonstrate its ability to control the disease in both laboratory and animal models, with an excellent safety profile.
Insilico Medicine's latest Pharma.ai updates showcase advancements in Biology42 and Chemistry42, enhancing antibody design and omics data analysis. The company's AI software suite has demonstrated significant efficiency improvements in practical applications, setting a benchmark for AI-driven drug research.
Researchers are applying Model-Based Systems Engineering to enhance system resilience and protect against cyber threats in aerospace. The initiative aims to create robust frameworks for safeguarding emerging technologies, with potential benefits including job creation and skills development.
Researchers discover a novel metabolic pathway, glyoxalase system, that regulates excessive immune responses by targeting a previously underexplored metabolic pathway. The GLO2-SLG-D-lactylation pathway suppresses inflammatory signaling, reducing inflammation in acute and autoimmune disease settings.
Researchers have discovered a hidden switch in breast cancer that uncovers PHGDH's role as both a metabolic and transcriptional regulator. PHGDH suppresses genes vital for immune cell function, steering macrophages toward tumor-fighting behavior. The study offers promising new strategies for reprogramming the tumor microenvironment.
A study by Surrey researchers found that body image worries and pressure from parents, coaches, and schools are major reasons why many young women quit sports. The study suggests that making sports feel safe and supportive can help retain girls in the game.
The American Heart Association and Major League Baseball will offer walk-up style Hands-Only CPR instruction at the 2025 MLB All-Star Game. Participants will learn compression-only CPR, a skill that can be equally effective as traditional CPR in the first few minutes of emergency response.
A recent study on truncal acne found that material contact and gender play a significant role in outbreak severity. The researchers proposed the Truncal Acne Severity Scale (TRASS), which addresses a major gap in current methods by incorporating patient-centered metrics.
Cyanobacteria's microalgae-based technologies effectively remove antibiotics from wastewater through mechanisms attributed to the identified nitroreductase enzyme. Engineered bacteria expressing this enzyme degrade chloramphenicol with high efficiency, offering a sustainable biocatalyst for antibiotic pollution control.
Researchers at Keck Medicine of USC found that high doses of corticosteroids can limit the effectiveness of immunotherapies in treating non-small cell lung cancer. Corticosteroids, commonly prescribed for symptom management, were shown to stop T-cells from maturing, reducing their ability to attack cancer cells.
Astrocytes, long-neglected brain cells, are found to modulate behavioral flexibility and whole-body metabolism in mice with obesity. Researchers from CNRS and Université Paris Cité discovered that manipulating astrocytes in vivo can correct cognitive changes and influence metabolism.
Researchers analyzed data from 253 primate populations to quantify male-female dominance. They found diverse power relations across species, contradicting previous assumptions about male dominance.
Feralisation in rabbits leads to variable body sizes and skull shapes that don't simply revert to wild or domestic forms. The study suggests environmental factors drive these changes, potentially influenced by evolutionary pressures and habitat conditions.
A recent study suggests that virtual reality therapy is effective in treating psychosis, working faster than current cognitive behavioral therapy. The treatment involves exposing patients to simulated social situations to reduce avoidance behavior and anxiety.
A new framework for defining obesity may reclassify 1 in 5 overweight US adults as obese, but surprisingly shows similar mortality risk to those with normal weight. The study found that larger waist circumference at greater risk for death among postmenopausal women across all BMI categories.
Researchers introduced a novel low-thermal-effect gradient-doped crystal to improve brightness of high-power end-pumped Nd:YAG lasers. The optimized crystal extended absorption length, smoothed thermal gradients, and achieved conversion efficiencies above fifty percent.
A new computational method combines 4D flow MRI, CFD, and data assimilation to estimate blood flow in brain aneurysms with greater accuracy and efficiency. The approach focuses on the aneurysm region, reducing computational cost while improving flow estimation.
Researchers at the University of Cambridge have made a groundbreaking discovery on how neural stem cell grafts can restore myelin in MS lesions in mice. The study provides critical evidence supporting the safety and efficacy of human induced neural stem cell transplantation as a potential new treatment for progressive multiple sclerosis.
A new blood biomarker, p-tau217, has been identified as a potential predictor of Alzheimer's disease progression. This marker shows promise in identifying individuals at higher risk of developing the disease, allowing for early intervention and targeted treatment.
Scientists have discovered that repeat RNAs aggregate inside droplets but can be disassembled with an engineered piece of RNA. The study sheds new light on how these clusters form within biomolecular condensates and presents a potential therapeutic application.
Researchers found that elevated L-aspartic acid levels predict gastric cancer risk, while influencing treatment outcomes of Helicobacter pylori eradication and garlic supplementation. This study suggests using plasma L-aspartic acid profiling to tailor prevention efforts and identify high-risk individuals.
A new study reveals an AI-assisted technique that can measure and track aging cells, which are known to play a key role in wound repair and aging-related diseases. The tool uses nuclear morphometrics to analyze cell characteristics and distinguish between healthy and senescent cells.
A new report from NYU highlights the promise of community and global advocacy, organizational support, partnerships, and other strategies for integrating quality arts education in public schools. Successful initiatives include teacher development, technical support, and community engagement.
Researchers developed CL-RaA*, a novel path planning algorithm for fixed-wing UAVs, ensuring safe and efficient navigation in complex environments. The algorithm outperforms existing methods in terms of search speed and feasible path length.
Researchers from Shanghai Jiao Tong University proposed a method for neutron spectrum regulation to enhance the irradiation production efficiency of transuranium isotopes. The new method achieves efficient and precise neutron spectrum optimization, maximizing the production of transuranic isotopes.
A novel method predicts the working status of high-formwork support systems using a combination of finite element model simulations, deep learning, and large language models. The framework achieves superior performance over existing methods and demonstrates potential applications in complex structures.
Chihtong Lee's research on retractor blade geometry explores how small design changes can improve patient recovery after spinal surgery. Her work, conducted in collaboration with Baylor College of Medicine, showed that blades with soft, biocompatible coatings significantly reduced tissue stress and postoperative complications.
Researchers developed an AI-informed method for rapid protein evolution, integrating structural and evolutionary constraints. The approach, AiCE, outperforms traditional methods in predicting high-fitness mutations, enabling efficient protein redesign and applications in precision medicine.
Southwest Research Institute (SwRI) is expanding its heat exchanger testing capabilities to include megawatt-scale performance evaluations. This move addresses a significant market gap for high-heat transfer rates involving high-temperature and -flowrate applications in data centers, defense, and other fields.
A team of astronomers found that fast X-ray transients are associated with the explosive death of massive stars, including supernovae. The International Gemini Observatory and SOAR telescope observed the event, providing insight into its mechanisms.
A new framework, FlowViT-Diff, uses transformer-guided diffusion models to reconstruct high-resolution flow fields from low-resolution data. The method achieves superior accuracy and robustness compared to classical methods.
Researchers developed CoNi-MOF nanozymes with laccase-like activity using a gas-liquid interface dielectric barrier discharge (DBD) low-temperature plasma (LTP) technique, exhibiting high catalytic degradation of tetracycline. The novel approach offers an eco-friendly strategy for addressing antibiotic pollution in the environment.
A comprehensive seven-step information guide has been published in the British Journal of Surgery to support and protect patients considering pioneering surgery. The guide sets out essential information that surgeons must discuss with patients before undergoing innovative procedures.
A new study by Cornell researchers found that nearly half of U.S. grandchildren (47%) live within 10 miles of a grandparent, with significant numbers even closer. Families living closer together tend to have lower socioeconomic status but spend more time and money on each other.
A new approach to improve lithium-ion conduction in solid polymer electrolytes is presented through in situ polymerization within a covalent organic framework, boosting the performance of lithium metal batteries. This innovative design enhances ion transport efficiency and paves the way for high-performance lithium metal batteries.
Researchers found that individuals following Mediterranean or plant-based diets were less likely to develop chronic constipation. A diet rich in vegetables, nuts, and healthy fats may help prevent the condition.
Researchers discovered a deeper understanding of the energy back transfer (EBT) mechanism in upconversion luminescent materials. The study found that high power densities induce a transition from green to yellow luminescence, while maintaining bright green luminescence within a measured range.
Research investigates how late eating affects glucose metabolism, finding a link between late meal times and reduced insulin sensitivity. Genetic factors also play a role in determining individual eating behaviors and glucose regulation.
Researchers found that thick ice cover suppressed volcanic eruptions, but as glacial ice melts, pressure builds and magma is released, leading to more frequent and explosive eruptions. This phenomenon could occur worldwide, including Antarctica, and may have global climate impacts, including long-term warming.
Researchers identified a novel homozygous nonsense mutation in DLGAP5 responsible for human female infertility. The mutation led to abnormal oocyte maturation and impaired embryo development, with no cleavage embryos developing into blastocysts.
Researchers found no significant genotoxic effects of triazine UV filters in bacterial reverse mutation, chromosomal aberration, and micronucleus assays. Phototoxicity assessments also confirmed safety using 3T3 neutral red uptake and guinea pig models. The results support the use of these filters in topical applications.
Researchers at Lund University are advancing knowledge about lipid nanoparticles, which could guide them to the right destination within cells. The technique has potential for treating cancer, genetic disorders, and neurological conditions.
A new method for rapid generation of aircraft concept solutions based on generative artificial intelligence has been proposed, demonstrating the application potential of large language models in aircraft conceptual design. The method improved efficiency and innovation in the conceptual stage.
Frontiers has integrated Cactus' Paperpal Preflight and Clear Skies' Papermill Alarm and Oversight into its AIRA submission-screening system to boost fraud-detection capabilities. This integration strengthens the reliability and integrity of every manuscript submitted to Frontiers.
A new study reveals that civil servants who support the ruling party are more likely to stay engaged, while others tend to leave or disengage, leading to a less diverse and politicized civil service. This shift threatens the competence, neutrality, and public trust of the civil service.
Researchers discovered that breast cancer responds to CDK4/6 inhibitors by forming an immunosuppressive microenvironment, which can be mitigated with radiation therapy or immune-modulating drugs. The study also found a potential biomarker to predict treatment response in patients.
Research on MCL-1 protein reveals its critical role in cell survival and energy production, offering a roadmap for designing targeted cancer therapies with reduced side effects. The findings also shed light on fatal metabolic diseases in infants, providing potential new targets for future treatments.
A study by University of Colorado at Boulder found that nearly half of cannabis flower products contain more THC than their labels claim, while concentrates tend to be accurately labeled. The study emphasizes the importance of accurate labeling in the industry.