Researchers evaluated a tool based on NCCN Guidelines to identify high-risk medications and their association with frailty and outcomes in over 380,000 older adults diagnosed with cancer. The study found that each additional high-risk medication increased the odds of being mildly or moderately-to-severely frail by 66%.
A quicker and cheaper two-part MRI scan is just as effective as the current 30-40 minute scan in detecting prostate cancer. The PRIME trial confirms that this streamlined approach can diagnose cancer at the same rate as a full three-part scan, cutting scan time to 15-20 minutes and reducing costs.
A recent study found that two-thirds of clinical trial participants experienced complete remission from major depressive disorder five years after psilocybin-assisted therapy. The treatment also showed significant and large reduction in depression symptoms, with many participants reporting improved well-being measures.
Breakthrough Discoveries for Thriving with Bipolar Disorder (BD²) has announced a fourth round of Discovery Research funding for bipolar disorder. The program aims to support groundbreaking research into the genetic, molecular, cellular, circuit, and behavioral mechanisms of the disorder.
A new study from MIT neuroscientists reveals how rare variants of the ABCA7 gene contribute to Alzheimer's risk by disrupting lipid metabolism and cell membrane function. Treating neurons with choline can reverse some cellular effects of ABCA7 loss.
Scientists have discovered key circuit changes that lead to the maturation of reliable brain activity patterns in response to visual experience. The findings suggest that the brain develops a modular organization, with patches of neurons activating together in response to specific features, allowing for efficient learning and adaptation.
A team of researchers has received funding to study the PRPH2 gene, crucial for normal vision, but when mutated causes a range of retinal diseases leading to blindness. They aim to uncover the underlying mechanisms of PRPH2-associated pathology to develop effective therapies.
Researchers verified Stephen Hawking's Black Hole Area Theorem using gravitational waves, confirming the total surface area of black holes increases when they merge. This detection provides evidence for a fundamental law in physics, demonstrating the power of gravitational-wave astronomy.
The study reveals that enzymes KDM1A and KDM5C collaborate to prevent neurons from activating inappropriate genes, ensuring their proper function. This discovery opens new avenues to understand the origin of neurological disorders associated with intellectual disability.
Researchers at Pohang University of Science & Technology have successfully synthesized Prussian Blue with an octahedral morphology by using a specialized solvent. The new crystal shape enhances electrochemical reactivity and stable performance in sodium-ion hybrid capacitors.
A recent study analyzed newspaper images of home care in Finland, finding that they often portray older clients as passive and lonely, while care workers are depicted as active. The study's findings highlight the need to critically assess media imagery and its impact on perceptions and decision-making related to home care.
Researchers develop RNA-based molecular tool to interfere with phage replication, allowing for targeted therapy against bacterial pathogens. The approach has potential applications in treating infections caused by hospital germs like Pseudomonas aeruginosa.
Researchers at Penn State found that weight fluctuations and changes can lead to faster cognitive decline in older adults. The study analyzed data from 4,304 participants and showed that those with greater variability in weight experienced more rapid cognitive declines.
Researchers found that four common PFAS triggered fat buildup and cancer-related changes, with effects differing by sex. Liver cells from male and female donors responded differently to PFAS exposure.
The UC3M researchers will work on projects such as Adaptive optimization for AI to create faster and cheaper AI systems. They aim to develop smart thermal batteries using 3D printing and low-carbon materials inspired by natural structures.
Researchers identified a brain region called the bed nucleus of the stria terminalis (BNST) as a key player in controlling consummatory behaviors. Stimulating this area can drive mice to consume sweets, while inhibiting it leads to weight loss.
The Endocrine Society has recognized 12 exceptional endocrinologists with its 2026 Laureate Awards, honoring their groundbreaking research and clinical breakthroughs in treating hormone disorders. The winners include Robert M. Carey, Christopher Kevin Glass, Rebecca Reynolds, Samuel Klein, and Lisa B. Nachtigall, among others.
Astronomers have finally solved the mystery of globular clusters using detailed simulations, uncovering a new class of object that could be in our own galaxy. The study found multiple pathways for their creation and a new class of star system, “globular cluster-like dwarfs”, which sits between globular clusters and dwarf galaxies.
Researchers developed an unusual therapy using a cocktail of antibodies that protected mice from nearly every strain of influenza, including avian and swine variants. The therapy did not allow viral escape, even after repeated exposure in animals.
Researchers developed a plasmonic meta-RTWO with ultrahigh phase accuracy and figure of merit (FOM), overcoming traditional designs' limitations. The technology enables applications such as real-time calibration of antenna arrays in 6G massive MIMO systems and subpicosecond synchronization for terahertz quantum communication.
A survey of nearly 50,000 dog owners found that dogs became harder to train during the pandemic, with improvements noted once restrictions were lifted. Factors like age, breed, and size also influenced behavior, with mixed-breed dogs showing more fear, aggression, and need for attention.
A new study published in JAMA finds biparametric magnetic resonance imaging (MRI) to be more efficient than multiparametric MRI for prostate cancer diagnosis. By adopting biparametric MRI, the global healthcare system could see a substantial increase in scanner throughput and cost reduction.
Researchers found that lung cancer cells can form functional synapses with neurons, supporting their growth and survival. Disrupting glutamate signalling led to lower tumour burden and longer survival in experimental mice, highlighting promising therapeutic targets.
Researchers found that lung tumors reshape immune cells in the bone marrow before they reach the cancer, altering their function and leading to a stronger anti-cancer response. The study identified NRF2 as a key protein involved in this process and proposed blocking it as a potential strategy to enhance immunotherapy.
A Mediterranean-style diet has been found to improve intestinal function and mucosal immunity, preventing fat accumulation and optimizing microbiota composition. This diet also helps reduce the incidence and severity of infections in babies.
Scientists have successfully kept a tiny sliver of the mammalian cochlea alive and functional outside the body for the first time. The innovation allowed them to capture the live biomechanics of the cochlea's remarkable auditory powers, including exceptional sensitivity and sharp frequency tuning.
A study published in Cell Host & Microbe found a significant link between the maternal gut microbiome and preterm birth. The researchers identified Clostridium innocuum as a key bacteria species that may contribute to preterm birth by degrading estradiol, a critical hormone during pregnancy.
A new study by Brown University and Rice University found that state school finance reforms did not reduce racial and ethnic funding inequities and in some cases increased them. The reforms narrowed funding gaps by income but failed to address disparities by race and ethnicity.
A study published in Circulation found that abnormal cell growth in blood vessels leads to organ deterioration and failure in patients with APS. The researchers identified CCN1 and CCN2 proteins as key players in the process, raising hope for new treatment strategies.
A new network map study has identified the crucial roles of immune-mediated inflammation and tyrosinase in hyperpigmentation on sensitive skin. Oxyresveratrol was found to suppress melanin production in B16F10 cells, suggesting its potential as a treatment for hyperpigmentation.
The LIGO–Virgo–KAGRA Collaboration has used the sharpest gravitational wave signal to precisely test Hawking's area theorem and confirm the remnant black hole's nature. The detection confirms that the surface area of the remnant increased, consistent with Hawking's prediction.
A new UC Davis research suggests that smaller, specialized firms can protect their market position against Big Tech giants by strategically opening their data vaults and granting access to their market data. This can turn a formidable rival into a
UCSF researchers develop a new strategy to prime CAR T cell therapy by combining it with diabetes drugs, increasing the efficacy of NECTIN4-CAR T cells in treating urothelial carcinoma. The study shows that using thiazolidinediones enhances NECTIN4 expression, making tumor cells more susceptible to the treatment.
A newly detected black hole merger has provided the clearest evidence yet of how black holes work, confirming fundamental predictions by Albert Einstein and Stephen Hawking. The observations reveal insights into the properties of black holes and the nature of space-time, hinting at how quantum physics and general relativity fit together.
A new, free screening tool was designed to help kindergarten teachers quickly identify students who need extra academic or social-emotional support. The tool takes just 10-15 minutes per class and provides a baseline of what each student might need, helping teachers pinpoint areas for additional resources and training.
A retrospective cohort study found that children of racial and ethnic minority groups receiving CPR had higher odds of in-hospital mortality. Additionally, the odds of in-hospital mortality among children receiving CPR were higher at hospitals with the highest proportion of Black patients.
Researchers analyzed data from 33,183 individuals and found that minimally invasive approach was associated with lower complication risks compared to open surgery. This study suggests that expanded use of minimally invasive surgery in rural areas may help bridge the gap between rural and urban patients with colon cancer.
Researchers at NUS have developed a bioengineering approach to keep human lymph node tissue alive and functioning outside the body for several days. The method involves embedding thin slices of lymph node tissue in a soft gel that mimics the body's natural environment, allowing for detailed studies of immune cell behavior.
The US funding withdrawal could lead to a significant increase in tuberculosis-related deaths worldwide. According to the modelling study, this could result in approximately 2.2 million more deaths between 2025 and 2030, across high-burden TB countries.
Researchers at King's College London have discovered that cells use electricity to selectively target and eliminate the weakest neighbours, helping to maintain a balanced and healthy protective layer. This process, known as extrusion, is crucial for balancing cell division and death, and disrupting it can lead to disease.
The Journal of Psychiatry and Neuroscience has joined the Canadian Science Publishing portfolio, becoming the 23rd journal in the suite. This move expands CSP's publishing reach into the fields of psychiatry and neuroscience, with a focus on high-quality research and editorial independence.
Researchers at the University of Vienna used quantum mechanical calculations to understand the structure and properties of an iron-based catalyst. They found that the spins of three iron atoms are ideally aligned antiparallel to each other, but this condition cannot be satisfied for all three simultaneously due to spin frustration.
Researchers at NIST have discovered a way to design entangled quantum objects called qubits to correct errors caused by environmental noise. This approach enables the sensor to become more robust in the face of noise while maintaining its additional sensing advantage. The findings, detailed in Physical Review Letters, could lead to the...
Researchers create peptide hydrogel that controls drug release, improving treatment adherence and efficacy for conditions like tuberculosis and diabetes. The SABER platform uses reversible chemical bonds to slow down drug release, offering a promising solution for precise delivery.
The 2025 Childhood Obesity Conference, hosted by Pennington Biomedical's Greaux Health initiative, aims to educate healthcare providers and promote healthier futures for Louisiana's children through cutting-edge research and evidence-based strategies. Participants can earn up to 7.5 CMEs and gain practical tools to support healthier fu...
Researchers have developed a motion-compensation method that allows single-pixel imaging to capture sharp images of complex dynamic scenes. The new approach improves image quality and video smoothness in various scenarios, including surveillance and medical diagnostics.
Researchers at Washington University in St. Louis have identified a way for harmful bacteria like Pseudomonas syringae to bypass a plant's defenses using a protein called PmeR that detects auxin and activates genes making the germs more aggressive. This finding could lead to new approaches for protecting crops by understanding how bact...
The Institute of Science and Technology Austria (ISTA) invites journalists to apply for its annual residency program, offering 3-6 month stays on campus with access to cutting-edge research. This program supports compelling storytelling by engaging journalists with world-class researchers from various fields.
A study published in PLOS One found that US regional differences in traditional and existential wellness are linked to early colonization settlement patterns. Northeastern and Midwestern regions tend to have higher traditional wellness, while Southern residents exhibit higher existential wellness. These findings suggest that systemic d...
A new project aims to increase HPV vaccine uptake by harnessing AI to tailor health information to parents' specific concerns and communication styles. The AI-driven chatbot will simulate human conversation, addressing misconceptions and fears associated with the vaccine.
Researchers developed standardized guidelines to diagnose and treat cemental tears, reducing misdiagnosis and improving patient outcomes. The consensus identifies key risk factors, diagnostic strategies, and treatment principles, empowering clinicians to recognize and manage this hidden threat more effectively.
Researchers from TUM and Google Quantum AI realize Floquet topologically ordered state, a phase predicted but never observed, using 58 superconducting qubit quantum processor. They probe the system's underlying topological properties and witness dynamical 'transmutation' of exotic particles.
A new study associates Slit Guidance Ligand 2 (SLIT2) protein levels with neurocognitive test scores in middle-aged individuals, suggesting a potential biomarker for detecting mild cognitive impairment and early dementia. The research also found that SLIT2 levels in vitreous humor are up to seven times higher than in plasma.
Researchers found that northerly winds exacerbate ice loss in Antarctica by capping off polynyas, reducing ocean heat loss. This mechanism could be connected to human-induced climate change and potentially mitigated by reducing greenhouse gas emissions.
A recent study from the University of British Columbia found that AI-powered digital streamers, used to promote products through livestreams, barely outperform having no streamer at all. Improving form realism and behavioral realism, such as real-time Q&A interactions, can lead to significant sales boosts.
The University of Texas MD Anderson Cancer Center and Springer Nature will host a free conference on the tumor ecosystem, featuring presentations on cancer immunology, microbiome, disease evolution, and metastasis. Researchers can register for the event and submit abstracts to share their findings.
The Atlas blue butterfly has been found to have the highest number of chromosomes among multicellular animals, with 229 pairs. Researchers at the Wellcome Sanger Institute and IBE studied its genome, revealing that the extra chromosomes were broken up over time instead of duplicated.
Researchers found little evidence of disproportionate siting in Black counties, but a growing share of the Black population over time. Long-term demographic shifts after power plant openings led to higher Black population shares, with an average rise of 4% in 50-70 years.
A three-year study found that smartwatches can detect early signs of PTSD among Israelis who watched extensive media coverage of the Oct 7 attacks. Participants who developed PTSD showed sharper increases in stress levels and declines in mood, physical activity, and sleep quality.
A recent study published in the Lancet Primary Care tracked over 4,800 patients referred to the SCAN Pathway, a cancer diagnosis pathway designed for patients with non-specific symptoms. The study found that early diagnosis of cancers can save thousands of lives and reduce treatment costs for the NHS.