A new study reveals 145 significantly altered metabolites in ME patients, reshaping pathways in amino acid, lipid, and carbohydrate metabolism. Distinct metabolic signatures emerge for each ME subtype, alongside shared changes across all patients, offering new possibilities for precision diagnosis and treatment monitoring.
Breast cancer's reliance on lactate metabolism drives tumor progression, immune evasion, and metastasis. Researchers propose targeting lactate production and lactylation to develop more precise treatments with improved survival rates.
Weill Cornell Medicine leads a $14.9M NIH grant program to remove latent HIV from cells, aiming for effective cures. Researchers will use a personalized approach to develop tailored immunotherapies and broadly neutralizing antibodies against HIV.
A new study provides a framework for researchers to make their work more equitable and representative of local communities. The guidance highlights the importance of community-based research, where community members are actively involved in identifying research priorities and designing studies.
Researchers have discovered a way to turn material defects into an advantage for spintronic devices. By exploiting these imperfections, the team was able to boost both orbital Hall conductivity and angle, leading to a threefold improvement in switching energy efficiency.
A prospective study found that better control of inflammation during childhood leads to less stiffening of the esophagus and fewer disease complications. The study suggests that stiffness of blood vessels in the esophagus could be an important biomarker for disease progression, indicating which patients may benefit from current therapies.
A new study sheds light on how viruses pack their genetic material with high selectivity, achieved with over 99% accuracy. Understanding this process could help create lab-made versions of capsids for gene therapy and antiviral development.
A study along the Yangtze River found that comammox Nitrospira microbes adjust their nutrient exchange based on terrain type. This adaptation enables them to thrive in oligotrophic environments, with mountain-foothill regions having stronger microbial cohesion and closer connections between microorganisms.
FastUKB streamlines UK Biobank research workflows with bulk data extraction and intelligent data processing capabilities. It offers advanced statistical analysis tools, including linear regression and polygenic risk scoring, through a user-friendly interface.
A landmark review in JAMA calls for a shift in medical thinking to target the biology of aging itself. Geroscience aims to extend healthspan by delaying or preventing multiple conditions at once.
Researchers at the University of Sydney have discovered a new biological pathway that may help explain why people with type 2 diabetes are more prone to developing blood clots. A protein called SEC61B was found to disrupt calcium balance inside platelets, making them more likely to form clots.
The Congress of Neurological Surgeons has issued its first comprehensive guidelines on the care of adults with functioning pituitary adenomas (FPA), a prevalent and complex condition. The guidelines mark a pivotal step in standardizing care, optimizing patient outcomes, and promoting multidisciplinary coordination.
Researchers found two types of peripheral helper T cells in inflamed joints: stem-like and effector cells. Stem-like cells live in immune hubs and help activate B cells, while effector cells cause inflammation outside the hubs. Targeting stem-like cells may offer new treatment hope for RA patients.
A recent study by HKU researchers uncovers a brain signature that measures emotional intensity and distinguishes it from automatic physiological responses. This discovery has implications for developing emotionally intelligent AI systems and offers a better understanding of how our brains create emotional arousal.
Researchers from HKUMed discovered a previously unknown mechanism that allows HCC to grow more aggressively and evade existing therapies. They developed a new small molecule inhibitor called CL26, which targets the AGPAT4 protein and improves treatment options for HCC patients.
A study found that Nepali farmers perceive climate-related risks as a threat to their financial stability, leading them to focus on agriculture. The researchers suggest providing practical information and resources to help farmers explore alternative livelihoods.
A new study found that over 1 in 10 Medicaid-enrolled youths experiencing a mental health crisis are kept in hospital emergency rooms for three to seven days. The research highlights the shortage of appropriate care in Oregon and nationwide, with experts warning that boarding kids can worsen their conditions and demoralize families.
Pediatric high-grade glioma tumors have unique genetic patterns that can be targeted by immunotherapy. Researchers identified a specific protein structure, NRCAM, that is essential for cancer cell migration and invasion, making it an attractive target for new treatments.
Researchers found that siblings, friends, and extended family play crucial roles in helping parents keep their children safe on online gaming platforms like Roblox and Minecraft. Online safety risks include scams, anti-social behavior, and adult roleplays.
Researchers developed an AI framework to map interactions between content and algorithms on digital platforms, reducing the spread of misinformation. The system would allow users and platform operators to pinpoint sources of potential misinformation and promote diverse information sources.
A new blood test, PIPscore, has been developed to predict the efficacy of immunotherapy in triple-negative breast cancer (TNBC) patients. The test analyzes plasma proteins and achieved high accuracy in forecasting patient responses.
Researchers analyzed stone tools from Kenya's Homa Peninsula and found they were crafted from stronger, volcanic rocks brought from several miles away. This discovery pushes back the earliest known evidence of ancient humans transporting resources over long distances by 600,000 years.
Neurons in the gut produce adrenomedullin 2, which expands group 2 innate lymphoid cells and provides therapeutic benefit in inflammatory bowel disease preclinical models. Elevated expression of ADM2 was found in patients with inflammatory bowel disease, suggesting a promising therapeutic target.
Tumor electrophysiological abnormalities drive malignancy through membrane potential dysregulation, ion channel network remodeling, and microenvironmental signaling interactions. Precision therapies targeting these abnormalities have advanced significantly, including electric field therapies and nanoparticle systems.
A team of astrophysicists from the University of Bonn and Iran has reclassified Ursa Major III as a compact star cluster containing a black hole core. Simulations suggest that the object's high mass-to-light ratio can be explained by the presence of dark stars rather than dark matter.
A new study reveals that ancient microbes like Asgard archaea may have played a crucial role in the evolution of the cytoskeleton. The researchers discovered two proteins, FtsZ1 and FtsZ2, which behave differently and may represent an intermediate stage in the development of modern cytoskeletal networks.
Researchers identified eight key genes associated with leaf secondary compounds in tea plants, which drive phyllosphere microbiome assembly. The study highlights the crucial role of plant metabolites in shaping microbial functions and offers new opportunities for microbiome optimization.
Researchers at Penn State found an antagonistic relationship between two common plant viruses, TSWV and INSV, resulting in lower levels of the more severe virus. The study suggests that this interaction could help lead to better disease control in the future.
A new study by Bielefeld University and the University of Warwick found that morning coffee significantly improves mood and enthusiasm in young adults. The researchers also discovered that caffeine's effects on mood are consistent across individuals with varying levels of anxiety or depressive symptoms.
A new study published in Pharmacoeconomics and Policy finds that households facing catastrophic health expenditure have lower HRQoL scores, but family doctor services mitigate this negative effect. Effective factors include stable employment and higher education, while older age and multiple chronic conditions worsen HRQoL.
A cross-sectional analysis of 549 essential medicines in 72 markets reveals significant variation in prices and affordability. The study emphasizes the urgent need to promote equitable drug prices and improve access to life-saving medications.
A systematic review assessed 133 studies on 20 vaccines, finding that many are cost-effective and should be expanded in the National Immunization Program. High-quality vaccines like hepatitis B and domestic HPV-2 have low incremental cost-effectiveness ratios, making them suitable for prioritization.
A large-scale field study finds that anonymous reviews reduce disparities for Asian first authors, but women and early-career applicants score slightly worse. Anonymous reviews also show minimal differences in reliability and validity compared to non-anonymous reviews.
The 34th International Joint Conference on Artificial Intelligence (IJCAI) will take place in Montreal, Canada, from August 16 to 22, 2025. The conference aims to showcase the frontiers of artificial intelligence research and applications, with a focus on AI's impact on society.
Researchers at Penn State developed a new extraction workflow that improves oil recovery from tight shale formations by up to 15%, while providing long-term storage for carbon dioxide emissions. The innovative approach enhances cyclic CO2 injection, a decades-old method that bolsters extraction from naturally occurring rock formations.
Researchers found that roads with passing zones have 11% fewer total crashes and 12% fewer fatal/injury-causing crashes compared to sections without marked passing zones. The study suggests that wider, straighter, flatter roads with more visibility are associated with lower crash risk.
Recent studies have shown promising results for triple-targeted cancer therapy, new PET imaging tracers tracking immune activation, and reducing PET scan doses while maintaining diagnostic accuracy. These advancements hold promise for improving cancer treatment outcomes and precision medicine.
Researchers have identified a previously unknown molecular mechanism behind chemoresistance in acute myeloid leukemia (AML), a type of blood cancer. The study found that a protein called RUNX1C plays a key role in this process, and blocking its activity with RNA-targeting tools can improve chemotherapy's effectiveness.
The 'slicing + dictionary' method reduces resource requirements, improves query efficiency, and enhances flexibility in medical big data analysis. It overcomes limitations of traditional methods by empowering ordinary researchers.
Researchers have discovered a new type of stem cell that can transform from muscle to bone, which may lead to more effective treatments for fractures. The study found that Prg4+ cells were crucial in repairing bones and could be stimulated or introduced directly to the fracture site to accelerate healing.
A University of Utah geoscientist analyzed carbon and oxygen isotopes in lake sediments to document profound changes arising from agriculture and rail causeway. The study reconstructs the lake's water and carbon budgets through time, highlighting two distinct human-driven shifts: one related to settlement arrival and another to the con...
The FDA-approved MI Cancer Seek test is a comprehensive molecular profiling assay that delivers accurate and reliable results from minimal tissue input. It identifies key biomarkers linked to FDA-approved treatments for several major cancers, including breast, lung, colon, melanoma, and endometrial cancers.
A new study found that probiotics significantly reduced the presence of antibiotic-resistant bacteria and multidrug-resistant bacteria in the infant gut, while also promoting a more typical gut microbiome. This breakthrough has major implications for the global AMR crisis, particularly for preterm infants.
The magnitude 7.7 Myanmar earthquake had the highest recorded rupture velocity, exceeding 5.3 km/s, a phenomenon known as supershear propagation. This was confirmed by analysis of satellite images and seismic station recordings.
A study published in Science Advances reveals that traditional Himalayan crops like black peas are more ecologically resilient and have higher protein levels compared to commercial crops like green peas. The research highlights the nutritional profile of black peas, which are rich in protein, minerals, and fiber.
Researchers predict and experimentally demonstrate novel intrinsic HOTIs in homogeneous photonic metamaterials, with hinge states protected by higher-dimensional topological invariant. The discovery provides deeper insights into the interplay between geometry-induced gauge fields and topological invariants.
A team from the University of Münster has developed a method for recycling dry-processed lithium ion battery cathodes, separating materials and granulating them for reuse. The process is attractive not only for sustainability but also for cost efficiency.
A new POD method integrates ISL data with onboard BDS-3 observations to determine the orbits of LEO and MEO satellites simultaneously. The approach reduces LEO orbit errors from over 20 cm to about 1 cm, offering low-latency, high-accuracy solutions without heavy reliance on ground tracking stations.
Researchers at Umea University have demonstrated a custom-built laser facility generating ultrashort laser pulses with extreme peak power and precisely controlled waveforms. The Light Wave Synthesizer 100 (LWS100) spans 11 meters in length, capable of producing 100 terawatts for a few millionth of a billionth of a second.
A new study reveals the molecular mechanisms that enable SAR11, the most abundant marine bacteria, to survive in nutrient-poor environments. The research demonstrates ultra-high-affinity transporters that capture carbon sources, influencing global biogeochemical cycles and ecosystem management.
Researchers at Peking Union Medical College Hospital have developed bi-functional molecules combining PD-1 blockade with precision IL-2 delivery to revive 'sleepy' T cells. This combination enhances immune cell response, reducing toxicity and improving cancer treatment outcomes.
Researchers have developed an ultra-compact antibody that specifically binds to CD155 in lung cancer cells, inhibiting tumor growth and increasing cancer cell death. This breakthrough technology shows remarkable therapeutic potential for treating lung adenocarcinoma with minimal side effects.
Contamination from laboratory reagents, particularly silica membranes, can create false virus-host associations in metagenomic sequencing data. Researchers developed the PVDDC database to standardize virus-host relationships and trace contamination.
Human embryos exert significant forces during implantation to break down surrounding tissue and penetrate the uterus. The study reveals that effective invasion is associated with optimal matrix displacement, highlighting the importance of these forces in the implantation process.
A new study maps planetary boundary of functional biosphere integrity, finding 60% of global land areas outside safe zone and 38% in high-risk zone. Human demand for biomass and land use are major contributors to the strain on the biosphere.
A new attribution study by the Potsdam Institute for Climate Impact Research shows that adaptation measures have reduced economic losses from flooding by 63 percent and fatalities by 52 percent in Europe since 1950. Despite climate change, vulnerability has declined across the continent, with some regional differences.
Researchers at the University of Vermont found an exact solution to a model that behaves as a damped quantum harmonic oscillator. This discovery has significant implications for ultra-precision sensor technologies and the measurement of quantum distances.
Researchers at Wyss Institute develop in vitro method to induce meiosis in human cells, enabling replication of critical step in egg and sperm cell development. The breakthrough could lead to modeling defects and creating healthy gametes for individuals with infertility.
Research at the University of Rochester Medical Center and University College Dublin has revealed key insights into multisensory integration in the brain. The study found that when changes occur in both visual and auditory inputs, auditory and visual decision processes unfold in parallel but come together in the motor system.
Researchers used machine-learning models to design nanoparticles that can deliver RNA to cells more efficiently. The approach accelerated the identification of optimal ingredient mixtures in lipid nanoparticles, leading to better delivery vehicles for RNA vaccines and mRNA therapies. This could dramatically speed up the development of ...