Research teams at ETH Zurich have solved the puzzle of nuclear envelope assembly, showing that Torsin-1A and CLCC1 complexes work together to enable membrane fusion. This finding offers a new therapeutic approach for primary dystonia, a rare movement disorder affecting about six in 100,000 people worldwide.
The authors propose a 'Discovery Compact' that includes predictable, multi-year funding, support for the scientific workforce, and translation research policy to accelerate discovery-to-application. The compact also emphasizes government anticipatory governance, scientific integrity, and public accountability.
Families of children with B-cell acute lymphoblastic leukemia (B-ALL) experience substantial and lasting challenges, including household employment changes and marital status changes, beginning early after diagnosis. These challenges persist throughout treatment and have significant financial, social, and emotional impacts on families.
ACLM launches a new medical school curriculum and an updated food-as-medicine course to help medical schools meet federal and state nutrition education requirements. The curriculum provides 40 hours of nutrition instruction and a longitudinal educational experience that helps students understand how nutrition influences chronic disease.
Juvmo, a Parkinson's disease drug, has been approved by the FDA and offers a new treatment option for patients, potentially reducing side effects. The drug's unique mechanism of action provides relief from motor symptoms, and its approval marks a significant milestone in the research of UVA Health scientists.
Women with PMOS/PCOS may be at higher risk for Alzheimer's disease and dementia due to metabolic comorbidities like insulin resistance and obesity. The condition's impact on brain health and memory could be related to common health issues that often occur alongside PMOS.
A survey of 15-year-olds worldwide suggests that boys' underperformance may be due to negative attitudes towards academic effort, with larger gaps in more developed countries. Boys are less likely to agree that trying hard is important, and their responses correlate with individual academic performance, especially in reading.
A recent study reveals that devaluation is the primary factor driving the academic gender gap, with 38% of women experiencing devaluation compared to 16% of men. The study, which surveyed over 10,000 academics, found that devaluation was the most strongly associated factor with women considering leaving or leaving academia altogether.
Researchers compared Sjögren's syndrome-associated bronchiectasis to non-associated cases, exploring demographic, clinical, and microbiologic characteristics. The study aimed to provide insights into the intersection of bronchiectasis and NTM disease, with potential implications for treatment and management.
A new study has linked exposure to the safer plastic additive DINCH during pregnancy to lighter and smaller newborns. Higher levels of DINCH in the urine of pregnant women resulted in a 27-gram reduction in newborn birth weight, highlighting potential risks of chemical additives on fetal development.
A $13.3 million randomized clinical trial is testing whether weekly semaglutide can reduce alcohol and opioid use, and reduce justice involvement among adults with alcohol and opioid use disorder. The study aims to improve employment, health, and housing outcomes among participants, and will enroll up to 1,200 adults with the conditions.
A new report from Digital Science raises concerns about the adequacy of U.S. research security policies for short-term researchers, finding nearly half held U.S. affiliations for 24 months or less. The report proposes a risk-calibrated approach to strengthen research security without restricting international collaboration.
A study published in Menopause Journal found that physical activity, such as walking and yoga, can reduce depressive symptoms and improve quality of life during menopause. The review of 12 randomized controlled trials revealed that aerobic-based exercise and mind-body activities had strong effects on psychological symptoms.
Researchers analyzed nearly half a million cells from dozens of patients' tumors to understand how pancreatic cancer cells continuously evolve over time. The study found that specific genetic changes, such as increased activity of the MYC gene, enable cancer cells to resist therapy and spread rapidly.
A new mechanism of plasma turbulence in the solar wind was discovered, revealing a clear structure in unstructured space plasma. The findings, published in The Astrophysical Journal Letters, show that turbulent magnetic fields exhibit a clear reversal of magnetic field rotation sense over a certain wavelength.
The Safe Social Media Act aims to protect children's physical and mental health through digital safety rules and a regulator. The proposed act includes a Digital Safety and Data Protection Commission and temporarily restricts accounts for children under 16 until platforms meet enforceable standards.
A 100-year study of UK Good Housekeeping magazine recipes reveals a narrowing of seafood options to just five species: cod, haddock, tuna, salmon, and prawns. The study, led by Dr Ruth Thurstan, shows how decades of changes in fish supply and trade influenced domestic cooking habits.
A study published in the Canadian Medical Association Journal found that 5% of practising physicians report disabilities, with mental health, visual, and mobility disabilities being the most common. The research emphasizes the importance of accessible work environments and equitable policies to promote the well-being and retention of p...
A recent study identified a protein in the placenta involved in vascular development, challenging previous beliefs about its function. The protein, soluble platelet-derived growth factor receptor beta, plays a role in infant vascular development and may affect maternal health.
Jie Zhuang, a University of Tennessee professor of soil science, is among nine international SSSA Fellows recognized for his contributions to soil science and research. He has received numerous awards and is a Fellow with the American Association for the Advancement of Science (AAAS).
Stanford researchers have developed a novel material designed to address the challenges of glycine-based, electrified medical devices. The material, engineered with a novel process, maintains piezoelectric performance for 60 days, a significant improvement over previous versions. The team aims to test the material in more extreme envir...
A study by CU Anschutz researchers has found a possible link between the APOE4 gene, fat in the brain, and inflammation, which may help explain how genetic risk factors for Alzheimer's disease affect the brain. The study suggests that the ApoE protein can change how brain immune cells handle fat and trigger inflammation.
A large study led by Oregon State University found that brain cancer risk increases with exposure to elevated concentrations of radon, a known lung carcinogen. The research, published in Neuroepidemiology, suggests that residential radon exposure may contribute to the overall burden of central nervous system cancers.
DNA vaccines deliver genetic instructions encoding selected antigens, stimulating humoral and cellular immune responses. Emerging technologies, including artificial intelligence and synthetic biology, may further broaden the platform's capabilities.
The new AI models can predict scenarios of aerosol concentrations and cloud properties, separating the aerosol effect from meteorological factors. The project aims to improve climate predictions and extreme weather forecasts, helping American communities prepare for and protect against climate-related challenges.
The critical zone, a thin layer of soil, groundwater, bedrock, and vegetation, supports nearly all life on the planet and is degrading due to human activities and climate change. A career geologist, Paul Doss, advocates for a bigger role in understanding ecosystems.
Researchers explore targeting mitochondria to treat triple-negative breast cancer, a form of breast cancer with limited treatment options. Mitochondrial dysfunction may contribute to chemoresistance, and disrupting mitochondrial dynamics could lead to cancer-cell death.
UChicago researchers successfully created a 2D topological insulator using the 'carpet' growth method, a technique that produces uniform-thickness films of bismuth telluride. The material exhibits near-lossless energy transmission, with potential applications in electronics and quantum computing. The researchers used molecular beam epi...
Piezo channels play a crucial role in orthodontic treatment by detecting mechanical pressure and translating it into biological activity. Piezo-targeted therapies may provide new opportunities for more precise orthodontic care.
The EP4 receptor is a key regulator of inflammation and a promising therapeutic target for various inflammatory diseases. Targeting this receptor could provide more precise approaches to controlling inflammation, offering safer and more targeted treatments.
A new review highlights FTO's complex role in gastrointestinal cancers, influencing tumor growth, metastasis, and treatment resistance. FTO-targeting approaches may complement immunotherapy, raising possibilities for combination treatment strategies.
Long non-coding RNAs (lncRNAs) regulate cancer treatment resistance by altering gene expression, interacting with microRNAs and proteins, and influencing chromatin. LncRNAs such as MALAT1, HOTAIR, and PVT1 have been associated with pathways that can help cancer cells withstand treatment.
A team of researchers at Penn State has developed a new type of soft computer using water-based droplets, connected by membranes, to process information in wet environments. The networks, inspired by the human brain, can sense and process ions with lower energy cost than silicon chips, and demonstrate temporal computing capabilities,
Researchers created a small soft robot called BeetleBot that combines artificial muscles, a camera, and tactile sensors to perform tasks like gripping objects and avoiding obstacles. The robot uses bidirectional feedback to connect user control with sensory information, enabling practical tasks to be carried out.
The University of Oklahoma will continue its life-saving weather research with a $220M 5-year renewal from NOAA, marking its fifth decade of partnership. Researchers will focus on severe weather phenomena, forecast improvements, and societal impacts, providing innovative forecasts that reduce extreme weather impacts.
A new ice sheet model developed by UC Irvine and NASA JPL projects Thwaites Glacier's melting will contribute up to 30mm sea level rise by 2100, even without additional climate warming. The model factors in a 4-6km grounding zone, predicting accelerated detachment and ice flow.
A new UCLA study suggests that adding a targeted radioactive drug to stereotactic body radiation therapy may help delay the spread of recurrent prostate cancer. The treatment showed a 62% lower risk of progression or needing additional hormone therapy, and improved control of disease on conventional imaging.
Researchers at Oregon State University have developed a fast and low-cost sensor for detecting eugenol in food products. The sensor, which uses a nanocomposite material, can recover up to 99.9% of eugenol from real food samples, making it a promising technology for food safety and quality control.
Researchers found that people with a higher genetic risk for Alzheimer’s who volunteered or helped others showed slower cognitive decline. The study, which analyzed 22 years of data, found that even modest amounts of helping others provided significant cognitive benefits.
A new study finds that a warmer future may lead to stronger storms approaching Hawaiʻi, even as the total number of storms remains uncertain. The study also reveals changes in the relationship between El Niño and La Niña and Hawaiʻi's tropical cyclone risk.
A new framework proposes evidence sufficiency, selective prediction, and deferral pathways for multimodal AI in cardiovascular medicine. Missing data are not noise, but rather informative about patient state, clinician decisions, and health system access.
The study found that banded dotterels arrive in Australia about four days later each year, on average, between 2014 and 2025, due to a southward shift in winds circling Antarctica. This delay in arrival has led to a reduction in their estimated stay on Australian non-breeding grounds by around a quarter over the past decade.
Researchers developed a multimode band-engineering framework in 1D grating-based photonic crystal waveguides to meet growing demand for scalable and flexible filtering. Devices achieved TE-1-, TE-2-, and TE-3-pass filtering with measured bandwidths exceeding 200 nm, 123 nm, and 70 nm, respectively.
A new satellite-based study shows that recovery after severe drought is widespread but highly uneven across large river basins. Persistent deficits are concentrated in drylands and some inland basins that do not drain to the ocean, with water storage deficits that persist for years.
A new AI-physics model, ProNet, has been developed to predict air pollution more accurately than human forecasters, outperforming expert forecasts and uncovering hidden flaws in current chemical models. ProNet integrates neural networks with atmospheric physics, preserving physical realism and using routine data to diagnose where chemi...
A new species of ancient crocodile relative, Ctenosuchus tenuidens, has been discovered in Morocco with exceptionally thin, needle-like teeth. The animal's unique feeding habits suggest it likely fed on small fish, crustaceans, and other aquatic creatures.
A recent study from the University of Jyväskylä found that identity development continues into adulthood, with a positive association between identity and mental well-being. The study, which followed individuals from age 27 to 61, revealed that a well-developed identity is characterized by clear views formed through personal exploration.
Researchers have identified a potential target for treating metastatic cancers: trapping DNA rings in micronuclei, which lose their activity. This process may help prevent cancer growth and improve treatment success rates.
Researchers are developing new approaches to model interconnected biological processes, identify opportunities for intervention, and translate insights into measurable improvements in human health. Longevity therapeutics face an actionable regulatory framework to ensure clinical validation and market access.
A genome study identified seven host-associated ancestry clusters in scabies mites, which broadly correspond to host origin rather than geographical location. The findings provide a resource for future One Health surveillance of human scabies and animal sarcoptic mange.
A study in China's Poyang Lake basin found greater contamination and resistance-related risks in river sources than in enclosed reservoirs, with mobile genetic elements strongly associated with resistance-gene abundance. The findings suggest differentiated monitoring should prioritize river sources, the Gan River sub-basin, and Poyang ...
A review grades the evidence behind 38 ATP-induced cell death genes, identifying direct and indirect evidence, context-dependent mechanisms, and insufficient evidence. The review also releases a public gene resource, ATPexGen, to summarize what is known about AICD.
A large-scale study analyzing routine clinical data from nearly 60,000 cancer patients reveals new insights into cachexia. The findings show that cachexia can be predicted using routine data, allowing for timely support and interventions. This breakthrough could help improve patient outcomes and quality of life.
A lightweight computational method predicts intrinsically disordered proteins with high accuracy, outperforming existing tools. The IDP-T5CKNN model uses an existing protein language model and K-Nearest Neighbour classifier to achieve state-of-the-art results on benchmark datasets.
A new spatial planning framework identifies potential suitable distribution areas for mangroves, salt marshes, and seagrasses, revealing a 7-24 times larger expansion capacity. Existing reserves cover only 20% of high-priority zones, with most areas dependent on active restoration and conservation.
Researchers found that horse chestnut leaf miner damage alters leaf tissue structure and function, affecting photosynthesis and plant defense. Chlorophyll fluorescence imaging can detect early signs of damage, potentially improving plant protection measures.
Houston Methodist researchers are investigating the brain's role in underactive bladder, a condition that affects men and women, and leaves patients with limited treatment options. The study aims to identify abnormal neurologic activity that could guide targeted neuromodulation therapies.
Researchers developed a decoupled initialization framework that tackles key challenges in visual-inertial odometry, improving initialization success, accuracy, and efficiency. The method uses aggregated visual constraints, estimates gyroscope bias, and refines states through joint refinement and landmark-free triangulation.
A new study found that rainfall has a significant impact on river ecosystems, altering food webs and biodiversity. In rivers with less annual rainfall, secondary production and biomass turnover rates increased, leading to a characteristic bottom-heavy biomass pyramid.
The University of North Carolina at Chapel Hill will lead a consortium to detect and stop Alzheimer's and pulmonary fibrosis at their earliest molecular stage, years before symptoms appear. The project, called IMPEDE, aims to develop an early-detection biomarker for Alzheimer's disease and advance preclinical treatments.