Researchers have characterized the association between cellular senescence and human brain structure in both development and late life. The study found that senescence-related gene expression is linked to brain volume and cortical organization, with distinct roles depending on cell type and stage of life.
Researchers have found that chemicals in exhaled breath can reveal the composition of the bacteria living in the intestines, providing a potential non-invasive test for monitoring and diagnosing gut health issues. Breath samples from children with asthma were able to predict the presence of the bacterium linked to the condition.
Researchers found that TL1A, a key immune signaling protein, stimulates the growth of new white blood cells in the bone marrow, which then promote tumor formation in the gut. The study suggests that blocking TL1A activity could be an effective strategy to treat IBD and prevent associated colorectal tumors.
A new study finds that hospitals treating more patients with Medicare Advantage plans face higher readmission penalties despite taking similar actions to prevent repeat hospitalizations. The analysis highlights the need to incorporate Medicare Advantage data into the Hospital Readmissions Reduction Program.
Dr. Manuel A. Friese has been recognized for his groundbreaking work studying the interactions between inflammation and nerve cell death, which drives disease progression in multiple sclerosis (MS). His research aims to identify new therapeutic targets and bring the field closer to stopping disease progression.
The study demonstrated that black ginseng extract reduces MMP-1 expression and suppresses PGE2 levels in human foreskin fibroblasts, promoting skin homeostasis. It also identified rare ginsenosides as key molecules involved in the anti-inflammatory effects of BGE.
Cancer researchers have identified a key mechanism by which cancer cells protect themselves from the immune system. The study found that MYC protein can bind to RNA molecules, eliminating alarm signals that would activate the immune defense.
Researchers developed a novel, computer-based method called CoBiSe to design and produce genetically encoded fluorescence-based biosensors for rapid and simple production. The new iron sensor 'IronSenseR' detects iron (II) with high sensitivity without binding to iron (III) or other metal ions.
Scientists have developed a novel immunotherapy approach that targets tumor macrophages, converting them from immune suppressors to killers. The therapy, using engineered CAR T cells, has shown promising results in preclinical models of metastatic ovarian and lung cancer.
A new study reveals that strong Central Pacific El Niños self-destruct due to negative feedbacks from distant oceans, while weaker events survive by forming a lasting partnership with the North Pacific climate pattern. This discovery enables forecasting months in advance with over 80% accuracy.
Science MMAI Gym trains LLMs in medicinal chemistry, biology, and clinical development with precision required in pharma R&D. Partner models emerge with up to 10x improvements in performance, matching state-of-the-art specialist models.
Myosteatosis is a key predictor of poor clinical outcomes across a spectrum of liver diseases, with associations to severe disease phenotypes, hepatocellular carcinoma, and increased mortality. Nutritional intervention, exercise prescription, and potential management strategies are proposed to address this condition.
The American Heart Association is hosting multiple pre-conference symposia at the International Stroke Conference in New Orleans, February 4-6, 2026. These symposia cover topics such as state-of-the-science stroke nursing, brain health, and addressing disparities in stroke care. The events are designed to advance stroke and brain healt...
Researchers developed a new imaging technology called fast-RSOM that captures detailed images of the smallest blood vessels directly through the skin. This technology can detect early signs of cardiovascular risk, enabling doctors to intervene sooner and guide personalized therapies.
Insilico Medicine presents three abstracts at the 2026 Crohn's & Colitis Congress highlighting clinical, preclinical safety, and efficacy data for ISM5411. The first-in-human Phase 1 results show no serious adverse events or deaths reported, with a favorable pharmacokinetic profile supporting gut restriction.
Researchers at UW-Madison have resurrected a 3.2-billion-year-old nitrogenase enzyme to improve our understanding of the origins of life on Earth and potentially recognize signs of life elsewhere.
A new study published in The Journal of Clinical Endocrinology & Metabolism found a causal link between high body mass index (BMI) and dementia. High blood pressure was identified as a driving factor behind the increased risk. Researchers suggest that preventing or treating obesity and high blood pressure could help reduce dementia risk.
Bacterial infections are common and severe complications in patients with liver cirrhosis, with a global prevalence of 35.1% reported. The most common infection sites were the gastrointestinal tract, ascites fluid, and urinary tract, with gram-negative organisms more frequent than gram-positive organisms.
A new study by Penn State researchers found that the level of transparency in artificial intelligence (AI) systems affects users' trust. When systems meet or exceed users' expectations, trust increases without needing detailed explanations. However, when expectations are not met, users require more information and a deeper understandin...
Fecal microbiota transplantation (FMT) holds promise in treating chronic liver diseases by restoring gut-liver axis balance. The consensus recommends FMT for various etiologies, excluding drug-induced liver injury, with strict donor selection and management guidelines to ensure safety.
A nationwide study found that Parkinson's disease is more common among individuals with higher socioeconomic status and in the northern provinces of the Netherlands. The risk increases with age, peaking between 75 and 85 years, and is higher among men.
A team of researchers at EPFL developed a robotic hand that can detach from its arm and 'crawl' to grasp multiple objects, overcoming human asymmetry and limitations. The device can perform 'loco manipulation' with seamless autonomy and has potential applications in industrial, service, and exploratory robotics.
A study reviews decades of research on Hsp70's role in neurodegenerative diseases, highlighting its protective effects and potential therapeutic value. The review reveals that different Hsp70 isoforms interact with co-chaperones and cellular pathways to determine protein clearance.
Smoking exposure induces tumor microenvironment promoting sorafenib resistance in HCC by modifying the 14-3-3η proteome. Arsenic trioxide suppresses tumor progression with synergistic effect when combined with sorafenib.
A new theory of proprioception challenges traditional understanding by incorporating frontier bionic evidence. The proposed framework reconceptualizes proprioception as a dynamic augmentable interface, enabling functional movement and potentially improving rehabilitation outcomes in sports injuries and neurological diseases. Researcher...
A team of researchers from Chonnam National University explores how boosting consumer trust can increase adoption of second-life EV battery tech. They found that transparent safety inspections and tailored messaging can improve adoption outcomes.
Researchers develop Dual Perigee, a lightweight algorithm that streamlines network connections to enable secure and low-latency data sharing in IoT networks. The study reduces block-related delays by 48.54% compared to standard approaches.
A study by Chungnam National University finds that climate adaptation can significantly reduce migration from drought and armed conflict in Africa. Countries with stronger adaptive capacity experience lower migration levels during crisis conditions, highlighting the importance of policies addressing environmental and security threats.
A recent study found that organic matter carried from rivers into the Arctic Ocean creates more clouds and keeps the region cooler. Aerosol particles formed by this biological matter act as 'seeds' for cloud formation, increasing their ability to form bright, long-lasting clouds.
A new Perspective article explores the role of biofilms in health during long-duration spaceflight and how this research can reshape our understanding of microbial communities on Earth. The study highlights the importance of biofilms in enabling human and plant health, particularly in space-based environments.
Researchers found that combining selective CDK2 inhibitor BLU-222 with CDK4/6 inhibitors produces strong, durable anti-tumor effects across preclinical models of breast cancer. This approach targets cancer cells' reliance on CDK proteins and restores control over the cell cycle in resistant tumors.
Research reveals that chemotherapy alters the gut microbiota, producing indole-3-propionic acid, which travels to the bone marrow and rewires immune cell production. This leads to a metastasis-refractory state in preclinical models and improved survival outcomes in patients with colorectal cancer.
Smartwatches with PPG and ECG functionality improve atrial fibrillation detection, detecting it four times more often than standard care. Researchers detected heart arrhythmia in 21 patients using smartwatches compared to five in those receiving standard care after six months of monitoring.
A new study has found that living walls can significantly enhance urban biodiversity by attracting pollinators and other wildlife. The research revealed that soil-based living walls with plants in soil attracted more wildlife than those with artificial substrates, and specific plant species like ivy and honeysuckle were most effective.
Researchers have developed a new AI method called Riff-Diff to construct artificial biocatalysts, resulting in enzymes that are significantly faster, more stable and versatile. The technology allows for precise design of protein structures around active centres, making enzyme design more accessible to the wider biotechnology community.
A team of researchers from Institute of Science Tokyo developed a novel enzyme, MAN, that efficiently converts common nucleotide substrates into RNA nucleotides with remarkable efficiency. This method simplifies the production of RNA building blocks by using inexpensive and stable polyphosphate as a phosphate donor.
Researchers at Kobe University have identified a specific bacterial strain, Staphylococcus epidermidis and Corynebacterium tuberculostearicum, as the primary causes of foot odor in Nagashima-type palmoplantar keratosis. Topical application of benzoyl peroxide reduces odor by decreasing C. tuberculostearicum levels.
Researchers found that humans in northern Mozambique use distinct calls, trills, grunts, whoops, and whistles when communicating with honeyguide birds. These regional dialects allow communities to coordinate cooperation with greater honeyguides, revealing a striking parallel to human language diversification.
Researchers have developed a new way to produce fluorescence by using molecular stacking, which can lead to the creation of smarter and more sensitive pressure sensors. The study focused on two crystalline organoboron compounds that exhibit piezofluorochromism, changing color in response to pressure.
Researchers at Université libre de Bruxelles discover a single thermodynamic quantity that explains how membranes exchange lipids and how this process affects biological behavior. This framework has far-reaching implications for understanding various biological mechanisms and potentially controlling their behavior.
Researchers explore microneedle technology as a novel delivery system for efficient and minimally invasive intradermal drug delivery. The review highlights the design of functional microneedles with specific structures to overcome biological barriers in various tissues, improving therapeutic outcomes.
The latest research on water striders, a true bug family, sheds light on their evolutionary history, revealing that most lineages originated up to 50 million years ago. The study, led by Dr. Michael Raupach, used genome analysis to reconstruct the family tree and identify key drivers of biodiversity.
Researchers have developed a new class of engineered nanoparticles that can bind to and degrade specific disease-related proteins. This technology has the potential to treat diseases such as dementia and brain cancer by eliminating harmful proteins.
Researchers used a custom-designed microscope to image individual lunar regolith grains, revealing the carriers and origins of their magnetism. The study provides insights into the Moon's internal structure and thermal evolution history.
Researchers visualized how light is transformed inside a chiral metasurface in both real space and real-time, achieving nanometer spatial resolution and femtosecond temporal resolution. The team found that the asymmetric near fields are a genuine signature of the chiral geometry.
Researchers have made progress in creating human milk oligosaccharides through bioengineering, enabling the industrial-scale production of complex HMOs. This allows infant formula to mimic human milk's compositional complexity, potentially offering benefits for gut microbiota development and immune protection.
A Murdoch University review found that people with MS experience difficulties navigating society and feel ashamed about their condition. The study highlights gaps in the ICF framework, which may not capture the full emotional and social burden of living with MS.
A study from Flinders University found that patients with progressive disease, which describes the way cancer grows, have varying survival rates depending on whether their existing tumours re-grow or new ones appear. Understanding this progression can help doctors make better decisions about future treatment strategies.
A new study published in British Journal of Cancer found that reducing annual alcohol consumption by one litre per person could lower mortality from several major cancers. The strongest impacts were seen in people aged 50 and older, with estimates suggesting a substantial reduction in cancer-related deaths without preventive action.
Researchers have developed an on-chip nonlocal metasurface for color router, exploiting symmetry-broken quasi-bound states in the continuum to modulate light extraction intensity and spectral output. The approach achieves efficient, narrowband color routing while minimizing energy utilization efficiency loss from spatial multiplexing.
A team of astronomers has discovered a supermassive black hole with extreme growth rates, contradicting current models. The black hole is emitting bright X-rays and radio waves, hinting at unknown physical mechanisms. This finding provides a rare glimpse into time-variable black hole growth in the early Universe.
The ŌURA–NUS Joint Lab combines wearable biometric data with sleep science expertise to study how sleep and physical activity shape long-term health outcomes. The lab aims to generate insights that help individuals, clinicians, and health systems shift from reactive care to proactive preventive health.
A recent study by King's College London found that diagnosis rates for depression, asthma, and osteoporosis remained lower than expected after the COVID-19 pandemic. The study analyzed data from over 29 million people in England and found that diagnosis rates recovered differently across ethnic and socioeconomic groups.
Severe vitamin D deficiency is associated with a higher rate of hospitalisation for respiratory tract infections such as bronchitis and pneumonia. Middle and older-aged adults are at a high risk of developing respiratory tract infections, which can lead to serious health issues.
A new study suggests that gaps in the nation's stroke transfer system reduce survivors' chances of receiving critical treatment and increase disability. Patients with longer delays in hospital transfer experienced worse disability after their stroke, highlighting missed opportunities for many stroke patients.
Researchers discovered that certain bacteria wrap their rotating flagella around their cell bodies to form a screw thread, allowing them to propel forward through narrow passages. This mechanism enables bacteria to navigate complex environments and even infect host insects.
Researchers have developed a recyclable photocatalyst that harnesses visible light to efficiently remove fulvic acid and other organic pollutants from water. The BiOCl MXene composite achieved removal rates of up to 98.43% for fulvic acid in just 30 minutes, with high durability and versatility.
The British Ecological Society has announced the winners of its Capturing Ecology photography competition. The top prize was awarded to a photographer who captured a striking image of a UK wetland ecosystem.
A recent study published in The Lancet Neurology found that patients with acute ischemic stroke who experience prolonged transfer times are more likely to leave the hospital with significant disability. The study of over 20,000 patients highlighted the need for shorter transfer times to improve patient outcomes.
A new study urges a realistic and systems-based path forward for biochar deployment, highlighting technical variability, policy gaps, and sustainability constraints. The authors argue that biochar can be a powerful tool when designed with its limits in mind, but only if viewed as critical infrastructure within a circular economy.