Researchers developed a novel way to identify aggressive cancer cells by observing how they physically interact with their environment. The new technology uses specially designed microscopic surfaces to distinguish between aggressive and less aggressive cells.
A new study from the University of Michigan reveals that nearly a third of registered nurses and advanced practice nurses in Michigan carry substantial student loans, influencing their decision to leave the profession. The proposed education loan caps threaten US healthcare access by limiting the pathway for advanced clinicians and nur...
Researchers at Helmholtz Munich discovered that gut bacteria can directly deliver proteins into human cells, shaping immune responses. This new mechanism may help explain how changes in gut bacteria contribute to inflammatory diseases like Crohn's disease.
A new study shows that perceiving AI as a 'job killer' negatively influences attitudes towards democracy, leading to decreased trust in institutions and reduced political engagement. The research highlights the importance of targeted communication in shaping public perceptions of artificial intelligence.
Researchers at Florida Atlantic University have developed a patent-pending shark deterrent that can be used to reduce bycatch in fisheries. The device produces an electric field that repels sharks from bait without affecting target fish, and has been shown to reduce catches of coastal sharks by 62-70%.
Caring for grandchildren may help prevent cognitive decline in older adults, according to a recent study published by the American Psychological Association. Grandparents who provided childcare scored higher on tests of memory and verbal fluency compared to those who didn't.
Researchers identified Fab antibody fragments that target the IgE Cε2 domain, effectively stripping IgE from mast cells. The most potent Fab clones showed rapid efficacy in cellular assays and in vivo anaphylaxis models, demonstrating potential as a next-generation anti-allergy therapy.
Researchers introduce a novel fabrication technique to create high-resolution, low-resistance graphene electrodes for transparent and flexible devices. The method achieves exceptionally low electrical resistance and high pattern fidelity without etching-induced defects or chemical contamination.
The Einstein Foundation Award honors researchers, institutions, and initiatives worldwide who significantly advance research quality across all disciplines. The €350,000 prize recognizes efforts to promote a culture of integrity and responsible leadership.
Researchers have developed a flexible, hair-like device that tracks vital signs of a fetus in real-time during surgery. This innovation provides continuous monitoring without invasive access, enabling faster interventions to prevent complications.
A 40-year greening project in China's Taklamakan Desert has successfully reduced atmospheric carbon dioxide levels and increased solar-induced fluorescence, indicating a measurable carbon sink. The project demonstrates the potential of afforestation to mitigate climate change, despite being only a small dent in global emissions.
A new study finds that U.S. middle-aged adults experience higher loneliness, depressive symptoms, and poorer memory and physical strength compared to peers in Nordic Europe. This decline is largely attributed to the lack of comprehensive family policies, inadequate healthcare access, and rising income inequality.
Two studies found that minor adjustments in sodium content could produce significant public health benefits without requiring individual behavior change. The research suggests reducing salt in packaged and prepared foods could prevent cases of cardiovascular disease, stroke, and deaths.
Sangwoo Lee brings over 20 years of experience in communications to lead MDPI's operations in South Korea. The appointment coincides with the launch of MDPI's 500th journal, Journal of Innovation, with Prof. Dr. Junic Kim as founding Editor-in-Chief.
Research reveals that higher lifetime alcohol consumption is associated with a higher risk of colorectal cancer, especially for rectal cancer. Quitting drinking can lower a person’s risk, according to the findings published in CANCER, a peer-reviewed journal.
A large-scale study found that adhering to the EAT–Lancet planetary health diet was significantly associated with a reduced risk of incident CKD. The diet emphasizes fruits, vegetables, legumes, and limited consumption of added sugars and fats.
A recent study finds that the largest trees in Peruvian Amazon store disproportionately large amounts of carbon, making it difficult to achieve net-zero emissions. Protecting these trees can help conserve biodiversity and forest microclimates against future climate change.
Current smokers are more likely to experience four symptoms associated with Long COVID, including arthralgia, chest pain and dyspnea. Dual users of combustible and heated tobacco products also show a stronger correlation with symptoms, suggesting the added use may worsen symptoms.
Researchers have introduced QuaTrEx, a software package that combines materials modeling methods to simulate the behavior of nanoribbons made of over 42,000 atoms. This breakthrough enables the simulation of realistic electronic devices, paving the way for improved performance in next-generation transistors.
Researchers have demonstrated that Janus nanoparticles can disrupt drug-resistant bacteria's defenses, restoring the effectiveness of conventional antibiotics. The approach uses nanoparticles to create pores in bacterial membranes, allowing antibiotics to flood in and execute their killing function.
A 82-year-old woman was treated with hyperbaric oxygen therapy for severe carbon monoxide poisoning after conventional oxygen therapy failed to produce significant improvement. The patient demonstrated considerable neurological recovery and full communication abilities after a single session of HBOT.
In sepsis, endothelial cells undergo programmed death-apoptosis, pyroptosis, ferroptosis, and excessive autophagy, leading to barrier collapse. Targeted therapeutic strategies include glycocalyx protectors, barrier stabilizers, anticoagulant approaches, which aim to repair or replace the damaged endothelial barrier.
Researchers at NUS Medicine discovered that genetic vectors can efficiently spread antibiotic resistance within the gut, enabling even highly virulent bacteria to acquire drug resistance. This finding sheds light on the emergence of 'superbugs' in healthcare settings.
A new book highlights geothermal systems' potential to transform the global power supply, with a 'significant knowledge gap' hindering effective deployment. Researchers propose machine learning methods for optimizing geothermal energy systems and address challenges in thermal energy production.
Computational analysis reveals two strategies: stealthy plasmids pick up new genes first, while manipulative plasmids help them spread rapidly. This 'stealth-first' process can aid in predicting future resistance threats and tracking their emergence.
A team of researchers studied the effect of antisolvent addition rate and initial solute concentration on localized liquid-liquid phase separation in a ternary water/ethanol/butylparaben system. Their findings show that high antisolvent addition rates and high initial solute concentrations enhance the likelihood of LLPS, highlighting t...
A real-world study compared LLMs to human physicians in challenging lung cancer cases, finding that LLMs excel in rare cases with high comprehensiveness and specificity scores. However, they struggle with refractory cases, where physicians' reasoning stability is crucial.
Researchers found that circadian regulation shapes tumor microenvironment and determines patient responses to immune checkpoint blockade therapies. Disrupting these rhythms can suppress immune responses and diminish treatment efficacy.
Research investigates vortex-induced motion in semi-submersible FOWTs under varying incidence angles, revealing the influence of structural components on wake dynamics. The study's findings suggest optimizing platform design to reduce fatigue and enhance operational stability.
This study analyzed RA-related mortality trends in US postmenopausal women from 1999 to 2023, revealing a significant decline in age-adjusted mortality rates from 5.75 to 2.51 per 100,000. Despite the overall decrease, disparities persist by race/ethnicity and region.
SPH simulations provide physically consistent insights into flow dynamics, impact forces, and affected areas in catastrophic hazard scenarios. High-quality visualization enables intuitive representations that support emergency planning and decision-making.
Researchers identified three molecularly distinct subtypes of endometrial cancer with different clinical outcomes and therapeutic vulnerabilities. The study suggests that stratifying patients based on network-level molecular disruptions may offer more clinically actionable insights for treatment selection.
Researchers identified a cell-penetrating peptide from scorpion venom that targets heat shock protein HSP90β and promotes fat-burning transcription factor PPARα activity. This approach enhances fatty acid oxidation and reduces liver fat, inflammation, and fibrosis in diet-induced mouse models of metabolic liver disease.
Researchers created pea-sized mini-stomachs with three main regions, replicating human stomach function and acid secretion. The study models a rare genetic disease, paving the way for personalized treatment and accelerated clinical approval.
The review highlights the dynamic balance between pro-inflammatory and tolerogenic macrophage states at the maternal-fetal interface. Imbalance or impairment of these cells is linked to adverse pregnancy outcomes such as miscarriage, placenta-related disorders, and preterm birth.
A new approach combining Principal Component Analysis (PCA) and Discrete Wavelet Transform (DWT) enables accurate damage localization even with a limited number of sensors. The method reduces costs while improving detection accuracy, supporting broader implementation in real-world bridge health monitoring.
This review analyzes molecular mechanisms of DDR pathways in mediating chemotherapy resistance, elucidating correlations with BRCA1/2 deficiency and ATM/ATR signaling pathway dysregulation. The study presents a novel molecular synergy model between DDR regulation and Immune Checkpoint Blockade to enhance immunotherapy responses.
The conversion of waste lignocellulosic biomass into high-value soil amendments can enhance soil structure, increase water retention, and lock away carbon. Several technological pathways are explored, including slow pyrolysis, mild torrefaction, and solid-state fermentation.
The inaugural issue of SES features an editorial, review articles, and research papers on frontier topics such as fire risk assessment and AI-enabled emergency technology upgrading. These studies provide valuable insights for academia, industry, and policymakers.
This study found differences in fecal microbiome and bile acid content between preterm infants with parenteral nutrition-associated cholestasis (PNAC) and those without PNAC. PNAC development was associated with higher abundance of Proteobacteria, Fusobacteriota, and lower Bacteroidota in cholestatic infants.
The Institute of Science and Technology Austria (ISTA) has received a significant donation to advance trustworthy AI technology. The €5 million gift from Garrett Camp will support fundamental research in artificial intelligence, focusing on interdisciplinary collaboration and long-term impact.
A study by Stanford Medicine researchers found that people with colorblindness have a 52% higher mortality rate over 20 years compared to those with normal vision due to delayed diagnosis. The study suggests that missing the early sign of blood in urine can lead to worse outcomes.
A new study in China's major grain belts reveals region-specific soil tests can guide smarter, lower input rice farming. The research found that paddy soils in two regions release nitrogen differently and that these differences can be predicted using fast laboratory tests.
A new special issue explores how artificial intelligence can enhance soil carbon storage and ecosystem health in farmlands, forests, and grasslands. The journal Biochar publishes original studies on biochar production, processing, and applications.
Researchers have discovered a way to harness methane-eating microbes to produce valuable resources like animal feed, green plastics, and cleaner fuels. These microbes can also remove dissolved methane and nitrite from wastewater, offering a potential solution for reducing greenhouse gas emissions.
A new study demonstrates a health care approach matching treatment intensity to individual risk levels can significantly reduce self-harm and depression among at-risk adolescents and young adults. The randomized clinical trial found significant reductions in self-harm behaviors, improved patient satisfaction, and high follow-up rates.
Firefighter gear can create challenges that jeopardize performance and safety, with nearly 40% of non-fatal injuries linked to muscle and bone strain. Researchers found that full gear reduces mobility by up to 20 degrees in joints and increases the risk of injury through adapted movements.
Researchers at UC Riverside find that faulty gene PTPN2 increases susceptibility to harmful bacteria like AIEC, leading to gut inflammation and IBD. The studies suggest that restoring PTPN2 function or using medications like JAK inhibitors may help control harmful bacterial growth.
A multidisciplinary team at USC has developed selective compounds that inhibit an enzyme tied to brain inflammation in people at genetic risk for Alzheimer’s. The inhibitors preserve normal brain function and cross the blood-brain barrier, suggesting a promising therapeutic approach for neurodegenerative diseases.
A landmark study has identified over 100 ancestry-independent regions of the genome that influence schizophrenia risk in African Americans and other ancestrally diverse populations. The findings address a long-standing gap in psychiatric genetics and offer a more inclusive view of the disease’s biological underpinnings.
Scientists have developed a new technique that combines rotational ultrasound tomography (RUST) with photoacoustic tomography (PAT) to create 3D color images of soft tissues and blood vessel function. This method has the potential to enhance breast tumor imaging, monitor nerve damage caused by diabetes, and brain imaging.
The American Heart Association warns of cold weather's impact on cardiovascular disease. To stay heart-healthy in winter storms, know the dangers and take necessary precautions.
Researchers at Rice University replicated Thomas Edison's 1879 light bulb experiment, discovering that the carbon filament used in his design could have produced turbostratic graphene. This finding sparks curiosity about what other information lies buried in historical experiments and how modern techniques can reveal new insights.
This study introduces a new FAP-targeting peptide that shows strong tumor uptake and effective tumor growth inhibition when paired with lutetium-177. Additionally, researchers have identified distinct metabolic and structural brain patterns that differentiate probable LATE, Alzheimer disease, and their frequent overlap.
The new NIH policy on research using human fetal tissue could undermine the development of life-saving therapies for various diseases. The ISSCR urges NIH to reconsider its decision and engage constructively with the scientific community to support biomedical research.
Researchers found that Ralstonia's unique exo polysaccharide 1 (EPS-1) film allows the bacteria to spread rapidly through plant xylem vessels, causing rapid wilting. The team used precise measurements of the viscoelastic properties of EPS-1 to understand its role in making Ralstonia a devastating plant killer.
Residential wood burning accounts for over one-fifth of wintertime exposure to outdoor fine particulate matter, linked to increased risks of heart disease and premature death. By reducing indoor wood burning, Americans could decrease outdoor air pollution and save thousands of lives.
Researchers have developed a novel generative AI model called Collaborative Competitive Agents (CCA) that improves complex image editing tasks. The CCA system utilizes multiple Large Language Model-based agents working collaboratively and competitively, resulting in a more robust and accurate editing process.
The University of Cincinnati Cancer Center is testing approaches to neutralize an enzyme complex that enables cell division in KRAS-mutated lung cancers. The grant aims to identify the best strategy to suppress this enzyme and prevent long-term tumor growth.
Researchers developed a design manual to turn commercial Zn foil into ultra-stable anodes through simple, low-cost inorganic coatings. The coatings suppressed dendrite growth and hydrogen evolution, increasing cell lifespan and areal capacity.