Brown University researchers discovered that as cells age, their ability to defend against parasitic strands of genetic material called transposable elements deteriorates. This breakdown allows the newly freed transposons to take full advantage, potentially leading to a decline in cell function and health.
Researchers from Brown University found fossilized conduits on Mars that suggest water once flowed beneath the planet's surface. The conduits, formed by underground cracks, indicate an active hydrology and a possible habitable environment.
A study by Brown University researchers found that the protein apoE4 is surprisingly useful in promoting neuron growth, even though it's associated with Alzheimer's disease. The findings suggest a better method for growing neurons outside the body, which could be used to treat neurodegenerative diseases.
A study published in the Proceedings of the National Academy of Sciences found that human melanocytes rely on the TRPA1 ion channel to detect UVA light and trigger the production of melanin. This discovery strengthens the evidence of a parallel between the skin's response to UVA light and the eye's detection of light.
Researchers at Brown University found that DNA molecules are more likely to be captured at or near an end than in the middle when pulled through a solid-state nanopore. The discovery is attributed to the application of polymer network theories, including Jell-O theory, which predicts more configurations with ends facing the pore.
The Irene Diamond Fund's gift will support Brown's Program in Public Health in developing and disseminating successful interventions for older adults. The initiative aims to improve quality of life and reduce care costs through collaborations with healthcare providers and community health centers.
In Ethiopia, a study found that only 66% of patients with HIV disclosed their status to their spouse, while 17% disclosed to siblings and 16.8% to other relatives. The lack of disclosure hinders treatment and prevention efforts.
A new meta-analysis of 10 studies involving over 203,000 patients with anemia and heart attacks found that liberal blood transfusions increased the risk of death by 12% and had twice the odds of another heart attack. The study calls for rigorous randomized trials to determine when transfusions are appropriate.
A study by Brown University biologists found that the PACMAD clade of grasses developed an anatomical predisposition to C4 photosynthesis due to evolutionary pressures. The clade's bundle sheath cells became larger, facilitating more efficient CO2 transfer when temperatures rise or plants become stressed.
A new study by Brown University finds that farm soils mediate the environmental consequences of modern farming, particularly with phosphorus, a key agricultural nutrient. The research compares soybean production in US, Brazil, and Argentina, revealing how soil type and management impact phosphorus usage and environmental pollution.
A new study in rats identifies a region called the postrhinal cortex that links objects to places in the brain, integrating spatial and nonspatial information upstream of the hippocampus. This finding has implications for treating traumatic brain injuries and neuropsychiatric diseases such as schizophrenia and depression.
A Brown University analysis found that states spending more on home-delivered meals under the Older Americans Act have fewer low-care nursing home residents. Home-based meals emerged as a statistically significant factor affecting state-to-state differences in low-care nursing home population.
Researchers at Brown University have made the first direct measurements of cause-and-effect responses between the nonspecific thalamus and the prefrontal cortex. The study reveals that inhibitory neurons respond strongly to thalamic signals, leading to a pattern of excitation in the cortex that sustains attention and arousal over time.
A new study reveals that insects prefer exotic plants over natives, maintaining balance in ecosystems. Native plants are less susceptible to these insects and can thrive alongside exotics.
Nearly 23% of American women aged 16-49 have high levels of lead, mercury, and PCBs in their blood. Risk factors include age, fish consumption, heavy drinking, and breastfeeding. Women should learn about their risks before becoming pregnant.
A new study by Brown University researchers found that men with more consistently made sperm have better swimming abilities. The research suggests that variability in sperm length may be a sign of trouble with the production process, potentially affecting fertility.
Researchers have developed a new index to assess patients' progress with prosthetic arms, grading performance on 18 everyday tasks. The Activities Measure for Upper Limb Amputees (AM-ULA) considers movement quality and body compensation, providing clinicians with a reliable tool to evaluate treatment effectiveness.
Scientists discover unique space weathering process on asteroid Vesta, distinct from other asteroids like the Moon, where meteorite impacts mix soils mechanically rather than forming nanoparticles.
A new analysis found that the Medicare rule blocking simultaneous hospice and skilled nursing facility care at the end of life results in patients receiving less aggressive treatments and dying outside of hospitals. Residents with concurrent hospice and SNF care were 87% less likely to die in the hospital compared to those without hosp...
Researchers at Brown University have discovered how ingesting too much silver leads to argyria, a rare condition where skin turns grayish-blue. The study shows that silver nanoparticles are broken down into silver salt in the stomach, which is then absorbed into the bloodstream and deposited in the skin.
A new paper by Dr. Leonard Mermel reveals that microgravity weakens the immune system while increasing antimicrobial resistance in some microorganisms. In a spacecraft, germs can remain airborne for longer periods and spread more easily due to power limitations and recirculated air.
A new graphene-cobalt material has been developed that can catalyze the oxygen reduction reaction nearly as well as platinum, with improved durability. The material is substantially cheaper than platinum and has shown promise for use in hydrogen fuel cells.
A new analysis of computer-delivered and face-to-face interventions found that while both methods can curb college drinking for a little while, in-person encounters produce lasting results. Computer-delivered interventions had positive effects in the first few months but lost significance after 14 weeks.
Researchers at Brown University have been awarded a $1.75 million grant to develop new catalysts for producing chemicals from carbon dioxide instead of fossil fuels. The goal is to reduce the chemical industry's carbon footprint and stabilize production costs.
Scientists developed a genetically engineered fruit fly model to study temperature-dependent seizures. The model reveals that disease-causing mutations lead to breakdowns in brain regulation, causing excessive electrical activity. Researchers hope this discovery will lead to the development of new treatments for febrile seizures.
Computer scientists at Brown University have been awarded $1.5 million to develop new algorithms and statistical methods for analyzing large genomic datasets. The project aims to identify genetic mutations that drive cancer by comparing gene sequences of healthy tissue to those of cancerous tissue.
Researchers at Brown University are studying new optical materials to overcome size limitations in light-matter interactions at the quantum scale. Harnessing this power could enable technologies like high-capacity optical memory and secure encryption.
A study found that high antibody levels for Porphyromonas gingivalis were associated with a two-fold risk of pancreatic cancer, while high levels of antibodies for commensal oral bacteria were linked to a 45-percent lower risk. The study strengthens the suggestion that oral bacteria may be indicators of pancreatic cancer risk.
A study found that detecting specific HPV biomarkers, such as E6/E7 antibodies, in combination with tumor characteristics can help identify patients with a better prognosis. This approach may lead to more targeted treatment for head and neck cancers.
A study published in Journal of Consumer Research found that people vary widely on the level of detail required for understanding a product. Explanation fiends require more details to feel informed, while explanation foes feel confident with superficial explanations. Understanding what consumers want is crucial for marketers.
Researchers from Brown University developed a computer program that recognizes sketches as they're drawn in real time, with around 56-percent accuracy. The program uses a large database of sketches to teach a computer how humans sketch objects, enabling better sketch-based interface and search applications.
A new study reveals that abstaining from smoking significantly affects teenagers' mood, cravings, and withdrawal symptoms in a manner similar to adults. Contrary to expectations, teenagers who had smoked for only two years showed strong negative effects after just one day of abstinence.
Researchers designed molecular beacons that bind to mRNA of three genes expressed only when stem cells transform into bone cells, allowing for real-time monitoring of gene expression. The technology provides a tool for discovering optimal conditions for stem cell differentiation and identifying desired tissue cells.
A new strategy for managing Medicare's costly dialysis program has been implemented, bundling total costs and discouraging lapses in quality. The changes aim to rein in health care costs, but concerns remain about the potential impact on patient treatment and overall healthcare expenditure.
A statistical review of four studies on Lyme disease retreatment suggests flaws in design, analysis, and interpretation that challenge the evidence against treatment. The review found inconclusive results and potential benefits from antibiotics, leading experts to question the guidelines' recommendation against retreatment.
Researchers from Brown University and ATMI Inc. report the best-ever transparency and conductivity performance for an ITO made using a chemical solution, potentially offering a low-cost method for manufacturers. The team created conductive films with 93% transparency and comparable conductivity to glass plates.
A computer program calibrated to model accurately HIV spread in NYC predicts significant reduction in infection rate with comprehensive intervention strategies. The model simulates individual behavior and transmission networks, providing detailed examination of how interventions affect the epidemic.
A new study found that basal cell carcinoma risk can persist even after multiple instances of the disease, with predictors including a history of eczema and early sun exposure. Researchers are exploring preventive medication options to minimize damage.
A new study finds that mice have a unique neural circuitry for processing instinctually important smells like those associated with predators. The TAAR-expressing neurons form an independent olfactory subsystem, distinct from the more common olfactory receptor neurons, which detect a broader range of smells.
Researchers at Brown University have discovered a pyramid in El Zotz, Guatemala, that provides new information about the Maya civilization. The temple features ornate masks depicting different phases of the sun and stucco carvings revealing how the Maya conceived of the heavens.
Researchers at Brown University found that training can improve recognition of rapidly presented objects by making the second target object a distinct color. This allows people to switch their attention more quickly and perceive the second target as effectively as a fifth of a second later.
Researchers at Brown University have discovered a way to determine unique leukocyte mixes from blood samples using DNA methylation. The technique can distinguish between various types of cancer and non-cancer conditions, offering a powerful tool for medical research and clinical diagnosis.
A new article by Brown University researchers reveals that adopting generic drugs was crucial to the success of the President's Emergency Plan for AIDS Relief (PEPfAR). The program has reduced its annual per person spending on antiretroviral medicines to $300, and now provides treatment to nearly 2 out of 3 individuals in need.
Researchers at Brown University have developed a new system that allows surgeons to control their own views during laparoscopic surgery, leading to faster and more accurate performance. In a small in vitro trial, surgeons with individual views outperformed those with shared views, completing tasks up to 3 times faster.
Researchers at Brown University found that selenium nanoparticles can reduce Staphylococcus aureus bacteria on implant materials by up to 90%. The coating is more effective than current silver-based alternatives, which are less biocompatible and expensive.
Researchers at Brown University discovered over 800 tiny genetic loops, called lariats, in human tissues, providing new insights into RNA splicing decisions. The location of branchpoints on these lariats reliably predicts where splicing will occur, enabling the creation of an algorithmic model with 95.6% accuracy.
Brown University engineers create a biochip called SMART that can detect influenza by identifying specific RNA sequences and separating them from other biological debris. The device is small, low-cost, and fast, making it potentially useful in first-aid kits.
Research by Brown University ecologists finds that recreational fishing causes a trophic cascade, leading to the collapse of salt marshes along Cape Cod. The absence of top predators allows Sesarma crabs to overgraze, causing ecosystem decline.
A new study found that hospitals are increasingly holding elderly Medicare recipients for observation instead of inpatient care, leading to higher out-of-pocket costs. The shift may be driven by hospitals and physicians seeking to avoid unfavorable Medicare audits targeting hospital admissions.
Researchers developed a new model to understand collective behavior of defects during ion bombardment, revealing three mechanisms: dual layer formation, subway-glide mode growth, and adatom island eruption. This breakthrough enables predictive design capability for controlling surface patterns and stresses in nanotechnology products.