Researchers found that dentin's mechanical coupling between collagen protein fibers and mineral nanoparticles allows it to withstand extreme forces. The nanostructure design enables dentin to last longer than synthetic filling materials.
Researchers have identified a crucial protein complex, ASC-1, that guides the development of motor neurons and their target muscles. This breakthrough could lead to new insights into general disease mechanisms and potentially regenerative therapies for conditions like paraplegia.
A new study by Charité researchers reveals that the true cost of treating patients with chronic inflammatory bowel disease exceeds reimbursement levels under the current German DRG system, highlighting the need for a more accurate cost recovery method.
Researchers used a 7T MRI scanner to visualize myocardial injury in patients with hypertrophic cardiomyopathy, detecting minute clefts that were previously impossible to see. The technology offers high-resolution imaging and could lead to more accurate diagnoses of heart diseases.
Researchers have developed a blood test to predict the development of preeclampsia, enabling early diagnosis and prevention of complications. The test measures the ratio of serum sFlt-1 to PlGF proteins, allowing for reliable prediction within one week.
Researchers from Charité's Bernstein Center for Computational Neuroscience tested whether people can cancel decisions based on brain waves. They found that a person's decisions are not at the mercy of unconscious and early brain waves, but can actively intervene in the decision-making process.
A study by Charité researchers has identified a specific protein and its splice variant as crucial in the development of cardiac hypertrophy. Initial activation of this protein leads to an increase in production of proteins associated with early cardiac development, causing the abnormal thickening of heart muscle.
A study published in PLOS ONE reveals that the causes of congenital face blindness can be traced back to an early stage in the perceptual process. People with this condition are unable to use facial features to identify others, but their brains respond differently when shown a face.
The TransLUMINAL-B project aims to study metastasis formation in luminal breast cancers, a common type of the disease. By understanding how individual malignant cells spread through the body, researchers hope to predict prognosis and develop more targeted treatments.
Biosimilars are complex proteins that provide therapeutically equivalent alternatives to expensive biologics, reducing treatment costs in rheumatology and other fields. The introduction of biosimilars into clinical practice requires careful management to ensure patient safety and efficacy.
A team of researchers at Charité - Universitätsmedizin Berlin found that peripheral macrophages can be repurposed to clean up beta-amyloid deposits in the brain. However, even with stimulation, these cells were ineffective and require further investigation into a missing stimulus.
Researchers have deciphered a new molecular signaling pathway that promotes muscle loss in heart failure patients. The study found that suppressing this pathway may inhibit muscle atrophy, offering high potential for therapeutic options.
Research reveals that stored memories are coded as permanent changes in neuronal communication and connection strength, influencing response behavior and gene expression. The study demonstrates that spine calcium responses can undergo long-term enhancement through ryanodine receptor activation.