A new research project led by Charité - Universitätsmedizin Berlin aims to shed light on European post-war history by focusing on the shared concern for people's health. The 'Leviathan' project, awarded an ERC Synergy Grant, will study the development of medicine and healthcare between 1945 and 1990 in both Eastern and Western Europe.
A team of researchers from Charité - Universitätsmedizin Berlin has identified a new endogenous mechanism that enables the skin to actively kill bacteria. The discovery involves mast cells and interleukin 6, which stimulate the release of antimicrobial peptides that target bacteria.
Researchers developed a new classification method using artificial intelligence to identify primary cancerous tissue in head and neck cancers. The method achieved an accuracy of over 99% in distinguishing between primary lung squamous cell carcinomas and head and neck metastases, offering potential benefits for patients.
A new research group at Charité - Universitätsmedizin Berlin is studying the connection between gut bacteria and high blood pressure. The goal is to develop personalized treatments that improve the gut microbiome's function and prevent organ damage.
A new Emmy-Noether Independent Junior Research Group is exploring the mechanisms behind certain bacteria causing disease in some people but not others. The team aims to develop strategies for preventing symptoms and restoring gut health.
Researchers discovered a new mechanism by which microorganisms protect themselves against highly reactive molecules known as free radicals. By accumulating lysine and altering their metabolism, yeast cells can produce antioxidant glutathione, increasing their resistance to cell damage.
The Berlin University Alliance, consisting of Freie Universität Berlin, Humboldt-Universität zu Berlin, Technische Universität Berlin, and Charité - Universitätsmedizin Berlin, has won a major award in the German Excellence Strategy competition. The alliance will receive up to 196 million euros over seven years to create an integrated ...
Researchers at Charité - Universitätsmedizin Berlin found that non-invasive coronary computed tomography (CT) angiography is equally accurate to catheter angiography for diagnosing coronary artery disease. The study suggests that CT angiography can be a suitable diagnostic technique for patients with low to intermediate probability of ...
Researchers discover that gastric stem cells release a protein called intelectin 1 to bind to Helicobacter pylori bacteria, preventing damage. This mechanism is triggered by the presence of H. pylori and stimulates stem cell proliferation and tissue regeneration.
Researchers aim to develop personalized treatments for addiction by studying mechanisms of control and decision-making. The center will use mobile health technologies, apps, and imaging techniques to analyze cognitive performance and mood states of addicts.
Researchers found the alpine marmot to have low genetic diversity, lower than any other wild mammal studied. Climate-related adaptations during the last ice age led to reduced genetic mutation rates and longer generation times, making it difficult for the species to recover its diversity.
Researchers from TU Berlin and Charité investigate how motion sickness affects automated driving, with a focus on alleviating discomfort. Over 40% of respondents experienced symptoms during car rides, highlighting the need for technical measures to reduce kinetosis.
Researchers found that comic-style information improves patient comprehension and reduces anxiety before cardiac catheterization. The comic booklet was shown to be effective in explaining procedural details and postoperative advice, with patients reporting feeling better prepared for surgery.
A new study aims to develop a standardized skin care guidance for elderly people in residential care, addressing common skin problems and improving quality of life. The SKINCARE study will investigate the effectiveness of the new program and provide training for care workers.
A new research unit at Charité - Universitätsmedizin Berlin aims to improve the identification and diagnosis of rare genetic diseases by analyzing non-coding DNA sequences. The researchers will develop software for whole-genome data analysis, enhancing our understanding of gene regulation and transcription.
Two new Emmy Noether Independent Junior Research Groups at Charité will explore the use of deep brain stimulation to treat neurological disorders and the regulation of immune responses in the nervous system. The groups, led by Dr. Andreas Horn and Dr. Christoph Klose, will receive over €1.7 million in funding for three years.
Researchers found that lower blood pressure is associated with increased risk of death in adults over 80, and those who've had a heart attack or stroke. This study's results suggest adjusting antihypertensive treatment based on individual needs, moving away from blanket approaches.
Scientists have deciphered the process by which viruses induce their hosts to transcribe viral genetic information, producing daughter viruses. The discovery sheds light on the 'viral exploitation' mechanism used by bacteriophages, such as lambda phage, and may contribute to the development of new antibacterial drugs.
For the first time, researchers from Charité - Universitätsmedizin Berlin have measured the 'Bereitschaftspotential' (readiness potential) outside a laboratory and under extreme conditions. This finding will help advance brain-computer interface development, enabling quadriplegics to control neuroprosthetics and regain hand function.
A study by researchers from Charité - Universitätsmedizin Berlin has identified a molecule, c-Maf, that regulates the balance between the immune system and gut microbiota. This finding may lead to new therapies for chronic inflammatory bowel disease.
The RESTORE Health initiative aims to develop advanced therapies for curative treatments, backed by an international and interdisciplinary community. The consortium plans to invest up to €1 billion in new research projects over the long term.
Researchers found the immune system plays a crucial role in maintaining healthy intestinal stem cells and preventing bowel cancer by enhancing DNA repair mechanisms. The study discovered that cells of the innate immune system can recognize genotoxic environmental factors, such as glucosinolates, and send signals to epithelial stem cell...
A team from Charité has identified the Chi3l3 protein as a key player in the body's innate ability to repair damaged myelin sheaths in multiple sclerosis. By understanding this molecular signal, researchers aim to develop new drugs that can restore electrical insulation around nerve cells.
Charité is leading three new EU-funded projects: ReSHAPE, VirtualBrainCloud, and ENDOSCAPE. The ReSHAPE project aims to develop a treatment for transplant rejection using regulatory T cells, while VirtualBrainCloud creates personalized brain simulations for neurodegenerative diseases. ENDOSCOPE develops non-viral gene delivery technolo...
Researchers have determined general population quality of life normative data for 15 individual countries, allowing for regional comparisons and valid QLQ-C30 score interpretation. National differences in quality of life scores were found, with respondents from Austria and the Netherlands reporting higher scores.
The partnership aims to consolidate research cooperation and explore diverse topics such as poverty, digital economy, and energy transition. Funding will support academic formats like workshops, conferences, and symposia, as well as young researchers' exchange and laboratory work.
Researchers developed a computer model predicting prostate cancer progression using tumor genomes from nearly 300 patients. This enables clinicians to develop tailor-made treatments, potentially improving patient outcomes.
Researchers from Charité - Universitätsmedizin Berlin studied genetic factors behind different tumor subtypes and their prognoses. They found that telomere maintenance mechanisms play a crucial role in the development of malignant tumors, enabling precise predictions of disease prognosis.
The study reveals the molecular mechanisms of phytochromes, which convert light into cellular information, and their potential applications in oncology and genetic disease treatment. Understanding these proteins can help develop non-invasive imaging techniques and light-controlled tools for medical applications.
Researchers at Charité - Universitätsmedizin Berlin aim to develop new treatment strategies for chronic and acute kidney diseases through a €10.5 million funded Collaborative Research Center. The project focuses on identifying common pathways of kidney injury and developing tailored treatments.
Researchers have developed an effective monoclonal antibody treatment, lanadelumab, that can reduce the frequency of life-threatening swelling attacks in patients with hereditary angioedema. The treatment has shown a 90% reduction in attack rate and can be self-administered every two weeks.
A new Research Training Group will develop computer-based tools for cancer research, addressing key challenges in data analysis and interpretation. The program aims to promote international networking and provide comprehensive training for researchers.
Surjo Soekadar, a renowned neuroscientist, has been appointed Germany's first Professor of Clinical Neurotechnology at Charité. He aims to enhance brain functions such as attention, memory, and emotional control using innovative brain-computer interfaces.
Researchers found corticosteroids, biologics, and immunosuppressive agents to be effective for treating urticarial vasculitis. Antihistamines and other anti-inflammatory drugs were ineffective, contrary to common practice.
Researchers have found that CRISPR-Cas9 generates a strong immune response in humans, with T cells reacting to the Cas9 protein in almost all healthy subjects. However, the study also highlights the need for new solutions to prevent dangerous immune reactions, particularly for genetic diseases requiring in vivo modifications.
A team of researchers from Charité - Universitätsmedizin Berlin has been awarded an ERC Synergy Grant to study the effects of play on brain mechanisms involved in learning. The six-year project aims to understand the neurobiology of learning and how learning through play affects the brain.
Researchers studying vampire bats and Morbillivirus aim to understand how viruses persist inside the body and trigger new infections. The project aims to gain fundamental insights into RNA virus persistence and potentially shed light on diseases like SSPE.
Researchers, led by Dr. Nikolaus Wenger, are developing neural prostheses for brain-computer interfaces to treat neurological disorders. The goal is to understand how the brain processes information and develop a prosthesis that can transmit signals back to the nervous system.
Researchers found that epigenetic changes in genes related to dopamine neurotransmission are associated with lower IQ test results. The study suggests environmentally-induced gene activity plays a significant role in intelligence.
Researchers from Charité - Universitátsmedizin Berlin have developed a new generation of pain medications that can prevent brain- and gut-related side effects associated with conventional opioids. The drugs are designed to work only at sites affected by injury or inflammation.
Researchers at Charité are investigating how certain genomic mutations contribute to childhood cancers, using advanced DNA sequencing technologies. They aim to develop personalized cancer therapies for pediatric patients.
A study published in The Lancet found that telemedical interventional management reduced unplanned hospitalizations by 44% and increased life expectancy for patients with heart failure. Patients who received remote patient management interventions also showed significant reductions in all-cause mortality, regardless of their location.
Researchers found that deep brain stimulation affects different neural pathways for motor and cognitive functions. The treatment shows improved effects on motor control and fewer adverse cognitive effects.
Charité researchers Dr. Klose, Dr. Polansky-Biskup, and Dr. Triantafyllopoulou receive funding for projects on enteric nervous system regulation and epigenetic fine-tuning of T cells to improve adoptive cell therapy
A new drug, upadacitinib, has been shown to be effective in patients with moderate to severe forms of rheumatoid arthritis who have not responded to conventional treatments. The drug, a selective inhibitor of Janus kinase 1, has been found to improve joint swelling and pain symptoms in a phase III clinical trial.
Researchers have successfully tested a medicine that can treat hereditary angioedema by inhibiting the kallikrein enzyme, preventing severe swelling. The daily administration of the drug has been shown to prevent symptoms from developing, offering a new hope for patients suffering from this rare genetic disease.
The Virtual Brain neuroinformatics platform is integrating into the EU's Flagship Human Brain Project to promote efficiency and reproducibility in research. The platform will enable researchers to refine computer models, develop efficient simulation technology, and improve study reproducibility.
A new blood test can determine an individual's internal clock, allowing for personalized drug administration and more effective treatment. The test identifies biomarkers that reliably report internal time, differentiating early and late types.
Researchers developed a new ultrasound technology, time-harmonic elastography, to diagnose liver fibrosis in obese adolescents without invasive biopsies. The technology accurately distinguishes between patients with no or mild fibrosis and those with moderate or advanced fibrosis.
Scientists from Charité-Universitätsmedizin Berlin have produced high-resolution snapshots of the 50S subunit assembly process in bacteria. The study provides insights into the molecular mechanisms of ribosome assembly and reveals potential targets for developing new antibacterial drugs.