Two new Collaborative Research Centers at Charité will investigate the use of diagnostic imaging technology to visualize pathological changes in the extracellular matrix. This research may contribute to the early detection of diseases and improve therapy monitoring. The centers aim to uncover new insights into memory consolidation and ...
Subarachnoid hemorrhage can disrupt brain signaling, leading to extreme constriction of blood vessels and energy deprivation. The 'negative ultraslow potential' is an electrophysiological correlate of infarction and tissue death due to inadequate blood supply.
Scientists at Charité and Stanford University decipher the molecular step of cellular signal transmission involving G protein-coupled receptors (GPCRs) and arrestin. The study's findings could lead to the development of specific drugs targeting diseases like asthma, schizophrenia, hypertension, and cancer.
Researchers at Charité - Universitätsmedizin Berlin have developed a new drug to treat patients with genetic obesity caused by a leptin receptor defect. The treatment has shown significant weight loss in patients, and the study's findings provide insights into the fundamental signaling pathways regulating satiety.
The PRECISE4Q project aims to develop computer-based predictive modeling to personalize and optimize treatment strategies for stroke patients. The project will collect large data sets from different sources, integrating them into self-learning computer models to minimize the burden of stroke on individuals and society.
The TrueBrainConnect project aims to develop complex models capable of predicting different mental states based on EEG data. The researchers hope to identify early precursors of disease and delineate different types of dementia, leading to improved prognosis for neurological disorders.
A new study published in the American Journal of Obstetrics and Gynecology found that an app-based self-care program using acupressure reduced menstrual pain in young women by up to 58% after six months. The app, Luna, was used by participants who received either standard care or a self-acupressure intervention.
Researchers discovered a new mechanism by which live vaccines induce immunity through TLR8 recognition. This triggers protective immune responses and improves vaccine safety and efficacy. The study's findings have the potential to develop new vaccines combining the benefits of live and modern subunit vaccines.
A recent study published in Cell reveals that disruptions in blood cell production can lead to anemia, specifically Diamond-Blackfan anemia. The research found that reduced ribosome levels and impaired translation processes contribute to the disorder's development.
In humans, a massive wave of electrochemical energy release in the brain occurs after oxygen deprivation, known as 'spreading depolarization', which can trigger pathophysiological cascades. Researchers have found that this event is similar to animal studies and that it remains reversible if circulation is restored before nerve cells die.
Researchers found that people from Western Germany have higher levels of narcissism than those from Eastern Germany, with a greater impact on the younger generation. Self-esteem scores were opposite, with East Germans recording higher scores.
Researchers have found that changes in adipose tissue lipid metabolism contribute to the development of heart failure. The study suggests that targeting fat tissue may provide a new approach to treating heart disease.
Researchers found that Hedgehog signaling proteins keep cancer stem cells alive and are required for their survival. The study suggests targeting the Hedgehog pathway could eliminate cancer stem cells and prevent recurrence.
Researchers develop optimized titanium-mesh scaffolds that promote faster and more effective bone regeneration. The study found that softer implants enhanced healing, with results applicable to various types of bone defects.
Researchers found that astronauts' core body temperature increases gradually over 2.5 months, eventually reaching 38°C (100.4°F), impairing physical and cognitive performance. In space, sweat evaporation is slower than on Earth, leading to overheating during exercise.
Researchers found a direct link between symptom severity and treatment outcomes in patients with isolated dystonia, using deep brain stimulation. Brain activity patterns reveal disease severity, and oscillatory brain activity in the 'theta band' is associated with dystonic symptoms.
The Science Bridge project aims to promote cooperative projects in neuroscience and medical sciences through conferences, exchange programs, and joint funding bids. Twin Institutes will be established, fostering the free exchange of ideas between Western and Middle Eastern/South Asian research institutions.
Researchers at Charité's NeuroCure Cluster of Excellence have identified a protein mechanism responsible for rapid signal transmission between nerve cells. The discovery, published in Nature Neuroscience, reveals that bridging by synaptotagmin allows high-speed transmission via synapse fusion.
Researchers found that activating programmed cell death (necroptosis) in white blood cells leads to inflammation and auto-antibody attachment, contributing to disease progression. Inhibiting necroptosis may offer a new treatment approach for ANCA vasculitis.
Researchers at Charité found that retinol saturase plays a role in adaptive processes in liver cells, increasing with body weight and reducing negative metabolic effects associated with excess glucose exposure. The enzyme's inactivation may offer a new approach to treating metabolic liver disease and its related issues.
A newly-discovered reflex arc disrupts hormone secretion by adrenal glands, leading to increased bacterial infections. Trauma-induced spinal cord injuries weaken the immune system, resulting in severe infections and hindering nervous tissue regeneration.
Researchers found that maternal inflammation can lead to changes in the fetal brain, particularly in the amygdala, which plays a crucial role in emotional processing. This association has been linked to impaired impulse control and an increased risk of psychiatric disorders.
Researchers developed a human lung tissue model to study pneumonia and found that viral pathogens inhibit the immune system's ability to fight bacterial infections. A new drug-based treatment was tested, which inhibits tyrosine kinase-2, restoring the immune system's ability to combat bacterial pathogens.
Researchers have discovered that correct connections between brain regions are essential for optimal relief of Parkinson's Disease symptoms using deep brain stimulation. By analyzing brain connectivity, they were able to predict the best possible outcome and optimize electrode placement.
A study published in PLOS ONE found that tablet-based, multimedia-enhanced training significantly improved internal medicine exam performance. The integrated program combined theoretical training with clinical practice, utilizing digital media and learning materials to enhance knowledge acquisition.
A recent study published in Annals of Internal Medicine reveals that Nazi-era physicians were required to study medical ethics in German medical schools, with a focus on the 'people's body' over individual health. This challenges the notion of medical ethics as a universal construct.
Researchers identified a key mutation in a tumor suppressor gene as the cause of a rare genetic disorder that leads to myelodysplastic syndrome. Children with this condition develop a shortage of normal blood cells due to disrupted bone marrow function.
Omalizumab, an asthma drug, demonstrates significant symptom improvements and prevention in patients with cold urticaria and symptomatic dermographism. The treatment was found to be effective in nearly half of patients with symptoms after exposure to stimuli.
A more flexible approach to study design can significantly improve the efficiency of preclinical research, according to a recent study published in PLOS Biology. By using group sequential designs, researchers can enhance predictive ability and reduce waste in animal studies.
A clinical study published in New England Journal of Medicine shows that a single dose of siRNA can significantly reduce LDL cholesterol levels by up to 52.6% after two doses, offering long-lasting protection for high-risk patients.
Researchers at Charité - Universitätsmedizin Berlin have discovered a new mechanism of action for painkillers that produces substantial pain relief in inflamed tissues without causing severe side effects. The prototype, NFEPP-prototype, binds to opioid receptors only in acidic environments, avoiding respiratory depression and dependency.
The study reveals that arrestin's C-edge loops interact directly with the membrane, forming a new type of binding. This discovery opens up new avenues for understanding the role of the membrane in GPCR-arrestin interactions and developing drugs with fewer side effects.
Two specific proteins recognize defective mRNAs and trigger their destruction, maintaining cell survival. The study reveals a direct competition-based approach for targeting aberrant ribosomes.
Researchers have made significant progress treating anti-NMDA receptor encephalitis with a new regimen, including patients who previously did not respond. The treatment, which includes bortezomib, has shown to quickly improve clinical symptoms and reduce antibodies responsible for the disease.
Researchers found that food withdrawal leads to the accumulation of p53 protein in liver cells, playing a crucial role in metabolic adaptation to starvation. This discovery may pave the way for new treatments for patients with metabolic or cancer-related disorders.
Researchers have shown that macrocyclic MRI contrast agents may reduce the risk of gadolinium brain deposition, a concern for patients with multiple sclerosis. Macrocyclic agents were found to minimize deposits in the cerebellum, whereas linear agents posed a higher risk.
The study found that human ALOX15 has a higher capacity for producing anti-inflammatory lipid mediators than its lower primate counterparts. This suggests an evolution to better control inflammation and speed up the healing process.
Carbon monoxide metabolism is linked to the body's circadian rhythms, and disruption can cause metabolic disorders such as diabetes or metabolic syndrome. Researchers have identified a reciprocal relationship between carbon monoxide production and the body's internal clock.
A research group led by Prof. Dr. Benjamin Judkewitz is working on a new approach to overcome light scattering limitations in optical microscopy, enabling images of deeper tissue layers. The European Research Council has allocated €1.49 million over five years to fund this endeavor.
A recent study published in Frontiers in Cellular Neuroscience has made significant discoveries about the effects of anesthesia on brain activity. The researchers found that neurons under anesthesia become highly synchronized and more sensitive to environmental stimuli, which challenges traditional views on consciousness.
Children develop IgE-antibodies to specific dust mite molecules early in life, often before disease onset, with 'molecular spreading' increasing risk of allergic rhinitis and asthma. Early sensitization and parental hay fever are key risk factors.
Scientists have identified thousands of 'spliced epitopes', previously thought rare, which are highly prevalent and play a key role in the immune response. This discovery may lead to new understanding of autoimmune diseases and open opportunities for vaccine development.
Researchers from Charité have found that high blood selenium levels are associated with a decreased risk of developing liver cancer. Selenium deficiency is identified as a major risk factor for liver cancer, with the third of the population having lowest selenium status facing a five- to ten-fold increased risk.
Researchers from Charité - Universitätsmedizin Berlin investigated whether earlier response time leads to improved prognosis. Patients who received thrombolysis during transfer were less likely to have a disability three months after their stroke.
Researchers at Charité - Universitätsmedizin Berlin have successfully treated two patients with rare genetic disorders causing severe hyperphagia. The new drug treatment, which targets the satiety center in the brain, resulted in significant weight loss and normalization of hunger feelings in both patients.
Researchers at Charité are developing a personalized virtual brain model using big data and advanced simulations. They aim to improve our understanding of cognitive performance by analyzing the interaction between individual brain components.
Researchers have successfully programmed a virus to transport genetic material to affected tissue and nerve cells, opening up new options for treating various diseases. The approach uses attenuated viruses to selectively target diseased cells, reducing damage to healthy ones.
Researchers found that metal ions released by cobalt-chromium-molybdenum alloys impair mesenchymal stromal cells' ability to differentiate into osteoblasts. This can lead to premature bone loss and revision surgery. The study's findings highlight the need for improved implant design and composition to optimize patient safety.
Research suggests that female patients with migraines have a significantly increased risk of cardiovascular disease, including stroke and heart attacks. The study found a 50% higher risk of developing cardiovascular events in women with a diagnosis of migraine.
A team of researchers, led by Prof. Dr. Sonja Entringer, is studying the effects of maternal stress during pregnancy on newborn cell biology and cellular aging. The study aims to understand how prenatal exposure to stress affects the unborn child's development and future health.