Researchers have identified a new factor influencing excess body weight in women, related to epigenetic marking of the POMC gene. The study found that women with an increased number of methyl groups attached to the gene are at a 44% higher risk of obesity.
The new Clinical Research Unit will investigate autoantibodies' role in neurological disorders, focusing on diagnosis and treatment. Researchers expect innovative therapies for patients with previously suspected diseases.
Researchers found that a triple combination therapy of elexacaftor, tezacaftor, and ivacaftor improves lung function and reduces inflammation in patients with cystic fibrosis. The treatment's positive effects last over 12 months, offering hope for better management of the disease.
An international consortium, led by Charité – Universitätsmedizin Berlin, is developing an AI-supported online platform to predict the course of multiple sclerosis (MS) on an individual basis. The project aims to make treatment more tailored and effective for specific patients.
Researchers found that severe spinal cord injuries can disrupt communication between the nervous system and immune system, leading to systemic immune deficiency. Blood markers associated with this deficit can help gauge individual vulnerability to infection.
A new study has provided insight into the mysterious evolution of DNA rings in tumors, revealing that nearly one-third of all tumors have these genetic structures. The researchers used a technology to trace the path of DNA ring development in neuroblastoma cells, finding that large rings contain cancer genes spurring cell growth.
A team of researchers conducted the largest proteomic study on yeast cells to gain a detailed picture of previously unknown gene functions. The study revealed general principles governing protein expression and identified thousands of proteins with their biophysical properties.
A clinical study has shown that vaccination during pregnancy can effectively prevent severe respiratory syncytial virus (RSV) disease in infants. The vaccine was found to be well-tolerated and provided over 80% protection against RSV illness, with benefits expected for vulnerable populations worldwide.
A new study published by researchers at Charité - Universitätsmedizin Berlin found a significant link between early childhood trauma experienced by mothers and various health problems in their children. The research analyzed data from over 4,300 American mothers and their children, revealing that children of mothers with adverse experi...
Research at Charité – Universitätsmedizin Berlin identifies a possible explanation for migraine frequency during menstruation: higher levels of CGRP, a neurotransmitter that triggers migraines. The study found significant differences in CGRP concentrations between women with migraines and those without, suggesting a hormonal link.
Researchers discovered a causal mechanism behind BPTA syndrome by identifying a change in the HMGB1 protein that disrupts cellular self-organization. This disruption leads to developmental disorders and predisposition to cancer, with hundreds of comparable genetic changes associated with various conditions.
Researchers found that cells exchanging amino acids and glycerol with each other lived up to 25% longer. The study suggests this collaborative exchange extends the lifespan of cells within a community as a whole.
Researchers at Charité – Universitätsmedizin Berlin have discovered a cystic fibrosis drug effective in laboratory experiments, raising hope it can treat pneumonia regardless of the pathogen. The study found that CFTR plays a key role in pulmonary edema and that a CFTR modulator, ivacaftor, can prevent this condition.
A new algorithm developed by researchers at Charité improves motor symptoms comparable to standard of care treatment, increasing efficiency in deep brain stimulation for Parkinson's disease. The study suggests a promising result for imaging-based algorithms to simplify clinical practice and improve therapeutic outcomes.
A recent study on Omicron's origins has been retracted due to contaminated genome sequences, casting doubt on the variant's emergence timeline. The Charité team, led by Prof. Jan Felix Drexler, is conducting a review of their analyses to address these concerns.
Researchers discovered a brain network that reduces Alzheimer's symptoms when stimulated, paving the way for further studies. A small group of participants benefited from deep brain stimulation, with the optimal stimulation site located at the intersection of two fiber bundles connecting regions deep in the brain.
Researchers found viruses with Omicron-specific mutations in COVID-19 patients in six African countries two months before the variant was detected. The study suggests that Omicron emerged gradually, evolving from existing human immunity, and spreading rapidly across Africa before global detection.
A study published in Nature identifies the central functions of group 2 innate lymphoid cells (ILC2s), which play a crucial role in combating parasitic diseases and promoting mucus production. The researchers found that ILC2s are essential for immune response and cannot be replaced without compromising its effectiveness.
Researchers have used single-cell sequencing to uncover novel gene expression patterns in injured kidney cells, providing new avenues for biomarker discovery and treatment. The studies reveal that epithelial cells of all tubule segments are involved in the injury processes, with distinct molecular patterns across patients.
Researchers used Neuropixels probes to measure the activity of synaptically connected retinal and midbrain neurons, revealing a mosaic-like neural connection. The study provides new insights into visual processing and strengthens our understanding of blindsight.
A Charité study found that SARS-CoV-2 can trigger chronic fatigue syndrome (ME/CFS) in patients. Approximately half of post-COVID patients met the diagnostic criteria for ME/CFS, with distinct differences in laboratory results and disease progression between groups.
A new combination drug therapy addressing the disorder's underlying defects has been found to be beneficial for primary school-aged children with cystic fibrosis. The study, conducted at Charité – Universitätsmedizin Berlin, confirmed that earlier treatment can slow disease progression and improve lung function and quality of life.
A study by Charité researchers found that SARS-CoV-2 causes limited direct tissue damage, instead triggering an inflammatory response through alveolar macrophages. This suggests that most cases of SARS-CoV-2 infection show relatively moderate disease severity.
Researchers have elucidated the molecular mechanism of selenocysteine insertion into proteins, revealing a complex interaction between ribosomes and mRNA signaling sequences. This discovery has important implications for understanding human health and disease, particularly in relation to cancer prevention and thyroid function.
A team of international researchers, led by Prof. Dr. Anton Henssen, has won €24 million funding to research the role of ring-shaped strands of DNA in cancer development and how to fight them. They plan to study the structure of the rings, gene expression regulation, and potential therapy targets.
Charité is leading four new EU projects tackling environmental impact on mental health, developing a cell therapy for IgA nephropathy, and improving AI-assisted stroke care. The projects aim to advance research and innovation in these areas.
Researchers at Charité - Universitätsmedizin Berlin have discovered a novel mechanism that restricts cell division in healthy stomach tissue, protecting against cancerous changes. However, Helicobacter pylori infection deactivates this mechanism, enabling cells to grow uncontrollably and increasing the risk of stomach cancer.
Researchers at Charité, MDC, and FU Berlin have studied the mechanisms of action of antibody and dexamethasone treatments for COVID-19. They found that combination therapy is more effective in reducing viral activity and inflammation in lung tissue, suggesting a potential game-changer in treating severe cases.
Researchers have identified a biomarker that indicates high risk of impending stroke post-subarachnoid hemorrhage, enabling early treatment initiation in comatose patients. Electrodiagnostic monitoring detects 'spreading depolarizations' caused by toxic by-products of blood breakdown, allowing clinicians to intervene before it's too late.
A large-scale genetic study has identified 287 genomic regions associated with schizophrenia and 120 specific genes linked to the disorder. These findings provide new insights into the biological processes underlying schizophrenia, offering potential avenues for novel therapies.
Dystonia is characterized by involuntary movements and postures, limiting daily activities. A new study maps specific brain networks for treatment success in patients with cervical and generalized dystonia. The findings reveal distinct stimulation sites depending on the type of dystonia, offering a more targeted approach to improving t...
A study by Charité researchers found that fungal pathogens benefit from cooperative relationships, exchanging metabolites and becoming tolerant to anti-fungal drugs. This mechanism also provides growth advantages for metabolically competent cells, reducing their susceptibility to hundreds of antimicrobial substances.
A comprehensive analysis suggests that cardiac computed tomography (CT) provides a safe alternative to cardiac catheterization for patients with stable chest pain and suspected CAD. The trial confirms CT's diagnostic accuracy, while also showing lower procedure-related complications.
Researchers have discovered a new mechanism that causes relapse in multiple myeloma by upregulating the protein CDK6, which controls cell division. Using proteomics and mass spectrometry technology, they found that adding a CDK6 inhibitor to treatment can reverse drug resistance and improve survival odds.
A team of researchers from Charité – Universitätsmedizin Berlin have elucidated the process underlying drug resistance in aggressive pancreatic cancer. They found that inhibition of the RUNX1 protein limits cancer growth and may lead to effective treatment options.
A team of researchers from Charité – Universitätsmedizin Berlin has identified a neural network that generates tics, which could lead to improved treatment of people with Tourette syndrome. The study found that targeting this network via deep brain stimulation can alleviate symptoms in patients.
A multidisciplinary team of researchers has identified a key signaling pathway involved in tumor formation in lymphoma. The study found that the SENP6 gene controls DNA repair and its loss leads to cancer development.
Experts from Charité – Universitätsmedizin Berlin will deliver SARS-CoV-2 tests and train laboratory staff to monitor the Mu variant, which has spread widely throughout Colombia. The team will also support local authorities with antibody testing and knowledge transfer to inform pandemic control decisions.
Researchers analyzed 140 neuroblastoma samples to understand the genetic changes associated with the disease. They found that mutations can disappear and reappear, occurring in distinct sections or individual cells, making targeted therapy less effective.
A retrospective analysis of anonymized health claims data reveals that three in four sepsis survivors experience post-sepsis morbidity, with over half of those under 40 developing new diagnoses. Average treatment costs for the first three years after discharge are €29,000.
Researchers found that macrophages play a central role in COVID-19-related respiratory failure, leading to fibroproliferative ARDS and prolonged ventilation. Extensive tissue damage and scar tissue formation are characteristic of severe lung failure.
The new research center aims to develop a comprehensive understanding of heart failure with preserved ejection fraction (HFpEF) and improve treatment options. The researchers will study the underlying causes, molecular mechanisms, and effects on the cardiovascular system.
A Charité study confirms the efficacy of gene therapy in improving muscle function and reducing mortality in children with spinal muscular atrophy. The treatment, onasemnogene abeparvoven, was found to be effective in children under two years of age, offering a promising alternative to existing treatments.
Researchers discovered that SARS-CoV-2 causes an early release of the immune-dampening TGFβ messenger, disrupting the innate immune response. This disruption impairs natural killer cells' ability to eliminate virus-infected cells, leading to severe disease.
Scientists have elucidated and visualized the 3D molecular structure of the melanocortin 4 receptor (MC4R), a crucial component of appetite regulation. The study's findings provide insights into the protein's interaction with hormones and potential targets for drug interventions to treat severe obesity.
Researchers found that prior exposure to common cold coronaviruses boosts the body's immune response to SARS-CoV-2, with cross-reactive T cells recognized by the immune system. The study's findings suggest a protective effect against severe disease and improved vaccine efficacy in younger individuals.
Researchers from Charité and the German Cancer Consortium studied colorectal cancer cells using single cell sequencing to identify adaptations that render treatment ineffective. The study provides insights into the development process of cancer and suggests ways to improve current treatment approaches.
A large clinical trial has identified empagliflozin as a treatment option for heart failure with preserved ejection fraction, reducing risk of hospitalization or death by 21 percent. The drug also showed fewer symptoms and mild side effects.
A clinical trial has shown that a triple combination therapy consisting of elexacaftor, tezacaftor, and ivacaftor is safe and effective in cystic fibrosis patients with rare genetic defects. The treatment improves CFTR function, lung function, and quality of life in these patients.
Scientists at Charité - Universitätsmedizin Berlin have identified a crucial communication pathway between peripheral circadian clocks, enabling tissue-level synchrony. Disrupting this pathway can lead to timing disruptions and increase the risk of metabolic disorders.