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Chiba University


New study expands the scope of aza-friedel−crafts reactions

Researchers developed a general para-selective aza-Friedel-Crafts type reaction of phenols with imines, opening up new possibilities for the rapid and safe synthesis of medicines and advanced materials. The bulky PyBidine-Ni(OAc)2 catalyst facilitated highly para-selective reactions with up to 99:1 selectivity.

SourceChiba University·JournalACS Catalysis·TypeExperimental study·DateJul 20, 2023

New study shows glutaminase 2 regulates glucose metabolism in pancreatic β-cells

A recent study published in Scientific Reports has uncovered the crucial role of glutaminase 2 in maintaining glucose homeostasis in pancreatic β-cells, particularly under conditions of hyperglycemia. The research team found that impaired GLS2 activity drives the onset of diabetes mellitus by disrupting insulin and glucagon regulation.

SourceChiba University·JournalScientific Reports·TypeExperimental study·DateJul 5, 2023

Unraveling brood parasitism in predatory mites

Researchers found that predatory mite species prefer to lay eggs near guarded host eggs when egg predators are present, increasing offspring survival. However, this comes at a cost for the host, which faces increased risk of thrip egg predation by the adult female parasite.

SourceChiba University·JournalFunctional Ecology·TypeObservational study·DateJun 6, 2023

How “extracellular chaperones” help remove abnormal proteins

A team of researchers identified the substrates targeted by alpha 2-macroglobulin for degradation. They developed a novel assay to detect its role in lysosomal degradation of extracellular proteins. This finding suggests that an array of extracellular chaperones cooperate to protect against misfolded proteins.

SourceChiba University·JournalScientific Reports·TypeExperimental study·DateMay 11, 2023

Sounds from nature: A soothing remedy for gambling addiction

A study by Chiba University researchers found that nature sounds significantly reduced stress levels and improved mood in participants with pathological gambling. Exposure to digital nature sounds of insects lowered oxyhemoglobin concentrations in the prefrontal cortex, indicating physiological relaxation.

SourceChiba University·JournalJournal of Integrative and Complementary Medicine·TypeExperimental study·DateApr 27, 2023

Non-invasive imaging of spatiotemporal ion distribution across cell membranes

Researchers at Chiba University developed a non-invasive imaging technique using electrical impedance tomography to study spatiotemporal ion distribution on cell membranes. The method successfully measured anisotropic transmembrane transport and calculated associated transport coefficients, providing insights into biological functions ...

SourceChiba University·JournalMeasurement·TypeExperimental study·DateFeb 21, 2023

Polycatenanes in mesoscale

A Japanese research group led by Professor Shiki Yagai has successfully created polycatenanes, self-assembled molecule rings that can be observed under a microscope. By using atomic force microscopy, they confirmed the structure of poly[22]catenane made up of as many as 22 connected rings, reaching up to 500 nm in length.

SourceChiba University·JournalNature·DateJul 15, 2020