Researchers found abnormal brain activity patterns due to bladder problems, potentially leading to disrupted sleep and attention issues. The study suggests targeting the locus ceruleus neural circuitry for potential treatment improvements in patients with bladder dysfunctions.
A new study by researchers at Children's Hospital of Philadelphia may lead to an emergency treatment for heart attack patients. By targeting gene pathways and inhibiting enzymes, the approach has shown promising results in reducing tissue damage and cell death during ischemia.
Researchers at Children's Hospital of Philadelphia discovered a genetic variant linked to all types of childhood arthritis, which may be a key factor in the development of juvenile idiopathic arthritis. The study suggests that targeting this gene could lead to more effective treatments with fewer side effects.
A study published in American Journal of Clinical Nutrition found that children born to mothers who gained excessive weight during pregnancy are more likely to be overweight at age seven. The researchers suggest that encouraging healthy eating and exercise before and after pregnancy may help prevent childhood obesity.
A new study found that kinship care provides protective value in terms of well-being and stability for children in out-of-home care. Three years after placement, nearly two-thirds of children in kinship care were in long-lasting settings with family, compared to only a third in foster care.
A large study of health records from 38 American children’s hospitals has measured adverse events that increase length of stay and overall cost. The researchers found that infections, respiratory failure following surgery, and postoperative sepsis are the most frequent adverse events.
A study by Children's Hospital of Philadelphia researchers identified a chromosome region that predisposes children to developing neuroblastoma, a fatal childhood cancer. The discovery could lead to the development of novel treatments and better interventions.
A large multicenter study found that corticosteroids do not reduce mortality or hospital stays in children with bacterial meningitis. The study analyzed medical records of 2,780 children and showed no significant difference in outcomes between those who received and did not receive corticosteroids.
Researchers have successfully used gene therapy to restore vision in three young adults with a rare form of congenital blindness. The study showed significant improvements in visual acuity and sensitivity to light, setting the stage for further studies.
A study by Children's Hospital of Philadelphia found that in the US and Asia, boys are twice as likely to receive growth hormone treatment for short stature compared to girls. The gender disparity is smaller in Europe and Australia, suggesting cultural biases towards male height in some countries.
Cardiology researchers at The Children's Hospital of Philadelphia have developed a synthetic material that can bind to various gene therapy vectors, allowing controlled local release of therapeutic genes. In an animal study, the new formulation showed significant reduction in restenosis, a hazardous narrowing of blood vessels.
A study found that nearly 1 in 50 US children missed MMR immunization after media coverage of the alleged autism link. Pediatricians' recommendations were a key factor in determining vaccination rates.
A recent study by Children's Hospital of Philadelphia found that children with congenital heart disease are at a higher risk of inattention and hyperactivity. The research, which involved 109 children aged five to 10, showed that nearly half of them required remedial services in school.
A genetic marker for obesity has been refined to better understand its role in various human populations. The finding suggests an ancient mutation that first arose in Africa may be a key factor in the development of obesity.
A novel brain cancer drug showed promising results in mice but caused permanent bone damage in younger animals. The study raises concerns about using similar drugs to treat children's cancers until further understanding of possible risks is gained.
Children examined by the same doctor are more likely to receive proper preventive health screenings, including lead poisoning, anemia, and tuberculosis. Researchers found that continuity of care is crucial for vulnerable pediatric patients.
Researchers found that obese teenagers who lost weight showed an increase in bone mineral content, contrary to expectations, and this effect was largely explained by changes in body fat and muscle during the weight loss program. This finding raises important questions about the impact of early onset obesity on lifelong bone health.
Dr. Vivian Cheung, a pediatric neurologist at Children's Hospital of Philadelphia, has been selected as a Howard Hughes Medical Institute Investigator. Her research focuses on translating genetic discoveries into improved medical treatments by analyzing gene expression and its association with disease susceptibility.
Researchers at Children's Hospital of Philadelphia developed a simple test to accurately predict risk of serious jaundice in newborns, combining bilirubin levels and gestational age. The study found that about 70% of babies were low-risk, while 13% were high-risk and 17% were in the middle category.
Scientists have successfully used magnetic fields and nanoparticles to deliver healthy cells to targeted sites in blood vessels. The research, done in animals, may lead to a new method of delivering cells and genes to repair injured or diseased organs in people.
Researchers have identified lung injury in nonsmokers exposed to secondhand cigarette smoke using a special type of magnetic resonance imaging. The study found structural changes in the lungs similar to those found in smokers, suggesting early signs of emphysema or chronic bronchitis.
A study on lung transplantation for children with cystic fibrosis found no survival advantage for young patients, contradicting previous research. Pediatric pulmonologist Julian Allen calls for more judicious referrals and social support for families making decisions about treatment.
The study found that children who received continuous peripheral nerve blockade (CPNB) for pain management after orthopaedic surgery had better pain control and a shorter hospital stay. The catheter system offers continuous relief for up to 100 hours, potentially cheaper than alternative treatments and long hospital stays.
A study by The Children's Hospital of Philadelphia found that nearly one in four children with heart disease are overweight or obese, highlighting the need for doctors to counsel families on safe exercise routines. The researchers also noted that discussions about weight control were relatively uncommon during cardiology clinic visits.
A study found that children with Down syndrome have significantly higher body mass index and percentage of body fat compared to their siblings. Leptin levels also correlate with these differences, suggesting a genetic predisposition to leptin resistance in individuals with Down syndrome.
Genetics experts at The Children's Hospital of Philadelphia will investigate Ring chromosome 20 syndrome, a rare disorder causing severe epilepsy and mental retardation. The study aims to identify patients, establish cell lines and analyze patterns of gene expression to guide future treatments.
Researchers at Children's Hospital of Philadelphia successfully delivered beneficial gene to entire mouse brain with one injection, correcting diseased areas. The technique has potential for treating rare genetic neurological disorders like Tay-Sachs disease and Sly syndrome.
Researchers have developed a biodegradable nanoparticle delivery system that uses magnetic forces to target specific cells in the body. The system has shown promise in reducing cell proliferation and delivering anti-growth genes to stents, which could help maintain blood flow.
Researchers at Children's Hospital of Philadelphia identified a gene variant associated with an increased risk of Crohn's disease in children. The study found that 64% of children with the disease had a specific variant form of the ATG16L1 gene, compared to 52% of healthy children.
Researchers have identified a new gene, KIAA0350, associated with an increased risk of type 1 diabetes in children. The study used genome-wide association to analyze DNA samples from 1,046 children with the disease and found a significant link between a specific genetic variant and the development of type 1 diabetes.
A new study published in the Journal of the American Medical Association found that daily antibiotics do not prevent future urinary tract infections and may actually increase the risk of resistant bacteria. The study analyzed data from over 74,000 children with at least two clinic visits between 2001 and 2006.
A study of 382 healthy children revealed that over half had low blood levels of vitamin D, with 55% having inadequate levels. Vitamin D deficiency may contribute to bone diseases like rickets and other health issues.
A recent study found that children with serious complex illnesses are more likely to die at home than in hospitals, especially among African American and Hispanic patients. The shift towards home care raises questions about how to provide optimal care and resources for very sick children.
Researchers have made progress in treating neuroblastoma, a difficult pediatric cancer, with new approaches such as radioactive isotopes and targeted therapies. However, further understanding of the disease's precise biology is needed to guide optimal treatment choices.
Researchers have identified a well-known cell receptor that sends a 'nondanger' signal to dampen the immune system. This discovery raises the possibility of targeting this receptor to prevent overzealous immune responses in transplant patients and alleviate symptoms of autoimmune diseases like rheumatoid arthritis.
Adult stem cells are not responsible for producing insulin, contrary to previous research. Instead, beta cells slowly divide to replenish their own population. This discovery advances basic knowledge of insulin biology and could lead to eventual therapies.
Researchers report on patients who suffered toxic side effects from taking excessive doses of niacin, a common vitamin used to pass urine drug tests. The study warns against this practice due to the risks of liver toxicity, hypoglycemia, and other serious health issues.
A new US study found that nearly four out of five hospitalized children receive medications approved for adults, highlighting the need for further research on pediatric drug approval. The study also revealed that children who undergo surgery or have severe illnesses are more likely to receive off-label drugs.
Researchers have identified a novel biological pathway that may contribute to cases of mental retardation and autism, with mutations in two genes causing brain abnormalities and milder symptoms than classical forms of Cornelia deLange syndrome.
A recent study of 4,500 American adolescents found that sedentary activities and higher body mass index (BMI) are associated with higher systolic blood pressure. Encouraging adolescents to reduce their sedentary activity may improve their blood pressure and lower their later risk of cardiovascular disease.
Researchers used positron-emission tomography (PET scan) to diagnose a type of congenital hyperinsulinism, achieving an accuracy rate of 96% in locating the abnormal spot. The technology is highly effective in pinpointing focal lesions, guiding surgeons to curative organ-sparing surgery.
Researchers found that higher levels of hopefulness among pediatric nurses correlate with greater comfort and competence in providing palliative care. Nurses who received more palliative care education reported being more hopeful and confident in their abilities.
A new research effort harnesses in-depth understanding of genes and molecular pathways to develop highly specific drugs designed to kill leukemia cells while causing few or no toxic effects on normal cells. The goal is to streamline advances in molecular medicine to find new treatment options for infant leukemia.
A study by Children's Hospital of Philadelphia researchers found that p53 regulates insulin-like growth factor-I (IGF-I) signaling, which may contribute to cancer progression and aggressiveness. The study also suggests that inhibiting IGF-I signaling could lead to novel therapies for cancer.
Researchers used gene therapy to modify signaling pathways in the brain, significantly reducing epileptic seizures in rats. The study suggests that altering specific signaling pathways in nerve cells after a brain insult may help prevent epilepsy.
A new study by Children's Hospital of Philadelphia reports that hospital costs for influenza-related admissions in children are significantly higher than previously thought, with costs ranging from $7,000 to $40,000. The study supports the economic case for annual flu vaccinations, especially for high-risk conditions.
A new study found that traumatic brain injury reduces potassium-chloride co-transporter 2 (KCC2) levels in the dentate gyrus, leading to abnormal activity and seizures. The research also suggests that this imbalance may impair memory formation, particularly antegrade memory.
A large multicenter study found that adult survivors of childhood cancer are more than three times as likely to have chronic health conditions and eight times as likely to experience severe or life-threatening conditions. Long-term survivors were particularly vulnerable to second cancers, heart conditions, and endocrine abnormalities.
A recent study found that women who take multivitamins early in pregnancy may reduce their child's risk of developing certain types of brain tumors. The protective effect was strongest when multivitamins were taken close to conception, with a weakly significant reduction in the risk of medulloblastoma and primitive neuroectodermal tumors.
Researchers developed culturally sensitive cartoons to measure aggressive behavior in African American inner city schoolgirls. The cartoon versions were found to be as valid as written descriptions in measuring how these girls interpret social situations.