A study finds that citizens do a better job of picking threatened species than the US Fish and Wildlife Service. Citizen-initiated listings are more likely to pose conflicts with development, but those species are also significantly more threatened on average.
Scientists have identified a group of blood markers that show consistent findings in patients with Alzheimer's disease and mild cognitive impairment. The study found four proteins that correlated with beta-amyloid levels in cerebrospinal fluid, providing potential clues for an early diagnosis.
A new study found that Cognitively-Based Compassion Training (CBCT) improved the mental and physical health of adolescents in foster care by reducing anxiety and increasing feelings of hopefulness. CBCT also reduced inflammation levels, which is a fundamental risk factor for chronic illnesses.
Researchers have discovered that tPA can protect brain cells from oxygen and glucose loss after a stroke, even when its clot-dissolving powers are removed. A modified version of tPA could provide benefits to patients without increasing the risk of bleeding.
Researchers identified five rare mutations in the AFF2 gene that appear to increase the chances a boy will develop an autism spectrum disorder (ASD). Mutations in X chromosome genes affect four times more boys than girls. The study bolsters a growing consensus that rare variants contribute significantly to ASD risk.
Researchers at Emory University School of Medicine have identified a new class of anti-inflammatory compounds that inhibit the Nox2 enzyme, which produces reactive oxygen species. This approach may be more effective than traditional antioxidants in treating conditions like stroke, heart failure, and neurodegenerative diseases.
Researchers have identified a master regulator gene, Spi-B, essential for the development of M cells, which play a crucial role in initiating immune responses. This discovery could aid research on oral vaccines and inflammatory bowel diseases by providing valuable insights into M cell differentiation and function.
Researchers at Yerkes National Primate Research Center found that a single light-shock event isn't enough to make rats afraid of the light, but a repeat of the pairing is. This priming effect could lead to new insights into learning and memory treatments or interfere with troubling memories.
An Emory University analysis suggests environmental factors trigger the monarchs' choice of winter homes, rather than genetic differences. The researchers found extensive gene flow between eastern and western monarchs, challenging the prevailing theory of distinct populations.
Researchers found that a mutation in the BTBD9 gene in fruit flies disturbs sleep patterns, similar to restless legs syndrome (RLS) in humans. The mutant flies have altered dopamine levels and are more mobile during wakefulness.
Researchers have made a significant discovery that the pandemic 2009 H1N1 vaccine can produce antibodies against not only the H1N1 virus but also other influenza virus strains including H5N1 and H3N2. This breakthrough brings the team closer to developing a pan-influenza vaccine that can reliably induce broadly cross-reactive antibodies.
Researchers have shown that gene therapy can induce the formation of extra sensory hair cells in young mice, but this approach has limitations in older animals. Introducing a specific gene called Atoh1 into the cochleae of young mice can produce electrical signals and connect with neurons.
Researchers used fMRI technology to scan the brains of alert dogs, revealing how they react to human signals. The study aims to decode canine mental processes and understand their empathy and language abilities.
Researchers discovered a link between ACE inhibitors and ARBs and lower PTSD symptom scores in patients taking these medications. The findings suggest that these blood pressure medications could be valuable tools for treating or preventing post-traumatic stress disorder.
Researchers found that a monkey's social status affects its immune system, allowing for accurate predictions of an individual's rank. The study used microarrays to analyze gene expression levels and showed that inflammation patterns change along with social rank.
Researchers developed a novel compound that stops cancer cells from invading healthy brain tissue, improving treatment outcomes in animal models. The compound, imipramine blue, is combined with chemotherapy to enhance its effectiveness.
Researchers developed a noninvasive imaging technique using magnetic resonance spectroscopy to detect 2-hydroxyglutarate, a chemical produced by some brain tumors' warped metabolism. The technique can predict the presence of IDH1/2 mutations with 98% accuracy and may help doctors tailor treatment plans.
Researchers at Winship Cancer Institute developed a technique to remove cancer cells' defenses against radiation by disabling their ability to repair DNA. The experimental method uses RNA molecules that shut down genes needed for DNA repair, making brain and lung cancer cells more sensitive to X-ray radiation.
Researchers found that blocking PD-1 molecule after antiretroviral therapy interruption can significantly enhance viral control in SIV-infected monkeys. The effect depends on maintaining measurable immune cell response following therapy.
SIV's natural hosts, non-human primates, display a unique immune response to the virus, characterized by low immune activation and efficient preservation of immune cells. This study suggests that understanding these adaptations could inform medical care for people living with HIV.
Scientists at Emory University and GeoVax Labs developed a vaccine that protected nonhuman primates against multiple SIV exposures over three years. The vaccine regimen included a DNA prime vaccine with GM-CSF, which enhanced immune responses and provided 70-84% overall protection.
Research found microneedle vaccine patches are more effective than traditional inoculation methods against influenza virus in mice. The patches trigger a local increase of cytokines and activate dendritic cells, leading to a strong innate immune response.
Research suggests that T cells play a role in stress-dependent hypertension, and that medications targeting the immune system may also help control anxiety disorders. Mice studies found that T cell deficiency led to reduced blood pressure sensitivity to stress.
Researchers found that a memory training strategy can help people with mild cognitive impairment (MCI) remember specific information, such as object locations. The technique showed increased activity in the hippocampus, a critical brain region for forming new memories.
Researchers propose that depression and related behaviors arose from genetic variations that helped ancestors fight infections, reducing mortality. This theory links depression to inflammation and physiological responses that were selected for reducing mortality from infection.
Researchers at Emory University identified a new function for p14 ARF, a gene that normally prevents cancer. The protein regulates tumor-induced angiogenesis, attracting new blood vessels to growing tumors. Restoring p14 ARF interferes with this process, suggesting a potential therapeutic target.
A recent study by Emory University found that fruit flies infected with blood-borne parasites consume alcohol to increase their survival rate. The researchers discovered that the toxic effects of alcohol can be protective against infectious disease and raise an important question about whether other organisms, including humans, could c...
Scientists at Emory University School of Medicine identified a new group of compounds that block signals from EP2, a receptor involved in inflammation. The compounds could potentially treat neurological diseases such as epilepsy and stroke.
Researchers found that listening to sentences with textural metaphors activates the parietal operculum, a region associated with sensing texture through touch. This suggests that our brains use sensory experiences to understand metaphorical language.
Researchers used whole-exome sequencing to diagnose a type of severe metabolic disease, identifying the genetic mutation responsible. The study showcases the potential for this technique to aid in diagnosing congenital disorders of glycosylation, offering new hope for families affected by these conditions.
A recent Emory University neuro-imaging study found that personal values, especially those considered 'sacred', are processed differently in the brain. This distinct cognitive process is linked to activation of neural systems associated with rules-based thought processes.
Researchers analyzed 28 studies on real-world lifestyle interventions for type 2 diabetes prevention and found a significant average weight loss of 4% after one year. The cost-effectiveness of these programs was shown to be comparable to the Diabetes Prevention Program (DPP) trial, making them a viable option for preventing diabetes.
Clearside Biomedical aims to treat age-related macular degeneration and glaucoma with a new microinjection technology that targets the back of the eye. The technology developed by Georgia Tech and Emory University uses hollow microneedles to deliver therapeutics precisely to specific locations in the eye.
A new study published in Archives of General Psychiatry found that deep brain stimulation is a safe and effective intervention for treatment-resistant depression in patients with unipolar and bipolar disorders. After four weeks of single-blind stimulation, 58% of patients achieved remission and showed significant improvement in function.
Researchers identify PDHK enzyme as a key player in cancer cell metabolism, enabling targeted anti-cancer therapy. Inhibiting PDHK activity slows tumor growth and reduces glucose uptake by cancer cells.
The partnership aims to strengthen national public health institutes globally, leveraging IANPHI's peer-assistance model and the CDC's expertise. The project will focus on four low-resource countries, with the goal of creating sustainable capacity building efforts.
Researchers at Emory Vaccine Center found that infusing immune cells back into patients after a period of conditioning can revive exhausted cells. This cell-based treatment, combined with an antibody against PD-1, reduced viral levels by a factor of four and made the virus undetectable in some mice.
Researchers discovered that targeting host enzymes with imatinib reduces M. tuberculosis load and enhances traditional antibiotics' effectiveness. This approach limits infection and may reduce antibiotic-resistant strains.
Researchers at Emory University School of Medicine have identified a garlic oil component that can deliver the benefits of hydrogen sulfide to the heart. At low concentrations, diallyl trisulfide has been shown to protect the heart from damage by reducing damaged tissue and lowering reactive oxygen species.
Hepcidin, a hormone that regulates iron levels, may be targeted to treat atherosclerosis. Suppressing hepcidin reduces iron levels in white blood cells, promoting reverse cholesterol transport and interfering with atherosclerosis progression.
A new study finds that atherosclerotic plaques often form in regions of low shear stress immediately downstream, creating conditions favorable for additional plaque buildup. High shear stress is typically found within existing plaques, suggesting its role in maintaining their stability.
A nationwide study finds depression and a history of suicide attempts in young people markedly increase their risk for dying from heart disease. Women are particularly at risk, with a three times higher risk of cardiovascular disease and 14 times higher risk of ischemic heart disease.
A new method visualizes mechanical forces on cell surfaces in real-time, providing detailed view of forces as they occur. The technique has potential to diagnose and treat diseases related to cellular mechanics.
Patterns formed by a new DNA letter, 5-hydroxymethylcytosine (5-hmC), suggest it has specific functions in stem cells and brain. The study's findings indicate that 5-hmC may poise genes to be turned on after being repressed.
Theoretical chemists at Emory University have solved an important mystery about the rates of chemical reactions and the Polanyi rules. They found that a pre-reactive long-range force can align the reaction of a chlorine atom with methane, inhibiting the reaction. The research has implications for the development of cleaner fuels.
A new method has enabled the accurate sequencing and identification of genetic variants on the X chromosome, a hotspot for genes linked to autism and intellectual disability. The technology allows for fast and efficient analysis, potentially leading to easier clinical diagnosis and novel discoveries.
Researchers at Emory University School of Medicine have identified a set of genes that act in muscles to modulate aging and resistance to stress in fruit flies. Mutations in these genes speed up the process of aging and make the flies more sensitive to oxidative stress.
Researchers at Emory and Johns Hopkins universities have quantified the data capacity of a biochemical signaling pathway for the first time, finding that it is significantly lower than expected. The study suggests that cells may use alternative methods to communicate when their primary pathways are insufficient.
Researchers at Winship Cancer Institute of Emory University have identified a way to keep the cancer-preventive properties of celecoxib while avoiding its risks. The study shows that celecoxib inhibits an enzyme called GSK3 in lung cancer cells, causing apoptosis and disappearance of a protein called c-FLIP.
Researchers identified FOBISIN, a compound that targets 14-3-3 proteins, which are dysregulated in multiple cancers. X-ray analysis showed FOBISIN permanently bonds to the protein when exposed to radiation, triggering potent anticancer activity