A study by Fox Chase Cancer Center found that targeted educational initiatives improved the number of lymph nodes retrieved during colorectal cancer surgery. The interventions increased the percentage of operations with at least 12 nodes removed over four years, leading to more accurate staging and improved survival for patients.
A study by Fox Chase Cancer Center found that approximately 17% of individuals were at high-risk, while 70% were at moderate-to-high risk. The researchers emphasize the importance of accurately assessing cancer risk to provide targeted prevention support.
Patients undergoing robotic-assisted partial nephrectomy experience improved outcomes, with faster recovery times and lower blood loss. This minimally invasive approach enables earlier return to normal activity, reducing the delay in treatment for patients with kidney cancer.
A new robotic approach to surgically treat urothelial cancer of the kidney is proving to be effective, offering benefits such as less bleeding and scarring, shorter hospital stays, and faster recovery times. The minimally invasive surgery allows for the preservation of kidney function in patients with stage 3 chronic kidney disease.
A study by Fox Chase Cancer Center found that patients with Medicare are less likely to undergo kidney-sparing surgery for renal cell carcinoma compared to those with private insurance. This disparity affects the quality of care and has implications for healthcare reform.
Researchers have developed an engineered antibody called DTA-1 that helps the immune system overcome its natural reluctance to attack tumor cells. In a mouse model of melanoma, DTA-1 led to rejection of 50-60% of tumors by impairing regulatory T cells, providing new hope for improved cancer treatment options.
Researchers at Fox Chase Cancer Center identified a genetic pattern that may predict how patients respond to imatinib mesylate, and found genes that could be suppressed to enhance therapy effectiveness. The study's findings suggest potential new strategies for improving treatment outcomes in gastrointestinal stromal tumor patients.
Researchers at Fox Chase Cancer Center found that smaller doses of human chorionic gonadotropin (hCG) can prevent breast cancer in rats. The study suggests that even shorter exposure to hCG may offer protective benefits against the disease.
Researchers have identified a panel of proteins that could serve as harbingers of cancer in pancreatic lesions, allowing for earlier treatment. The technique can detect these biomarkers in tiny amounts of fluid from small cysts, potentially improving diagnosis and treatment.
Fox Chase researchers have shown that manipulating the amount of Hsp70 can restore function to mutated proteins, which could potentially reduce severity or correct certain hereditary diseases. By modifying the chaperone environment, they hope to give Hsp70 better opportunities to rescue broken proteins.
Survivors of early-stage lung cancer who engage in regular physical activity experience improved mood, vigor, and physical functioning. Moderate exercise, such as brisk walking a few times a week, may promote better quality of life and reduce depressive symptoms.
A phase III, international randomized clinical trial supports a new standard of treatment for women with advanced ovarian cancer, reducing complications and post-operative deaths. The study demonstrates that neoadjuvant chemotherapy followed by interval debulking surgery can be the preferred treatment for patients with very extensive d...
A study by Fox Chase Cancer Center researchers reveals that BubR1 protein plays a crucial role in chromosome distribution during mitosis. Mutating this protein may cause genetic shuffling similar to that seen in cancer cells, making it a potential target for cancer treatment enhancement.
Fox Chase researchers create bispecific antibody ALM that attacks two signaling proteins on breast cancer cell surfaces, halting growth. The molecule could deliver therapeutic drugs directly to cancer cells or aid in early detection.
Researchers found that video-assisted thoracic surgery (VATS) for stage I non-small cell lung cancer results in shorter post-operative hospital stays and faster removal of chest tubes compared to traditional open surgery. The study also showed comparable outcomes in terms of surgical success and complication rates.
A new study from Fox Chase Cancer Center suggests that young women with DCIS are not more likely to experience recurrence than older women. The study analyzed data from 440 patients treated between 1978 and 2007 and found no significant difference in recurrence rates based on age.
Researchers found that older men with high-risk prostate cancer who received hormone therapy lived longer and experienced fewer PSA increases compared to those without treatment. A longer duration of hormone therapy resulted in improved overall survival rates, especially among those over 70.
A new Fox Chase Cancer Center study suggests men with early stage prostate cancer treated with radiation therapy should begin hormone therapy immediately if their PSA level rises quickly and doubles within six months at any time after treatment. The study also supports foregoing hormones if the PSA doesn't rise as quickly. These findin...
Researchers at Fox Chase Cancer Center have developed a prediction tool that estimates the benefit of adding androgen deprivation therapy to radiation therapy for high-risk prostate cancer patients. The tool takes into account disease burden and individual patient characteristics, allowing for personalized treatment recommendations.
A new study at Fox Chase Cancer Center found that irradiating axillary and supraclavicular lymph nodes may not improve outcomes for breast cancer patients with negative lymph nodes. The research suggests avoiding radiation to these areas may reduce serious side effects such as lymphedema and pulmonary problems.
A study by Fox Chase Cancer Center found that breast cancer survivors reported a high level of overall quality of life several years after treatment, with some improvements over time. The survey tool used measured health outcomes using the EQ-5D instrument and compared results to a general US adult population.
A team of Fox Chase researchers has identified a single genetic mutation as a key factor in the development of colorectal cancer. By studying individuals with a inherited 'one-hit' gene mutation, they discovered molecular changes that signal cancer presence and potential targets for preventive drugs.
A new study suggests that routine use of MRI scans in women with newly-diagnosed breast cancer may lead to delays in treatment and an increase in mastectomies. The study found that younger women were more likely to receive MRIs, but failed to improve surgical outcomes.
A study by Fox Chase Cancer Center found 27% of college students exhibit symptoms of tanning dependence, similar to substance addictions. Thinness and cigarette smoking are linked to higher rates of tanning dependence, suggesting potential avenues for prevention.
Researchers have identified a novel activity, called mitotic checkpoint factor 2 (MCF2), that prevents cells from dividing with improperly separated chromosomes. This finding may help increase the efficiency of cancer drugs and improve our understanding of mitosis.
Researchers at Fox Chase Cancer Center have discovered a small molecule that locks an essential enzyme in an inactive form, potentially leading to the development of new antibiotics. The discovery targets morpheeins, proteins made from individual components that can reconfigure themselves within living cells.
A quality-control audit found high compliance with Fox Chase Cancer Center's Partners program, which shares advanced cancer treatment guidelines with community hospitals. The study suggests that this partnership is an effective model for quickly disseminating advances in cancer treatment.
Excess IGF-1R protein indicates reduced responsiveness to Gleevec in gastrointestinal stromal tumors. Alternative treatments may be effective for patients with high IGF-1R levels.
Ning Wong, a physician at Fox Chase Cancer Center, has received the ASCO Career Development Award for her exceptional work in genitourinary malignancies and health services research. The $200,000 grant will support her independent clinical cancer research program.
Researchers at Fox Chase Cancer Center have identified a molecule, IPA-3, that can shut down PAK1, an enzyme involved in pathways leading to breast cancer. The molecule achieves high selectivity for PAK1 by binding to its auto-regulatory arm, preventing the enzyme from becoming active.
Research found that indoor tanning is a concern for all age groups, with 20% of 18-39 year olds and 10% of 50-64 year olds tanning indoors. Older adults who tan indoors have higher skin cancer risk due to cumulative exposure.
Researchers at Fox Chase Cancer Center have discovered that a genetic misalignment can turn a normally quiet developmental gene into a potent driver of T-cell lymphoma in adult mice. The study found that the Dlx5 protein, which is not typically active in healthy adult cells, can be targeted for inhibition to slow cancer growth.
The initiative aims to bring team-based science to bear on major cancer research questions, integrating expertise and resources to solve the most challenging problems. Twelve proposals were reviewed by an external scientific advisory panel, and four Keystone Programs were awarded $5 million in funding over five years.
A new study finds that women with higher levels of perceived stress are more likely to have an impaired immune response to HPV16, increasing their risk of developing cervical cancer. Most HPV infections in healthy women will disappear spontaneously over time.
Researchers are developing new drugs that can modulate male hormone receptors to improve muscle weight without stimulating prostate glands. Studies have shed light on the complex mechanisms behind estrogen receptors in different tissues.
Researchers discovered a correlation between pre-treatment biopsy samples and post-treatment positive biopsies in high-risk prostate cancer patients. This information can help doctors tailor radiation treatment to reduce recurrence rates.
Children of BRCA mutation carriers are more likely to support genetic testing, despite potential risks and benefits. A study found that 40% of parents and their adult offspring supported testing minors, with half in favor only in certain circumstances.
A new study by Fox Chase Cancer Center reveals that most American adults engage in multiple behaviors increasing their exposure to UV rays, including infrequent sun protection and indoor tanning. The study found that younger adults, men, Caucasians, smokers, and those with fair skin are more likely to engage in these high-risk behaviors.
A study at Fox Chase Cancer Center found that men with female relatives testing positive for a BRCA mutation have an increased risk of developing prostate and breast cancer, yet many are unaware of this risk. The study highlights the need for better communication between healthcare providers and male family members about genetic test r...
A large-scale analysis of over 2,000 patients reveals that men with high-risk prostate cancer who receive radiation therapy after a prostatectomy are less likely to experience disease recurrence. Additionally, men whose cancer persists after surgery benefit from reduced cancer spread if they receive salvage therapy.
A prospective study found that quality of life surpasses classic predictors like disease stage and tumor size in determining survival. Patients with better quality of life scores had a significantly higher rate of survival.
Men with low-risk prostate cancer who miss two or more radiation treatments in an eight-week course face a higher chance of their cancer recurring. The study of nearly 1,800 patients found that controlling cancer within the prostate and preventing its spread outside makes the greatest difference for these patients.
A new study by Fox Chase Cancer Center found that higher doses of radiation therapy for prostate cancer do not lead to decreased sexual function. The research used intensity-modulated radiation therapy (IMRT) and showed no significant difference in sexual function scores between two treatment groups.
Researchers found that women with early-stage breast cancer who received intensity-modulated radiation therapy (IMRT) had significantly fewer cases of serious dermatitis compared to those receiving conventional radiation. The study also showed that patients treated with IMRT experienced a shorter duration of dermatitis.
A study of 6,162 breast cancer patients found that smoking does not lead to more aggressive or advanced breast cancers at diagnosis. Researchers analyzed data from 1970 to 2006 and discovered no correlation between tobacco use and tumor stage or aggressiveness.
Researchers found that PET scans at 3 months post-treatment can evaluate tumor response earlier and more accurately than current methods. Stereotactic body radiotherapy may be as effective as surgery in treating small tumors, but early detection is crucial to prevent treatment delays.
A new study reveals that more than half of parents with a BRCA mutation share their genetic test results with children under 25. Many children experience initial negative reactions and struggle to understand the significance of this information. Further research is needed to address the emotional impact on these families.
Postmenopausal Asian women who consume a meat-sweet Western diet are at higher risk of developing breast cancer compared to those on a vegetable-soy diet, according to the study. The researchers found that high intake of the meat-sweet pattern increased estrogen-receptor-positive breast cancer among overweight postmenopausal women.
Researchers found that two proteins, HEF1 and Aurora A, control the temporary disappearance of cilia during normal cell division, leading to an untimely disassembly. This loss of cilia may contribute to cancer development by disrupting cellular response to environmental cues.
Researchers at Fox Chase Cancer Center discovered that memory CD8 T cells can protect against viral diseases without migrating to the site of infection. These cells rapidly multiply and kill target cells inside the lymph node, decreasing viral spread to vital organs.