A Fox Chase Cancer Center study found IMRT to be cost-effective for men with intermediate-risk prostate cancer, improving quality-adjusted survival and reducing the need for additional treatments. The study's findings suggest that IMRT may offer better value compared to traditional conformal radiotherapy.
Fox Chase Cancer Center researchers have identified hypermethylation of BRCA1 and RASSF1A genes as a potential target for detecting ovarian cancer in blood. The study found that 82% of patients with ovarian cancer had hypermethylated genes in their blood DNA, making it a promising diagnostic tool.
Knudson was awarded the basic sciences prize for his role in establishing the theory of tumor suppressor genes, which opened a new horizon in modern cancer genetics. His work holds implications for both treatment and prevention, and has led to advances in understanding human cancer.
A study has identified a biomarker that can predict which colon cancer patients are most likely to respond to a specific chemotherapy regimen. The enzyme thymidine phosphorylase (TP) is found in some, but not all, cancers and is believed to activate the drug capecitabine.
Researchers at Fox Chase Cancer Center have discovered genetic markers that can predict how well patients with colorectal cancer will respond to certain chemotherapy drugs. The study found that variations in genes involved in metabolizing irinotecan may be useful predictors of response and side effects.
Cohen's team found that fibroblast activation protein (FAP) and focal adhesion kinase (FAK) are overexpressed in over 90% of pancreatic adenocarcinomas, suggesting they may contribute to poor outcomes. However, selective inhibition of these proteins shows promise in preclinical models.
Researchers have identified a critical regulatory region for the development of the enteric nervous system, which plays a vital role in gastrointestinal functions. Genetic mutations in this region may lead to incomplete development of the enteric nervous system, often causing Hirschsprung disease.
Fox Chase Cancer Center and Wilex partner to accelerate development of anti-cancer drug for breast cancer treatment. The open-label Phase I study will evaluate safety and biological activity of WX-UK1 in combination with chemotherapy agent capecitabine.
A study by Fox Chase Cancer Center researchers has identified the human ABCA2 transporter as a potential therapeutic target for Alzheimer's disease. The protein is also involved in cancer drug resistance and plays a role in cholesterol transport and myelination, which may contribute to the development of Alzheimer's disease.
Researchers developed a non-invasive test to detect kidney cancer using gene changes found in urine samples. The test accurately identified stage I disease and showed no false positives.
A study found that over half of men taking part in a prostate cancer risk assessment program reported using dietary supplements to prevent the disease. The most commonly used supplements were vitamins and minerals, with saw-palmetto being one popular option.
The partnership aims to educate junior, cadette and senior girl scouts about the responsibilities of nurses, educational requirements and general health and wellness information. The program showed increased interest in pursuing nursing careers among participating scouts.
Anaphylactic and anaphylactoid reactions can occur in cancer patients receiving potentially life-prolonging agents, necessitating expert nursing care. Nurses play a critical role in monitoring patients, stabilizing reactions, and providing emotional support.
The article highlights the complexities of managing cancer pain in patients with a history of addiction, emphasizing the need for multidisciplinary care teams. The Pain Management Center at Fox Chase Cancer Center offers innovative strategies, including patient contracts and collaboration between nurses and physicians.
Dr. Bruner, a renowned radiation oncology nurse, has been recognized by the Oncology Nursing Society for her groundbreaking work in cancer research and patient care. Her research focuses on enhancing participation of minorities in clinical studies and improving treatment outcomes.
The article discusses Fox Chase Cancer Center's implementation of certified nursing assistant (CNA) positions to support experienced nurses. The CNA program has led to a significant decrease in turnover rates, with a reduction of over 20% since its introduction in 2001.
Scientists at Fox Chase Cancer Center successfully extracted high-quality RNA from archived tissue samples using the Paradise Reagent System. This innovation allows researchers to identify genetic changes in cancer that span years, enabling personalized therapy.
Researchers found 53 smoking-induced genetic alterations in mice exposed to tobacco smoke, with CYP1B1 enzyme overexpression linked to estradiol activation. This finding may help understand why female smokers are more susceptible to lung cancer than male smokers.
Researchers found that COX-2 over-expression promotes loss of basement membrane in ovarian epithelium cells, leading to disorganization and cancer. The study suggests COX-2 inhibitors may prevent cancer development by reducing basement membrane loss.
A recent study has revealed a connection between FAP, a protein involved in tadpole tail resorption, and accelerated tumor growth in humans. Researchers found that producing high levels of FAP in the tumor microenvironment promotes cancer growth. The study also explores the potential use of antibodies to block FAP's action.
A new urine-based test has been developed to detect kidney cancer, showing promising results in early diagnosis. The test identified gene changes in the urine of patients with kidney cancer that matched those found in tumor samples, indicating its potential as a diagnostic tool.
A Fox Chase Cancer Center researcher has developed a new model for studying prions, which are misfolded proteins responsible for diseases such as BSE and Alzheimer's. The study aims to unravel the molecular basis of prion formation, which is crucial for developing treatments.
Researchers at Fox Chase Cancer Center discovered a novel DNA-repair gene mutation that causes resistance to cancer drugs, particularly in colorectal cancer. The defective MED1 enzyme interferes with chemotherapy's effectiveness, making cancers resistant to widely used treatments.
A study of 85 breast cancer patients reveals low complication rates for reconstruction after radiation therapy, with no major complications in TRAM flap recipients and only 5% of implant patients experiencing major complications. The study also found that TRAM patients had superior cosmetic scores compared to implant recipients.
A study of 1,204 men treated with radiation therapy found that hormone therapy significantly increases the risk of moderate to severe genitorurinary and gastrointestinal side effects. Hormone therapy can extend lives but complicates treatment decision-making.
A recent study found that whole-breast irradiation after lumpectomy significantly reduces the risk of recurrence in other parts of the breast. The use of tamoxifen in addition to radiation was associated with the lowest risk of recurrence.
A study by Pollack and colleagues finds that a high Ki-67 biomarker is linked to increased risk of distant metastasis and death in prostate cancer patients. The researchers also suggest that Ki-67 can help identify high-risk patients who may benefit from alternative treatment strategies.
A recent study found that practice type and patient race are significant predictors of enrollment in clinical trials. Academic settings and white patients showed higher rates of trial participation, while non-academic sites and African-Americans had lower rates.
A study tested the ASTRO consensus definition of biochemical failure after combined radiation treatment and hormone therapy, finding it may not accurately predict future disease progression. The study suggests that approximately 20-30% of patients will experience biochemical failure but not continued rises in PSA levels
High doses of radiation therapy directed at the prostate significantly impact cancer control in high-risk patients. The major site of treatment failure is the prostate, highlighting the importance of high doses in this group.
Researchers analyzed a large dataset of prostate cancer patients treated with radiation therapy alone. The study examined multiple definitions of biochemical control and found three alternate definitions that offered more accurate predictions of treatment failure.
A recent study published at Fox Chase Cancer Center found that breast cancer patients who did not smoke had significantly better long-term outcomes than those who smoked after undergoing lumpectomy and radiation treatment. The study of over 1,000 patients showed that smoking cessation is crucial in managing breast cancer.
A multi-center study led by Fox Chase Cancer Center oncologist aims to develop an interactive internet-based tool to assess patient values and information needs, providing education on cancer treatment and communication skills training. The goal is to improve doctor-patient communication and patient satisfaction.
The Fox Chase Breast Cancer and Environmental Research Center will investigate how natural environmental exposures affect breast cancer predisposition. The center, funded by NIH agencies, will collaborate with other centers to analyze the effects of specific environmental agents on mammary tissue development.
A systematic review and meta-analysis found that men with a family history of prostate cancer have an increased risk of developing the disease. The study revealed a 2.9 fold increased risk when the affected relative was a brother, highlighting the importance of identifying at-risk populations for targeted screening.
Research suggests that obesity increases breast cancer risk in postmenopausal women by raising serum estrogen levels. The study analyzed blood samples from over 1,600 women and found a significant link between obesity and increased estrogen levels, highlighting the importance of controlling this modifiable risk factor.
Researchers from Fox Chase Cancer Center have discovered a rare genetic mutation in PBGS enzyme, resulting in a drastic structural rearrangement. This change can lead to the production of new protein complexes and potentially develop novel herbicides or antibacterial agents.
Researchers have developed a new generation of targeted cancer therapies using bispecific antibodies that target multiple proteins in cancer cells, increasing radiation sensitivity and specificity. The therapy is expected to improve treatment outcomes for patients with breast and ovarian cancers.
Researchers at Fox Chase Cancer Center developed a transgenic mouse model of epithelial ovarian cancer, allowing scientists to study the disease's progression from early stages. The model has the potential to facilitate advances in early detection and treatment of ovarian cancer.
Researchers found that the arginine variant of p53 is more efficient at killing cells and travels out of the nucleus to function in the mitochondria. This discovery could lead to personalized cancer treatment by tailoring therapy based on a patient's p53 variant type.
Postmenopausal women with higher serum concentrations of estrogen and testosterone have twice the risk of developing breast cancer as those with lower levels. This is according to an international study published in the Journal of the National Cancer Institute.
Fox Chase Cancer Center researcher Glenn F. Rall is studying whether a link exists between the measles vaccine and the development of autism. He believes that maternal exposure history to measles may afford protection to offspring, but more research is needed.
A retrospective analysis of 574 patients with non-small cell lung cancer found that older patients tolerated chemotherapy regimens comparable to younger patients. However, psychological distress and neutropenia were more prevalent in the elderly population. The study suggests that functional status is a key factor in determining treatm...
Researchers at Fox Chase Cancer Center have discovered that the drug Oltipraz can inhibit tumor growth by blocking blood vessel formation, while also increasing protective detoxification enzymes in the body. This dual mechanism of action may make Oltipraz a promising agent for both cancer prevention and treatment.
The study reveals that endothelial cells emit signals to encourage the growth of emerging organs, such as the liver and pancreas, even before functioning blood vessels arise. This discovery may lead to a better understanding of organ development and regeneration.
Fox Chase Cancer Center has become the nation's first cancer specialty hospital to receive Magnet Nursing Services Recognition Award. The award recognizes its commitment to delivering high-quality patient care through a work environment that rewards professional nursing.
A new study found that cancer genetic testing can impact marital satisfaction, with couples experiencing increased anxiety and distress when discussing the process. Supportive spouses play a crucial role in mitigating these effects, while unsupportive responses can exacerbate relationship strain.
A Phase III trial shows long-term hormone suppression can control recurrence and improve survival in prostate cancer patients. The treatment significantly reduces disease-free survival, local progression, and freedom from distant metastasis.
A study published in Urology suggests that patients treated with radiation therapy for prostate cancer have a high chance of being disease-free after four years, with minimal risk of recurrence. Patients with favorable prognoses also show a lower risk of treatment failure sooner than those with less favorable prognoses.
Fox Chase Cancer Center molecular biologist Dominique Broccoli has been awarded a $100,000 V Foundation Scholarship to investigate the role of telomeres in cellular aging. Her research aims to understand how telomere length limits cell growth and renewal, potentially leading to new approaches for limiting tumor growth.