Scientists identify uroguanylin as a potential target for controlling appetite and obesity. They also found a link between Parkinson disease and fat levels in the blood, with implications for treating this neurodegenerative disorder.
Researchers identified parkin as a regulator of fat uptake by liver cells, impacting blood fat levels and potentially linking to Parkinson's disease. The study found that increased parkin protein levels are associated with high-fat diets and mutant human cells.
A team of researchers has discovered that a genetic mutation in the CDKAL1 gene can lead to misreading of specific parts of the insulin-producing gene, resulting in decreased insulin production and impaired cell function. This finding sheds light on the underlying mechanisms of Type 2 diabetes.
A study in mice found that a genetic variation in the CDKAL1 gene leads to misreading of insulin-producing genes, causing decreased insulin production and impaired cell function. Meanwhile, researchers discovered that breast cancer cells evade the antitumor activity of NK cells by modifying their environment.
Researchers found that breast tumor cells can evade NK cell antitumor activity by promoting self-tolerance. The study suggests that restoring NK cell function could benefit individuals with breast cancer.
Researchers have developed a new method to assess psychoactive compounds' effects on eye movements in mice, which can be used to predict efficacy and detect side effects. This approach shows promise for guiding more efficient drug development for brain-related conditions.
Researchers developed a new method to assess CNS drug action using eye movements in mice, which showed promise for treating diseases such as Huntington's disease. Additionally, studies revealed that the protein GSK-3 is critical for lithium's effects on behavior in bipolar disorder patients.
A recent study confirms that long-term azithromycin treatment is associated with increased infection with nontuberculous mycobacteria, a serious complication in cystic fibrosis patients. The team identified autophagy impairment as the underlying mechanism, highlighting a clinical danger of pharmacological blockade.
Research confirms long-term azithromycin treatment increases infection with nontuberculous mycobacteria, a serious complication in cystic fibrosis. Azithromycin blocks autophagy, impairing immune cells' ability to kill bacteria.
A team of researchers discovered that consuming a fat solution attenuated behavioral and nerve cell responses to sad emotion, suggesting a link between gut-brain signaling and emotional state. This finding has significant implications for various mental health conditions, including obesity and depression.
New data from two independent research groups provides hope that a therapeutic approach can be developed to treat SMA. Prolactin treatment increases SMN levels, improves muscle movement, and enhances survival in mouse models of severe SMA.
A study by Lukas Van Oudenhove and colleagues found that a fat solution to the stomach attenuates behavioral and nerve cell responses to sad emotion in humans. This discovery has implications for treating disorders such as obesity, eating disorders, and depression. Additionally, two independent research groups have generated new data o...
Researchers have identified a protein called MYLIP as a potential new target for lowering LDL cholesterol levels, which are associated with atherosclerotic cardiovascular disease. Additionally, platinum-based drugs have been found to promote anticancer immune responses by disrupting the mechanisms used by tumors to inhibit immune cells.
A team of researchers has identified the MYLIP protein as a potential new target for lowering LDL cholesterol levels. The study found that the N342S polymorphism is associated with high total cholesterol and increased LDL receptor degradation in humans.
Perlecan domain V protects nerve cells from death and promotes blood vessel growth after stroke, enhancing brain repair. Elevated levels of perlecan domain V were detected in rodent models of stroke, suggesting it may provide a nontoxic therapy to improve stroke outcomes.
Researchers have identified a way to exploit brain's self-repair mechanism to protect nerve cells and enhance brain repair after stroke. Estradiol has been shown to protect male rats against beta-cell failure in rodent models of type 2 diabetes, suggesting estrogen receptors as a viable therapeutic target.
Researchers identified PXR as a key protein sensing xenogens, which enhances cancer characteristics in human cells. Activation of PXR leads to colon cancer growth through FGF19 induction, suggesting environmental factors may influence tumor recurrence.
Researchers have identified a new potential target for treating Parkinson's disease by blocking T-type calcium channels, which may alleviate movement disorders. This approach has shown promise in a rat model of PD, suggesting a novel therapeutic strategy.
Researchers identify VIP signaling pathway key for normal brain development, finding that environmental factors can influence final brain size. A new approach to treating Parkinson's disease is also suggested with T-type calcium channel blockade.
A VIP signaling pathway is key to normal brain development, and environmental factors can affect the final brain size. Researchers used a mouse model to study microcephaly, identifying a cellular and molecular mechanism that disrupts brain development.
Researchers have found that HDL cholesterol from patients with coronary artery disease has impaired anti-inflammatory effects on blood vessel-lining cells and fails to stimulate repair of the blood vessel lining. This study highlights the importance of considering not just abundance but also biological functions of HDL in preventing CAD.
Researchers found that ghrelin hormone is required for prolonged psychosocial stress to promote preference and intake of high-fat food in mice. This discovery could lead to new therapeutic targets for curbing stress-related food behavior.
Researchers discovered that ghrelin is required for prolonged psychosocial stress to promote preference for high-fat food in mice. A ketogenic diet also suppresses seizures by reducing adenosine levels, while HDL from patients with coronary artery disease has different effects on blood vessel lining cells compared to healthy individuals.
Researchers identified a molecular mechanism behind the ketogenic diet's antiepileptic effects, reducing seizures in mice by lowering Adk protein expression. The findings suggest less-restrictive diets and pharmaceutical approaches could be effective alternatives to conventional treatments.
Researchers have found that adult stem cells from the human olfactory system can provide a new source of cells to treat brain disorders. These cells, known as OE-MSCs, have been shown to migrate to damaged areas and stimulate nerve cell growth, improving learning and memory in mice.
Researchers found that adult stem cells from the human nose can repair damaged brain tissue, while a cancer probe made of silica nanoparticles is effective at targeting tumors. Additionally, inhibiting a protein MRP4 could provide a new way to treat pulmonary hypertension.
Researchers found that myeloid-derived suppressor cells mediate immune suppression during pregnancy, allowing tumors to spread more easily. This mechanism may also be relevant to lung cancer patients with poor prognosis.
Research in mice reveals a link between pregnancy and tumor dissemination, with decreased NK cell activity and myeloid-derived suppressor cells contributing to metastasis. The study suggests that these immune cells may represent a shared mechanism of immune suppression during pregnancy and tumor growth.
Researchers identified PKC-delta as a critical regulator of cisplatin-mediated kidney toxicity, and inhibiting it protected the kidneys without blocking chemotherapy efficacy in mouse models. Additionally, studies divided breast cancers into subtypes to identify effective therapies for triple-negative breast cancer patients.
Researchers at Georgia Health Sciences University have identified PKC-delta as a critical regulator of cisplatin-mediated kidney toxicity. Inhibiting this protein not only protected the kidneys but also enhanced the antitumor effects of cisplatin in mouse tumor models.
Researchers identified a new probiotic bacteria-derived soluble protein that provides therapeutic protection against intestinal inflammation. The protein, p40, was delivered to the colon and protected mice from colitis through an EGFR-dependent mechanism.
Researchers identified a new probiotic bacteria-derived soluble protein that can protect intestinal cells from inflammation and injury in mice models of colitis. The protein's delivery to the colon provided therapeutic protection against ulcerative intestinal inflammatory disorders.
Researchers have identified stem cell population that can reverse nerve cell loss in individuals with Parkinson disease. Protein-based human iPS cells efficiently generate functional dopamine neurons and treat a rat model of the disease.
Researchers developed CD4 aptamer-siRNA chimeras that inhibit HIV infection in primary cells and humanized mice. These agents protect against vaginal transmission of HIV when applied vaginally to humanized mice.
Researchers have identified a stem cell population that can reverse nerve cell loss in individuals with Parkinson disease. Protein-based human induced pluripotent stem (iPS) cells were found to efficiently generate functional dopamine neurons and treat a rat model of the disease. These findings suggest a potential new treatment approac...
A team of researchers has detailed the molecular mechanism by which FTY270 causes adverse effects in the lungs of mice with multiple sclerosis. The study suggests that developing a drug targeting S1P receptors on immune cells could provide a therapeutic with decreased side effects.
Scientists at Johns Hopkins University developed an approach to sensitize prostate cancer cells to radiation therapy by knocking down the expression of a gene responsible for DNA repair. Meanwhile, researchers at Weill Cornell Medical College found that a multiple sclerosis drug causes adverse effects in the lungs by degrading S1P rece...
Scientists selectively sensitized prostate cancer cells to radiation therapy by knocking down a key protein repair gene. The approach shows promise for treating locally advanced prostate cancer, reducing disease recurrence.
Researchers have found that mouse induced pluripotent stem (iPS) cells and embryonic stem (ES) cells produce highly similar definitive endoderm when differentiated in vitro. This suggests that iPS cells could be used for developing cell-based therapies for diseased endoderm-derived tissues.
Researchers discovered that immune cells play a crucial role in the worsening of atopic dermatitis when exposed to food allergens, with implications for prevention and treatment. Additionally, studies identified TIF1-gamma as a tumor suppressor in mouse and human chronic myelomonocytic leukemia.
Researchers found that skin contact with food allergens can lead to the reprogramming of gut-homing T cells into skin-homing T cells, exacerbating atopic dermatitis. This discovery has important implications for preventing and treating atopic dermatitis in patients with food allergies.
Researchers have identified a key role for fibulin-5 in preventing pelvic organ prolapse (POP) by facilitating elastic fiber assembly and inhibiting MMP9 activity. This discovery may lead to nonsurgical treatments targeting elastic fiber-degrading proteins.
A team of researchers has identified a key role for the protein fibulin-5 in preventing pelvic organ prolapse (POP) in mice. Fibulin-5 prevents POP by facilitating the assembly of normal elastic fibers and inhibiting the activity of MMP9, a protein that degrades these fibers. Increased levels of MMP-9 were found in vaginal tissue sampl...
Researchers have identified a small molecule compound that specifically inhibits TrkB action, showing potent behavioral effects in mice and promising antidepressant and anti-anxiety activity in humans. The discovery could lead to the development of a new class of psychiatric drugs for depression treatment.
Researchers have identified a low-molecular weight TrkB antagonist with potent behavioral effects that suggest it will have antidepressant and anti-anxiety activity in humans. The compound, ANA-12, was discovered through a screen of stable small molecules that could specifically inhibit TrkB action. Additionally, a study on type 1 diab...
Researchers have discovered a protein that improves vascular regeneration in mice with heart attacks, and found that manipulating this protein could be used to treat various vascular diseases. Additionally, studies on mouse models have revealed plasticity in the pathways that control insulin secretion, offering new insights into diabet...
Researchers discovered that injecting DKK2 improved vascular regeneration in a mouse model of myocardial infarction. This suggests potential for pharmacological manipulation to treat various vascular diseases.
Researchers found that PUMA protein induces apoptosis in intestinal epithelial cells, leading to inflammation and UC development. Increased PUMA levels were detected in diseased tissues of UC patients, suggesting its potential as a therapeutic target.
Researchers found that the protein PUMA is responsible for inducing apoptosis in intestinal epithelial cells in response to inflammation, suggesting a promising target for ulcerative colitis therapies. Meanwhile, DNA methylation studies revealed targeted gene silencing and potential cancer-initiating events.
Research suggests that specific genes are silenced by DNA methylating enzyme Dnmt3b, similar to those found in human tumors. This targeted silencing may be an initiating event in cancer development.