Researchers found that minocycline effectively targets and reduces HIV replication in immune cells, providing an additional layer of defense against the virus. The antibiotic may improve current treatment regimens for HIV-infected patients when used in combination with HAART.
Research at Johns Hopkins Medicine found that underprivileged African-American, Hispanic, and low-income patients with brain tumors are significantly less likely to be referred to high-volume specialty hospitals. This finding contradicts federal health care agency recommendations for equal access and quality of care.
A Johns Hopkins emergency physician describes the daily struggle of making emotionally difficult ethical decisions amidst a massive influx of patients and limited medical resources. The essay outlines how standards of care were adjusted to prioritize those most likely to benefit from treatment, raising concerns about inhumane medicine.
A small study shows eprotirome decreases LDL cholesterol as much as doubling statin dose without harmful side effects. The researchers found that eprotirome lowered blood lipids such as triglycerides and Lp(a), which are associated with increased cardiovascular disease risk.
A landmark study published in the Journal of the American Medical Association found that live kidney donors suffer few ill effects from the procedure and are likely to live as long as those with both kidneys. The study analyzed data from over 80,000 live kidney donors in the United States.
Researchers at Johns Hopkins Children's Center report encouraging results in children with egg allergies who consume increasingly higher doses of egg protein. The study found that more than half of the children could tolerate 5 grams of eggs without an allergic reaction, experiencing mild to moderate symptoms.
A new study by Johns Hopkins scientists found that Notch-blocking drugs can kill brain cancer stem cells in mice, with a 70% reduction rate. However, further experiments suggested that additional therapies or increased dosage of Notch-blocking drugs may be necessary to target all cancer stem cells.
Two studies found that anomalies in the DISC1 gene and its interaction with Kal-7 protein disrupt dendritic spine formation, leading to weaker connections between neurons. This abnormal connectivity is thought to contribute to the onset of schizophrenia symptoms in young adulthood.
Hospitals in the US could save hundreds of millions of dollars annually by reusing medical equipment such as laparoscopic ports and cutting tools. With proper sterilization and testing, these devices can be safely reused multiple times.
Researchers at Johns Hopkins have developed a new approach to detect cancer using whole genome sequencing, identifying rearrangements of DNA that can be found in tumor cells. This approach, called Personalized Analysis of Rearranged Ends (PARE), may help clinicians tailor treatments and monitor tumor levels after therapy.
Researchers at Johns Hopkins Medicine have identified a key protein, TRPV2, that plays a crucial role in helping macrophages capture and destroy germs. The protein helps macrophages bind to bacteria more effectively, which enables the immune system to clear infections more efficiently.
A new study from Johns Hopkins Medicine reveals that obesity in all forms increases the risk of developing kidney stones. The researchers found that obese individuals had a higher incidence of kidney stones compared to non-obese individuals, with no difference in risk between mild and severe obesity.
A recent study at Johns Hopkins Children's Center found that a high-fat ketogenic diet is both effective and safe for controlling seizures in the long term. The diet, which consists of high-fat foods and very few carbohydrates, has been shown to reduce seizure frequency by nearly 80% in patients treated for a minimum of 16 months.
Scientists studying fruit flies have discovered a critical step in fly vision that is also linked to human retinal dystrophies, which cause visual impairments or blindness. The study's findings suggest that using flies as a model organism can lead to the development of new therapies for treating human retinal degeneration.
A Johns Hopkins researcher warns that medical safety checklists are no magic wand and require a culture change to be effective. Checklists can work in certain situations, such as central-line infection prevention, but over-reliance on them can lead to distractions and errors.
A third of seniors over 65 wait too long for lifesaving kidney transplants because their doctors don't list them for organs suitable for younger patients but not for themselves. Older adults have shorter life spans than younger recipients, but accepting older kidneys can increase survival rates.
A Johns Hopkins Hospital campaign made seasonal flu vaccinations free and convenient, resulting in a double national average vaccine rate of 71.3% among staff. The hospital's policy requiring employees to wear face masks if not vaccinated also encouraged vaccination.
Researchers at Johns Hopkins Medicine discovered that sugar-based protein modification called O-GlcNAcylation regulates cell division. Disrupting this process can lead to polyploidy, a condition exhibited by many cancer cells. The findings have implications for new treatments for diseases like cancer.
A new checklist called CURVES (Choose and Communicate, Understand, Reason, Value, Emergency and Surrogate) has been developed to quickly assess a patient's decision-making capacity in emergency situations. The acronym helps physicians determine whether a patient is able to make decisions in life-or-death situations.
The study shows that a simple, standardized checklist can virtually eliminate central-line catheter bloodstream infections. By combining the checklist with culture change and continuous monitoring, hospitals can sustainably reduce infection rates, making them more transparent to patients.
Johns Hopkins researchers have discovered how Argonaute protein binds to microRNAs, shutting down protein production. This finding sheds light on the regulation of genes and has implications for treating diseases linked to genetic regulation, such as cancer.
Research by Johns Hopkins Medicine found that children of Hispanic mothers who speak Spanish spend nearly two-and-a-half hours watching TV, compared to about 90 minutes for children with English-speaking mothers. The study suggests cultural perceptions and lack of programming in Spanish may contribute to the difference.
Researchers found that even mild to moderate kidney disease can lead to physical, emotional, intellectual, and social challenges in children. Children with chronic diseases currently do not qualify for special education until their scores decline dramatically. Early attention to quality-of-life issues is crucial.
A recent study by Johns Hopkins Medicine found that pediatricians often fail to follow up with families after referring children with suspected developmental delays for further testing and treatment. This can lead to delayed treatment and poorer outcomes for these children. The study highlights the need for improved referral systems an...
A new study with Brazilian dwarves suggests human growth hormone deficiency has no effect on normal lifespan. Contrary to previous claims, HGH levels do not seem to positively or negatively impact lifespan.
Researchers have identified five cases of toilet-seat dermatitis, a skin condition that can be caused by wooden toilet seats or exposure to harsh cleaning chemicals. The study recommends using paper toilet seat covers, replacing wooden seats with plastic ones, and avoiding harsh cleaners to prevent the condition.
Researchers at Johns Hopkins Medicine found that proper daily maintenance of central lines was key in preventing infections in children. The study showed a 43% drop in bloodstream infections from catheters by following simple rules for catheter care, including regular cleaning and hand washing.
A Johns Hopkins study reveals that musculoskeletal issues are the leading cause of medical evacuation from war zones in Iraq and Afghanistan. Psychiatric diagnoses also increased over four years, despite mental health teams. Most evacuated personnel do not return to duty.
A new study by Johns Hopkins researchers suggests that limiting the depth of sedation during procedures could safely cut the risk of postoperative delirium by 50 percent. Lighter sedation was associated with a one-day reduction in the duration of delirium in those patients who still emerged from surgery confused and disoriented.
A Johns Hopkins neurologist argues that futile and expensive end-of-life care can be a major contributor to the unaffordable cost of healthcare. He suggests weighing patient autonomy against societal costs and suggests 'nudging' families towards comfort care, particularly in cases of premature births.
A study by Johns Hopkins researchers found that a small group of physicians, accounting for 3.7% of claims, drove 72% of workers' compensation costs. These 'cost-intensive providers' were found to have a significant impact on system health care costs independent of injury severity.
A Johns Hopkins Children's Center study found that even small amounts of lead in healthy children's bodies can impair kidney function, with those having higher levels showing decreased kidney filtration rates. The researchers measured kidney function using two tests and found a link between higher lead levels and worse kidney function ...
A study of critically ill H1N1 children found that serious complications developed quickly and unpredictably, with great variations from patient to patient. The virus behaves variably in different patients, highlighting the need for rapid screening tests and preemptive antiviral medications.
Researchers have found an antidepressant, clorgyline, can blunt and reverse muscle enlargement and weakened pumping function associated with heart failure. The drug blocks the action of enzyme monoamine oxidase-A and stops its breakdown of a key neurohormone, norepinephrine.
Researchers have developed a vaccine that appears to reduce leukemia cells in some chronic myeloid leukemia (CML) patients taking the drug Gleevec. The study found significant reductions in residual cancer cells and complete remission in seven patients.
Researchers found that expressing mutant DISC1 during prenatal periods, postnatal periods, or both led to distinct brain alterations and behaviors resembling schizophrenia or mood disorders. The study suggests that manipulating DISC1 expression timing may help develop new therapies for psychiatric disorders.
Researchers found that people who quit smoking have a 70% increased risk of developing type 2 diabetes in the first six years without cigarettes compared to non-smokers. Weight gain after quitting is suspected to be the cause of this increased risk, which returns to normal after 10 years.
A new ALS drug, talampanel, has shown some ability to slow the loss of major daily life activities such as speaking, walking and dressing. The study found that talampanel slowed progression of ALS by 30 percent, according to the ALS Functional Rating Scale.
Researchers used a classic staining method to observe how semaphorin regulates the creation of synapses and their distribution in the brain involved in conscious thought. The discovery could have an impact on understanding early origins of neurological disorders like autism, schizophrenia, and epilepsy.
Researchers found that injecting triamcinolone into the eye may slow proliferative diabetic retinopathy progression, but not macular edema. Steroid treatments reduced the risk of retinopathy progression without significantly improving vision outcomes.
Researchers identified a link between Sec24b and Vangl2 genes in mouse spinal cord development, which may lead to new research on all spinal defects. The discovery opens doors for investigating the root of spinal cord defects in humans.
Researchers identified a family of proteins called Mrgprs that functions as itch receptors in a rare subset of nerve cells. The study found that MrgprA3 is the primary itch receptor for chloroquine, leading to potential new treatments for nonallergic itch.
A Johns Hopkins-led study finds that while the US has more accessible high-priced cancer drugs, many patients in both countries face financial obstacles due to high out-of-pocket costs. The UK system is considered fairer, but both nations struggle with rationing and end-of-life care decisions.
Researchers propose that gene variants contribute to heterogeneity in populations, giving generations more opportunity to survive in a fluctuating environment. This idea may help explain the presence of common diseases and how organisms adapt quickly enough to environmental change.
A phase I/II study at Johns Hopkins Medicine has shown that mini stem cell transplantation can safely reverse severe sickle cell disease in nine out of ten patients. The procedure, which uses intravenous transplants of blood-forming stem cells from healthy donors, promotes the coexistence of host and donor cells.
Researchers at Johns Hopkins have developed therapies using gene therapy and stem cells to increase blood flow, improve movement, and decrease tissue death. The findings hold promise for developing clinical therapies to save limbs from amputation.
Research from Johns Hopkins Children's Center found that children with sickle cell disease who contract H1N1 virus are three times more likely to develop acute chest syndrome and five times more likely to need ICU care. The study highlights the need for these children to be included in flu vaccination lists.
Researchers at Johns Hopkins Medicine have discovered a protein called Twist that accurately distinguishes stem cells driving aggressive breast cancer from other cancer cells. The protein's presence alone can flag a tumor cell as a breast cancer stem cell, suggesting new potential for early detection and treatment strategies.
Researchers found that stem cells from flies lacking SOCS protein had more integrin, allowing them to stick to the niche better than neighboring germline stem cells. This model can be applied to other stem cell niches such as cancer, where cancer stem cells become a danger when they become sticky.
A recent study by Johns Hopkins scientists suggests that repeated ecstasy use significantly raises the risk of developing sleep apnea in otherwise healthy young adults. The researchers found that the more participants had used MDMA in the past, the more severe their apnea was likely to be.