Researchers identified insulin as a primary signal that helps communicate meal timing to the body clock, driving daily physiological rhythms. This discovery could lead to new therapies targeting insulin signaling and emphasize the importance of meal timing for maintaining healthy body clocks.
Researchers have found evidence of pre-cancerous lung tumours in mice using a blood-based test, suggesting a potential early detection method for lung cancer. The study used mice with a mutation in the KRAS gene to model the disease and found that circulating DNA levels correlated with tumour size.
A new study reveals that astrocytes can lead the tempo of the body's internal clock and control daily behavior patterns in mammals. The discovery could pave the way for new treatments to manage circadian rhythm disruptions related to health conditions like jet lag, sleep disorders, and dementia.
Researchers developed a dual-action virus that kills cancer cells while targeting adjacent fibroblasts shielding them from the immune system. The therapy showed promise in human cancer samples and mice without causing toxicity.
A study of over 60,000 adults found that higher biomarker levels for dairy fat consumption are associated with a lower risk of developing type 2 diabetes. The researchers suggest re-examining the metabolic benefits of dairy fat, but note limitations and potential biases in their findings.
Scientists have found an old antibiotic that selectively kills cells producing high levels of ALDH1 in melanoma tumors. The therapy shows promise for complementing existing treatments and may offer a new approach to targeting drug resistance.
A study using machine learning and data from 550 children with varying learning difficulties identified four clusters of cognitive challenges that did not match previous diagnoses. The researchers found that working memory and phonological skills deficits often overlap, affecting both reading and math abilities.
Researchers have successfully created 3D human liver tissue from human stem cells and implanted it into mice with liver disease, demonstrating improved liver function. The study showcases a promising approach to developing human liver tissue implants that could reduce the need for animal testing.
Scientists have developed a new drug discovery system that can specifically target phosphatase enzymes, which were previously considered undruggable. The system identified a molecule that successfully targeted a phosphatase to reduce accumulation of disease-associated proteins in mouse brains.
Researchers from Medical Research Council crack how first life on Earth replicated itself using a new type of genetic replication system. The system uses a triplet code to copy folded RNA, enabling the replication of ribozymes and supporting simple living systems.
Scientists developed a new laboratory test to diagnose peanut allergies with high accuracy and safety. The mast activation test (MAT) measures biomarkers associated with allergic reactions and can detect peanut allergy in children as young as six months old.
A new blood test detects circulating tumour DNA to predict if the breast cancer drug palbociclib is working, allowing for earlier treatment adjustments. The test was found to be effective in identifying patients who are not responding well to the treatment.
Healthy people carry mutations in their mitochondrial DNA, which can appear unexpectedly in previously unaffected families due to a bottleneck effect where only healthy mitochondria survive. The study reveals that every developing egg cell may carry faulty mitochondria, which can cause severe diseases if they repopulate the egg.
A new study discovered how our body clocks impact wound healing, with wounds sustained at night taking up to 60% longer to heal compared to daytime injuries. The research found that skin cells move to the wound site faster during daylight hours, leading to increased collagen deposition and improved healing.
A recent study published in Nature Communications has identified 52 previously unknown genes that play a crucial role in human hearing. The research used 'knock-out' mice to assess their hearing thresholds and found that these genes can lead to mild to severe hearing loss or difficulties at specific frequencies.
Researchers found that formaldehyde, a toxin, is also used to fuel the one-carbon cycle in cells, producing DNA and amino acids. This discovery could lead to new cancer therapies by targeting this pathway.
A recent study identified five genetic variants associated with higher levels of isoleucine, leucine, and valine, which are linked to an increased risk of type 2 diabetes. The researchers also found that these genetic variants were more common in individuals with impaired metabolism of branched-chain amino acids.
A genetic signature related to metabolism has been identified as a predictor of poor patient prognosis in cancer. The discovery could lead to the development of targeted treatments and personalized therapy approaches. Further validation is needed to confirm the link between mitochondrial function and cancer survival.
Research published in Medicine & Science in Sports & Exercise found that babies born with a low birth weight are more likely to be rated below-average at school sports by their teacher at age 13. Those with a low birth weight were also less likely to participate in exercise and sports across adulthood, from ages 36 to 68.
A study published in Nature found that excess fumarate resulting from enzyme loss leads to epigenetic changes promoting epithelial-to-mesenchymal transition, a process driving tumor metastasis. This understanding may provide key strategies for cancer therapy targeting metastasis caused by fumarate accumulation.
Researchers have identified a gene associated with age-related hearing loss in mice, which could lead to investigations into the equivalent human gene and potential screening programs to predict susceptibility. This discovery may ultimately inform treatment development or timing of interventions.
Scientists have discovered a key component of the HIV virus that it uses to infect cells while avoiding detection by the immune system. They identified iris-like pores in the capsid shell that suck in nucleotides needed for replication, explaining why HIV is successful at evading the immune system.