A study reveals CHOP/GADD153-dependent apoptosis is driven by micro-RNA miR-216b expression in response to endoplasmic reticulum stress, with significant implications for various diseases. The findings provide molecular insights into the role of CHOP in regulating cell death and have potential applications for novel therapies.
The Medical University of South Carolina's Hollings Cancer Center is awarded a grant to explore lipid signaling mechanisms in cancer cell proliferation, resistance to apoptosis, and metastasis. The project aims to develop new therapeutic strategies for solid tumors, including liver, prostate, and urinary cancers.
Researchers urge regulators to balance e-cigarette regulations with evidence of benefits in helping smokers quit, while avoiding harm to non-smokers. The study proposes a framework for maximizing population health and encourages innovation in the vaping industry.
Researchers at the Medical University of South Carolina discovered that the M10 peptide protects against fibrotic damage in a mouse model of ILD and is likely due to its modulation of the TGF-β1 pathway. The anti-fibrotic effects of M10 may also be effective in treating other forms of pulmonary fibrosis.
A recent U.S. Preventive Services Task Force recommendation suggests pairing smoking cessation with lung cancer screening to maximize benefits and reduce risk. This guideline aims to provide tobacco treatment in conjunction with lung screening to encourage smokers to quit.
Researchers have resolved the first protein structure in a family of proteins called transcription terminators, revealing their role as traffic signals for coordinating transcription and gene replication. The study provides insight into the mechanisms underlying cellular aging and tumor growth.
A randomized controlled trial found that single covered, self-expanding metallic stents (cSEMS) resolved benign obstructions of the pancreatic and biliary ducts with fewer ERCP sessions, compared to traditional plastic stents. cSEMS were also more effective in achieving stricture resolution within 181 days.
Researchers at MUSC report findings on the mechanisms underlying impaired ciliogenesis and abnormal kidney development characteristic of PKD. Depletion of dynamin-binding protein or Tuba disrupts renal ciliogenesis, leading to uncontrolled production of cysts.
A clinical study found that veterans with subclinical PTSD experience a 29% drop in symptoms after treatment, compared to 14% for those with full PTSD. This discovery highlights the potential benefits of early-stage PTSD treatment and could lead to cost-effectiveness in treating this common disorder.
A multi-center trial will test the effectiveness of Harvoni in treating hepatitis C virus (HCV) in liver transplant patients. The $3.8M grant, funded by Gilead Sciences, aims to evaluate the drug's cure rate and compare it to existing treatments.
Satish Nadig, a promising young researcher, has received the National Institutes of Health's Mentored Clinical Scientist Research Career Development Award. The $580,000 grant will support his three-year study on targeted drug delivery for organ transplantation, aiming to minimize harmful effects of immunosuppressant therapy.
Researchers at MUSC have discovered a safe method for producing retinal pigment epithelial-like cells using human proteins, which can be transplanted to treat macular degeneration. The study also found an effective way to repair the damaged Bruch's membrane beneath these cells, rejuvenating the tissue.
The Medical University of South Carolina is developing a statewide telehealth network for children's hospitals, which aims to provide quick access to specialized pediatric care. The network, supported by a $1 million grant, will help equip smaller medical centers with resources and expertise.
The Charleston Alcohol Research Center has received a $7 million NIH grant to fund innovative treatments for alcohol addiction. The center aims to develop new therapies using transcranial magnetic stimulation and other technologies.
A new class of drug, YELIVA™ (ABC294640), has shown promise in slowing the growth of castration-resistant prostate cancer cells by inhibiting the sphingolipid pathway. The study found that treatment with YELIVA™ increased dihydroceramide levels and reduced expression of key oncogenes.
A $4 million NSF grant will fund research at MUSC and UAB to map changes in blood flow when specific neurons fire. This could lead to new treatments for neurological diseases by understanding the mechanisms of neurovascular communication.
Researchers found that saturated fat, but not unsaturated fat, raises sphingosine-1-phosphate levels in obese people, leading to inflammation and non-alcoholic steatohepatitis. This discovery may lead to new treatments to prevent liver disease in obese patients.
Researchers found a link between pre-kallikrein levels and thickened blood vessels in type 1 diabetes patients. Elevated plasma PK levels are an independent risk factor for whole-body diabetic vascular disease, similar to high triglycerides or high blood pressure.
A new study suggests that hydroxyurea can be effective in reducing the risk of stroke for some children with sickle cell disease. The Transcranial Doppler with Transfusions Changing to Hydroxyurea (TWiTCH) study, stopped early due to positive preliminary results, showed that transitioning from regular blood transfusions to daily doses ...
A $13.5 million funding award from the Patient-Centered Outcomes Research Institute (PCORI) will support a study analyzing the safety and effectiveness of three blood-thinning drugs used to prevent post-surgery blood clots in patients undergoing hip and knee replacement.
Researchers at MUSC are exploring a new treatment for chronic pancreatitis using Alpha 1 anti-trypsin (AAT), which has shown promise in preventing diabetes and improving liver implantation. The study aims to examine the effects of AAT on human islets in patients with pancreatic cancer.
A study using mobile health technology has shown that patients taking kidney transplants can improve their medication adherence and blood pressure levels, leading to better patient outcomes. The innovative approach aims to reduce premature graft loss by providing personalized computer-automated monitoring systems.
In a phase 1 trial, VRC01 antibody suppressed HIV levels by more than tenfold in six patients not on antiretroviral therapy, with some experiencing undetectable levels for up to 3 weeks. However, immune responses limited efficacy in others, highlighting the need for new strategies to prevent viral reservoirs.
Researchers at Medical University of South Carolina pioneer bilateral epidural prefrontal cortical stimulation, providing significant improvement in depressive symptoms. Five patients showed average improvement of 54.9% after seven months, including three who reached remission.
A new study published by researchers at the Medical University of South Carolina suggests that the risk of cancer from radiation exposure during cardiac CT scans is substantially lower than previously reported for general populations. The study found a cancer risk of 1 in 1000, which mirrors more closely the typical patients who receiv...
Researchers at Medical University of South Carolina present a new theory that may lead to effective heart failure treatments by identifying the role of matrix metalloproteinases (MMPs) in the disease. The study suggests that MMPs, similar to those found in cancerous tumors, contribute to the progression of heart failure, leading to the...
New research from Medical University of South Carolina finds the cancer risk from cardiac CT radiation exposure is 1 in 1000, significantly lower than previous estimates of 1 in 114. The study highlights the importance of personalized patient selection guidelines to minimize radiation risks.