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PLOS


How the microbiota controls neutrophil activity

The microbiota controls neutrophil activity by producing Serum Amyloid A (Saa), a host protein that restricts aberrant activation while enhancing migration to wounds. Saa reduces bactericidal activity and expression of pro-inflammatory genes in neutrophils.

SourcePLOS·JournalPLOS Pathogens·DateMar 7, 2019

How does the body respond to diffuse cutaneous leishmaniasis?

A study in PLOS Neglected Tropical Diseases analyzed gene expression in patients with diffuse cutaneous leishmaniasis, revealing a heightened presence of B cell transcripts and unique patterns of macrophage activation. The research also identified new targets for vaccine development against this rare and neglected tropical disease.

SourcePLOS·JournalPLOS Neglected Tropical Diseases·DateMar 7, 2019

Study confirms and quantifies Zika-microcephaly link in Brazil

A study published in PLOS Medicine has confirmed and quantified the association between Zika virus infection during pregnancy and microcephaly in Brazil. The research found that women infected with Zika virus early in pregnancy were almost 17 times more likely to have a child with microcephaly.

SourcePLOS·JournalPLOS Medicine·DateMar 5, 2019

Pan-filovirus T-cell vaccine protects mice from Ebola and Marburg

A new pan-filovirus T-cell vaccine has been developed to protect against multiple filovirus species, including Ebola and Marburg. The vaccine induces killer T cells against conserved regions of inner filovirus proteins, offering potential protection against other known and unknown viruses in the filovirus family.

SourcePLOS·JournalPLOS Pathogens·DateFeb 28, 2019

Study shows economic burden of dengue fever

A study of dengue fever's economic burden in Burkina Faso, Kenya, and Cambodia found high costs for patients in African countries. The average cost of inpatient care was $26 in Burkina Faso and $134 in Cambodia.

SourcePLOS·JournalPLOS Neglected Tropical Diseases·DateFeb 28, 2019

How bird feather patterns form

Researchers discovered that EDA/EDAR signaling drives the wave of patterning, while FGF20 induces cell aggregation and compresses the epidermis to intensify FGF20 expression. This process shapes the precise hexagonal array of feathers in birds.

SourcePLOS·JournalPLOS Biology·DateFeb 21, 2019

Study looks at seasonal and geographic trends in syphilis

Researchers analyzed temporal and demographic patterns in gestational syphilis and mother-to-child-transmission of syphilis in a Brazilian region. They found no annual endemic period, but increased cases during February and a failure in the notification system.

SourcePLOS·JournalPLOS Neglected Tropical Diseases·DateFeb 21, 2019

Zebra stripes are not good landing strips

A new study published in PLOS One found that zebra stripes deter horse flies from landing on them by reducing the likelihood of a successful bite. The striped coat prevented flies from slowing down and failing to land, leading to fewer bites.

SourcePLOS·JournalPLOS ONE·DateFeb 20, 2019

Engineered DNA vaccine protects against emerging Mayaro virus

Researchers have developed a novel DNA vaccine capable of inducing protective immunity against the Mayaro virus, which causes fever, rash, and joint pain. The vaccine demonstrated complete protection from death and clinical signs of infection in a mouse model, offering a promising solution for combating this emerging infectious disease.

SourcePLOS·JournalPLOS Neglected Tropical Diseases·DateFeb 7, 2019

Why Asian horses don't get sick with the flu

Researchers sequenced avian influenza viruses from wild birds in Mongolia and found that they replicate in horse respiratory tracts without causing tissue damage. The study suggests that equine infections by avian viruses are more common than thought, with the failure to acquire key genetic changes being the main barrier to disease eme...

SourcePLOS·JournalPLOS Pathogens·DateFeb 7, 2019

What happens when sand fleas burrow in your skin?

Researchers report five cases of severe tungiasis in traditional Amerindian communities, highlighting the disease's potential for life-threatening progression. Treatment with dimeticone oil has shown effectiveness in resolving inflammation and restoring mobility within a week.

SourcePLOS·JournalPLOS Neglected Tropical Diseases·DateFeb 7, 2019

Do fish recognize themselves in the mirror?

Researchers tested cleaner wrasse for self-awareness using a mirror test, finding that fish respond to their reflection and attempt to remove marks. The study raises questions about how to assess animal intelligence and challenges previous assumptions about self-awareness in non-human animals.

SourcePLOS·JournalPLOS Biology·DateFeb 7, 2019

Effects of teenage motherhood may last multiple generations

A study found that grandchildren of adolescent mothers have lower school readiness scores and lag behind in physical and social development. The multigenerational effect suggests that interventions targeting children born to adolescent mothers should also consider their own grandchildren.

SourcePLOS·JournalPLOS ONE·DateFeb 6, 2019

Educational intervention cuts unnecessary antibiotic prescriptions in China

A study published in PLOS Medicine found that an educational intervention trained rural Chinese primary care doctors to prescribe antibiotics more appropriately, reducing unnecessary prescriptions for childhood upper respiratory tract infections by 36%. The intervention's long-term benefits were sustained even a year after its conclusion.

SourcePLOS·JournalPLOS Medicine·DateFeb 5, 2019

Masculine fitness program improves physical activity of European men

A new European Fans in Training (EuroFIT) program has shown promise in increasing physical activity among male football fans in Europe. The 12-week group-based program resulted in improved physical activity and reduced sedentary time, with participants also experiencing improvements in diet, body weight, and well-being.

SourcePLOS·JournalPLOS Medicine·DateFeb 5, 2019

How whipworms wreak havoc on the gut

A recent study published in PLOS Pathogens reveals that whipworms disrupt the balance between gut immune cells and microbiota, leading to uncontrolled inflammation and tissue damage. The researchers discovered that a specific receptor, IL-10R?, plays a critical role in regulating these interactions.

SourcePLOS·JournalPLOS Pathogens·DateJan 31, 2019

Zika vaccines should induce responses by CD4+ T cells

A study published in PLOS Pathogens suggests that CD4+ T cells are essential for local control of viral infection and can confer protection against lethal doses of the Zika virus. The findings support the development of vaccines targeting this cell type, which may be safe and effective against infection in multiple contexts.

SourcePLOS·JournalPLOS Pathogens·DateJan 24, 2019

Heart disease risk begins in the womb

A new study finds that offspring whose mothers had complicated pregnancies may be at greater risk of heart disease later in life. The research suggests that the prenatal environment can directly influence long-term cardiovascular health. Antioxidant therapy during pregnancy could potentially protect against heart disease in offspring.

SourcePLOS·JournalPLOS Biology·DateJan 22, 2019

Dengue virus immunity may protect children from Zika symptoms

Researchers found that prior and recent dengue virus infection was associated with protection from symptomatic Zika virus infection in a pediatric cohort. However, previous exposure did not affect the rate of total Zika virus infection. The study suggests that prior dengue virus immunity might cross-protect against symptomatic Zika.

SourcePLOS·JournalPLOS Medicine·DateJan 22, 2019

How sex pheromones diversify: Lessons from yeast

The study found that one pheromone operates strictly while the other is free to undergo diversification, a mechanism that may lead to reproductive isolation and speciation. This asymmetric system allows for flexible adaptation to mutational changes while maintaining recognition of mating partners.

SourcePLOS·JournalPLOS Biology·DateJan 22, 2019

Blocking hormone uptake burns more fat

A new study reveals that blocking the uptake of a hormone called norepinephrine in fat cells increases metabolism and burns stored fat. The discovery highlights the importance of beige fat tissue, which plays a key role in thermogenesis and regulating body temperature.

SourcePLOS·JournalPLOS Biology·DateJan 17, 2019

Combination therapy treats leishmaniasis, HIV patients

Researchers have developed a more effective treatment for visceral leishmaniasis (VL) in HIV patients, combining AmBisome with miltefosine. The combination therapy achieved parasite clearance rates of up to 88% compared to 55% with monotherapy.

SourcePLOS·JournalPLOS Neglected Tropical Diseases·DateJan 17, 2019