Researchers at Rosalind Franklin University have identified a new therapeutic approach for treating cystic fibrosis. The treatment uses antisense oligonucleotides to restore CFTR function by removing stop mutations. This strategy has shown promise in treating CF patients with class I mutations and similar types of mutations.
Rosalind Franklin University of Medicine and Science has been awarded a $2 million matching grant to develop and open state-of-the-art wet lab space for collaboration with industry partners. The funding will also benefit Lake County communities by attracting biotech companies and creating new jobs, internships, and training programs.
A massive study coalesced three decades of research to find that men and women's brains differ slightly in size, not sex or gender. Brain size is the only clear-cut difference, with women's brains being about 11% smaller than men's, impacting certain features such as gray matter and connectivity.
A new therapeutic approach for CLN3 Batten disease has been developed by a team led by Rosalind Franklin University researcher Michelle Hastings. The treatment uses antisense oligonucleotides to target the mutated gene causing the disease, showing promise in rodent models and human cells cultured from patients.
Researchers at Rosalind Franklin University have solved the complete structure of mitochondrial ATP synthase using cryo-electron microscopy, revealing secrets about energy production in cells. The discovery provides evidence for inhibiting enzymes and sheds light on disease-causing mutations.
Researchers at Rosalind Franklin University are investigating a new approach to treating patients with both severe bleeding and traumatic brain injury (TBI). The study aims to find a way to stabilize patients with vasopressin or similar compounds, while maintaining blood flow to vital organs.
Researchers at Rosalind Franklin University are investigating the role of oxytocin in stress-induced psychiatric disorders, aiming to identify new targets for pharmacotherapy. The study has the potential to shed light on commonalities and differences in fear and anxiety circuitry between males and females.
The NIH grant supports collaboration with German researchers to develop a new reprogramming technology that can replace neurons lost through stroke, traumatic brain injury, and brain diseases. The goal is to restore function and potentially lead to new therapies for neurological injuries and diseases.
A study by Rosalind Franklin University of Medicine and Science identifies a specific brain circuit in the amygdala as crucial for empathy, providing hope for new treatments of social difficulties in autism. The findings suggest that targeting this region may help individuals with autism spectrum disorder develop social abilities.
Researchers at Rosalind Franklin University of Medicine and Science found no significant difference in brain amygdala volume between healthy men and women in a meta-analysis of dozens of studies. The study's findings suggest that there is more similarity than difference between the sexes, with minimal overlap in key brain structures.
Researchers at Rosalind Franklin University and Oregon Health & Science University developed a breakthrough study on treating congenital diseases in utero using antisense oligonucleotides injected into the amniotic cavity. The procedure resulted in targeted alteration of gene expression for up to a month after birth.
A new study by Rosalind Franklin University researchers has discovered that hydrogen sulfide levels regulate chronic inflammation caused by obesity. The findings suggest targeting the Orai3 calcium channel as a novel treatment for obesity-related inflammation and related health issues.
Researchers found joiner neurons that can be pre-positioned for rapid recruitment into memories, changing how brain networks adjust to build memories. This discovery has implications for understanding memory formation and developing new strategies for brain injury recovery.
A meta-analysis of structural MRI volumes found no significant difference in hippocampal size between men and women. The study challenges common claims about sex differences in the brain, citing minimal differences in key areas such as emotional expressiveness, verbal memory, and brain communication.
Researchers have developed a novel therapeutic approach to treat deafness and balance impairment by injecting mice with an antisense oligonucleotide that targets a specific gene mutation. The treatment, which was tested on mice engineered to model human Usher syndrome, successfully rescues hearing and cures balance problems.
Researchers have found that Isradipine slows the destruction of dopamine-producing neurons in a mouse model, potentially preventing Parkinson's disease or slowing its progression. The study aims to develop clinical trials in humans to test the drug's efficacy.
A new study published in Diabetes Care identifies two critical factors that increase the risk of recurrent wounds in diabetics: the location under the big toe and poor blood flow. This information can help physicians predict and prevent complications, including gangrene and amputation.
A new study suggests that antibiotic therapy for diabetic foot infections can be predicted using specific laboratory and clinical tests. The study found that deep wounds or high white blood cell counts significantly increased the risk of bad outcomes.
Lawrence Lavery and David Armstrong have received a major NIH grant to study methods for treating diabetic foot ulcers and evaluating compliance and health economic outcomes. The two-year study will utilize advanced techniques such as activity monitoring and healing prediction.
A recent study suggests that the 'probe to bone' test, used to diagnose bone infections in people with diabetes, may not be as reliable as thought. The test, which feels for bone inside a wound, is only slightly better than chance when used alone.
A study validates the Infectious Disease Society of America's guidelines for classifying diabetic foot infections, confirming a simple system can predict hospitalization and amputation. The free online classification system will guide therapy and patient communication.
Researchers found that taking Lipitor reduced the risk of secondary stroke by 16% and major coronary events by 35%. The study suggests that initiating statin treatment shortly after a stroke may be beneficial for patients at high risk.
The study found that nearly 9 in 10 amputations performed are instigated by an infection. Poor circulation was not the primary cause of amputation but rather determined its level, highlighting the importance of preventing infection to prevent severe outcomes.
Two landmark papers unveiled significant breakthroughs in preventing amputations in diabetes patients. Novel Negative Pressure Wound Therapy technology has been shown to simplify complex wounds, while powerful antibiotics have demonstrated comparable efficacy when administered once daily.
Scientists have found that CART peptides are essential for the maximal effects of cocaine and amphetamine, leading to a novel target for treating stimulant drug addiction. The study showed reduced responses to these drugs in mice lacking CART peptides.
A new method to create a reversibly immortalized beta-cell line offers significant progress in developing an effective treatment for type 1 diabetes. The breakthrough, achieved by manipulating human beta-cells, has successfully controlled blood sugar levels in diabetic mice for over 30 weeks.
Dr. Francis White, a leading expert in neuropsychopharmacology, has received the prestigious MERIT Award from the National Institute on Drug Abuse. His research focuses on understanding the neurobiology of dopamine systems and their role in addiction, with implications for developing new treatments.