Young female athletes who stop menstruating may experience weakened bone structure and increased risk of fractures despite regular exercise. A new study found that amenorrhea in athletes can lead to abnormal bone microarchitecture, a significant public health concern.
A meta-analysis of 10 randomized clinical trials found that topiramate-treated patients lost 11.8 pounds more on average than placebo group members, with a higher success rate for weight loss over 28 weeks.
Girls with anorexia nervosa saw significant increases in bone density at the spine and hip after receiving physiological estrogen therapy, according to a new study. However, they still had lower bone density than healthy-weight controls.
A new study finds daily BPA exposure lowers male fertility in mice, causing reduced sperm counts and testosterone levels. Mice exposed to twice the recommended safe dose showed structural defects in their testicles and were considered subfertile.
A study found that formoterol improves fat burning and protein metabolism in men, increasing metabolism by over 10% and fat oxidation by nearly 25%. The results suggest potential benefits for preventing obesity and muscle loss in humans.
Research shows bariatric surgery significantly increases fracture risk, with patients experiencing a 2.3-fold higher chance of bone fractures compared to the general population. Patients who underwent gastric bypass surgery had an increased risk of fractures at nearly all skeletal sites, including feet and hands.
A study presented at The Endocrine Society's annual meeting found that women with worse facial wrinkles during early menopause tend to have lower bone density. This association was independent of age and body composition, suggesting a potential link between skin health and bone quality.
An experimental gene therapy has reversed type 1 diabetes in mice with a nearly 80 percent success rate, reversing autoimmune destruction of insulin-producing beta cells. The treatment uses neurogenin3 and betacellulin to stimulate new islet growth and inhibits immune system activity.
Men with prostate cancer treated with hormone deprivation therapy may be at increased risk of developing diabetes or metabolic syndrome. According to the study, men in the ADT group had a twofold increased probability of having diabetes compared to those who did not receive hormonal therapy.
Women with obesity before and after diagnosis have a higher risk of dying from breast cancer. Obesity is strongly linked to death due to breast cancer, particularly in estrogen receptor-positive cases.
A new animal study suggests that fetal programming of disease risk to the next generation depends on parental gender. The study found that exposure to stress hormones in the womb can program potential health effects, but the effects differ between mothers and fathers.
A study of 75 obese men found that bariatric surgery can reverse low testosterone levels and symptoms of male sexual dysfunction. After weight loss, testosterone levels increased significantly, indicating a potential causal relationship between obesity and low testosterone.
Researchers found that metyrapone, a stress hormone-reducing drug, impaired memory recall for negative events in men, but not neutral ones. The study offers hope for future clinical treatments of post-traumatic stress disorder by allowing people to 'write-over' traumatic memories during therapy.
A study found that vitamin D deficiency is associated with higher fat levels in both black and white children, but racial differences exist in fat tissue distribution. Vitamin D was also linked to lower levels of good cholesterol in all subjects.
A recent study published in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism found that higher metabolic rates are associated with early natural mortality, indicating potential acceleration of aging. Higher energy expenditure was linked to increased risk of organ damage and accumulation of toxic substances.
The Endocrine Society released a new Clinical Practice Guideline for the evaluation and treatment of pituitary incidentalomas. The guideline recommends a complete history and physical examination, including visual field examinations if necessary, for patients with a pituitary incidentaloma.
A recent study found that mice with low ghrelin levels in their mothers experienced impaired uterine development, leading to reduced fertility. Female children of obese women may be more likely to struggle with reproductive issues as adults.
Higher levels of perfluorocarbons associated with increased odds of experiencing menopause in women between 42 and 64 years old. Women with high PFCs also had lower estradiol concentrations.
A recent study found that maternal fructose consumption during pregnancy results in sex-specific changes in fetal and neonatal endocrinology, with female fetuses showing higher leptin and blood glucose levels. Male offspring also exhibit increased plasma fructose levels and hypoinisulinemia.
A recent study published in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism found that individuals with fatty liver were significantly more likely to develop type 2 diabetes than those without. Fatty liver was shown to be an independent risk factor for type 2 diabetes, regardless of insulin resistance levels.
Researchers found that people taking bisphosphonates lived longer than those without osteoporosis and even gained an extra five years of life. The study, published in the Journal of Clinical Endocrinology and Metabolism, suggests a possible link between bone health and toxic metal release.
A recent study found higher BPA levels in women with PCOS compared to controls, and an association between BPA and increased testosterone levels. Researchers suggest that BPA may exacerbate hormonal imbalances in women with PCOS.
A recent study found that exposure to room light in the late evening can significantly suppress melatonin levels, leading to reduced sleep quality and increased risks of diabetes. The study's findings have important health implications for shift workers exposed to indoor lighting at night.
A recent study found that lower and higher vitamin D levels are associated with an increased likelihood of frailty in older women. Women with optimal vitamin D levels (20.0-29.9 ng/ml) were at the lowest risk, while those with levels below 20 ng/ml or above 30 ng/ml had a higher risk of frailty.
A novel test has been developed to accurately diagnose Turner syndrome in girls, allowing for timely management of co-morbid conditions. The new test can be performed on cheek swabs or newborn screening blood spots and has shown a high accuracy rate in detecting the disorder.
Researchers identified placental growth factor as a promising diagnostic biomarker for ectopic pregnancies. The study found that PIGF levels were reduced in samples from tubal ectopic pregnancies compared to intrauterine pregnancies.
The Endocrine Society releases a clinical practice guideline for the nutritional and endocrine management of adults after bariatric surgery. The guideline features evidence-based recommendations to prevent weight regain and co-morbidities, including type 2 diabetes, polycystic ovarian disease, and fatty liver.
A study found that testosterone treatment improved muscle mass, strength, and quality of life in frail elderly men, but these effects were not maintained six months after treatment. Researchers suggest a multi-disciplinary approach, including resistance exercise and lifestyle options, to interrupt the downward spiral into frailty.
A consensus statement from The Endocrine Society and the US Centers for Disease Control and Prevention calls for improved testosterone testing standards. The recommendations aim to increase accuracy, reliability, and comparability of measurements over time.
Researchers found that androgen deprivation therapy is associated with structural decay of cortical and trabecular bone in men with prostate cancer. The study used virtual bone biopsies to assess bone microarchitecture and found a link between testosterone deficiency and increased fracture risk.
A new consensus statement recommends regular glycemia screening and early identification of patients at metabolic risk to slow or reverse beta-cell decline. The Endocrine Society has launched a website to promote pathophysiology-based clinical practices and aid primary care physicians in interpreting concepts of disease pathogenesis.
A new study found that higher baseline leptin and lower ghrelin plasma levels before dieting may predict weight regain in individuals. The research suggests that personalized weight-loss programs targeting appetite hormones could improve long-term success rates.
A new study published in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism has found that high levels of the stress hormone cortisol are strongly associated with an increased risk of cardiovascular death among both healthy individuals and those with pre-existing cardiovascular disease. The study, which evaluated ov...
The Endocrine Society recommends that every newborn be screened for CAH, and positive results be followed up with confirmatory tests. The guideline also outlines treatment recommendations, including minimizing glucocorticoid dosage and considering patients' quality of life.
A new study published in The Journal of Clinical Endocrinology & Metabolism found that vitamin D deficiency is associated with increased arterial stiffness in black teens. Researchers discovered that higher doses of vitamin D supplementation (2,000 IU) improved cardiovascular health and reduced central arterial stiffness.
A study of over 786 cases found that thiazolidinediones, a common diabetes medication, increased the risk of fractures in postmenopausal women and men with diabetes. Higher doses of TZDs were associated with greater fracture risk.
A new nonsteroidal therapy, IGFBP-3, has significantly decreased disease signs of asthma in mice by inhibiting the NF-kB inflammatory pathway. This could lead to a new alternative therapy for patients resistant to current steroid treatments.
A large US multicenter study suggests that older men with higher testosterone levels are more likely to have a heart attack or other cardiovascular disease. Higher total testosterone levels relate to an increased risk of coronary disease, particularly in those above 495 ng/dL.
Researchers developed a groundbreaking laboratory model of hormone-induced human prostate cancer initiation and progression, offering new insights into the disease's hormonal mechanisms. The model enables the study of cancer development from normal tissue to initiation and progression, facilitating preventive therapy testing and accele...
A new study found nearly half of the elderly Dutch population had vitamin D deficiency, which may increase the risk of metabolic syndrome. The condition is characterized by high blood pressure, abdominal obesity, abnormal cholesterol profile, and high blood sugar.
A lifestyle intervention program reduced body fat and improved fitness in preschoolers from migrant families. The program taught children to increase physical activity, improve nutrition, get more sleep, and reduce media use.
A new study found that preschool children with tooth decay are more likely to be overweight or obese than the general population. The study also discovered that both normal-weight and overweight children consume excessive calories, regardless of their weight status.
Children of mothers with high blood sugar during pregnancy are more likely to have low insulin sensitivity, a risk factor for type 2 diabetes. Obesity does not account for the association, and children exposed to high maternal blood sugar levels in the womb also exhibit exaggerated insulin secretion after meals.
Women who experience early menopause are more than twice as likely to have a heart attack, stroke, or other cardiovascular disease event later in life. The study also found that early menopause remained a risk factor even after controlling for hormone replacement therapy and major cardiovascular risk factors.
Menopausal hormone therapy may offer significant benefits to some women, particularly those starting treatment a short time after menopause. The Endocrine Society's new statement suggests that MHT can lead to a 30-40% decrease in mortality and a 90% reduction of menopausal symptoms.
A new study reveals that oral micronized progesterone relieves hot flashes and night sweats in postmenopausal women, with a 56% improvement rate. The natural hormone form offers an effective alternative to estrogen for those who cannot or prefer not to use it.
A new study finds women with polycystic ovary syndrome (PCOS) have higher bisphenol A (BPA) blood levels, associated with increased male hormones and reproductive problems. The study suggests that women with PCOS should limit their exposure to BPA due to its potential adverse effects on hormone balance.
A new study by The Endocrine Society reveals that chemicals remaining in Boulder Creek after wastewater treatment change the gender of fish. Native male fish were found to be feminized, with intersex individuals also present downstream of the wastewater treatment plant.
A new study conducted in animals found that early life exposure to BPA may cause long-lasting harm to testicular function. The study showed that even low levels of BPA exposure during critical developmental periods can lead to decreased testosterone secretion in male offspring.
A study found that ghrelin hormone increases the appeal of high-calorie foods over low-calorie foods, suggesting a potential mechanism for weight loss. Ghrelin levels may help regulate calorie intake by altering food preferences during fasting periods.