Mesenchymal stem cells exhibit significant cell-to-cell variation in their capacity to survive upon implantation. The Tulane professor's three-year project aims to gain insight into the molecular mechanisms underlying this variation, with the goal of improving survival rates and advancing regenerative therapies.
Researchers found that moderate and vigorous exercise reduce intrahepatic triglyceride content, a key indicator of NAFLD, with no significant difference between the two. Exercise also leads to significant weight loss and reduced body fat mass in patients with obesity.
Researchers have identified how low testosterone raises diabetes risk by impairing insulin regulation in the pancreas. Testosterone triggers key signaling mechanisms that produce insulin, and its absence leads to glucose intolerance.
A Tulane University study found cities hosting Super Bowl teams experience a 18% increase in flu deaths among those over 65, due to increased transmission at social gatherings.
A new study has developed a painkiller that targets the same opioid receptor as morphine but with fewer side effects. The peptide-based drug produced longer pain relief without respiratory depression and impaired motor coordination, unlike morphine.
Researchers at Tulane National Primate Research Center are working on a new tuberculosis vaccine by modifying Mycobacterium tuberculosis to lose stress response gene SigmaH. Monkeys vaccinated with the modified strain showed better resistance to infection and protective immune responses in their lungs.
A new study by Tulane University reveals that exposure to light at night can render breast cancer cells resistant to tamoxifen. In contrast, complete darkness and high melatonin levels significantly slow tumor growth and enhance tamoxifen's effectiveness.
A new treatment for severe hemophilia A patients with inhibitors has been shown to be highly effective in preventing bleeding events. The study, published in the New England Journal of Medicine, found that FEIBA infused three times a week resulted in a 62% reduction in all bleeding events and a 72% reduction in target joint bleeding.
Scientists have discovered that Simian Immunodeficiency Virus (SIV), an ancestor of HIV, is thousands of years old, challenging previous estimates. The research suggests SIV may be even older than a million years and has implications for understanding the origin of HIV.
Tulane University will establish an International Center of Excellence in Malaria Research for West and Central Africa, aiming to achieve malaria control in the region. The seven-year project will involve 48 investigators from 10 institutions, including four African partners.
Eliminating malaria from Hispaniola would demonstrate the feasibility of global eradication efforts. The authors recommend advanced mosquito control methods, diagnosis systems, and community education to combat the parasite. Success requires unwavering political will from both governments.
A large population-based study of diabetes in China estimates that 92.4 million adults age 20 or older have diabetes, while 148.2 million adults have prediabetes, a key risk factor for cardiovascular disease. The researchers recommend national strategies for preventing, detecting and treating diabetes.
Researchers at Tulane University aim to evaluate antibodies from patients infected with the Lassa virus to develop a vaccine or treatment. The goal is to better understand how these antibodies neutralize the virus and ultimately prevent or treat the deadly disease.
The Tulane Cancer Center is conducting a phase III randomized clinical trial for Alpharadin, an injectable treatment targeting radioactive substance Radium-223. Early trials suggest it may prolong survival for men with bone metastases from prostate cancer.
Ruth's Hospitality Group, Inc. donates the site of its New Orleans restaurant to Tulane University to create a neighborhood-based medical home providing care regardless of insurance status or ability to pay. The new center will serve over 1,200 patients per month and offer expanded services.
Tulane University is partnering with South American universities to address the high burden of cardiovascular disease in the region, which claims one-third of chronic disease deaths. The new center will focus on research, training, and health education to prevent and treat CVD through quantitative methods and skills development.
Researchers aim to identify genetic signals for regeneration in salamanders, a model for human limb growth, with the goal of developing therapies to enhance regenerative response. The team hopes to create a comprehensive database of genes involved in regeneration to inform how to coordinate complex structures in humans.
Researchers at Tulane University are developing detection kits for Lassa viral hemorrhagic fever, which affects 300,000-500,000 people annually in West Africa, causing 5,000 deaths. The $7.07 million NIH grant will help complete the development and commercialization of these kits to aid public health and bioterrorism defense.
A new study offers insights into Uganda's post-conflict reconstruction, highlighting the need for accountability, truth commissions, and economic development. The research suggests that a majority of respondents believe peace can be achieved in northern Uganda, but social infrastructures and livelihoods require rebuilding.
Hurricane Katrina's impact on Gulf Coast forests can cancel out a year's worth of new tree growth in other parts of the country. The study found that 320 million trees were killed or severely damaged, releasing significant amounts of carbon into the atmosphere.
A recent study published in The Journal of Immunology found that SIV infection in monkeys does not always lead to AIDS, contradicting current thinking. Researchers propose that host/virus co-adaptation enables monkeys to limit T cell immune activation and apoptosis, a mechanism that contributes to disease progression.
Tulane University will receive $14 million to train public health workers and establish monitoring systems in Ethiopia, while also supporting programs in Haiti, Brazil, South Africa, and other high-risk countries. The grant aims to rebuild infrastructure and combat the spread of HIV/AIDS in these countries.
A Tulane University study examines the relationship between alcohol consumption and stroke risk in a large sample of Chinese men, finding that heavy drinking increases the risk of stroke. The research reveals that even moderate levels of alcohol intake can lead to higher risk of death by stroke.
A Tulane University/University of California-Berkeley study reveals that people exposed to war crimes are more likely to choose violent means to achieve peace. The survey of 2,585 adults in northern Uganda found that those with PTSD and depression symptoms were less likely to support nonviolent methods.
A Tulane University study published in the American Journal of Epidemiology found a significant association between cigarette smoking and erectile dysfunction. The research suggests that quitting smoking may help reduce the risk of erectile dysfunction, with estimated 22.7% of cases potentially attributable to cigarette smoking.
A Tulane University study suggests that bats may have been responsible for the origin of the deadly Marburg hemorrhagic fever outbreak in the Democratic Republic of Congo. The research identified multiple genetic variants of the virus, indicating repeated introductions from a primary reservoir rather than person-to-person spread.
A recent study in Zambia found that abstinence messages were not enough to prevent HIV infection among unmarried women aged 13-20. Women from more conservative denominations abstained longer and had lower rates of condom use during first sex, highlighting the need for targeted prevention strategies.
Researchers will explore ways to harness the body's natural healing process to heal deep wounds, including bone, muscle, nerves, and soft tissues. The goal is to develop regeneration of tissue in humans, inspired by the salamander's ability to fully restore lost tissue.
A recent study by Tulane University has shown that vaginal gels containing microbicides can effectively prevent HIV transmission in monkeys. The researchers tested three compounds, which were found to be effective when used alone or in combination, with minimal side effects.
Tulane University has received $4.1 million to continue its work on the President's Emergency Plan for AIDS Relief in several countries. The university will also conduct a five-year study on liver cancer due to liver fluke infection in Southeast Asia.
Researchers at Tulane University have received a multi-million dollar grant to develop diagnostic tests for hemorrhagic fevers, such as Lassa fever. The goal is to create tests that can be performed in biosafety level 1 labs, making them accessible in West Africa.
The Tulane Primate Center is expanding its facilities with a new grant, providing state-of-the-art housing and nursery facilities for monkeys. The center will also establish a national nonhuman primate breeding colony resource to meet increasing demand for these animals.
Diabetics with hypertension can significantly reduce cardiovascular disease risks by taking diuretics, according to a new study. The medication has been shown to be more protective against heart failure and stroke in patients with diabetes and high blood pressure.