Researchers create strategy to trick ATM gene into overlooking premature termination codons, restoring full-length protein production and alleviating symptoms. The treatment uses aminoglycosides to make PTCs invisible to the cell's machinery, showing promise for halting disease progression and cancer risk in A-T patients.
Researchers at UCLA have discovered a new mechanism in bacteriophages that allows them to rapidly evolve new variants to target bacterial resistance. This discovery has the potential to create
A UCLA/UA study reveals that the ear plays a crucial role in processing auditory signals, influencing speech and language development. The left ear provides extra amplification for tones like music, while the right ear enhances rapid sounds like speech.
Researchers found that two prokaryotes merged to form the first eukaryote, creating a 'ring of life' that has significant implications for all multicellular forms of life. The study sheds light on the origins of eukaryotes and their genetic background.
A UCLA study found that a diet rich in DHA, an omega-3 fatty acid, dramatically reduces the impact of the Alzheimer's gene and prevents synaptic brain damage. Consuming more DHA can be easily controlled through food choices such as fish, eggs, or supplements.
African-Americans and Asians are less likely to trust the public health system's response to a bioterrorist attack. The UCLA study found that only 63% of African Americans and 68% of Asians/Pacific Islanders believe the system would respond fairly.
A UCLA study of 1308 seniors found that 24% reduced or discontinued medications due to out-of-pocket costs. Many struggled to pay for essential medications and rent/bills.
Researchers found that a specific adult stem cell travels to the lung through the bloodstream and produces collagen, leading to scar tissue formation. Blocking this mechanism may reduce pulmonary fibrosis, offering new treatments for related disorders like rheumatoid arthritis.
A UCLA study found that HIV-coping programs for families with infected parents reduced dropout rates, teenage pregnancy, and public welfare claims among children. The program also improved mental health outcomes and social relationships.
A UCLA team successfully controlled and detected a single electron's spin in an ordinary commercial transistor chip. This achievement demonstrates that conventional silicon technology is adaptable enough to accommodate the future electronic requirements of new technologies like quantum computing.
A study published in Science reports the effectiveness of a new compound, BMS-354825, against Gleevec-resistant Chronic Myeloid Leukemia (CML) cells. The compound targets secondary mutations that allow cancer to evade therapy, offering hope for patients who have relapsed on Gleevec.
Researchers used MRI to study myelin insulation in brain connections, finding they deteriorate three times faster in older adults with Alzheimer's disease. This breakdown disrupts brain function and leads to cognitive decline.
Researchers found that obese individuals have disrupted ghrelin patterns, with lower blood levels at night, contradicting common expectations. This discovery may lead to new targets for treating obesity and explore drugs that make people more sensitive to their internal cues.
Researchers recreated mammalian cell self-organization patterns in a test tube using mathematical formulas dictating cell interactions. This may help improve tissue regeneration methods and understand mechanisms behind birth defects and heart disease.
The UCLA-Maryland Center for Multiscale Plasma Dynamics will investigate three plasma mysteries: sawteeth, tearing instabilities, and transport barriers. The research aims to improve the performance of the international thermonuclear experimental reactor (ITER) and develop a safe, nearly limitless energy source.
The study shows that quality of childhood healthcare is good, but parents express a need for key child development issues. Parent satisfaction ratings are strongly related to the care received, increasing with more time, in-depth discussions, and family-centered care.
Researchers found that combining Avastin with chemotherapy improves median survival, reduces risk of death and increases response rates in patients with advanced colorectal cancer. The study showed a nearly five-month improvement in patient survival, demonstrating the potential of targeting tumor blood supply as a viable treatment option.
A new study explores the context of Coach Wooden's practices, revealing that meticulous planning and economy of talk were key to his pedagogical approach. The research also sheds light on Wooden's views on praise, teaching by example, and the importance of creating opportunities for players to learn.
Researchers at UCLA successfully synthesized three identical, mutually interlocking Borromean rings around six metal templates. The complex seven-step synthesis required the use of computational chemistry and a high-risk approach.
Researchers found that moderate exercise, combined with antioxidant vitamins C and E and the amino acid L-arginine, significantly reduced atherosclerosis lesions by 40% compared to high cholesterol diet alone. Exercise also lowered blood pressure and prevented unwanted blood clotting.
Researchers found a synergistic effect between Herceptin and chemotherapy agents, increasing tumor shrinkage in 79% of patients. The combination also showed unusually long times to progression, providing hope for improved breast cancer treatment options.
Researchers at UCLA deciphered the mystery of distant memory recall using a three-pronged experiment. They found that the anterior cingulate plays a special role in keeping early memories alive, while kinase II is critically involved in preserving our oldest memories.
Researchers create peptide coatings that disguise particles, allowing them to track proteins in live cells. This technology enables molecular-level studies and has potential applications in biology, medicine, and electronics.
A UCLA study found that providing Head Start parents with easy-to-understand health-care guidance can lead to significant reductions in emergency room and clinic visits, resulting in cost savings for Medicaid. The study showed a 48% reduction in unnecessary ER visits and a 37.5% decrease in clinic visits for routine illnesses.
Researchers at UCLA have made a groundbreaking discovery about the biology of fear, finding that yohimbine accelerates the process of overcoming conditioned fear in mice. By enhancing the effects of natural adrenaline release, yohimbine allows mice to overcome their fear four times faster than those treated with vehicle or propanolol.
A UCLA study finds that FoxP1 and FoxP2 genes shared by humans and songbirds may play a critical role in human speech and speech disorders. The study suggests that understanding these genes could lead to new medications for speech disorders.
A novel model of human brain aging identifies midlife breakdown of myelin as a key factor in the onset of Alzheimer's disease later in life. Lifestyle changes, hormone replacement therapy, education, and treatment with common medications may help prevent myelin degradation.
A study by UCLA researchers found that individuals with shy personalities tend to have higher viral loads and faster disease progression, even on antiretroviral therapy. This suggests that high-stress individuals may be more susceptible to HIV replication due to their heightened nervous system response.
A randomized, double-blind study found that baclofen significantly reduced cocaine use in recovering addicts when used with substance abuse counseling. The study monitored 70 outpatients for 16 weeks and showed a decrease in recent cocaine use compared to the placebo group.
A recent UCLA study found that bullying is a widespread issue in schools, with up to 18% of students experiencing it. The study reveals that bullies are often popular and respected, while victims suffer from depression, social anxiety, and loneliness.
A recent UCLA study found that Caribbean island lizards share genetic material due to ocean currents, which carry them from one island to another. This challenges the long-held assumption that species on separate islands evolve independently.
Research using fMRI scans found left-hemisphere activation in infant brains during speech stimulation, suggesting early language lateralization. The study challenges the long-held assumption that language dominance is progressive until puberty.
Researchers have made a breakthrough in understanding the origin of pediatric brain tumors, finding that they may develop from cells with characteristics similar to neural stem cells. This new perspective on brain cancer could lead to improved diagnostic tests and treatments.
The partnership aims to address unequal burden of cancer on minority communities by providing access to clinical trials and strengthening cancer research programs. The collaboration will enhance cancer treatment capability and produce healthier outcomes for patients in South Central Los Angeles.
A new UCLA test measures HDL cholesterol's ability to reduce inflammation, potentially better predicting heart disease risk. The study found that patients with pro-inflammatory HDL had a higher risk of heart disease despite normal or high cholesterol levels.
A UCLA study has found that younger women with breast cancer often experience persistent energy loss and psychological difficulties, despite overall good quality of life. The study highlights the need for targeted interventions to support these subgroups.
Researchers found that more socially involved female baboons had higher reproductive success rates and lower infant mortality. This contradicts the long-held assumption that social relationships are only beneficial for mothers.
A new study reveals that PET scans can significantly improve the accuracy of predicting Alzheimer's disease progression in patients with early memory complaints. By analyzing brain metabolic patterns, doctors can better diagnose and intervene earlier, potentially delaying cognitive decline.
Researchers found that men's brains showed greater activity in cognitive regions when given pain stimuli, while women's brains responded more strongly in limbic regions. These differences may have evolved due to distinct roles of men and women in stress responses, with women's brains being more nurturing and protective.
A nationwide initiative aims to support nursing staff in quitting smoking, with $100 free services and partnerships with organizations. The program seeks to expand nursing leadership in tobacco control, addressing a long-standing barrier in the profession.
A UCLA study found 54 genes produced differently in male and female mouse brains prior to hormonal influence, suggesting genetic influences on sexual differences. The research may help explain why people feel male or female and inform the development of treatments for intersex infants.
Researchers found that social exclusion activates the same part of the brain as physical pain, leading to elevated activity in the anterior cingulate cortex. The study's authors theorize that this automatic response evolved to protect human survival and well-being.
A randomized, controlled clinical trial found that Tai Chi Chih increased immunity to the varicella zoster virus in older adults at risk for herpes zoster. The study showed significant improvements in both immunity and physical functioning without any negative effects.
A team of researchers used a computer game to study human navigation, identifying distinct brain cells responsible for spatial mapping (place cells) and goal-directed behavior (goal cells). The study demonstrates that humans use both visual and cognitive processes to navigate their environment.
The University of California, Los Angeles (UCLA) has received a significant National Science Foundation (NSF) award for its plasma research, enabling the development of new computational infrastructure and innovation. The NSF funding will support key areas of research, including fusion energy, astrophysics, and space weather.
A UCLA study discovered that fatigued breast cancer survivors have increased levels of circulating T lymphocytes and CD4+ T cells, which correlate with elevated inflammation markers. The findings suggest an immunologic basis for fatigue in breast cancer survivors.
A UCLA study reveals a significant shortage of surgeons is looming due to an aging population. The study finds that surgeries performed on older adults will have the highest increase in demand by 2020, with ophthalmology leading the way.
A new UCLA study suggests that coronary heart disease may be accelerated in younger HIV-infected people. The research found that the rate of coronary heart disease in young HIV-positive men and women was significantly higher than in their HIV-negative counterparts.
The UCLA Center for Astrobiology will focus on four themes: extrasolar planetary systems, habitability of planets and their satellites, Earth's early environment and life, and evolution of biological complexity. The center aims to detect planets beyond our solar system using new methods and study the factors that control habitability.
A UCLA-led study found that individuals with bipolar depression who continued taking antidepressants in conjunction with mood stabilizer medication after remission had a lower risk of depression relapse. The study's lead author, Dr. Lori Altshuler, suggests guidelines similar to those for unipolar depression may be more effective.