Researchers demonstrated that microneedle patches can deliver clinically-relevant doses of drugs like naltrexone, reducing side effects and required dosage. The study also found lower production of metabolites, which may cause adverse reactions.
Recent studies confirm oatmeal's ability to lower total cholesterol levels and reduce LDL 'bad' cholesterol without adverse effects. Whole-grain oats are also linked to improved blood pressure, Type 2 diabetes, and weight management outcomes.
A new study found that levo-thyroxine treatment did not lower weight or BMI in children with acquired hypothyroidism. Most subjects gained weight, while about a third experienced short-term weight loss due to extremely severe cases of the disease.
A team of researchers has discovered a tumor-suppressor gene called Par-4 that kills cancer cells but not normal cells. The mice born with this gene live longer and have no toxic side effects, making it a potentially therapeutic application for treating cancer without harming patients.
The University of Kentucky Center for the Study of Violence Against Children has been awarded a four-year, $1.6 million grant to develop and disseminate evidence-based practices for treating traumatic stress in children exposed to violence. The project will establish a clinical training institute and train regional partners to deliver ...
COPD is a leading cause of morbidity and mortality globally, with smoking being a primary risk factor. The International Burden of Lung Disease (BOLD) Study found that eastern Kentucky had one of the highest rates of COPD in the world.
A study by the University of Kentucky found that OTC strength orlistat (Alli) resulted in significant weight loss, with participants losing approximately 7-15 pounds over four months. The study also demonstrated a reduction in LDL-cholesterol and associated heart health benefits.
A University of Kentucky study finds that doses higher than a baby aspirin may not prevent cardiovascular events and increase bleeding risk. The research suggests that using the minimum effective dose of 75-81 mg may be optimal for most patients.
Jeffrey L. Osborn, a University of Kentucky professor, has been named the 2007 Arthur C. Guyton Teacher of the Year by the American Physiological Society for his classroom teaching and research on renal sodium and water balance. He received a $1,000 honorarium and funding to attend an APS meeting.
UK pharmaceutical sciences graduate student Abby Ho and assistant professors Kyung-Bo Kim and Royce Mohan developed a new compound dubbed UK-101 that acts directly on LMP2, a component of the immune proteasome variant abundantly expressed in certain tumors. The researchers found that UK-101 inhibits LMP2 while not attacking normal cell...
Dr. Jayakrishna Ambati's research on macular degeneration has led to a breakthrough discovery that may help patients fight the condition. With a $750,000 grant, Ambati will develop a phase 1 clinical trial to test new therapies for age-related macular degeneration.
A new five-year study published in the New England Journal of Medicine found that stable heart patients received no significant benefit from undergoing angioplasty compared to those treated with medication alone. The study showed a 19.5% rate of death, heart attack, and stroke among medication-only patients versus 20% for PCI recipients.
A new thrombin-receptor antagonist (TRA) has shown significant reduction in serious cardiovascular events, mainly heart attacks, with no increase in bleeding risks in a high-risk patient population. The study found a 46% lowering in serious cardiovascular events, an early and strong efficacy signal for this novel antiplatelet compound.
Research suggests that out-of-body experiences can occur during both sleep-wake transitions and near-death experiences, possibly due to brain arousal system disturbances. The study found a strong association between sleep paralysis and out-of-body experiences in near-death experience subjects.
Researchers at the University of Kentucky are exploring a novel gene therapy approach using DNA nanoparticles to deliver proteins beneficial to brain cells. This technology has shown potential in rescuing dormant brain cells, causing them to produce dopamine, and improving symptoms in animal models of Parkinson's disease.
A study found that Lexington's 100% smoke-free public places ordinance had no negative economic impact on the city. Employment at restaurants grew by 3% after the law was enacted, while bar employment remained stable. The findings support previous studies suggesting that smoke-free laws do not harm businesses.
A new study has identified a gene that regulates adult stem cell growth, which could lead to increased doses of chemotherapy and faster recovery times for cancer patients. The discovery also opens up possibilities for treating other diseases such as liver disease and diabetes.
The project, led by the University of Kentucky and the Kentucky Geological Survey, allows instruments to gather data on earthquakes' effects on bedrock and soil. The observatory will add new data to the existing network, helping geologists better define the earthquake hazard in the region.
The Commonwealth of Kentucky received a $400,000 SAMHSA grant to improve youth suicide prevention services. Dr. Julie Cerel, an assistant professor at the University of Kentucky, played a key role in securing the grant and will oversee its evaluation.
Patients with peripheral arterial disease (PAD) undergoing interventional heart procedures are at higher risk for dying within a week and experiencing complications such as blood clots and bleeding. The study analyzed nearly 20,000 patients and found PAD to be a strong predictor of life or death in these cases.
Scientists identified SFLT-1 as the protein responsible for preventing blood vessel growth in corneas. Deactivating this protein allows angiogenesis to occur, leading to conditions such as macular degeneration and cancer. The discovery opens doors to new treatments by harnessing the natural anti-angiogenic properties of the eye.
Project AGE provides master's students with field experiences and aging-rich training, focusing on individual, community, and policy issues. The program aims to educate leaders in geriatrics to meet the needs of an increasingly older population and their families.
A three-year project led by geologist Brandon Nuttall found that the deeper parts of Devonian black shales in Kentucky could store up to 28 billion tons of injected CO2. The analysis of 43 shale samples from recent drilled wells indicates that the area alone could sequester 6.2 billion tons of CO2.
Scientists at the University of Kentucky are testing a lotion that stimulates melanin production, reducing UV damage and increasing skin protection. The treatment has promising results, offering an alternative to traditional sunless tanning products and tanning beds.
A new study published in the New England Journal of Medicine found that a specific drug, enoxaparin, significantly reduces major bleeding risks during stent and angioplasty procedures. The researchers also showed that patients receiving this drug were more likely to achieve optimal blood thinning levels.
The new guidelines offer 13 principles for rehabilitating drug offenders, aiming to reduce recidivism and crime rates. Implementing evidence-based treatment programs can lead to significant financial savings, with every dollar spent on addiction treatment resulting in a four to seven dollar reduction in community spending.
As heart procedures increase, it's essential to monitor success of new treatments and technology to keep costs down and quality high. Financial incentives from insurance companies and peer review teams can help improve care while reducing expenses.
A study published by the University of Kentucky found that smokers with chronic pain tend to smoke at higher rates than those without pain. However, over half of these smokers are considering quitting. The research suggests that addressing smoking cessation as part of pain management could lead to improved health outcomes.
Dr. Ambati, a University of Kentucky researcher, has received the prestigious 2006 Lew R. Wasserman Award for his work on age-related macular degeneration. The award comes with a $55,000 grant to support his research and will be used to hire additional staff.
Researchers at the University of Kentucky have developed a blood test to detect lung cancer in early stages, showing 90% accuracy in predicting non-small-cell lung cancer. The test identifies the body's immune response to tumors and could become the first blood test to predict cancer since the PSA test was introduced.
A recent study by UK researcher Cerel explores the connection between parental death and psychiatric problems in children. The results indicate that while bereavement has a negative impact, it is less severe than clinical depression.
Abdominal aortic aneurysm affects 78.8 million baby boomers, with over half at risk by age 50; researchers seek pharmacological solution with $8.5M NIH funding.
A new curriculum at the University of Kentucky aims to teach healthcare professionals to evaluate and prescribe medications in a cost-effective manner, reducing influence from pharmaceutical marketing. The program will be taught online and in classrooms to medical students, physician assistants, and practicing clinicians.
A UK study found that saliva can be tested for signs of periodontal disease, a condition characterized by persistent inflammation and tissue breakdown. The research team identified biomarkers in saliva that could aid in diagnosing and monitoring the disease.
The UK College of Social Work is launching a quality improvement center to study the effects of private agencies on child welfare services. Research and demonstration projects will be conducted to test the effectiveness of selected privatization models.
A UK researcher found that VEGF promotes angiogenesis in macular degeneration, but also has an anti-angiogenic effect via SPARC. Controlling SPARC levels may be key to controlling angiogenesis in diseases like cancer. This discovery opens new avenues for treating diseases related to angiogenesis.
A University of Kentucky researcher has identified bioactive fragments of complement C3 and C5 as causal markers of age-related macular degeneration (AMD) progression. These components stimulate the development of wet AMD, and their presence in drusen may indicate high risk for progression.
A promising new therapy has been approved by the FDA for patients with moderate to severe ulcerative colitis, offering improved lives through reduced inflammation and increased mobility. Nearly 70% of patients experienced clinical response and remission within a year of treatment.
Researchers at the University of Kentucky have discovered a way to significantly reduce the power consumption of transistors in computer chips by applying rapid thermal processing directly on gate insulators. This technique can improve the insulating qualities of gate insulators, reducing direct tunneling current by up to 100,000 times.
Researchers at the University of Kentucky developed carbon nanotube membranes that allow for fast transit approaching the speed of biological channels. The membranes' scalable fabrication enables industrially useful chemical separations.
Researchers at UK and ChemPharma aim to develop an effective treatment for inclusion in the Strategic National Stockpile by creating orally administered dosage formulations. The project, funded by $1,204,374 over 21 months, seeks to improve distribution and administration of radioprotective drugs during mass exposure situations.
A new study finds that a lower dose of orlistat can help overweight individuals lose weight and improve their health. The medication, supported by over 100 clinical studies, demonstrated significant weight loss and reductions in cholesterol and blood pressure.
Researchers at UK developed a new approach to controlling mosquitoes, which can prevent various forms of encephalitis including West Nile and malaria. The study was conducted in collaboration with colleagues from Johns Hopkins University.
Yates received $3,000 and a certificate, as well as covered travel expenses to the meeting, in recognition of his research in nuclear chemistry and radiochemistry. A five-day symposium will be held at the 2006 spring meeting of the American Chemical Society (ACS) in Atlanta.
A University of Kentucky professor has received the prestigious Young Investigators Award in recognition of their groundbreaking work in biophysics. The award honors their dedication to advancing the field through innovative research and contributions.
Researchers found direct decompressive surgery plus postoperative radiotherapy to be the most effective treatment, enabling 84% of patients to walk after treatment. This approach also reduced dependence on corticosteroids and opiod analgesics, showing significant benefits for patients with metastatic cancer.
Carol Jordan, director of the UK Center for Research on Violence Against Women, is being honored with a national justice award for her 23-year career in helping women and children who have faced sexual assault, intimate partner violence, child abuse, stalking, and other crimes. The $10,000 award will support endowment efforts to establ...
The 'I'm a Kid Too' project engages adoptive children with severe medical diagnoses in photo-documentation, promoting healing and self-expression. The program also educates healthcare professionals through visual storytelling, aiming to treat children as individuals, not just diagnoses.
The Kentucky Geological Survey is involved in global climate change research, studying opportunities to sequester carbon in the Midwest and Southeast regions. The survey will continue to examine subsurface formations for carbon storage and investigate coal seams along the Virginia-Kentucky border.
Researchers found that soy-based meal replacements led to greater weight loss and improved cholesterol levels compared to milk-based alternatives. Additionally, soy intake was shown to reduce serum glucose values, suggesting a role in maintaining overall health and slowing diabetes development.